Digital Commons Network^™

Rediscovery Of A Lost Paratype Of The Boulder Darter, Etheostoma Wapiti, Michael H. Doosey

Southeastern Fishes Council Proceedings

No abstract provided.

Molecular Staging Of Node Negative Patients With Colorectal Cancer., Terry Hyslop, Scott A Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Metastatic disease is the principle cause of death from colorectal cancer. In that context, the most significant indicator of overall survival and therapeutic response to adjuvant chemotherapy is the presence of metastatic tumor cells in regional lymph nodes. Although histopathologic analysis of lymph nodes is central to all colorectal cancer staging paradigms, its prognostic and predictive value is limited. Indeed, about 30% of patients with histopathology-negative lymph nodes (pN0) die from metastatic disease, reflected by microscopic lymph node metastases that are overlooked by standard techniques. These unrecognized tumor cells are especially important when considering racial disparities in outcomes in colorectal …

Loss Of Mef2d Expression Inhibits Differentiation And Contributes To Oncogenesis In Rhabdomyosarcoma Cells., Meiling Zhang, Jamie Truscott, Judith Davie

Articles

BACKGROUND: Rhabdomyosarcoma (RMS) is a highly malignant pediatric cancer that is the most common form of soft tissue tumors in children. RMS cells have many features of skeletal muscle cells, yet do not differentiate. Thus, our studies have focused on the defects present in these cells that block myogenesis.

METHODS: Protein and RNA analysis identified the loss of MEF2D in RMS cells. MEF2D was expressed in RD and RH30 cells by transient transfection and selection of stable cell lines, respectively, to demonstrate the rescue of muscle differentiation observed. A combination of techniques such as proliferation assays, scratch assays and soft …

Exploring Linkages Between Consumer Food Co-Operatives And Domestic Fair Trade In The United States, Leslie Duram

Publications

Consumer Food Co-operatives (co-ops) have provided consumers an alternative to corporate supermarkets and big-box stores since the 1960s. Producers seeking broader marketing opportunities often turn to co-ops. This study examines how, within Alternative Food Networks (AFNs), co-ops play a role in the emergence of the Domestic Fair Trade movement in the US. The Domestic Fair Trade (DFT) movement is based on the idea that family farms and small- to mid-sized farms in the global north are facing many of the same pressures as producers in the global south. The Domestic Fair Trade Association (DFTA) in the United States is the …

Additional Quantitative Trait Loci And Candidate Genes For Seed Isoflavone Content In Soybean, M Akond, Bazelle Richard, Bobby Ragin, Harmin Herrera, Umerah Kaodi, Cevdet Akbay, Stella K. Kantartzi, Victor Njiti, Abdelali Barakat, Khalid Meksem, David A. Lightfoot, My Abdelmajid Kassem

Articles

Seed isoflavone content of soybean (Glycine max L. Merr.) is a trait of moderate heritablity and an ideal target for marker selection. To date over 20 QTL have been identified underlying this trait among seven populations. The objectives of this study were to identify additional QTL and candidate genes controlling isoflavone content in a set of recombinant inbred line (RIL) populations of soybean grown in two different seasons. Variations of isoflavones namely daidzein, glycitein and genistein contents over two growing seasons and locations suggests that isoflavones are influenced by both genes and environments. Six QTL were identified on five …

Intrinsic Disorder In Pten And Its Interactome Confers Structural Plasticity And Functional Versatility, Prerna Malaney, Ravi Ramesh Pathak, Bin Xue, Vladimir N. Uversky, Vrushank Davé

Molecular Medicine Faculty Publications

IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have identified tumor suppressor PTEN as an intrinsically disordered protein (IDP) and elucidated the molecular principles by which its intrinsically disordered region (IDR) at the carboxyl-terminus (C-tail) executes its functions. Post-translational modifications, conserved eukaryotic linear motifs and molecular recognition features present in the C-tail IDR enhance PTEN's protein-protein interactions that are required for its myriad cellular functions. PTEN primary and secondary interactomes are also enriched in IDPs, most being cancer related, revealing that PTEN functions …

Alpha 1-Antichymotrypsin, An Inflammatory Protein Overexpressed In The Brains Of Patients With Alzheimer’S Disease, Induces Tau Hyperphosphorylation Through C-Jun N-Terminal Kinase Activation, Ethika Tyagi, Tina Fiorelli, Michelle Norden, Jaya Padmanabhan

Molecular Medicine Faculty Publications

The association of inflammatory proteins with neuritic plaques in the brains of Alzheimer’s disease (AD) patients has led to the hypothesis that inflammation plays a pivotal role in the development of pathology in AD. Earlier studies have shown that alpha 1-antichymotrypsin (ACT) enhances amyloid beta fibrillization and accelerated plaque formation in APP transgenic mice. Later studies from our laboratory have shown that purified ACT induces tau hyperphosphorylation and degeneration in neurons. In order to understand the mechanisms by which inflammatory proteins enhance tau hyperphosphorylation, we injected interleukin-1β (IL-1β) intracerebroventricularly into mice expressing human ACT, human tau, or …

