Digital Commons Network^™

Efficacy Of Phosphatidic Acid Ingestion On Lean Body Mass, Muscle Thickness And Strength Gains In Resistance-Trained Men, William Mccormack

Health and Human Sciences Faculty Works

Background: Phosphatidic acid (PA) has been reported to activate the mammalian target of rapamycin (mTOR) signaling pathway and is thought to enhance the anabolic effects of resistance training. The purpose of this pilot study was to examine if oral phosphatidic acid administration can enhance strength, muscle thickness and lean tissue accruement during an 8-week resistance training program. Methods: Sixteen resistance-trained men were randomly assigned to a group that either consumed 750 mg of PA (n = 7, 23.1 ± 4.4 y; 176.7 ± 6.7 cm; 86.5 ± 21.2 kg) or a placebo (PL, n = 9, 22.5 ± 2.0 y; …

The Effect Of A Dietary Supplement (N-Oleyl-Phosphatidyl-Ethanolamine And Epigallocatechin Gallate) On Dietary Compliance And Body Fat Loss In Adults Who Are Overweight: A Double-Blind, Randomized Control Trial, William Mccormack

Health and Human Sciences Faculty Works

Background: A dietary supplement containing a blend of 170mg of N-oleyl-phosphatidylethanolamine (NOPE) and 100mg of epigallocatechin-3-gallate (EGCG) has been shown to improve compliance to low caloric diets. Considering the cost of dietary ingredients, many manufacturers attempt to determine the lowest efficacious dose. Thus, the purpose of this study was to evaluate the efficacy of 8-weeks of supplementation with a daily intake of 120mg of NOPE and 105mg of EGCG in conjunction with a low caloric diet and regular, moderate exercise on dietary compliance in healthy, overweight adults. An additional purpose was to examine the effect of this supplement/diet/exercise paradigm on …

Body Mass Index Change In Adulthood And Lung And Upper Aerodigestive Tract Cancers, Heather Tarleton

Health and Human Sciences Faculty Works

Body mass index (BMI) has been inversely associated with lung and upper aerodigestive tract (UADT) cancers. However, only a few studies have assessed BMI change in adulthood in relation to cancer. To understand the relationship between BMI change and these cancers in both men and women, we analyzed data from a population-based case-control study conducted in Los Angeles County. Adulthood BMI change was measured as the proportional change in BMI between age 21 and 1 year before interview or diagnosis. Five categories of BMI change were included, and individuals with no more than a 5% loss or gain were defined …

Philosophy And Theology: After-Birth Abortion, Christopher Kaczor

Philosophy Faculty Works

The article focuses on the issues related to philosophy and theology. It cites the example of an article based on the topic by philosopher Michael Tooley in the year 1972. As mentioned, article made critics of abortion squirm and also tried to extend the ethics of exclusion to cover not just prenatal but also postnatal human beings.

Review Of Robert P. George And Christopher Tollefsen, Embryo: A Defense Of Human Life, Christopher Kaczor

Philosophy Faculty Works

No abstract provided.

Role Of Twin Cys-Xaa9-Cys Motif Cysteines In Mitochondrial Import Of The Cytochrome C Oxidase Biogenesis Factor Cmc1, Deepa V. Dabir

Biology Faculty Works

The Mia40 import pathway facilitates the import and oxidative folding of cysteine-rich protein substrates into the mitochondrial intermembrane space. Here we describe the in vitro and in organello oxidative folding of Cmc1, a twin CX9C-containing substrate, which contains an unpaired cysteine. In vitro, Cmc1 can be oxidized by the import receptor Mia40 alone when in excess or at a lower rate by only the sulfhydryl oxidase Erv1. However, physiological and efficient Cmc1 oxidation requires Erv1 and Mia40. Cmc1 forms a stable intermediate with Mia40 and is released from this interaction in the presence of Erv1. The three proteins are shown …

Society, Demography And Genetic Structure In The Spotted Hyena, Heather E. Watts

Biology Faculty Works

Spotted hyenas (Crocuta crocuta) are large mammalian carnivores, but their societies, called 'clans', resemble those of such cercopithecine primates as baboons and macaques with respect to their size, hierarchical structure, and frequency of social interaction among both kin and unrelated group-mates. However, in contrast to cercopithecine primates, spotted hyenas regularly hunt antelope and compete with group-mates for access to kills, which are extremely rich food sources, but also rare and ephemeral. This unique occurrence of baboon-like sociality among top-level predators has favoured the evolution of many unusual traits in this species. We briefly review the relevant socio-ecology of spotted hyenas, …

Selective Mutism And Art Therapies, Dalene Erickson

Theses and Dissertations

Selective Mutism (SM) is a social anxiety disorder characterized by a child's inability to speak in selected social situations, usually school. The causes of SM are multi-factorial. Affected children often have a history of anxiety, linguistic and motor disorders. Current therapies include a mix of anti-anxiety medication, behavioral modification therapy and anxiety reduction techniques.

