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Slaves In The Family: Testamentary Freedom And Interracial Deviance, Kevin Noble Maillard

College of Law - Faculty Scholarship

This Article addresses the deviance of interracial sexuality acknowledged in testamentary documents. The language of wills calls into question the authority of probate and family law by forcing issues of deviance into the public realm. Will dramas, settled in or out of court, publicly unearth insecurities about family. Many objections to the stated intent of the testator generate from social prejudices toward certain kinds of interpersonal relationships: nonmarital, homosexual, and/or interracial. When pitted against an issue of a moral or social transgression, testamentary intent often fails. In order for these attacks on testamentary validity to succeed, they must be situated …

Rethinking Children As Property, Kevin Noble Maillard

College of Law - Faculty Scholarship

Despite the collective view in law and social practice that it is intrinsically taboo to consider human beings as chattel, the law persists in treating children as property. Applying principles of property, this Article examines paternity disputes to explain and critique the law’s view of children as property of their parents. As evidenced in these conflicts, I demonstrate that legal paternity exposes a rhetoric of ownership, possession, and exchange. The law presumes that a child born to a married woman is fathered by her husband, even when irrefutable proof exists that another man fathered the child. Attempts by the non-marital …

The Color Of Testamentary Freedom, Kevin Noble Maillard

College of Law - Faculty Scholarship

Wills that prioritize the interests of nontraditional families over collateral heirs test courts’ dedication to observing the posthumous wishes of testators. Collateral heirs who object to will provisions that redraw the contours of “family” are likely to profit from the incompatibility of testamentary freedom and social deviance. Thus, the interests of married, white adults may claim priority over nonwhite, unmarried others. Wills that acknowledge the existence of moral or social transgressions—namely, interracial sex and reproduction—incite will contests by collateral heirs who leverage their status as white and legitimate in order to defeat testamentary intent. This Article turns to antebellum and …

Platelets Induce Apoptosis During Sepsis In A Contact-Dependent Manner That Is Inhibited By Gpiib/Iiia Blockade, Matthew Sharron, Claire E. Hoptay, Andrew A. Wiles, Lindsay M. Garvin, Mayya Geha, Angela S. Benton, Kanneboyina Nagaraju, Robert J. Freishtat

Genomics and Precision Medicine Faculty Publications

Purpose

End-organ apoptosis is well-described in progressive sepsis and Multiple Organ Dysfunction Syndrome (MODS), especially where platelets accumulate (e.g. spleen and lung). We previously reported an acute sepsis-induced cytotoxic platelet phenotype expressing serine protease granzyme B. We now aim to define the site(s) of and mechanism(s) by which platelet granzyme B induces end-organ apoptosis in sepsis.

Methods

End-organ apoptosis in murine sepsis (i.e. polymicrobial peritonitis) was analyzed by immunohistochemistry. Platelet cytotoxicity was measured by flow cytometry following 90 minute ex vivo co-incubation with healthy murine splenocytes. Sepsis progression was measured via validated preclinical murine sepsis score.

Measurements and Main Results …

2012 Uab Summer Research Expo, University Of Alabama At Birmingham

Expo Programs

Catalog of undergrauate student research poster presentations with abstracts.

Anxiety Symptoms, Parent Anxiety And Functional Impairment In Pediatric Cardiology Patients With Noncardiac Chest Pain And Benign Cardiac Complaints, Cassandra Jo Mcdonnell

Dissertations

Chest pain is regularly encountered in pediatric medical settings. Because of the popular association of chest pain with coronary artery disease and myocardial infarction adults, it is often frightening for both patients and parents. However, up to 88% of pediatric chest pain patients receive no medical explanation for their pain. Chest discomfort in the absence of medical explanation that is characterized by no more than one typical angina symptom is classified as non-cardiac chest pain (NCCP). This study examined parent anxiety, child anxiety and chest pain related functional impairment in a sample of pediatric patients with NCCP in comparison to …

