Digital Commons Network^™

Interleukin-6 Inhibition For Patients With Acute Myocardial Infarction: A Systematic Review And Meta-Analysis, Mohammed Y. Alasmary, Mohammed J. Almalki, Faisal H. Almalki, Waleed D. Khubzan, Mohammed H. Rajab, Mohammed S. Almalki, Hussam A. Almalki, Omar M. Alsuwat, Hussam M. Alghannami

Saudi Medical Journal

Objective: To explore the outcomes associated with interleukin-6 (IL-6) pathway blockade, using tocilizumab, in patients with ST-elevation myocardial infarction (STEMI) and non (NSTEMI). Acute myocardial infarction (AMI) denotes myocardial necrosis due to ischemia and presents in distinct electrocardiographic phenotypes. Inflammation driven by IL-6 contributes to ischemia-reperfusion injury, with tocilizumab showing promise in reducing myocardial damage and improving outcomes.

Methods: This work followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Framework and was registered in international prospective register of systematic reviews (PROSPERO). Relevant studies were identified through structured searches of PubMed, MEDLINE, the Cochrane Library, and Google Scholar up …

Cure Sickle Cell Initiative Recommendations On Common Data Elements For Sickle Cell Disease Gene Therapy Trials, Sophie Lanzkron, Victoria H. Coleman-Cowger, Alexis A. Thompson, C. Patrick Carroll, Traci Clemons, Michael Debaun, Julie Kanter, Punam Malik, Deepa Manwani, Francis John Pierciey, Mark C. Walters, Sherita Alai

Cardeza Foundation for Hematologic Research

The Cure Sickle Cell Initiative (CureSCi), created by the National Heart, Lung, and Blood Institute, has developed data standards to increase interoperability and meta-analysis of studies specifically investigating gene therapy for sickle cell disease (SCD). The aims of the CureSCi Common Data Elements (CDE) initiative are to facilitate the development of safe, effective, and accessible gene therapies. Five working groups (WGs) comprising people living with SCD, stakeholders, clinicians, and researchers reviewed current definitions used for SCD clinical studies, including those from the American Society of Hematology, US Food and Drug Administration, PhenX catalog of consensus measures for phenotypes and exposures, …

U.S. Black Men’S Perceptions Of The Similarities And Interplay Among Mind-Body Practices, Spirituality, And Religion: A Qualitative Study, Khanh Pham

Theses and Dissertations

This qualitative study explored U.S. Black men’s perceptions of relations among mind-body practices (MBPs), spirituality, and religion to understand how these factors might influence Black men’s health. Reflexive thematic analysis was used to analyze data from individual semi-structured interviews with 18 Black male MBP instructors. Five themes were generated. The themes were (1) spirit(uality) is the foundation for Black men’s experience of life seen and unseen, (2) MBPs and religion are rooted in spirituality, (3) MBPs, religion, and Black culture share common characteristics, (4) MBPs and religion facilitate holistic wellbeing, and (5) confusion and negative perceptions about MBPs, spirituality, and …

Automated Detection Of Bacterial Flagellar Motors, Eben J. Lonsdale

Undergraduate Honors Theses

With advances in cryogenic electron tomography, the ability to study bacterial structures in their cellular context has improved. However, 3D images of bacteria, called tomograms, have a low signal-to-noise ratio. This makes annotating structures of interest difficult, as traditional computer vision models struggle with tomograms and manual annotation is time consuming. We build on the results of the BYU Kaggle competition to create an ensemble model capable of automatically annotating flagellar models with nearly around 85% accuracy.