The Growing Pains Of Graham V. Florida: Deciphering Whether Lengthy Term-Of-Years Sentences For Juvenile Defendants Can Equate To The Unconstitutional Sentence Of Life Without The Possibility Of Parole, Therese A. Savona

St. Thomas Law Review

This article will provide a basic understanding of Eighth Amendment jurisprudence and then explores how the most recent United States Supreme Court cases of Graham v. Florida and Miller v. Alabama affect juvenile resentencing. Additionally, this article addresses the most recent trend presented in juvenile cases where the juvenile defendant is charged as an adult, tried as an adult, and sentenced accordingly. Specifically, the issue of a lengthy term-of-years sentence in states such as California and Florida appear to be the battleground of diverse opinions, more so perhaps than other states.

Biology Department Newsletter, No. 3, Sacred Heart University

Biology Newsletter

No abstract provided.

This Is What Democracy Looks Like: Art And The Wisconsin Uprising, Kim Cosier

Journal of Social Theory in Art Education

In February of 2011, an enormous popular political movement came to life in Wisconsin. For many people who were engaged in the month-long occupation of the Capitol in Madison, the Wisconsin Uprising was their first experience with direct political action. For the artists who are the focus of this article, taking part in the Wisconsin Uprising seemed like a natural outgrowth of their many years of socially engaged artmaking. In this article, I offer a brief overview of the Wisconsin Uprising followed by a discussion of the contributions of the artists in the protests in the context of their larger …

The Xenopus Lefty (Xlefty) Prodomain Negatively Regulates Xlefty Activity And Is Necessary For Proper Xlefty Secretion, Adrian Amelio Vasquez

Wayne State University Theses

In vertebrates, the TGF #914; superfamily of secreted peptides are stringently regulated since they are responsible for multiple cell processes and behaviors that give rise to the proper patterning of embryonic tissues. Examples of members of the TGF #914; superfamily are Nodal and Lefty. Dysregulation of these proteins can lead to many diseases and developmental syndromes in humans.

Lefty functions by antagonizing Nodal an essential organizer signal that patterns dorsal mesoderm and the embryonic axes. Loss of Lefty expression results in excess Nodal signaling which has been shown to cause several perturbations including metastatic cancer. Although studies have clearly shown …

Exploring The Dynamics Of Identity Based Conflict And The Possibility For Its Sustainable Management: A Study Of The Persistent Ethno-Religious Conflict In Wukari Area Of Taraba State, Nigeria, Jude A. Momodu, G.I. Matudi, Abiodun L. Momodu

Ethnic Studies Review

This article explores the dynamics of identity-based conflict and the possibility for its management. The study in particular focuses on the persistent ethno-religious conflicts in the Wukari Area of Taraba State, Nigeria. The real issues precipitating the persistent ethno-religious conflicts and the costs of the conflicts were clearly brought to the fore. The study proposes a new paradigm for managing social conflicts at the community level through the 'use of community solutions for community problems' which will involve the constructive participation of all of the stakeholders in the community. This paper concludes by making a proposal for the establishment of …

Professional Product Review Vol. 8 No. 2, American Dental Association, Council On Scientific Affairs

Professional Product Review

A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.

Ambient Air Pollutant Pm10 And The Risk Of Preterm Birth In Lanzhou, China, Nan Zhao

Public Health Theses

ABSTRACT

Background: Early studies have inconsistently linked ambient air pollutant PM₁₀ exposure during pregnancy to the risk of preterm birth. However, majority of early studies were based on registry data which could result in misclassification of exposure due to the lack of detailed home and work addresses, as well as failed to collect information on potential confounders. China has the world's most polluted cities and suffers the second largest burden of preterm births. Very few studies, however, have been conducted in China to investigate the association between PM₁₀ exposure and preterm birth. Building upon a birth cohort study …

Landscape Characteristics Of Upland Sandpiper Habitat In Michigan, Jacob Lawrence Korte

Wayne State University Theses

Grassland bird populations have declined across North America due to habitat loss but at a disproportionately higher rate in the midwestern United States, where extensive coverage of grasslands and other open land ecosystems have been converted to other land cover types. The upland sandpiper (Bartramia longicauda Bechstein, UPSA) is a migratory, area-sensitive, terrestrial shorebird that breeds in grasslands and other open land ecosystem types across their North American range. Although breeding habitats of the Great Plains contain the greatest concentrations of this species, anthropogenic openings such as hayfields and pastures serve as surrogate habitat elsewhere, as do remnant patches …