Modeling Of Pharmacokinetics Of Cocaine In Human Reveals The Feasibility For Development Of Enzyme Therapies For Drugs Of Abuse, Fang Zheng, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Publications

A promising strategy for drug abuse treatment is to accelerate the drug metabolism by administration of a drug-metabolizing enzyme. The question is how effectively an enzyme can actually prevent the drug from entering brain and producing physiological effects. In the present study, we have developed a pharmacokinetic model through a combined use of in vitro kinetic parameters and positron emission tomography data in human to examine the effects of a cocaine-metabolizing enzyme in plasma on the time course of cocaine in plasma and brain of human. Without an exogenous enzyme, cocaine half-lives in both brain and plasma are almost linearly …

Reproductive Characteristics Of A Populus Euphratica Population And Prospects For Its Restoration In China, Dechang Cao, Jingwen Li, Zhenying Huang, Carol C. Baskin, Jerry M. Baskin, Peng Hao, Weilei Zhou, Junqing Li

Biology Faculty Publications

Populus euphratica is a dominant tree in riparian ecosystems in arid areas of northwest China, but it fails to regenerate in these systems. This study evaluates causes for the failure of sexual and asexual regeneration of this species in the wild. P. euphratica disperses as many as 85743 seeds/m² during summer, and the seeds germinate to 92.0% in distilled water and to 60.8% on silt. However, very few seeds (3.6%) can germinate on unflooded soil. The seed-rain season is prolonged by temporal variability in seed dispersal among individuals, which ensures that seedling emergence can occur during favorable conditions (i.e., …

On Nature Of The Gradient Echo Mr Signal And Its Application To Monitoring Multiple Sclerosis, Jie Luo

All Theses and Dissertations (ETDs)

Multiple Sclerosis is a common disease, affecting 2.5 million people world-wide. The clinical course is heterogeneous, ranging from benign disease in which patients live an almost normal life to severe and devastating disease that may shorten life. Despite much research, a fully effective treatment for MS is still unavailable and diagnostic techniques for monitoring MS disease evolution are much needed.

As a non-invasive tool, Magnetic resonance imaging: MRI) plays a key role in MS diagnosis. Numerous MRI techniques have been proposed over the years. Among most widely used are conventional T1-weighted: T1W), T2-weighted: T2W) and FLuid Attenuated Inversion Recovery: FLAIR) …

Hepatic Mitochondrial Efficiency In Lines Of Mice Differing In Feed Intake, Thomas Murphy

Department of Animal Science: Dissertations, Theses, and Student Research

Selection was practiced for high (MH) and low (ML) heat loss using direct calorimetry to create lines of mice differing in feed intake per unit BW (FI/BW). Selection occurred for both criteria in each of 3 replications (R); an unselected control (MC) was also maintained in each replicate. A total of 25 generations of selection was practiced; the 9 lines are presently maintained without selection. As a percentage of MC, mice of MH and ML lines differed in heat loss and FI/BW by 56 and 34%, respectively, when selection ceased. The 218 male mice measured in the present study came …

Titanium Nitride And Nitrogen Ion Implanted Coated Dental Materials, Youssef S. Al Jabbari, Jennifer Fehrman, Ashley C. Barnes, Angela M. Zapf, David W. Berzins, Spiros Zinelis

School of Dentistry Faculty Research and Publications

Titanium nitride and/or nitrogen ion implanted coated dental materials have been investigated since the mid-1980s and considered in various applications in dentistry such as implants, abutments, orthodontic wires, endodontic files, periodontal/oral hygiene instruments, and casting alloys for fixed restorations. Multiple methodologies have been employed to create the coatings, but detailed structural analysis of the coatings is generally lacking in the dental literature. Depending on application, the purpose of the coating is to provide increased surface hardness, abrasion/wear resistance, esthetics, and corrosion resistance, lower friction, as well as greater beneficial interaction with adjacent biological and material substrates. While many studies have …

Dynamics Of Depression Storage During Sprinkler Irrigation And Precipitation Events, Michael B. Mckinney

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Surface depression storage (D_s) is the volume of precipitation excess which is stored by surface microrelief features of soils. The volume of water stored in surface depressions when precipitation rate exceeds infiltration rate reduces the amount of runoff generated. Because Ds is dependent on soil microrelief, land slope, and crop residue, tillage and management practices can have a considerable impact on the magnitude of this value.