Methylglyoxal And Glyoxal In High-Puff Disposable Electronic Cigarette Liquids: Unexpected Accumulation And Enhanced Cytotoxicity, Esther E. Omaiye, Wentai Luo, Kevin J. Mcwhirter, Man Wong, Prue Talbot

Civil and Environmental Engineering Faculty Publications and Presentations

Despite concerns regarding the potential health risks associated with EC use, their design, puff count, and e-liquid formulations have continued to evolve. Aldehydes are a key class of thermal degradation byproducts generated during the vaporization of EC fluids. This study tested the hypothesis that aldehyde concentrations would be elevated in used ECs with high puff numbers. Devices from multiple brands were analyzed to assess the impact of extended use on aldehyde formation. E-fluids were extracted from field-collected and user-donated devices and analyzed using gas chromatography/mass spectrometry to quantify 178 flavor chemicals, two synthetic coolants, nicotine, solvents, and aldehydes (methylglyoxal (MGO), …

Export Controls Policy & Procedure, Munster Technological University, Ireland

Policies & Procedures Documents

The aim of this document is to ensure the University meets its legal obligations under export controls and sanctions legislation, seeking to protect the University and its community from the risks of non-compliance, while supporting secure and responsible international collaboration and research.

Uranyl Complex Of 1,3-Bis(Ditertbutylphosphinoxidomethyl)Benzene, Maha M. Alotaibi, Md Abdul Goni, Eric Reinheimer, Tasneem A. Siddiquee

Chemistry Faculty Research

This short note presents a new molecule isolated and characterized from the reaction of uranyl nitrate with the PCP-type pincer ligand 1,3-bis(ditertbutylphosphinomethyl)benzene in the presence of UV light under ambient conditions. The new dinuclear uranyl-PCP complex was characterized by using FT-IR spectroscopy and single-crystal X-ray crystallography. As revealed by the crystal structure, the new complex had oxygen atoms coordinating from the phosphinoxides that were oxidized under ambient conditions. Each uranium atom of this dinuclear complex was found to exhibit pentagonal bipyramidal coordination geometry.

Transformative Practices: The Multiple Impacts Of The Mat Program At Al-Quds Bard College, Daniel Terris, Derek Furr

GHEA21 Open Educational Resources

This paper summarizes research on the impact of the Master of Arts in Teaching (MAT) program at Al-Quds Bard College, which since 2009 has trained more than 600 Palestinian K-12 teachers working across the West Bank and reaching over 120,000 students, many in disadvantaged communities. Supported in part by the Education Above All foundation, the program combines educational theory, discipline-based knowledge, classroom research, and reflective practice, requiring in-service teachers to experiment with new teaching approaches in their own classrooms. Multiple studies reviewed in the paper show that MAT graduates adopt more student-centered pedagogies—such as backward design, inquiry-based learning, and collaborative …

The Psychosocial Factors Influencing Hiv Testing Among Women In Ghana, Janet Okailey Okine

Electronic Theses and Dissertations Archive

HIV testing is still an important component of HIV prevention, and disparities persist among women in Ghana. This study examines psychosocial and socio-demographic factors influencing HIV testing behavior, using data from the 2022 Ghana Demographic and Health Survey. A binary logistic regression result revealed that older, more educated, and wealthier women, and women who utilized HIV test kits, exhibit a much higher likelihood of undergoing HIV testing. Awareness of HIV stigma reduces the likelihood of women undergoing testing. Variations existed depending on the place of residence. Women in rural and northern belts were less likely to undergo testing. Marital status, …

“Your ‘Magic Dick’ Won’T Fix Us”: The Lived Experience Of Women With Vaginismus, Alisun Fiona Hughes

Electronic Theses and Dissertations Archive

Genito-Pelvic Pain/Penetration Disorder, or what is commonly referred to as Vaginismus, is a pelvic floor dysfunction which causes penetration of the vagina to be painful or impossible. This qualitative study examines the lived experiences of women living with vaginismus, looking specifically at how they were socialized to perceive sex and how they navigate their condition. Grounded in theories such as Sexual Scripts Theory, Stigma Theory and Gender as Performance, this research analyzes how this condition is not just a biological trait, but also a socialized phenomenon that often causes a “spoiled identity”. Data was collected through an open-ended online survey …

The Technology Of Tradition And Biology Of Narrative: New Analogies For The Study Of Homer And Epic, Eunice Kim