Protective Effects Of The Alcohol Dehydrogenase-Adh1b Allele, Neil Dodge

Wayne State University Theses

Alcohol dehydrogenase is a critical enzyme in the metabolism of alcohol. Expression of three alleles at the ADH1B locus results in enzymes that differ in turnover rate and affinity for alcohol. The ADH1B*3 allele, which appears to be unique to African Americans, is associated with more rapid alcohol metabolism than the more prevalent ADH1B*1 allele. It has been previously demonstrated that the presence of at least one maternal ADH1B*3 allele confers a protective effect against alcohol teratogenicity in African American infants and children. This study was conducted to determine whether the presence of the ADH1B*3 allele in the mother or …

Investigating The Metal Binding Affinity Of Bacterial Zinc Transporters: Zupt And Truncated Znta (Znta-Pina), Fei Nie

Wayne State University Theses

Zinc is essential trace elements for all living organisms and serves as cofactor and structural cofactors for more than 300 enzymes. ZupT is one of the members of ZIP super family of transporter proteins, which were identified as iron and zinc transporter in Eukaryotes at first. However, recent evidence showed that some of members can also transport other metal ions, such as manganese or cadmium, and ZIP proteins also exist in bacteria. ZupT is responsible for zinc uptake in E. coli; however, its full metal selectivity is not yet characterized. In addition, the mechanism of transport is also unknown. Therefore, …

Construction Of A Conceptualization Of Personal Knowledge Within A Knowledge Management Perspective Using Grounded Theory Methodology, Eric M. Straw

CCAC Theses and Dissertations

The current research used grounded theory methodology (GTM) to construct a conceptualization of personal knowledge within a knowledge management (KM) perspective. The need for the current research was based on the use of just two categories of knowledge, explicit and tacit, within KM literature to explain diverse characteristics of personal knowledge. The construct of tacit knowledge has often been explicated and debated in KM literature. The debate over tacit knowledge arose from the complex epistemological roots of tacit knowing and the construct of tacit knowledge popularized by organizational knowledge creation theory. The ongoing debate over tacit knowledge in KM literature …

Platonic And Stoic Passions In Philo Of Alexandria, Loren Kerns

Faculty Publications - Portland Seminary

Philo of Alexandria forged his theory of the soul and its passions while expositing the meaning of Torah. Though writing as a Jewish teacher and disciple of Moses, his biblical reflections display a strong orientation toward Middle-Platonic philosophy. On the topic of the soul and its passions, however, Philo also exhibits significant Stoic influence. The introduction notes Philo’s apparent incompatible use of both the complex Platonic and the monistic Stoic psychological models. After assessing the degree to which Philo understood 'passion' to be a type of Stoic impulse or opinion (chapter one), chapter two demonstrates that Philo consistently drew upon …

Social Media, Law, And The Practical Application Within The Entertainment Industry, Martin F. Frascogna, Adrienn Karancsi

MC Law Review

No abstract provided.

The Role And Value Of A Shadow Program In The Law School Curriculum, Robert Hornstein

MC Law Review

No abstract provided.

Beyond Abortion: Why The Personhood Movement Implicates Reproductive Choice, Jonathan Will

Journal Articles

In 2008, an amendment was proposed to the Colorado Constitution that sought to attach the rights and protections associated with legal “personhood” to any human being from the moment of fertilization. Although the initiative was defeated, it sparked a nation-wide Personhood Movement that has spurred similar efforts at the federal level and in over a dozen states. Personhood advocates choose terms like “fertilization,” or phrases such as “human being at any stage of development,” to identify the “person”-defining moment in the reproductive process, and these designations have profound implications for reproductive choice. Proponents are outspoken in their desire to outlaw …

Does Regulation Chill Democratic Deliberation? The Case Of Gmos, Alison Peck

Law Faculty Scholarship

Breakthroughs in science and technology pose a challenge to the U.S. legal system: either regulate under pre-existing laws using a business-as-usual approach, or pass new laws to deal with new relationships and conflicts created by these breakthroughs. How does the legal process determine when to regulate and when to legislate? Does that process adequately ensure deliberative democratic debate and implementation of democratic consensus? Does it adequately protect urgent interests in the meantime? Currently, this determination is ongoing with regard to new scientific developments such as climate change science, and new technological developments such as hydraulic fracturing of unconventional natural gas …

Pre-Binding Sites In The Mdr Of Cll: Potential Tumor Suppressor Regulation, Christine E. Cutucache, Javeed Iqbal, Philip Bierman, Robert Gregory Bociek, Dennis D. Weisenburger, Shantaram S. Joshi

