Digital Commons Network^™

Introduction Of R-Lcs And Comparative Analysis With Fsc And Mahalanobis-Taguchi Method For Breast Cancer Classification, Benjamin Daniels, Steven M. Corns, Elizabeth A. Cudney

Engineering Management and Systems Engineering Faculty Research & Creative Works

Classification for medical diagnosis is an important problem in the field of pattern recognition. We introduce a new method for classification based on repeated analysis of information tailored to small data sets - the Rote Learning Classifier System. using the Wisconsin Breast Cancer study, this method was compared to three other methods of classification: Mahalanobis-Taguchi Systems, Finite State Classifiers, and Neural Networks. It was found that for the given data set, the Rote Learning Classifier System outperformed the other methods of classification. This new algorithm correctly classified over 92% of the data set. © 2012 IEEE.

The Daily Gamecock, Wednesday, July 25, 2012, University Of South Carolina, Office Of Student Media

July

No abstract provided.

Development Of One-Step Taqman® Real-Time Reverse Transcription-Pcr And Conventional Reverse Transcription-Pcr Assays For The Detection Of Equine Rhinitis A And B Viruses, Zhengchun Lu, Peter J. Timoney, Jena White, Udeni B R Balasuriya

Veterinary Science Faculty Publications

BACKGROUND: Equine rhinitis viruses A and B (ERAV and ERBV) are common equine respiratory viruses belonging to the family Picornaviridae. Sero-surveillance studies have shown that these two viral infections are prevalent in many countries. Currently, the diagnosis of ERAV and ERBV infections in horses is mainly based on virus isolation (VI). However, the sensitivity of VI testing varies between laboratories due to inefficient viral growth in cell culture and lack of cytopathic effect. Therefore, the objective of this study was to develop molecular diagnostic assays (real-time RT-PCR [rRT-PCR] and conventional RT-PCR [cRT-PCR] assays) to detect and distinguish ERAV from ERBV …

Politicizing Patents - Patenting Biotechnology In The Wake Of Section 33, Prometheus, And Cls Bank, Jonathan R. K. Stroud

Celebrating WCL Student Authors

Tucked into the America Invents Act is the first statutory exemption for any patentable subject matter. Section 33 renders unpatentable all claims “encompassing a human being.” By recognizing a vague subject matter – exception for human beings despite the fact that internal policies had long militated against such patent claims, Congress has politicized the patent law to an unheard-of degree. While textually consistent with internal USPTO policy, the passage of § 33 should not be seen as an invitation to litigators to expand § 101 unpatentable-subject-matter challenges to validity by including arguments that medical methods, genetic tests, biological chimeras, or …

The Daily Egyptian, July 25, 2012, Daily Egyptian Staff

July 2012

No abstract provided.

Detecting The Immune System Response Of A 500 Year-Old Inca Mummy, Angelique Corthals, Antonius Koller, Dwight W. Martin, Robert Rieger, Emily I. Chen, Mario Bernaski, Gabriella Recagno, Liliana M. Dávalos

Publications and Research

Disease detection in historical samples currently relies on DNA extraction and amplification, or immunoassays. These techniques only establish pathogen presence rather than active disease. We report the first use of shotgun proteomics to detect the protein expression profile of buccal swabs and cloth samples from two 500-year-old Andean mummies. The profile of one of the mummies is consistent with immune system response to severe pulmonary bacterial infection at the time of death. Presence of a probably pathogenic Mycobacterium sp. in one buccal swab was confirmed by DNA amplification, sequencing, and phylogenetic analyses. Our study provides positive evidence of active pathogenic …

Novel Photochromic Spirooxazine Dimers: Synthesis, Characterization, And Applications, Davita Watkins

Electronic Theses and Dissertations Archive

A major goal in material science is being able to influence macro-scale behavior by controlling the interactions occurring at the molecular level. For example, a surface functionalized with photochromic molecules can reversibly change its polarity, conductivity, or absorption properties. These unique characteristics can be achieved by changing the molecular state from passive to active using external stimuli. The specific goal of this research is to create a family of biphotochromic systems that display unique functionalities in various media for potential use in biomedical applications. For example, these photochromic systems can be applicable for different purposes, such as drug delivery or …

Annotation Of Cytochrome P450 Genes In "Harmonia Axyridis' And A Comparative Study Of Cyp Genes In "Harmonia Axyridis' And "Tribolium Castaneum', Supriya Priyadarshini Pati

Electronic Theses and Dissertations Archive

Our knowledge of beetle cytochrome P450 (CYP) genes was primarily obtained from studies of the model beetle and grain pest Tribolium castaneum.To gain additional insight into beetle CYPs and ultimately to inform our understanding of beetle CYP evolution, we identified and annotated all of the CYP genes present in a new draft genome of Harmonia axyridis by using traditional and automated methods for gene annotation. Overall, we identified somewhat fewer CYPs in H. axyridis (at least 94 genes and 3 pseudo genes representing 17 families and 42 subfamilies) compared to the number of of known CYPs in T. castaneum (137 …

High Schoolers Reach 105k Feet With History–Making Unh Scientific Balloon, David Sims

Media Relations

No abstract provided.