Open Access Fund Publications

In two separate, timely books Bozzone and Christensen draw from a wide range of scientific disciplines and modern parallels to consider how Homeric language and epic stories are in some ways living and alive. For Bozzone, who analyses the various formal features of Homer’s poetic technique by incorporating cognitive and linguistic frameworks, Homeric language is ‘living’ insofar as it operates on mechanisms analogous to those a speaker uses for natural languages and other kinds of speaking performances. Christensen, on the other hand, applies a series of biological analogies to epic poetry and imagines that the narrative of Homeric epic is …

The Effect Of Face Masks On The Perception Of Trustworthiness And Competence In Individuals With Autistic Traits, Farid Pazhoohi, Maryam Rostami-Aghoui, Leilani Forby, Keina Aoki, Alan Kingstone

School of Psychology

Facial expressions play a crucial role in social communication, influencing judgments of trustworthiness and competence. While previous research has examined how face masks affect trust and competence in general populations, little is known about their impact on individuals with high autistic traits, who often rely more on the mouth region for social cue interpretation. The present study investigates the effects of face masks on perceptions of trustworthiness and competence as a function of high and low autistic traits. Results show that masked faces are generally perceived as more trustworthy and competent than unmasked faces. The effect of mask wearing on …

2026-06-09 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from June 9, 2026.

Ora (Oneball Robotic Arm), Isabella Murillo, Juan Pablo Fernandez Garza, Gabriel Kotab, Catherine Epstein

Electrical and Computer Engineering Senior Theses

Confined spaces are dangerous and awkward to navigate environments, often putting those who work in them at risk. To reduce effort and human exposure to these hazards, robotic systems can be used to navigate and inspect these areas to limit, or even eliminate the need for human presence in confined spaces. This project proposes an autonomous robot that can navigate confined spaces while sending data back to the user. The robot features a spherical body that is capable of a zero rotational axis, with an external, magnetically attached head. This head contains scanners or tools that the user can remotely …

Teachers' Promoting Literacy Achievement For Middle School African American Male Students, Angelia Slavings

Walden Dissertations and Doctoral Studies

No abstract provided.

Trauma-Informed Conversational Agents For Mental Health: Understanding User Perspectives And Experiences, Xintong Lu, Shion Guha, Rachel Pfafman, Jessica Pater, Courtney L. Washington, Fayika Farhat Nova

Health Services and Informatics Research

Introduction:

Mental health conversational agents (MHCAs) offer scalable, accessible psychological support yet raise concerns about safety and appropriateness for trauma, exposed users. While trauma-informed care (TIC) principles, emphasizing safety, trust, empowerment, collaboration, peer support, and cultural sensitivity, are well-established in clinical practice, their application and user interpretation in chatbot contexts remain unexplored. This study aimed to explore (1) how users conceptualize trauma-informed care in the context of mental health chatbots and (2) what factors can help us predict whether users perceive their chatbot interaction as trauma-informed.

Methods:

A 59-item web-based survey (REDCap) assessed demographics, technology proficiency, adverse life experiences, chatbot …

Decorin Promotes Nascent Proteoglycan Retention In Cartilage Matrix By Strengthening Collagen Ii-Aggrecan Integration, Thomas Li, Gabriela Canziani, Yuchen Liu, Neil Patel, Biao Han, Mingyue Fan, Annie Porter, Bryan Kwok, Chao Wang, Qing Li, David E. Birk, Renato V. Iozzo, Irwin M. Chaiken, X. Lucas Lu, Robert L. Mauck, Lin Han

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Cartilage extracellular matrix (ECM), a hydrated collagen II-aggrecan composite, undergoes dynamic turnover during both normal homeostasis and disease-associated remodeling. This study elucidates a crucial role for decorin in promoting the retention and stability of nascent aggrecan within this matrix. By applying bio-orthogonal click-labeling, we demonstrate that loss of decorin accelerates the release of nascent aggrecan under both physiological and inflammatory conditions, without affecting its preferential localization to the pericellular matrix. Conversely, supplementation with exogenous decorin mitigates inflammation-induced loss of nascent aggrecan, supporting its potential as a therapeutic target. At the molecular level, decorin exhibits strong binding affinity for aggrecan, and …