Biology Faculty Publications

Chronic lymphocytic leukemia [CLL] is the most common adult leukemia and is heterogeneous in clinical presentation. CLL cases present with various chromosomal aberrations, including 11q23, 14q32, 17p, and trisomy 12, with the most common abnormality being deletion of 13q14 [1]. Although monoallelic deletion of 13q14 is common, there is a subset of patients who have complete nullisomy at 13q14, a locus that has been hypothesized to contribute to CLL pa thogenesis [2] due to loss of tumor suppressors [DLEU and miR-15a/16-1].We hypothesized that deletion of both copies of 13q14 would lead to uncontrollable proliferation …

Law Firm Malpractice Disclosure: Illustrations And Guidelines, Anthony V. Alfieri

Hofstra Law Review

Lawyers err every day, in hard and easy cases, in trials and transactions, and in large and small firms. By turns commonplace and noteworthy, the errors fall in both the private shadow and the public light of for-profit, nonprofit, and government practice. The literature of lawyer and, by extension, law firm error spans common law doctrines, state ethics rules and opinions, federal rules, practitioner treatises, restatements, and academic casebooks and commentaries. Despite the breadth of this literature, the intertwined problems of lawyer or law firm error and client malpractice disclosure remain unresolved and surprisingly underappreciated.

Against the backdrop of widening …

Applying The Revised Aba Model Rules In The Age Of The Internet: The Problem Of Metadata, Ronald D. Rotunda

Hofstra Law Review

When lawyers receive a document — whether hard copy or an electronic document — that they know the adversary sent them inadvertently (for example, a fax or email mistakenly sent to an adversary lawyer instead of to co-counsel), the black letter rule in Rule 4.4 requires the lawyer to notify the other side. However, this Rule does not require the receiving lawyer to return the document unread. Whether the receiving lawyer can use that document depends, in essence, on the law of evidence. If the court decides that the document lost its privileged status (perhaps because the sending lawyer acted …

Compartmentalized Thinking And The Clean Water Act, Christine A. Klein

UF Law Faculty Publications

Modern water pollution control traces back to the Federal Water Pollution Control Act of 1972 (Clean Water Act or CWA). Like other statutes of its period, the CWA addresses pollution of a single medium, water. Despite its goal of achieving aquatic integrity, the CWA succumbs to what this article refers to as “compartmentalized thinking.” That is, in drafting the CWA, Congress created a series of regulatory boxes that separate water into constituent parts recognized by law, but not by nature. Undertaking a deeper examination of the fragmentation instinct, this article turns to political theory and cognitive psychology for explanations. In …

Proceedings Of The Nebraska Academy Of Sciences: Anthropology

Nebraska Academy of Sciences: Programs and Proceedings

Presentations

A Marxist Approach to US Historical Archaeology: A Review and Summary of the History and Application of Marxism on the Field of Historical Archaeology in the US

John Collier, Anthropology, and the Indian New Deal

Colonoware and Culture: The Changing Interpretation of 17th Century Ceramic Traditions in the South Eastern United States

Creole Cottages and Garden Estates: Space and Purpose in Early New Orleans

Quality Control for In-field Photography: Digital Curationa and Non-collections of Artifacts

Assesing Lithics through Color Metrics

Refitting of Stone Artifacts Using Colorimetric Analysis

The Restroer of the Republic: An Analysis of Augustus’s Social, Moral, and …

Water-Use Strategies Of Japanese Knotweed (Fallopia Japonica), Lisa Nicole Cummins

Theses, Dissertations and Culminating Projects

Japanese knotweed, Fallopia japónica, is an herbaceous perennial that is invasive on many continents, including North America. Stands of Japanese knotweed are often located in riparian regions, disturbed sites, and along roadways. Recent studies have evaluated the impact of Japanese knotweed on the hydrologic cycle. Japanese knotweed may have the ability to markedly decrease stream discharge, potentially because of its high LAI. In the summer of 2010, a two-part study was conducted to determine the impact of water availability on the physiology and morphology of Japanese knotweed. A greenhouse study of Japanese knotweed measured transpiration and other factors that may …

Analyzing The Creative Problem-Solving Process: Inventing A Product From A Given Recyclable Item, Caralee K. Doak, Stacey M. Jambura, Jason A. Knittel, Audrey C. Rule

Curriculum & Instruction Faculty Publications

Detailed documentations of creative invention are scarce in the professional literature, but could be useful to those engaging in or studying the problem solving process. This investigation describes the creative process of graduate students (7 female, 4 male) in a problem-solving theory and practice course grappling with the task of creating products from four identical recyclable items that were circular, star-impressed bottoms of plastic juice bottles. Several popular models of the problem-solving process are compared to the participants’ steps in this invention problem. Participants first provided emotional reactions to the given ill-defined problem of making a product from the specified …