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2012

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Articles 4381 - 4410 of 22916

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A Molecular Survey Of S. Mutans And P. Gingivalis Oral Microbial Burden In Human Saliva Using Relative Endpoint Polymerase Chain Reaction (Re-Pcr) Within The Population Of A Nevada Dental School Revealed Disparities Among Minorities, Jay Ericksen Davis, Nicholas Freel, Allison Findley, Keaton Tomlin, Katherine M. Howard, Clifford C. Seran, Patricia Cruz, Karl Kingsley Aug 2012

A Molecular Survey Of S. Mutans And P. Gingivalis Oral Microbial Burden In Human Saliva Using Relative Endpoint Polymerase Chain Reaction (Re-Pcr) Within The Population Of A Nevada Dental School Revealed Disparities Among Minorities, Jay Ericksen Davis, Nicholas Freel, Allison Findley, Keaton Tomlin, Katherine M. Howard, Clifford C. Seran, Patricia Cruz, Karl Kingsley

Dental Medicine Faculty Research

Background: The University of Nevada, Las Vegas School of Dental Medicine recently opened an orthodontic treatment clinic to address the needs of the racially and ethnically diverse population of Southern Nevada, primarily focusing on the treatment and care of low-income and minority patients. Although orthodontic treatment and therapy has been shown to induce changes in the oral cavity, much of this evidence was collected from traditional White, teenage orthodontic clinic populations. The primary goal of this study was to describe the microbial burden of the cariogenic and periodontal pathogens, Streptococcus mutans and Porphyromonas gingivalis within the UNLV-SDM patient population.Methods: Representative …

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The Relationship Of Quizzing And Student Success In A College Level Core Statistics Course, David Glavin Aug 2012

The Relationship Of Quizzing And Student Success In A College Level Core Statistics Course, David Glavin

Mathematics & Statistics ETDs

This study investigated the relationship between quizzing and student success in an introductory college level statistics course. Demographic and student performance data were collected from a 100-level introductory Statistics course at the University of New Mexico during the Fall 2011 semester. Two statistical models were developed to determine if quizzing is related to student success as measured by final letter grades and final exam scores. Predictive modeling to determine the relationship between quizzing and students final exam scores using a Hierarchical Linear Model (HLM) found quizzing to be marginally significant (p-value = 0.0567). Probabilistic modeling using logistic regression to predict …

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Uranium-Series Geochronology And Stable Isotope Analysis Of Travertine From Soda Dam, New Mexico : A Quaternary Record Of Episodic Spring Discharge And Rivern Incision In The Jemez Mountains Hydrothermal System, April Jean Tafoya Aug 2012

Uranium-Series Geochronology And Stable Isotope Analysis Of Travertine From Soda Dam, New Mexico : A Quaternary Record Of Episodic Spring Discharge And Rivern Incision In The Jemez Mountains Hydrothermal System, April Jean Tafoya

Earth and Planetary Sciences ETDs

High precision uranium-series (U-series) geochronology provides data on timing of travertine deposition at Soda Dam, and a paleohydrologic record for the Valles Caldera hydrothermal system in Northern New Mexico for at least the last 500 ka. Travertine-depositing springs occur in San Diego Canyon, the only surface drainage outlet for the Valles Caldera, along the intersection of the Jemez fault zone (JFZ) and the Jemez River. This travertine-depositing hot spring system is part of the Valles Caldera geothermal system, which has been active throughout the Quaternary and explored for the past three decades for geothermal energy potential. New dates, compiled with …

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An Overview Of Laser Operation And Modelocking Of A Vertical External Cavity Surface Emitting Laser (Vecsel), Aaron Allen Aug 2012

An Overview Of Laser Operation And Modelocking Of A Vertical External Cavity Surface Emitting Laser (Vecsel), Aaron Allen

Optical Science and Engineering ETDs

VECSEL laser systems are important additions to the family of lasers. They exhibit a combination of desirable lasing features that are usually not simultaneously attainable. These features are high power, diffraction limited beam quality, intra-cavity frequency doubling, tunability, and ultrashort pulses generated from passive mode-locking. In this work, we give a brief overview of the VECSEL structure, previous VECSEL literature, how lasing in a VECSEL works, and how mode locking in a VECSEL works.