In Vivo Orf Overexpression Screening Identifies Ccn4 As A Regulator Of Glioblastoma Growth Validated Across Multiple Models, Pushan Dasgupta

Faculty, Staff and Students Publications

Despite current multimodal therapies for glioblastoma (GBM), its prognosis remains grim. Thus, a tremendous need exists to identify new genetic drivers that may serve as potential therapeutic targets in glioblastoma (GBM). We describe an in vivo overexpression screening strategy to identify drivers of glioblastoma where we have leveraged TCGA datasets to conduct a functional genomics screen of prioritized open reading frames (ORFs) that are overexpressed and/or amplified in GBM. To interrogate these potential drivers within a more relevant physiological context, the screening was accomplished in vivo in an orthotopic patient-derived glioma stem-like cell (GSC) model. Among 5 positive "hits" from …

Maximizing Room-Temperature Red Phosphorescence In Contorted Hexabenzocoronene Derivatives, Marko R. Ivancevic, Moses D. Ogbaje, Jesse A. Wisch, Daniel G. Oblinsky, Alice S. Fergerson, Emily C. Davidson, Gregory D. Scholes, Barry P. Rand, Chad Risko, Quinn C. Burlingame, Yueh Lin Loo

Chemistry Faculty Publications

Organic molecules exhibiting second-scale room-temperature phosphorescence (RTP) in the red/near-infrared are particularly rare because low-energy excited states that are characteristic of these chromophores are susceptible to nonradiative deactivation. Here, we observe second-scale red RTP from contorted hexabenzocoronene (cHBC) embedded in a rigid polymer. This RTP is uniquely efficient as approximately 23% of the steady-state photoluminescence originates from triplets. We propose that this efficient triplet generation stems from intersystem crossing (ISC) that outcompetes symmetry-forbidden fluorescence. Density functional theory and time-dependent density functional theory calculations suggest that ISC occurs from the lowest energy singlet state of cHBC into a nearly resonant triplet …

Publisher Correction: Whole Genome Sequence Analysis Of Pulmonary Function And Copd In 44,287 Multi-Ancestry Participants, Wonji Kim, Xiaowei Hu, Kangjin Kim, Sung Chun, Peter Orchard, Dandi Qiao, Ingo Ruczinski, Aabida Saferali, Francois Aguet, Lucinda Antonacci-Fulton, Pallavi P Balte, Traci M Bartz, Wardatul Jannat Anamika, Xiaobo Zhou, Junyi Duan, Jennifer A Brody, Brian E Cade, Martha L Daviglus, Harshavadran Doddapaneni, Shannon Dugan-Perez, Susan K Dutcher, Christian D Frazar, Stacey B Gabriel, Sina A Gharib, Namrata Gupta, Brian D Hobbs, Silva Kasela, Laura R Loehr, Ginger A Metcalf, Donna M Muzny, Elizabeth C Oelsner, Laura J Rasmussen-Torvik, Colleen M Sitlani, Joshua Smith, Tamar Sofer, Hanfei Xu, Bing Yu, David Zhang, John Ziniti, R Graham Barr, April P Carson, Myriam Fornage, Lifang Hou, Ravi Kalhan, Robert Kaplan, Tuuli Lappalainen, Stephanie J London, Alanna C Morrison, George T O'Connor, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Jerome I Rotter, Edwin K Silverman, Ani Manichaikul, Michael H Cho

Faculty, Staff and Student Publications

This corrects the article "Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants", 28.