When modeling irrigation systems and surface hydrology, depression storage is often treated as a static abstraction, meaning that maximum storage volume must be filled before runoff occurs. However, several researchers have documented …

Brain Microvascular Endothelial Cell Association And Distribution Of A 5 Nm Ceria Engineered Nanomaterial, Mo Dan, Michael T. Tseng, Peng Wu, Jason M. Unrine, Eric A. Grulke, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

PURPOSE: Ceria engineered nanomaterials (ENMs) have current commercial applications and both neuroprotective and toxic effects. Our hypothesis is that ceria ENMs can associate with brain capillary cells and/or cross the blood-brain barrier.

METHODS: An aqueous dispersion of ∼5 nm ceria ENM was synthesized and characterized in house. Its uptake space in the Sprague Dawley rat brain was determined using the in situ brain perfusion technique at 15 and 20 mL/minute flow rates; 30, 100, and 500 μg/mL ceria perfused for 120 seconds at 20 mL/minute; and 30 μg/mL perfused for 20, 60, and 120 seconds at 20 mL/minute. The capillary …

Using Next Generation Sequencing (Ngs) To Identify And Predict Micrornas (Mirnas) Potentially Affecting Schizophrenia And Bipolar Disorder, Vernell Williamson

Theses and Dissertations

The last decade has seen considerable research focusing on understanding the factors underlying schizophrenia and bipolar disorder. A major challenge encountered in studying these disorders, however, has been the contribution of genetic, or etiological, heterogeneity to the so-called “missing heritability” [1-6]. Further, recent successes of large-scale genome-wide association studies (GWAS) have nonetheless seen only limited advancements in the delineation of the specific roles of implicated genes in disease pathophysiology. The study of microRNAs (miRNAs), given their ability to alter the transcription of hundreds of targeted genes, has the potential to expand our understanding of how certain genes relate to schizophrenia …

Synthesis Of Half-Loaded Nitroimidazole Indocyanine Green Dyes Attached To Carbon Nanotubes, Courtney L. Stanford

Master's Theses

Indocyanine green dye is the only FDA approved NIR fluorescent dye that can be used in humans. 2-Nitroimidazoles are very effective radiosensitizers, have low cytotoxicity, and target hypoxic tissue. By coupling the two together, hypoxic tumors can be targeted and imaged. Previous work has been done to couple 2-nitroimidazole to both sides of the indocyanine green dye. This work focuses on expanding that concept to couple 2-nitroimidazole to only one side of the dye, thus allowing for the other end to be available to couple to another compound, generating a half loaded 2-nitroimidazole indocyanine green dye. In theory, this half-loaded …

Dietary Protein Influences Paracellular Calcium Transport: Two Molecular Targets, Belinda M. Kotler

Master's Theses

The effect of dietary protein on bone health remains controversial. We have shown that increasing dietary protein increases calcium absorption in both humans and rats with no change in bone resorption. We used a rat model in which dietary protein increases intestinal calcium absorption and whole body calcium retention, to explore the molecular basis for this effect. Female Sprague-Dawley rats were fed a low (5%) or high (40%) protein diet for 7 days. On day 7, duodenal mucosa was harvested and total RNA isolated. Microarray analyses using these RNA samples identified 208 genes whose expression was at least 1.5 fold …