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The Effect Of Carbon Dioxide On The Density And Compressibility Of Kimberlitic Magma, Alison R. Santos Aug 2012

The Effect Of Carbon Dioxide On The Density And Compressibility Of Kimberlitic Magma, Alison R. Santos

Earth and Planetary Sciences ETDs

Constraints were placed on the density of kimberlitic melts containing varying amounts of CO2 using high pressure sink/float experiments. The melt composition used was carefully selected and was prepared free of H2O and minor elements in order to focus on the effect of CO2. Experiments were run in graphite capsules over a pressure range of 4-10 GPa in a multi-anvil apparatus using Fo100 and Fo90 spheres as density markers. The compositions used contained 0, 3, 6, and 12 wt% CO2 and were derived from mixing the 0 and 12 wt% CO2 compositions together. Run products were analyzed with FTIR to …

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Conceptualizing Mental Health: A Qualitative Study On Mexican Immigrant Mothers' Definition Of Their Children's Mental Health In New Mexico, Cirila Estela Vasquez Guzman Aug 2012

Conceptualizing Mental Health: A Qualitative Study On Mexican Immigrant Mothers' Definition Of Their Children's Mental Health In New Mexico, Cirila Estela Vasquez Guzman

Sociology ETDs

Parents play a significant role in many areas of their childrens mental health, including understanding the concept, detection, utilization, and treatment options. Despite the importance of parents' role, there is relatively little research in the United States on Latino parents' conceptualization of the term mental health. This study focuses on understanding conceptualization patterns of children's mental health among low-income Mexican immigrant mothers. I utilize the social construction framework to investigate the social nature of the construct mental health. I also engage with the medicalization literature to shed light on the biomedical model's perspective on mental health. Nine focus groups were …

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Experimental Study Of Electrostatic Aerosol Filtration At Moderate Filter Face Velocity, Andres Sanchez Aug 2012

Experimental Study Of Electrostatic Aerosol Filtration At Moderate Filter Face Velocity, Andres Sanchez

Chemical and Biological Engineering ETDs

Electrostatic filtration media (electret) has been used in many applications due to its ability to efficiently collect submicron particles while maintaining a low pressure drop. Filter face velocities have ranged from 0.01-0.5 m/s in previous studies. However, in this study, measurements were conducted from 0.5-2.5 m/s, a region where Reynolds numbers range from 0.05-0.24. Within this regime, commonly used filtration theory is incomplete and does not predict performance of electret media, therefore data must be measured. Experimental measurements were conducted in various combinations of charge and neutralized filter media with aerosolized particles possessing the Boltzmann charge distribution or zero charge. …

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The Inkwell, Armstrong Atlantic State University Aug 2012

The Inkwell, Armstrong Atlantic State University

The Inkwell

No abstract provided.

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Development And Partial Characterization Of Agonistic Ox40 Aptamer Anti-Cblb Sirna Conjugates, Dawn Seales Aug 2012

Development And Partial Characterization Of Agonistic Ox40 Aptamer Anti-Cblb Sirna Conjugates, Dawn Seales

Open Access Theses

Tumors that develop in patients with fully functional immune systems evolve different mechanisms of immune suppression that must be counteracted for tumor immunotherapy to be effective. The proposed therapeutic aims to co-stimulate T-cells via OX40, a co-stimulatory receptor expressed on activated T-cells. Signaling via OX40 leads to prolonged survival of activated T-cells, enhanced memory formation, and protection against immunosuppression. In addition to boosting co-stimulation, we aim to enhance T-cell activation by downregulating Cbl-b, an E3 ubiquitin ligase that suppresses T-cell activation. An RNA aptamer that binds OX40 was conjugated to anti-Cbl-b siRNA and was shown by a luciferase reporter assay …

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The Law Applicable On The Continental Shelf And In The Exclusive Economic Zone, Moira Mcconnell Aug 2012

The Law Applicable On The Continental Shelf And In The Exclusive Economic Zone, Moira Mcconnell

Research Papers, Working Papers, Conference Papers

As an initial observation I note that this topic presents a challenge for comparative law scholars As one scholar suggested in correspondence about the questionnaire for this Session the topic is arguably simply a question of implementation of public international law rather than domestic and comparative law as such This view points to a problem of disciplinary boundaries and the potential overlap between comparative law and international law and the emerging regional law scholarship I mention this at the beginning of my General Report because that tension is apparent in both the National Reports and the questionnaire prepared for this …