Agrivoltaic Shading Reduces Soil Greenhouse Gas Fluxes In A Semi-Arid Vineyard, Marcelo Gomes Da Silva, Rafael M. Almeida, Carine Cocco, Engil Pereira

School of Earth, Environmental, & Marine Sciences Faculty Publications

Agrivoltaic systems are expanding in semi-arid regions, raising questions about how panel driven shading alters soil greenhouse gas exchange. We used automated chambers to measure high frequency soil CO2, N2O, and CH4 fluxes in a newly established vineyard agrivoltaic system in Texas across three shading intensities (0%, 35%, 88%) that represent the light environment beneath panels as shaped by panel tilt and solar trajectory. Shading primarily cooled the soil, reducing mean soil temperature from 35.9 °C (0%) to 32.5 °C (35%) and 30.5 °C (88%), while mean soil water content shifted modestly (0.125, 0.106, and 0.130 m3 m−3, respectively). Over …

Diagnosis Of Covid-19 Impact On The Construction Employment: Decline And Recovery, Anil Baral, Abdullah Alnuaimi, Yunping Liang, Baabak Ashuri, Mohsen S. Shahandashti

Durham School of Architectural Engineering and Construction: Faculty Publications

The Coronavirus Disease 2019 (COVID-19) had an unprecedented impact on U.S. construction employment. The assessment of employment declines and recoveries across various construction sectors, workforce demographics, and geographic regions helps develop inclusive long-term plans to overcome the setbacks of natural hazards, such as the COVID-19 pandemic. Existing methods for quantifying the employment decline from sudden shocks do not consider trends and seasonality of construction employment under normal conditions. Hence, it is not clear whether the employment declines are due to the impact of a disaster or associated with trends and seasonal patterns of employment. The objective of this research is …

Psychogastroenterology: An Introduction For Behavioral Health And Healthcare Professionals, Jerrod Brown Ph.D., M.A., M.S., M.S., M.S., M.S., M.S., Jeremiah B. Schimp Phd, Ma, Lpcc, Leanne Skehan Dcn, Msacn, Mph, Mba, Cns, Ches, Shelley Mydra Dmft, Lmft, Jonathan Ward Dc, Phd(C), Ms, Dibcn, Tiffany Flaten Cns, Ldn

Nutritional Neurocriminology Today

Although often difficult to discuss with clients, gastrointestinal (GI) issues affect an estimated 60 to 70 million Americans (American Gastroenterological Association, 2022). Yet only about 25% of those experiencing these conditions receive treatment. This is troubling because GI issues frequently co-occur with clinically significant consequences for physical health, psychological well-being, daily functioning, and overall quality of life. Designed for behavioral health and healthcare professionals, this brief article introduces the field of psychogastroenterology, with emphasis on symptoms, stigma, diagnosis, and treatment. Key topics include the gut-brain axis, common digestive health conditions, and the mental health implications associated with gastrointestinal disorders.

Pretty Much From Scratch: A Braided Essay On Autistic Diagnosis, Creativity, Identity, And Community, Jenée Stanfield

Ought: The Journal of Autistic Culture

This braided essay uses memoir and research to explore autistic diagnosis, creativity, identity, and community. It examines how the misinformation around these topics harm and “other” autistics: the fallacy of diagnostic objectivity/neutrality, the dual myths of autistic hyper- and hypo-creativity, and autism as an identity defined solely by medical professionals. The memoir sections play with point of view and genre.

Jenée is a late-realized autistic with ADHD and OCD, who identifies as neurodivergent and neuroqueer. She lives in Washington state with her spouse and dog. She has a Master of Fine Arts in Creative Writing and is currently a Master …

Opening Portals To The Posthuman: A Pedagogical Framework For Materializing Philosophy, Carlos Henrique Araujo De Aguiar

DRS Biennial Conference Series

This paper critiques dominant design pedagogies for their alignment with positivist and modernist paradigms, which limit design’s capacity for serious philosophical inquiry. It argues that Speculative and Critical Design (SCD) pedagogy offers an alternative philosophy, functioning as a powerful method for fomenting critical engagement by enabling students to materialize abstract concepts. Drawing on a case study from an undergraduate course on human-robot-cyborg relations, the paper employs the metaphor of 'portals' to analyse three thematic case studies. Each portal opens onto a distinct philosophical debate: the nature of reality and the self, the biopolitics of the body, and the networked subject. …