Accurate Methodology For Monitoring Biomembrane Events, Christine A. Winschel

Theses and Dissertations

Abstract ACCURATE METHODOLOGY FOR MONITORING BIOMEMBRANE EVENTS By Christine A. Winschel, Ph.D. A Dissertation submitted in partial fulfillment of the requirements for the degree of Doctorate of Philosophy in Chemistry at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Major Director: Dr. Vladimir A. Sidorov ASSOCIATE PROFESSOR, DEPARTMENT OF CHEMISTRY This study describes the synthesis and characterization of a new receptor (cyclen 1) capable of strong selective binding of pyrene-based anionic dyes under near-physiological conditions. This receptor comprises four naphthylthiourea groups tethered to a cyclen core via an ester linkage. The most important finding was the ability of cyclen 1 to …

Medication Monitoring In The Schools: An Investigation Of Current Practices Of Florida School Psychologists, Jason Hangauer

USF Tampa Graduate Theses and Dissertations

Prevalence rates of youth prescribed psychotropic medications have risen dramatically over the past decade. Many of these medications are prescribed to treat symptoms of a disorder that occur in the school setting. Some medications have negative side effects that can inhibit academic and social performance. School psychologists have been identified as professionals who are equipped to assist in monitoring both the beneficial and negative effects of medications for youth attending school. This study investigated the practices, training, types of disorders for which medication monitoring occurs, facilitators, and barriers to school psychologists engaging in medication monitoring in the schools. Survey data …

A Longitudinal Study Of The Effect Of At Birth Adoptions On Anxiety, Stress Hormones And Adolescent Alcohol Intake: A Nonhuman Primate Model, Whitney Faith Maxwell

Theses and Dissertations

Adopted individuals have an increased risk for a variety of psychopathological disorders. Studies of the effects adoption in humans are difficult to perform because of the difficulty separating genetic risk and treatment effects. This is a developmental study investigating the effects of at birth adoption using a nonhuman primate model. Three experimental paradigms were used to assess maternal treatment, stress-related behavior, and physiology late in infancy and again later in life. Rhesus monkeys were reared for their first six months of life by either their biological mother or an unrelated, lactating adult female. Adoptions occurred immediately following birth. At six …

Back Matter

The Journal of Purdue Undergraduate Research

No abstract provided.

Discovery Of Undescribed Brain Tissue Changes Around Implanted Microelectrode Arrays, Himanshi Desai

The Journal of Purdue Undergraduate Research

No abstract provided.

Healing Osteoarthritis: Engineered Proteins Created For Therapeutic Cartilage Regeneration, Kevin M. Cherry

The Journal of Purdue Undergraduate Research

No abstract provided.

Understanding Free Radicals: Isolating Active Thylakoid Membranes And Purifying The Cytochrome B6f Complex For Superoxide Generation Studies, Jason Stofleth

The Journal of Purdue Undergraduate Research

All life persists in an environment that is rich in molecular oxygen. The production of oxygen free radicals, or superoxide, is a necessary consequence of the biogenesis of energy in cells. Both mitochondrial and photosynthetic electron transport chains have been found to produce superoxide associated with cell differentiation, proliferation, and cell death, thereby contributing to the effects of aging. Aerobic respiration in mitochondria consumes oxygen, whereas photosynthesis in chloroplasts or cyanobacteria produces oxygen. The increased concentration of molecular oxygen may serve to allow greater availability for the production of superoxide by cytochrome bc complexes in photosynthetic membranes compared to those …

Is Local Produce Safer? Microbiological Quality Of Fresh Lettuce And Spinach From Grocery Stores And Farmers' Markets, Emiria Soendjojo

The Journal of Purdue Undergraduate Research

There is a growing demand for fresh, safe, high-quality, and locally grown vegetables. This study compared microbial populations in Romaine lettuce, Bibb lettuce, and spinach procured from grocery stores and farmers’ markets throughout the course of a summer. Standard microbial techniques were used to analyze 42 samples for the presence of total aerobic mesophilic and psychrophilic bacteria; yeasts and molds; surface and internalized coliforms and Escherichia coli; and the pathogens E. coli O157:H7 and Salmonella spp. Large variations in counts were found between produce types, sampling days, and between grocery and farmers’ market samples. The average highest microbial loads were …