The Alestle - Vol. 64 No. 41 - 07/25/2012, Southern Illinois University Edwardsville

The Alestle

Vol. 64 No. 41

A Climatological Analysis Of The Warm-Season Wind Regimes Of The Beaufort/Chukchi Seas Coasts, William J. Baule

School of Natural Resources: Dissertations, Theses, and Student Research

Climate records for wind speed, wind direction, and temperature are analyzed for the period from 1979-2009 for the Beaufort/Chukchi Seas region of the Arctic. Wind records have historically been subject to far fewer analyses than other meteorological variables, such as temperature or precipitation. This is particularly true for data sparse regions. Data were collected for a large area in the Beaufort/Chukchi Seas region, which includes portions of Russia, the United States, and Canada. Data from 250 stations were collected from a variety of networks throughout the region and uniformly quality controlled. Eight long-term stations were identified for data completeness and …

Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction In A Mouse Model That Exhibits Age-Dependent Progression Of Alzheimer's Disease-Related Pathology, Adam D. Bachstetter, Christopher M. Norris, Pradoldej Sompol, Donna M. Wilcock, Danielle Goulding, Janna H. Neltner, Daret St. Clair, D. Martin Watterson, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

Overproduction of proinflammatory cytokines in the CNS has been implicated as a key contributor to pathophysiology progression in Alzheimer's disease (AD), and extensive studies with animal models have shown that selective suppression of excessive glial proinflammatory cytokines can improve neurologic outcomes. The prior art, therefore, raises the logical postulation that intervention with drugs targeting dysregulated glial proinflammatory cytokine production might be effective disease-modifying therapeutics if used in the appropriate biological time window. To test the hypothesis that early stage intervention with such drugs might be therapeutically beneficial, we examined the impact of intervention with MW01-2-151SRM (MW-151), an experimental therapeutic that …

Wmu Board Of Trustees Formal Session July 25, 2012, Wmu Board Of Trustees

WMU Board of Trustees Meetings

Minutes of the July 25, 2012 WMU Board of Trustees meeting include:

• Recommendation re 2012/13 Tuition and Required Fees
• Estimated General Fund Beginning Board Budget FY 2012/13
• WMU Business Technology and Research Park map
• Services and Resources Agreement for WMU and WMU School of Medicine
• Personnel Report

Sex-Specific Habitat Use And Responses To Fragmentation In An Endemic Chameleon Fauna, Philip Shirk

Theses and Dissertations

Chameleons are an understudied taxon facing many threats, including collection for the international pet trade and habitat loss and fragmentation. A recent field study reports a highly female-biased sex ratio in the Eastern Arc Endemic Usambara three horned chameleon, Trioceros deremensis, a large, sexually dimorphic species. This species is collected for the pet trade, and local collectors report males bring a higher price because only this sex has horns. Thus, sex ratios may vary due to differential rates of survival or harvesting. Alternatively, they may simply appear to be skewed if differences in habitat use biases detection of the sexes. …

Constitutive Modelling Of Mullin's Effect In Swollen Nitrile Butadiene Rubber Under Cyclic Loading / Irmalisa Samsuri, Samsuri Irmalisa

Student Works (2010-2019)

Under cyclic loading, hyperelastic materials exhibit a particular stress softening behaviour called Mullin’s effect. Few efforts have been done to propose a mathematical model to represent this behaviour in rubber material. However, all attempts are only focusing on dry rubber. The study of Mullin’s effect in swollen rubber is quite important since a lot of parts or components made from rubber are exposed to aggressive solvent such as biodiesel. With the application of cyclic loading, the degradation of material becomes more rapid and leading to fatigue. In this study, the constitutive modelling of Mullin’s effect in swollen Nitrile Butadiene Rubber …

Tribology Study On Nanosilica-Filled Polyurethane (Pu) Composite Coating On Polypropylene Substrate / Nurehan Syamimi Ismail, Ismail Nurehan Syamimi

Student Works (2010-2019)

Acrylic based polyurethane coatings with nanoparticles embedded were prepared. The effects of nanoparticles of silica as fillers in the epoxy composite systems on tribological properties have been discussed in this article. The dispersed of nanosilica in polyurethane solution were prepared under magnetic stirring and various amounts of nanosilica powders were added so that the amount would turn out to be 3, 7 and 10% by weight respectively. The reference control was a pure polyurethane film with no nano silica content. The tribological tests were carried out by sliding against stainless steel in a pin on plate contact mode for friction …

Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe

Publications and Research

Western lifestyles differ markedly from those of our hunter-gatherer ancestors, and these differences in diet and activity level are often implicated in the global obesity pandemic. However, few physiological data for hunter-gatherer populations are available to test these models of obesity. In this study, we used the doubly-labeled water method to measure total daily energy expenditure (kCal/day) in Hadza hunter-gatherers to test whether foragers expend more energy each day than their Western counterparts. As expected, physical activity level, PAL, was greater among Hadza foragers than among Westerners. Nonetheless, average daily energy expenditure of traditional Hadza foragers was no different than …

James Smith V. George Hayman

2012 Decisions

USDC for the District of New Jersey

Signal Transduction Effects Induced By Erythropoietin In A Hnscc Model System, Shreya Desai

Theses and Dissertations

Head and Neck Squamous Cell Carcinoma (HNSCC) is an epithelial skin cancer of the upper aerodigestive tract, and is the sixth most common malignancy in the U.S. HNSCC patients undergoing chemotherapy commonly develop anemia, a condition in which the body lacks mature red blood cells (RBCs). Erythropoietin (EPO) is a systemically circulating hormone in the body that regulates the production of RBCs and is applied to treat anemia. Recently, several studies implicated shortened life expectancy of cancer patients by EPO administration. It may be due to an unexpected activation of survival and proliferation pathways of cancer cells by EPO because …

The Bg News July 25, 2012, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. July 25, 2012. Volume 102-Issue 112.

Fibroblast Growth Factor 23 Induces Left Ventricular Hypertrophy, Ansel Philip Amaral

Open Access Dissertations

Over one in ten adults manifests physiological evidence of chronic kidney disease (CKD), which significantly reduces life expectancy due to cardiovascular complications. Left ventricular hypertrophy (LVH) is at the center of this relationship and up to 90% of patients with CKD also manifest LVH. Fibroblast growth factor (FGF) 23 is a phosphorus-regulating hormone responsible for maintaining normal serum phosphate levels in early stages of CKD; furthermore, FGF23 levels rise during the course of the disease and correlate with the CKD stage. High plasma FGF23 levels are independently associated with elevated left ventricular mass, LVH and increased risk of mortality. These …

07-24-2012 Five Swosu Students Awarded Scholarships For Biomedical Research In Neuroscience, Southwestern Oklahoma State University

THE BARK ARCHIVE 2012

Ashley Rodriguez of Clinton is conducting research this summer through the SWOSU Department of Biological Sciences and Oklahoma Louis Stokes Alliance for Minority Participation (OK-LSAMP) under the mentorship of Dr. Andrea Holgado.

Scalia’S Ship Of Revulsion Has Sailed: Will Lawrence Protect Adults Who Adopt Lovers To Help Ensure Their Inheritance From Incest Prosecution?, Terry L. Turnipseed

College of Law - Faculty Scholarship

SCALIA’S SHIP OF REVULSION HAS SAILED: WILL LAWRENCE PROTECT ADULTS WHO ADOPT LOVERS TO HELP ENSURE THEIR INHERITANCE FROM INCEST PROSECUTION? Terry L. Turnipseed Associate Professor of Law Syracuse University College of Law in•cest (ĭn'sěst') Sexual relations between family members or close relatives, including children related by adoption. There is a growing trend in this country – startling to many – of adopting one’s adult lover or spouse for various reasons, mostly inheritance-based. Should one who adopts his or her adult lover or spouse be prosecuted for incest? Think about it: the person is having sexual relations with his or …

International Financial Standards And The Explanatory Force Of Lex Mercatoria, Cally Jordan

Faculty Papers & Publications

The global financial crisis has cast a strong light on some hitherto obscure corners of the financial world, provoking an outpouring of calls for concerted international action. “Hard law” having disappointed, can “soft law”, in the form of international financial standards, substitute for traditional national legislation. This article examines some of the difficulties associated with the “international standards as soft law” discourse.

First of all, conceptual problems in the “soft law” discourse itself reveal profoundly different patterns of legal thought cutting across national boundaries, resulting in different understandings of international financial standards. Secondly, recent experience, over the past decade, with …

Tcp Transcription Factor, Branch Angle Defective 1 (Bad1), Is Required For Normal Tassel Branch Angle Formation In Maize, Fang Bai, Renata Reinheimer, Diego Durantini, Elizabeth Kellogg, Robert Schmidt

Biology Department Faculty Works

In grass inflorescences, a structure called the “pulvinus” is found between the inflorescence main stem and lateral branches. The size of the pulvinus affects the angle of the lateral branches that emerge from the main axis and therefore has a large impact on inflorescence architecture. Through EMS mutagenesis we have identified three complementation groups of recessive mutants in maize having defects in pulvinus formation. All mutants showed extremely acute tassel branch angles accompanied by a significant reduction in the size of the pulvinus compared with normal plants. Two of the complementation groups correspond to mutations in the previously identified genes, …