Art therapy, (dance, drama and theater), has been shown to be beneficial in reducing anxiety and encouraging communication through forms other than speaking. Art therapy could be a valuable modality, benefitting children with SM.

I surveyed parents, teachers, former teachers of children with SM, and adults …

Parental Efficacy, Experience Of Stressful Life Events, And Child Externalizing Behavior As Predictors Of Filipino Mothers' And Fathers' Parental Hostility And Aggression., Aileen S. Garcia, Liane Peña Alampay

Psychology Department Faculty Publications

This study assessed relations of parental efficacy, experience of stressful life events, and child externalizing behavior to Filipino mothers and fathers’ parental hostility and aggression. Orally-administered surveys were conducted with 117 mothers and 98 fathers for the first year of data collection, and again a year later with 107 mothers and 83 fathers. Path analyses showed that mothers’ report of child externalizing behavior predicted subsequent parental hostility and aggression. For fathers, child externalizing behavior and experience of stressful life events predicted parental hostility and aggression. Additionally, fathers’ parental efficacy was found to moderate the relationship between experience of stressful life …

Ambulatory Care Visits By Taiwanese Dentists, Ying-Hwa Su, Shu-Min Huang, Yu-Wen Lin, Ming-Chung Ko, Chung-Yi Li

Journal of Dental Sciences

Abstract Background/purpose It is well recognized that various occupational hazards, including chemical, physical, and biological agents, can have adverse effects on dentists, whose heath is critical to the quality of dental care. However, little is known about the incidence of morbidity in Taiwan's dentist population. We carried out this study to investigate the overall and cause-specific incidence rates of ambulatory care visits by Taiwan's dentists. Materials and methods Data analyzed in this study were retrieved from Taiwan's National Health Insurance claims. We followed 7760 dentists who had a contract with the National Health Insurance program from 2003 to 2007. The …

Preferred Dna Binding Orientation Of The Hyperthermophile Protein Sac7d, Gokul Krishna Turaga

Dissertations

No abstract provided.

Structured Dna Probe Microarrays For Detection Of Acetotrophic Methanogens In Complex Solutions, Jonas Boateng

Dissertations

No abstract provided.

An Overview Of Patentable Subject Matter And The Effect Of Mayo Collaborative Services V. Prometheus Laboratories, Inc., Veronica Lambillotte

Case Western Reserve Law Review

No abstract provided.

President's Annual Report, Brooks Keel

Office of the President: Annual Report (Archived)

No abstract provided.

An Assessment Of The Impact Of Hafting On Paleoindian Point Variability, B. Buchanan, Michael J. O'Brien, J. D. Kilby, B. B. Huckell, M. Collard

History Faculty Publications (Archived)

It has long been argued that the form of North American Paleoindian points was affected by hafting. According to this hypothesis, hafting constrained point bases such that they are less variable than point blades. The results of several studies have been claimed to be consistent with this hypothesis. However, there are reasons to be skeptical of these results. None of the studies employed statistical tests, and all of them focused on points recovered from kill and camp sites, which makes it difficult to be certain that the differences in variability are the result of hafting rather than a consequence of …

Getting To Sometimes: Expanding Teachers' First Amendment Rights Through Garcetti's Caveat, Benjamin C. Galea

Case Western Reserve Law Review

No abstract provided.