Bovine Nutritional Needs: Digestibility Of Dry And Ensiled Forages When Feeding Young Dairy Heifers, Shirley Nigaglioni

The Journal of Purdue Undergraduate Research

The diets fed to growing animals are very important to ensure that young animals have the proper nutrients available for growth. When feeding dairy heifers, a farmer’s goal is to feed a very digestible diet that will provide nutrients to keep dairy heifers healthy and allow them to grow faster, while spending less money on feed. The objective of this study was to determine whether feeding heifers diets containing dry or ensiled forage (haylage) improved digestibility. Our hypothesis was that incorporating hay into the diet of 16-week-old dairy heifers would provide a more digestible source of nutrients. For this study, …

Is Distant Pollution Contaminating Local Air? Analyzing The Origins Of Atmospheric Aerosols, David Geng

The Journal of Purdue Undergraduate Research

Understanding the origin of aerosols in the atmosphere is important because of visual pollution, climate impacts, and deleterious health effects due to the inhalation of fine particles. This research analyzed aerosols characterized by their chloride, sulfate, and nitrate content as a function of size over a 3-month period. Due to wind patterns over coal-burning power plants, a higher concentration of local sulfate pollution was expected. Aerosols were harvested on the Purdue University campus using a high-volume air sampler with glass fiber filters and a five-stage impactor that separates the aerosols into five sizes. The filters were extracted in water to …

Introduction: Open Source Culture And Aesthetics, Antonio Ceraso, Jeff Pruchnic

Criticism

No abstract provided.

Controls And Improvements Of Molecular Assays For Microbiological Water Testing, David R. Wanless

Open Access Theses

The monitoring of recreational waters is important to gauge risks to human health. The methods currently used are time-intensive (18-24 hours to test results) and because of this, results may be inaccurate. There are now molecular techniques capable of delivering faster results on multiple microbiological targets, including source tracking markers. However, these techniques cannot be utilized most effectively until extraction efficiencies of environmental DNA are known. Earlier studies of bacterial indicators in recreational beach waters using quantitative polymerase chain reaction (qPCR) showed variation in the DNA extraction efficiency of filtered marine water samples. Silica-based binding matrix micro-columns used in DNA …

A New Look At Genre And Authenticity: Making Sense Of Reading And Writing Science News In High School Classrooms, Angela Marie Kohnen

Dissertations

This qualitative study examined the importance of the genre and authenticity as teachers sought to bring science journalism to the high school science classroom. Undertaken as part of the National Science Foundation-funded grant “Science Literacy through Science Journalism (SciJourn),” this work was conducted as a series of smaller studies addressing the following issues: the definition of the genre from the point of view of professional journalists; teachers’ motivation for joining the SciJourn project; qualities of science teachers compared to science journalists; science teachers’ approach to writing and writing response; and the teachers’ reflections on their own implementation strategies. Data collected …

Soil Biochemical Changes Induced By Poultry Litter Application And Conservation Tillage Under Cotton Production Systems, Regine Mankolo, Chandra Reddy, Zachary Senwo, Ermson Nyakatawa, Seshadri Sajjala

Agricultural and Environmental Sciences Faculty Research

Problems arising from conventional tillage (CT) systems (such as soil erosion, decrease of organic matter, environmental damage etc.) have led many farmers to the adoption of no-till (NT) systems that are more effective in improving soil physical, chemical and microbial properties. Results from this study clearly indicated that NT, mulch tillage (MT), and winter rye cover cropping systems increased the activity of phosphatase, β-glucosidase and arylsulfatase at a 0–10 cm soil depth but decreased the activity of these enzymes at 10–20 cm. The increase in enzyme activity was a good indicator of intensive soil microbial activity in different soil management …