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Phytochemical Composition Of Selaginella Spp. From Java Island Indonesia, Tatik Chikmawati, Ahmad Dwi Setyawan, Miftahudin Miftahudin Aug 2012

Phytochemical Composition Of Selaginella Spp. From Java Island Indonesia, Tatik Chikmawati, Ahmad Dwi Setyawan, Miftahudin Miftahudin

Makara Journal of Science

For a long time, people in West Java, Indonesia have used Selaginella as a traditional cure for several ailments including fever, minor wounds, broken bones, women’s health disorders or postnatal bleeding. However, information on the active compounds of the plant from Java Island has not been fully expounded. The objective of the research was to reveal the diversity of bioactive compounds and amentoflavone content of Selaginella from Java Island in order to optimize the use of this plant as a medicinal plant. Selaginella plants collected from 29 locations in Java were extracted and subjected to colorimetric and thin layer chromatography …

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Synthesis And Antiplasmodial Activity Of 2-(4-Methoxyphenyl)-4-Phenyl-1,10- Phenanthroline Derivative Compounds, Ruslin Hadanu, Mustofa Mustofa, Nazudin Nazudin Aug 2012

Synthesis And Antiplasmodial Activity Of 2-(4-Methoxyphenyl)-4-Phenyl-1,10- Phenanthroline Derivative Compounds, Ruslin Hadanu, Mustofa Mustofa, Nazudin Nazudin

Makara Journal of Science

A unique of synthetic methods was employed to prepare 2-(4-methoxyphenyl)-4-phenyl-1,10-phenanthroline (5) derivatives from 4-methoxy-benzaldehyde (1), acetophenone (2), and 8-aminoquinoline (4) with aldol condensation and cyclization reactions. The derivatives were tested through antiplasmodial test. The synthesis of derivatives compound 5 was conducted in three steps. The 3-(4-methoxyphenyl)-1-phenylpropenone 3 was synthesized through aldol condensation of 1 and 2 which has a yield of 96.42%. The compound 5 was synthesized through cyclization of compound 4 and 3 with 84.55% yield. The derivative of compound 5 was synthesized from compound 5 using DMS and DES reagents which refluxed for 21 and 22 h, to …

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Physiological Responses Of Jatropha To Drought Stress In Coastal Sandy Land Conditions, I Gusti Made Arya Parwata, Didik Indradewa, Prapto Yudono, Rukmini Kusmarwiyah Aug 2012

Physiological Responses Of Jatropha To Drought Stress In Coastal Sandy Land Conditions, I Gusti Made Arya Parwata, Didik Indradewa, Prapto Yudono, Rukmini Kusmarwiyah

Makara Journal of Science

Jatropha curcas L., an important tropical biofuel crop, is reputed for its drought resistance, however, its ability to perform in dry conditions has still hardly been investigated. Changes in leaf water status, chlorophyll content, leaf surface temperature, stomatal conductance, proline and abcisic acid (ABA) content, transpiration and photosynthetic rate were studied in four Jatropha genotypes (IP-1A, IP-2M, Local superior and Yellow leaf) and subjected to drought stress in coastal sandy land conditions in Central Java, Indonesia. Drought stress significantly decreased the leaf water status, leaf chlorophyll content, stomatal conductance, transpiration and photosynthetic rate, and increased leaf temperature, proline and ABA …

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Non-Saponifiable Lipid Composition Of Four Salt-Secretor And Non-Secretor Mangrove Species From North Sumatra, Indonesia, Mohammad Basyuni, Lollie Lollie Putri, Julayha Julayha, Hirosuke Oku Aug 2012

Non-Saponifiable Lipid Composition Of Four Salt-Secretor And Non-Secretor Mangrove Species From North Sumatra, Indonesia, Mohammad Basyuni, Lollie Lollie Putri, Julayha Julayha, Hirosuke Oku

Makara Journal of Science

Non-saponifiable lipid (NSL) of the fresh leaves and roots from two salt-secretor mangrove species, namely Aegiceras corniculatum (L.) Blanco and Avicennia alba Bl. and two non-secretor mangroves, i.e. Acrostichum aureum L. and Excoecaria agallocha L. was analyzed with special emphasize to triterpenoids and phytosterols. Identification of the triterpenoids and phytosterols was confirmed by comparison of their retention time on the GC column with those of authentic standards and on the interpretation of GC-MS spectra. Triterpenoids and phytosterols comprised the major proportion of NSL. The triterpenoids and phytosterols mainly consisted of 7 and 4 compounds. Triterpenoids were the largest constituent of …