Brain Penetration Of Tolfenamic Acid And Its Ability To Enhance The Cognitive Functions And To Lower Amyloid Pathology In Animal Models Of Alzheimer's Disease, Gehad Mohammed Subaiea

Open Access Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disease that is responsible for up to 80% of all dementia cases. Hallmarks of AD include the presence of beta-amyloid (Aβ) deposits and twisted strands of abnormal hyperphosphorylated tau forming neurofibrillary tangles (NFT_s), which ultimately lead to damage and death of nerve cells in the brain. Symptoms of the disease include impairments in cognitive and functional abilities that gradually worsen as the disease progress. Finally, in advanced AD, patients become unable to perform basic daily activities, become more susceptible to infections, and ultimately die. Only five drugs are FDA-approved for use in …

The Effectiveness Of Constructed Wetlands, Jessica L. Franks, Eric B. Snyder, Megan M. Woller-Skar

Student Summer Scholars Manuscripts

Wetland construction represents a vital tool to increase the number and extent of wetlands in the United States. However, there is uncertainty as to how effective constructed wetlands actually are and if they continue to function efficiently as they age. This study’s objective was to evaluate the constructed wetlands on Grand Valley State University’s Allendale campus. The wetlands studied were constructed in both 2009 (n=3) and 2011 (n=5), not specifically to mitigate for wetland loss; rather they are a proactive attempt to reduce erosion from excessive stormwater runoff in the GVSU ravines. We compared these to wetlands constructed in the …

Making Boundaries And Linking Globally: “Material Politics” Of Phytosanitary Regulation On Mexican Mangos, Kiyohiko Sakamoto

Theses and Dissertations--Sociology

This dissertation illuminates how phytosanitary (PS) regulations enable mango exportation from Mexico to the United States. PS regulations are technical and legal measures to prevent plant pests from proliferating or being transported to other places and are important regulatory mechanisms enabling the globalization of agriculture. My case study investigates how PS regulations enable Mexican mango exportation as an aspect of the globalization of agriculture, illustrating the consequences of PS regulations to humans and non-humans. More specifically, three research questions are posed: (1) How does the PS regulation network operate to draw distinctions between pest/non-pest, thereby enabling the export of Mexican …

Spatial And Temporal Patterns In Nutrient Standing Stock And Mass-Balance In Response To Load Reductions In A Temperate Estuary, Jason Seth Krumholz

Open Access Dissertations

The addition of excess organic matter into a system, commonly referred to as eutrophication (Nixon, 1995), is a widespread problem in estuaries throughout much of the world. To combat this trend, many management agencies are imposing regulations limiting the amount of nutrients (nitrogen and phosphorus) which can be discharged into coastal waters through wastewater treatment and agriculture. In 2005, the Rhode Island Department of Environmental Management (RIDEM) enacted legislation mandating that wastewater treatment facilities (WWTF) discharging their effluent into Narragansett Bay and its tributaries reduce the concentration of nitrogen in their effluent. This legislation will reduce wastewater nitrogen loading to …

Proteasome Regulation Of Caspase-8: Significance In Cancer, Michael Vincent Fiandalo

Theses and Dissertations--Molecular and Cellular Biochemistry

Anti-tumor therapeutic strategies based on combinations of chemotherapeutic agents with a death inducing ligand such as TNF-α Related Apoptosis Inducing Ligand (TRAIL), are directed towards selective and effective cancer cell apoptosis and enhanced therapeutic response. We previously demonstrated that proteasome inhibition sensitizes TRAIL resistant prostate cancer cells to TRAIL-mediated apoptosis via stabilization of the active p18 subunit of initiator caspase-8. The present study investigated the functional link between caspase-8 and the proteasome, by analyzing the impact of caspase-8 ubiquitination and proteasomal degradation on the outcomes of the extrinsic apoptosis pathway in cancer cells. Caspase-8 ubiquitination status was assessed by polyubiquitin …

The Cellular Nucleic Acid Binding Protein Regulates The Alzheimer’S Disease Β-Secretase Protein Bace1, Christopher J. Holler

Theses and Dissertations--Molecular and Cellular Biochemistry

Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the elderly population and is believed to be caused by the overproduction and accumulation of the toxic amyloid beta (Aβ) peptide in the brain. Aβ is produced by two separate enzymatic cleavage events of the larger membrane bound amyloid precursor protein, APP. The first, and rate-limiting, cleavage event is made by beta-secretase, or BACE1, and is thus an attractive therapeutic target. Our lab, as well as many others, has shown that BACE1 protein and activity are increased in late-stage sporadic AD. We have extended these findings to show that BACE1 …

Structural Basis Of Substrate Recognition In Thimet Oligopeptidase And Development Of Nanoparticles For Therapeutic Enzyme Delivery, Jonathan Mark Wagner