Utility Of Phylloplanins As Antibiotics, Selective Fungicides And For Enhancing Microbial Resistance In Plants, George Wagner, Ryan Sheperd

Plant and Soil Sciences Faculty Patents

The present invention relates to plant proteins produced by a plant's epidermal layer that contribute to the innate pest/disease resistance of the plant (“phylloplanins”), compositions comprising the phylloplanins and methods of using them. In particular the methods relate to inhibiting or preventing microbial, e.g., fungal or bacterial, growth on a subject, organism or surface by administering a phylloplanin. The invention also relates to transformed host cells that produce phylloplanins, and to transgenic plants producing phylloplanins conferring increased resistance to microbial infections/growth.

Comparison Of Therapeutic Dosimetric Data From Passively Scattered Proton And Photon Craniospinal Irradiations For Medulloblastoma, Rebecca M. Howell, Annelise Giebeler, Wendi Koontz-Raisig, Anita Mahajan, Carol J. Etzel, Anthony M. D'Amelio, Kenneth L. Homann, Wayne D. Newhauser

Faculty Publications

Background: For many decades, the standard of care radiotherapy regimen for medulloblastoma has been photon (megavoltage x-rays) craniospinal irradiation (CSI). The late effects associated with CSI are well-documented in the literature and are in-part attributed to unwanted dose to healthy tissue. Recently, there is growing interest in using proton therapy for CSI in pediatric and adolescent patients to reduce this undesirable dose. Previous comparisons of dose to target and non-target organs from conventional photon CSI and passively scattered proton CSI have been limited to small populations (n ≤ 3) and have not considered the use of age-dependent target volumes in …

Insights Into Salt Tolerance From The Genome Of Thellungiella Salsuginea, Hua Jun Wu, Zhonghui Zhang, Jun Yi Wang, Dong Ha Oh, Maheshi Dassanayake, Binghang Liu, Quanfei Huang, Hai Xi Sun, Ran Xia, Yaorong Wu, Yi Nan Wang, Zhao Yang, Yang Liu, Wanke Zhang, Huawei Zhang, Jinfang Chu, Cunyu Yan, Shuang Fang, Jinsong Zhang, Yiqin Wang, Fengxia Zhang, Guodong Wang, Sang Yeol Lee, John M. Cheeseman, Bicheng Yang, Bo Li, Jiumeng Min, Linfeng Yang, Jun Wang, Chengcai Chu, Shou Yi Chen, Hans J. Bohnert, Jian Kang Zhu

Faculty Publications

Thellungiella salsuginea, a close relative of Arabidopsis, represents an extremophile model for abiotic stress tolerance studies. We present the draft sequence of the T. salsuginea genome, assembled based on ∼134-fold coverage to seven chromosomes with a coding capacity of at least 28,457 genes. This genome provides resources and evidence about the nature of defense mechanisms constituting the genetic basis underlying plant abiotic stress tolerance. Comparative genomics and experimental analyses identified genes related to cation transport, abscisic acid signaling, and wax production prominent in T. salsuginea as possible contributors to its success in stressful environments.

Spatial/Landscape Genetics Of Native Plant Species In Arches And Canyonlands National Parks, Meeyoon Choo

Electronic Theses and Dissertations Archive

Stipa hymenoides and Sphaeralcea parvifolia are native to rangelands in western North America and have been selected as priority species for the restoration of degraded grasslands in the Colorado Plateau. To study the natural population structure of these species, individuals were collected from 44 populations of Stipa hymenoides and 23 populations of Sphaeralcea (22 populations of S. parvifolia and one population of S. grossulariifolia) distributed throughout southwest U.S. including Arches and Canyonlands National Parks in Utah. Amplified fragment length polymorphisms (AFLPs) were used to assess the genetic diversity and population genetic structure of both species. Moderate levels of genetic differentiation …

Social Influences And Intentions To Smoke In Adolescent Smokers: A Mediation Model, Ashley Jackson

Electronic Theses and Dissertations Archive

Research on the Theory of Planned Behavior has previously demonstrated that, as measures of subjective norms, descriptive norms and normative beliefs predict intentions to engage in behaviors such as smoking. Descriptive norms measuring the prevalence of parent and peer smoking have been investigated as predictors of intentions among adolescent smokers. Normative beliefs representing parent and peer attitudes toward smoking have also been shown to predict adolescents' plans to smoke. Within a sample of 356 adolescent smokers, the present study attempted to model the relationships between these measures of social influence and intentions using Structural Equation Modeling. Three emotional and cognitive …