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Urban Development In Costa Rica: The Direct And Indirect Impacts On Local And Regional Avian Assemblages, Jeff L. Norris Aug 2012

Urban Development In Costa Rica: The Direct And Indirect Impacts On Local And Regional Avian Assemblages, Jeff L. Norris

Dissertations

Urban development, the pinnacle of human land use, has drastic effects on native ecosystems and the species they contain. For the first time in recorded history there are more people living in cities than in the rural areas surrounding them. Furthermore, the global rate of urbanization continues increasing; raising serious concerns for earth's tropical regions as they harbor a disproportionate amount of the earth's species, and where the impacts of urban development on natural communities are poorly known. Therefore, for my dissertation research I investigated the impacts of urban development on avian community structure and organization at both local and …

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Biphenyl Inhibitors Of Carbonyl Reductase, Henry A. Charlier, Christopher K. Ewing Aug 2012

Biphenyl Inhibitors Of Carbonyl Reductase, Henry A. Charlier, Christopher K. Ewing

Boise State Patents

Compositions of matter and methods of treating cancer patients may prevent or limit cardiotoxicity during or after chemotherapy, and/or may prevent or lower resistance to anthracycline drugs, both of which are believed to be caused by the human enzyme carbonyl reductase. Thus, the compositions and methods may be used to reduce the dosages of anthracycline anti-cancer drugs necessary to produce a desired cancer-cell-killing performance. Preferred embodiments comprise treating cancer patients with a pharmaceutical composition comprising biphenyl compounds having two halogenated (or pseudo-halogenated) and/or hydroxylated, aryl groups that are linked by a bridging atom. The preferred composition of biphenyl compound(s) may …

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Mammalian Alteration/Deficiency In Activation 3 (Ada3) Is Essential For Embryonic Development And Cell Cycle Progression., Shakur Mohibi, Channabasavaiah B. Gurumurthy, Alo Nag, Jun Wang, Sameer Mirza, Yousaf Mian, Meghan Quinn, Bryan J. Katafiasz, James D. Eudy, Sanjit Pandey, Chittibabu Guda, Mayumi Naramura, Hamid Band, Vimla Band Aug 2012

Mammalian Alteration/Deficiency In Activation 3 (Ada3) Is Essential For Embryonic Development And Cell Cycle Progression., Shakur Mohibi, Channabasavaiah B. Gurumurthy, Alo Nag, Jun Wang, Sameer Mirza, Yousaf Mian, Meghan Quinn, Bryan J. Katafiasz, James D. Eudy, Sanjit Pandey, Chittibabu Guda, Mayumi Naramura, Hamid Band, Vimla Band

Journal Articles: Genetics, Cell Biology & Anatomy

Ada3 protein is an essential component of histone acetyl transferase containing coactivator complexes conserved from yeast to human. We show here that germline deletion of Ada3 in mouse is embryonic lethal, and adenovirus-Cre mediated conditional deletion of Ada3 in Ada3(FL/FL) mouse embryonic fibroblasts leads to a severe proliferation defect which was rescued by ectopic expression of human Ada3. A delay in G(1) to S phase of cell cycle was also seen that was due to accumulation of Cdk inhibitor p27 which was an indirect effect of c-myc gene transcription control by Ada3. We further showed that this defect could be …

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The Statesman, [Orientation Issue Fall 2012], Stony Brook University Aug 2012

The Statesman, [Orientation Issue Fall 2012], Stony Brook University

Stony Brook Statesman-Sucolian

[Orientation Issue Fall 2012]

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Trace Element Soil Contamination At Urban Community Gardens In Washington, Dc, Adam J. Long Aug 2012

Trace Element Soil Contamination At Urban Community Gardens In Washington, Dc, Adam J. Long

Environmental Analysis Program Mellon Student Summer Research Reports

In recent years, urban gardening has become a popular form of environmental, food, and social justice. Urban community gardens such as those in Washington, DC can reduce the environmental footprint of food production, provide access to healthy produce in “food deserts,” and provide other social, educational, and even financial benefits. However, the rising popularity of urban gardening has put many people in close contact with urban soils, which are likely to contain various contaminants due to concentrated human activity over extended periods of time. This study investigates heavy metal soil contaminants found in community gardens located in Washington, DC. 45 …

