Digital Commons Network^™

Teaching And Learning In Communities Of Faith, Linda Vogel, Robert Countiss

Leaven

No abstract provided.

Faith Development Theory: Handmaid To Biblical Discipleship, Rick Grover

Leaven

No abstract provided.

The Power Of The "Broken" And "Unknown", Larry James

Leaven

No abstract provided.

A Lesson From Maasailand, Greg Johnson

Leaven

No abstract provided.

Mission Problems, Mission Decisions, Charles Coulston

Leaven

No abstract provided.

Children's Day With Nobody's Child, James W. Crisfield

Leaven

No abstract provided.

Mr. Sweet-And-Awful, Matthew Sullivan

Fishladder: A Student Journal of Art and Writing

No abstract provided.

Clergy And Gender In Medieval England: A Bioarchaeological Approach, Alexandra Nicole Busot

Open Access Theses

In the Middle Ages, masculinity could best be defined by the ability of a male to impregnate women, protect dependents and serve as a provider for one's family. With the Gregorian Reform of the eleventh century came a campaign against clerical marriage, which thereby effectively disallowed men of faith to perform the traditional masculine gender roles. The clergy, while biologically male, were seemingly emasculated by their vows of chastity and expected to perform tasks that in many cases were considered to be feminine. For these reasons, some medievalists have proposed that the unique role that these men performed should be …

Unleashing A “True” Pser-Mimic In The Cell, Kaushik Panigrahi, David L. Nelson, David B. Berkowitz

David Berkowitz Publications

In this issue of Chemistry & Biology, Arrendale and coworkers demonstrate a new prodrug strategy for intracellular delivery of an α, α-(difluoromethylene)phosphonate phosphoserine mimic. The deprotected pseudo-phosphopeptide releases the pro-apoptotic FOXO3a-transcription factor from its 14-3-3-adaptor protein complex, resulting in leukemic cell death.

Production Of Mycobacterial Cell Wall Glycopeptidolipids Requires A Member Of The Mbth-Like Protein Family, Elizabeth Tatham, Sivagami Sundaram Chavadi, Poornima Mohandas, Uthamaphani R. Edupuganti, Shiva K. Angala, Delphi Chatterjee, Luis E N Quadri

Publications and Research

Background Glycopeptidolipids (GPLs) are among the major free glycolipid components of the outer membrane of several saprophytic and clinically-relevant Mycobacterium species. The architecture of GPLs is based on a constant tripeptide-amino alcohol core of nonribosomal peptide synthetase origin that is N-acylated with a 3-hydroxy/methoxy acyl chain synthesized by a polyketide synthase and further decorated with variable glycosylation patterns built from methylated and acetylated sugars. GPLs have been implicated in many aspects of mycobacterial biology, thus highlighting the significance of gaining an understanding of their biosynthesis. Our bioinformatics analysis revealed that every GPL biosynthetic gene cluster known to date contains a …

Xprime-Em: Eliciting Expert Prior Information For Motif Exploration Using The Expectation-Maximization Algorithm, Wei Zhou

Theses and Dissertations

Understanding the possible mechanisms of gene transcription regulation is a primary challenge for current molecular biologists. Identifying transcription factor binding sites (TFBSs), also called DNA motifs, is an important step in understanding these mechanisms. Furthermore, many human diseases are attributed to mutations in TFBSs, which makes identifying those DNA motifs significant for disease treatment. Uncertainty and variations in specific nucleotides of TFBSs present difficulties for DNA motif searching. In this project, we present an algorithm, XPRIME-EM (Eliciting EXpert PRior Information for Motif Exploration using the Expectation-Maximization Algorithm), which can discover known and de novo (unknown) DNA motifs simultaneously from a …

Structure Of A Calcium-Dependent 11r-Lipoxygenase Suggests A Mechanism For Ca2+ Regulation, Priit Eek, Reet Järving, Ivar Järving, Nathaniel C. Gilbert, Marcia E. Newcomer, Nigulas Samel

Faculty Publications

Lipoxygenases (LOXs) are a key part of several signaling pathways that lead to inflammation and cancer. Yet, the mechanisms of substrate binding and allosteric regulation by the various LOX isoforms remain speculative. Here we report the 2.47-Å resolution crystal structure of the arachidonate 11R-LOX from Gersemia fruticosa, which sheds new light on the mechanism of LOXcatalysis. Our crystallographic and mutational studies suggest that the aliphatic tail of the fatty acid is bound in a hydrophobic pocket with two potential entrances. We speculate that LOXs share a common T-shaped substrate channel architecture that gives rise to the varying positional specificities. A …