Theses and Dissertations--Molecular and Cellular Biochemistry

Neuropeptidases are responsible for degradation of signaling peptides in the central nervous system and periphery. Some neuropeptidases have also been shown to play a role as part of the cell’s hydrolytic machinery responsible for breaking down proteins and peptides into amino acids, and these enzymes therefore influence small peptide availability for antigen presentation. A better understanding of how neuropeptidases recognize their substrates could lead to therapeutics that modulate the activity of these important enzymes. Alternatively, re-engineering these enzymes to selectively hydrolyze undesirable peptides could make them attractive as therapeutics themselves. A key question in understanding the activity of these enzymes …

Biochemical Actions Of A Novel Cis-Terpenone, Lin Zhang

Theses and Dissertations

Abstract BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE By Lin Zhang, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Director: Qibing Zhou, Ph.D Assistant Professor Department of Chemistry

Quinone methides are reactive species due to their electrophilicity, and natural quinone methide analogs have broad biological activities. Based on known actions of cytochrome P450 enzymes, we hypothesized that trans-terpenones can be metabolized in cells to form a cascade of metabolite products, which may be biologically active due to the generation of quinine and quinone methide …

Evidence That The Density Of Self Peptide-Mhc Ligands Regulates T-Cell Receptor Signaling., Nadia Anikeeva, Dimitry Gakamsky, Jørgen Schøller, Yuri Sykulev

Department of Microbiology and Immunology Faculty Papers

Noncognate or self peptide-MHC (pMHC) ligands productively interact with T-cell receptor (TCR) and are always in a large access over the cognate pMHC on the surface of antigen presenting cells. We assembled soluble cognate and noncognate pMHC class I (pMHC-I) ligands at designated ratios on various scaffolds into oligomers that mimic pMHC clustering and examined how multivalency and density of the pMHCs in model clusters influences the binding to live CD8 T cells and the kinetics of TCR signaling. Our data demonstrate that the density of self pMHC-I proteins promotes their interaction with CD8 co-receptor, which plays a critical role …

Role Of Lysophosphatidic Acid In Regulation Of Cancer Cell Metabolism, Abir Mukherjee

Theses and Dissertations

The simplest phospholipid, lysophosphatidic acid (LPA), is a heat stable component of serum known for its proliferative and migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The mechanism behind LPA-mediated tumor cell growth and oncogenesis remains poorly understood. In this thesis project I used ovarian and other cancer cells as a model system to examine the hypothesis that LPA present in the tumor microenvironment is a pathophysiological determinant of hyperactive de novo lipogenesis and aerobic glycolysis, two hallmarks of cancer cells. We demonstrated that LPA induced …

First Record Of The Mite Family Ctenobelbidae (Acari, Oribatida) From Turkey: Ctenobelba (Ctenobelba) Ayyildizi Sp. Nov., Şule Baran

Turkish Journal of Zoology

The family Ctenobelbidae (Acari, Oribatida) is recorded for the first time from Turkey. A new species of genus Ctenobelba, Ctenobelba (Ctenobelba) ayyildizi sp. nov., is described based on the specimens collected from chestnut forest in the province of Manisa, Turkey. An identification key to the known subgenera of the genus is given. Scanning electron microscopy photographs of the newly described species are also provided. The new species differs from the related species by anteriorly diverging lamellae.

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

The Success And Continued Challenges Of The Yolo Bypass Wildlife Area: A Grassroots Restoration, Rachael E. Salcido

McGeorge School of Law Scholarly Articles

No abstract provided.

The Efficacy Of Inquiry-Based Learning In Undergraduate Physiology, James Depaepe, Tracy Campion

Northwest Journal of Teacher Education

Lecture, where learning is passive, remains a prevalent instructional method of teaching content. Contextualized approaches like Inquiry-Based Learning (IBL) where students are more actively engaged remains less common. For 25 years the literature has supported contextualized approaches. Nevertheless, recent papers have claimed IBL to be an unguided approach that has produced content knowledge deficits. Therefore, we tested whether undergraduate physiology content could be learned using IBL. Four groups of undergraduates (mean ages=23, N=60) took a ten-week physiology course using IBL. A content valid pretest and posttest measured content knowledge. A one-way ANOVA indicated no significant differences within or between groups …