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Research News: 2012, No. 1, University Of Mississippi. School Of Pharmacy Aug 2012

Research News: 2012, No. 1, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

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Synthesis And Catalytic Applications Of Platinum(Ii) And Palladium(Ii)-Pta And Dapta Complexes, Sitaram Acharya Aug 2012

Synthesis And Catalytic Applications Of Platinum(Ii) And Palladium(Ii)-Pta And Dapta Complexes, Sitaram Acharya

Dissertations

The cage-like tertiary phosphine, 1,3,5-triaza-7-phosphaadamantane (PTA) has recently received interest because of its water-solubility, air-stability, non-ionic, non-surfactant, and basic nature. These properties can solubilize transition metal complexes in the aqueous phase. A related air-stable derivative, N,N’-diacetyl-1-3-5-triaza-7-phosphaadamantane (DAPTA) has greater water-solubility than PTA, however, its coordination chemistry has not been significantly explored. This study involved the synthesis and characterization of a series of novel air-stable and water-soluble four-coordinated dialkyl, dialkynyl, dihalo, and halo(alkyl) complexes of platinum and palladium bearing PTA and DAPTA ligands. The alkyl complexes of the type MX(R)P2 (M = Pt, Pd; X = Cl, Br, I; R = …

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Summer Enrichment Program Honors Participants, Sherry Wallace Aug 2012

Summer Enrichment Program Honors Participants, Sherry Wallace

News and Events (Discontinued Series)

No abstract provided.

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An Annotated List Of Symmachia Hübner, [1819] (Lepidoptera: Riodinidae: Symmachiini) From Parque Nacional Da Serra Do Divisor, Acre, Brazil, With The Description Of A New Species, Diego Rodrigo Dolibaina, Luis Anderson Ribeiro Leite, Fernando Maia Silva Dias, Olaf Hermann Hendrik Mielke, Mirna Martins Casagrande Aug 2012

An Annotated List Of Symmachia Hübner, [1819] (Lepidoptera: Riodinidae: Symmachiini) From Parque Nacional Da Serra Do Divisor, Acre, Brazil, With The Description Of A New Species, Diego Rodrigo Dolibaina, Luis Anderson Ribeiro Leite, Fernando Maia Silva Dias, Olaf Hermann Hendrik Mielke, Mirna Martins Casagrande

Insecta Mundi

We provide an illustrated list of species belonging to the genus Symmachia Hübner, [1819] (Lepidoptera: Riodinidae: Symmachiini) collected during an expedition conducted between September 10-21, 2011 in the northern part of the Parque Nacional da Serra do Divisor, Acre, Brazil, a remote region of Amazon rainforest. A total of 46 individuals were collected belonging to 15 species. For all recorded species, drawings of male genitalia and behavioral information are provided to support future studies on the taxonomy of the group. A new species, Symmachia divisora Dolibaina and Leite, sp. nov., is described, and a revised status for Symmachia hetaerina hesione …

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Notes On The Distribution And Habitat Of Omethes Marginatus Leconte (Coleoptera: Omethidae), Arthur V. Evans, Kyle E. Schnepp Aug 2012

Notes On The Distribution And Habitat Of Omethes Marginatus Leconte (Coleoptera: Omethidae), Arthur V. Evans, Kyle E. Schnepp

Insecta Mundi

The known distribution of a rarely collected omethid, Omethes marginatus LeConte (Coleoptera), includes Arkansas, Connecticut, District of Columbia, Indiana, Maryland, New Jersey, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Virginia, and West Virginia. Collection and ecological notes on recent collections in Arkansas, Indiana, and Virginia are presented.

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The Genus Gromphas Brullé, 1837 In Peru (Coleoptera: Scarabaeidae: Scarabaeinae: Phanaeini), Luis Figueroa, W. D. Edmonds, Felipe Meza-Velez Aug 2012

The Genus Gromphas Brullé, 1837 In Peru (Coleoptera: Scarabaeidae: Scarabaeinae: Phanaeini), Luis Figueroa, W. D. Edmonds, Felipe Meza-Velez

Insecta Mundi

The genus Gromphas Brullé (Coleoptera: Scarabaeidae) comprises four species, of which G. aeruginosa (Perty) and G. amazonica Bates are known to occur in Peru. This paper presents a revised description of Gromphas as well as illustrated diagnoses and distributional and ecological data on the Peruvian species.