Visualizing Spatiotemporal Dynamics Of Apoptosis After G1 Arrest By Human T Cell Leukemia Virus Type 1 Tax And Insights Into Gene Expression Changes Using Microarray-Based Gene Expression Analysis., Mariluz Araínga, Hironobu Murakami, Yoko Aida

Journal Articles: Pharmacology & Experimental Neuroscience

BACKGROUND: Human T cell leukemia virus type 1 (HTLV-1) Tax is a potent activator of viral and cellular gene expression that interacts with a number of cellular proteins. Many reports show that Tax is capable of regulating cell cycle progression and apoptosis both positively and negatively. However, it still remains to understand why the Tax oncoprotein induces cell cycle arrest and apoptosis, or whether Tax-induced apoptosis is dependent upon its ability to induce G1 arrest. The present study used time-lapse imaging to explore the spatiotemporal patterns of cell cycle dynamics in Tax-expressing HeLa cells containing the fluorescent ubiquitination-based cell cycle …

Potential Role Of Inorganic Polyphosphate In The Cycling Of Phosphorus Within The Hypoxic Water Column Of Effingham Inlet, British Columbia, Julia M. Diaz, Ellery D. Ingall, Samuel D. Snow, Claudia R. Benitez-Nelson, Martial Taillefert, Jay A. Brandes

Faculty Publications

[1] The upper basin of Effingham Inlet possesses permanently anoxic bottom waters, with a water column redox transition zone typically occurring at least 40 m above the sediment‐water interface. During our sampling campaign in April and July 2007, this redox transition zone was associated with sharp peaks in a variety of parameters, including soluble reactive phosphorus (SRP) and total particulate phosphorus (TPP). Based on sequential extraction results, TPP maxima exhibited preferential accumulation of an operationally defined class of loosely adsorbed organic phosphorus (P), which may contain a substantial fraction of polyphosphate (poly‐P). This poly‐P may furthermore be involved in the …

June 22, 2012 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Cannabis-Dependence Risk Relates To Synergism Between Neuroticism And Proenkephalin Snps Associated With Amygdala Gene Expression: Case-Control Study, Didier Jutras-Aswad, Michelle M. Jacobs, Georgia Yiannoulos, Panos Roussos, Panos Bitsios, Yoko Nomura, Xun Liu, Yasmin L. Hurd

Publications and Research

Background Many young people experiment with cannabis, yet only a subgroup progress to dependence suggesting individual differences that could relate to factors such as genetics and behavioral traits. Dopamine receptor D2 (DRD2) and proenkephalin (PENK) genes have been implicated in animal studies with cannabis exposure. Whether polymorphisms of these genes are associated with cannabis dependence and related behavioral traits is unknown. Methodology/Principal Findings Healthy young adults (18–27 years) with cannabis dependence and without a dependence diagnosis were studied (N = 50/group) in relation to a priori-determined single nucleotide polymorphisms (SNPs) of the DRD2 and PENK genes. Negative affect, Impulsive Risk …

Two Boundaries Separate Borrelia Burgdorferi Populations In North America, Gabriele Margos, Jean I. Tsao, Santiago Castillo-Ramirez, Yvette A. Girard, Anne G. Hoen

Dartmouth Scholarship

Understanding the spread of infectious diseases is crucial for implementing effective control measures. For this, it is important to obtain information on the contemporary population structure of a disease agent and to infer the evolutionary processes that may have shaped it. Here, we investigate on a continental scale the population structure of Borrelia burgdorferi, the causative agent of Lyme borreliosis (LB), a tick-borne disease, in North America. We test the hypothesis that the observed d population structure is congruent with recent population expansions and that these were preceded by bottlenecks mostly likely caused by the near extirpation in the 1900s …

Ucla Faculty Survey Results 2001-2011, Uno Office Of Institutional Effectiveness

Assessment

Faculty survey institutional profile.

Multiple Molecule Effects On The Cooperativity Of Protein Folding Transitions In Simulations, Jacob I. Lewis, Devin J. Moss, Thomas A. Knotts Iv

Faculty Publications

Though molecular simulation of proteins has made notable contributions to the study of protein folding and kinetics, disagreement between simulation and experiment still exists. One of the criticisms levied against simulation is its failure to reproduce cooperative protein folding transitions. This weakness has been attributed to many factors such as a lack of polarizability and adequate capturing of solvent effects. This work, however, investigates how increasing the number of proteins simulated simultaneously can affect the cooperativity of folding transitions — a topic that has received little attention previously. Two proteins are studied in this work: phage T4 lysozyme (Protein Data …

Effects Of Reiki, Yoga, Or Meditation On The Physical And Psychological Symptoms Of Chemotherapy-Induced Peripheral Neuropathy: A Randomized Pilot Study, Paul G. Clark, Geronima Cortese-Jimenez, Eric Cohen