User-Centered Dread: A Lovecraftian Critique Of Design, Lewis Urquhart, Emma Lawrie

DRS Biennial Conference Series

This paper offers a speculative critique of contemporary design practice through the lens of Lovecraftian horror by critically interrogating assumptions embedded in user-centered design theory. Drawing on the oeuvre of 'weird fiction' author H.P. Lovecraft’s cosmically pessimistic mythologies, this paper explores three thematic dimensions - control, user unknowability, alien materiality - to reveal the limitations of human-centred design paradigms. Utlising examples from literature, film, and everyday experience, this critique demonstrates how design’s aspirational narratives, centered on mastery, empathy, and progress, are increasingly inadequate in addressing the complexities of a more-than-human world. The concept of 'user-centered dread' emerges as a central …

Emerging Hybrid Human-Genai Workflows To Optimise Human Ideation, Sketching And Design, Mauricio Novoa Munoz, Juan Antonio Islas Munoz, Alejandro Lozano Robledo

DRS Biennial Conference Series

This article presents findings on the reciprocal relationship between industrial design education and the industry it prepares graduates for. Particularly considering the growing impact of Generative Artificial Intelligence (GenAI) on ideation, sketching, design methodologies, and productivity. To inform this research, industry professionals currently integrating GenAI into their practice were consulted to establish benchmarks and highlight critical areas for updated pedagogical approaches and digital transformation, thereby ensuring that design learning and productivity workflows remain relevant. The study arises from an awareness of current workforce shifts that are anticipated to become more pronounced soon. Rapid technological advancements are driving significant cultural and …

Interspecies: A Collaborative Curatorial Inquiry Into New Romanticism, Mariana Pestana, Katerina Inglezaki, Carlos Pastor, Mathilde Gouin, Bernardo Gaeiras, Fernanda Costa, Mariana Simões

DRS Biennial Conference Series

This paper presents a situated, plural, and horizontal curatorial methodology centered on questioning rather than providing solutions in response to posthuman thought and practice. It inquires whether we might be witnessing the emergence of a New Romanticism in contemporary design and architecture concerned with interspecies relations. This romantic turn arises by acknowledging subjectivity and imagination while engaging critically with the complexities of the climate crisis. To this end, this paper examines the making of an exhibition that assembled material evidence from science, art, technology, and design. The exhibition was developed through a three-step curatorial framework aligned with the decentering narratives …

Making Sense Of Pain: Participatory Design Approaches To Understanding And Supporting People Living With Chronic Pain, Ivana Nakarada-Kordic, Jannisa Seck, Nathan Beetge, Cassandra Khoo, Stephen Reay

DRS Biennial Conference Series

Pain is universal, yet its invisible nature makes it difficult to express or understand. Understanding the intricate mechanics of chronic pain and how to manage it effectively can be particularly challenging. This paper describes research exploring how human-centred design, transdisciplinary collaboration, and participatory approaches can produce diverse design outcomes that support the management and treatment of chronic pain. Two case studies are presented: 1) an exploration of how pain might be expressed through illustration and storytelling to offer insight into lived experience, and 2) how experiences of pain could be made more tangible through physical artefacts to support patient–clinician communication. …

Designing For Radical Renewal: Innovation Outcomes Across Circular And Regenerative Approaches, Belinda Nors, Louise Møller Haase, Sara Nielsen

DRS Biennial Conference Series

This paper defines regenerative design in relation to current collaborative, sustainability-oriented innovation. Production and consumption patterns are largely linear, with circular economy efforts largely focused on recycling. Regenerative approaches are emerging but underdeveloped. Literature describes the Regenerative worldview and theoretical framework, and the few papers on methodology and practice highlight a need for greater definition of the field. An actionable design- and innovation methodology for the regenerative field is lacking. We conduct a scoping review and define the Regenerative design approach in relation to the current Circular Oriented Design approaches. We present the characteristics of the Value Preserving and Regenerative …