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Taking Aim At The Start Of Translation, Medha Raina, Michael Ibba Aug 2012

Taking Aim At The Start Of Translation, Medha Raina, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

No abstract provided.

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The Mre11 Nuclease Is Critical For The Sensitivity Of Cells To Chk1 Inhibition, Ruth Thompson, Ryan Montano, Alan Eastman Aug 2012

The Mre11 Nuclease Is Critical For The Sensitivity Of Cells To Chk1 Inhibition, Ruth Thompson, Ryan Montano, Alan Eastman

Dartmouth Scholarship

The Chk1 kinase is required for the arrest of cell cycle progression when DNA is damaged, and for stabilizing stalled replication forks. As a consequence, many Chk1 inhibitors have been developed and tested for their potential to enhance DNA damage-induced tumor cell killing. However, inhibition of Chk1 alone, without any additional exogenous agent, can be cytotoxic. Understanding the underlying mechanisms of this sensitivity is critical for defining which patients might respond best to therapy with Chk1 inhibitors. We have investigated the mechanism of sensitivity in U2OS osteosarcoma cells. Upon incubation with the Chk1 inhibitor MK-8776, single-stranded DNA regions (ssDNA) and …

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Role Of Sequence And Structure Of The Hendra Fusion Protein Fusion Peptide In Membrane Fusion, Everett Clinton Smith, Sonia M. Gregory, Lukas K. Tamm, Trevor P. Creamer, Rebecca Ellis Dutch Aug 2012

Role Of Sequence And Structure Of The Hendra Fusion Protein Fusion Peptide In Membrane Fusion, Everett Clinton Smith, Sonia M. Gregory, Lukas K. Tamm, Trevor P. Creamer, Rebecca Ellis Dutch

Molecular and Cellular Biochemistry Faculty Publications

Viral fusion proteins are intriguing molecular machines that undergo drastic conformational changes to facilitate virus-cell membrane fusion. During fusion a hydrophobic region of the protein, termed the fusion peptide (FP), is inserted into the target host cell membrane, with subsequent conformational changes culminating in membrane merger. Class I fusion proteins contain FPs between 20 and 30 amino acids in length that are highly conserved within viral families but not between. To examine the sequence dependence of the Hendra virus (HeV) fusion (F) protein FP, the first eight amino acids were mutated first as double, then single, alanine mutants. Mutation of …

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Development Of Repressible Systems To Control Gene Expression In Vaccinia Virus, Allison Titong Aug 2012

Development Of Repressible Systems To Control Gene Expression In Vaccinia Virus, Allison Titong

Master's Theses

Two vaccinia virus (VACV) expression systems that contain elements from the lactose (lac) and the tetracycline (tet) operons of E. coli were developed to repress the expression of a reporter gene, enhanced green fluorescent protein (EGFP), in the presence of tet operon inducers. In the first system, lac and tet operon elements were arranged in a gene circuit, and in the presence of increasing concentrations of a lac operon inducer (isopropyl-β-D-thiogalactoside, IPTG), EGFP expression increased in a dose dependent manner and at high IPTG concentrations, expression reached the same levels as a positive control virus. Importantly, in the …

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Sex Determination In Beetles: Production Of All Male Progeny By Parental Rnai Knockdown Of Transformer, Jayendra Nath Shukla, Subba Reddy Palli Aug 2012

Sex Determination In Beetles: Production Of All Male Progeny By Parental Rnai Knockdown Of Transformer, Jayendra Nath Shukla, Subba Reddy Palli

Entomology Faculty Publications

Sex in insects is determined by a cascade of regulators ultimately controlling sex-specific splicing of a transcription factor, Doublesex (Dsx). We recently identified homolog of dsx in the red flour beetle, Tribolium castaneum (Tcdsx). Here, we report on the identification and characterization of a regulator of Tcdsx splicing in T. castaneum. Two male-specific and one female-specific isoforms of T. castaneum transformer (Tctra) were identified. RNA interference-aided knockdown of Tctra in pupa or adults caused a change in sex from females to males by diverting the splicing of Tcdsx pre-mRNA to male-specific isoform. All the pupa and adults developed from Tctra …

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