Sociology, Anthropology and Social Work Faculty Research and Scholarship

Three complementary approaches for managing physical and psychological symptoms related to chemotherapy-induced peripheral neuropathy were evaluated against an education-only control arm. This study included 26 participants who were randomly assigned to weekly, hour-long sessions of yoga, Reiki, meditation, or an educational control experience for 6 weeks. Each participant completed pre–post measures of neurotoxicity, quality of life, psychological distress, and mindfulness. Descriptive analysis of the data indicated that all experimental group participants demonstrated improved within-group scores on quality of life and neurotoxicity outcomes following intervention; however, the improvements were not statistically significant. Neurotoxicity worsened significantly in the control group, but there …

Microwave-Assisted Polystyrene Sulfonatecatalyzed Synthesis Of Novel Pyrroles, Rosario Astrid Vargas Cardenas, Blanca Olinda Quintanilla Leal, Ashwini Reddy, Debasish Bandyopadhyay, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Background: Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation.

Results: Microwave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5- diemthoxytetrahydrofuran has been accomplished with excellent yield. This method produces pyrroles with polyaromatic amines.

Conclusion: The present procedure for the synthesis of N-aromatic substituted pyrroles will find useful application in the area of pharmacologically active molecules.

A Study Of The Eastern Oyster, Crassostrea Virginica, In Tampa Bay: Effects Of Perkinsus Marinus On Reproduction And Condition, Bridgit Melora Mccrickard

USF Tampa Graduate Theses and Dissertations

Abstract

Five sites in Tampa Bay, Florida, were sampled monthly from February 2006 to January 2007. These sites were located at the mouth of the Alafia River, in an inlet of Cross Bayou, on the easement of Gandy Bridge, near mangrove in Manatee County, and an inlet of Salt Creek, off Bayboro Harbor. Standard methods were used to determine shell height and Condition Index (CI). Intensity and prevalence of Perkinsus marinus were analyzed using Ray's Thioglycollate medium test, while Haplosporidium nelsoni was studied by histological examination. Histological methods were also used to determine sex ratios, reproductive phases, and egg diameters. …

Transdisciplinary Approaches To Ameliorating Racial Disparities In Prostate Cancer Outcomes, Chanita H. Halbert, Katrina Armstrong, John Holmes, David Fenstermacher, Janet Weiner, Carmen Guerra, J. S. Schwartz, Jerry C. Johnson, Edmund Weisberg, Chantal Montagnet, Benita Weathers, Charnita Zeigler-Johnson, Ernestine Delmoor, Timothy R. Rebbeck

Journal of Health Disparities Research and Practice

Though prostate cancer is the second leading cause of cause cancer deaths among men in the US, it ranks first among African American men in terms of incidence, morbidity, and mortality. To address this and other complex health issues, some researchers advocate transdisciplinary research as a framework for analysis; however, few examples exist that indicate how the framework should be applied. This report uses prostate cancer outcomes as a paradigm to describe how such a framework can be used to identify determinants of racial disparities. By integrating diverse scientific disciplines, methods, and analytic approaches from psychology, sociology, epidemiology and genetics, …

Spatial Information And Diagrams, Meghan Ertl-Bendickson

Macalester Journal of Philosophy

No abstract provided.

Could Consciousness Emerge From A Machine Language?, Genevieve Kaess

Macalester Journal of Philosophy

No abstract provided.

Consciousness And Ai: Reformulating The Issue, Patrick Holzman

Macalester Journal of Philosophy

No abstract provided.

A Defense Of A Wittgensteinian Outlook On Two Postmodern Theories, Sarah Halvorson-Fried

Macalester Journal of Philosophy

No abstract provided.

Western News, June 21, 2012, Western Michigan University

Western News (1972-2018)

Story highlights: Snyder announces new Wilson Fellows cohort; Legislators budget $750,000 for foster youth program; NCAA honors Broncos for academic skill; On Campus with Ellen Eberstein.

Strawberry Fields...For Now, Beth Potier

UNH Today Archive

No abstract provided.

Effects Of Ddt And Triclosan On Tumor-Cell Binding Capacity And Cell-Surface Protein Expression Of Human Natural Killer Cells, Tasia Hurd-Brown, Felicia Udoji, Tamara Martin, Margaret M. Whalen

Chemistry Faculty Research

1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) and triclosan (TCS) are organochlorine (OC) compounds that contaminate the environment, are found in human blood and have been shown to decrease the tumor-cell killing (lytic) function of human natural killer (NK) cells. NK cells defend against tumor cells and virally infected cells. They bind to these targets, utilizing a variety of cell surface proteins. The present study examined concentrations of DDT and TCS that decrease lytic function for alteration of NK binding to tumor targets. Levels of either compound that caused loss of binding function were then examined for effects on expression of cell-surface proteins needed for …