Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2012

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 19741 - 19770 of 22917

Full-Text Articles in Entire DC Network

Evaluation Of Ecological Risk Based On The Sediment And Water Quality In Klang Strait, Malaysia / Seyedeh Belin Tavakoly Sany, Seyedeh Belin Tavakoly Sany Jan 2012

Evaluation Of Ecological Risk Based On The Sediment And Water Quality In Klang Strait, Malaysia / Seyedeh Belin Tavakoly Sany, Seyedeh Belin Tavakoly Sany

Student Works (2010-2019)

Sediment and water monitoring was performed from Nov. 2009 to Oct. 2010 to assess and evaluate the spatial and temporal distribution of physical and chemical parameters and biological variables such as PAHs, trace metals (Hg, Cd, Pb, Cu, Mn, Zn, Cr, Ni, V, and Fe), the structure of the benthic community in the sediment, nutrients and chlorophyll a in the water. Sediment and water samples were collected from 22 stations, which covered three coastal ports (North Port, West Port and South Port) and a control point. The primary objectives of this study were to evaluate the sources of pollutants and …

Go to article

Effect Of Elevated Carbon Dioxide Levels On Growth And Biochemical Composition Of Selected Microalgae / Saraswathy D/O Ramachandran, Saraswathy Ramachandran Jan 2012

Effect Of Elevated Carbon Dioxide Levels On Growth And Biochemical Composition Of Selected Microalgae / Saraswathy D/O Ramachandran, Saraswathy Ramachandran

Student Works (2010-2019)

The fixation of carbon dioxide by microalgae plays a major role in mitigation of carbon dioxide in the atmosphere as it can reduce the “Greenhouse” effects. In this study, ten strains of microalgae from the University of Malaya Algae Culture Collection (UMACC) were used for selection of potential strains with high biomass, lipid, protein and carbohydrate productivity. The microalgae screened included freshwater and marine strains including one isolated from palm oil mill effluent (Chlorella UMACC 275). The microalgae strains were grown in flask cultures for 12 days in batch culture with continuous aeration from an aquarium air-pump. Of the microalgae …

Go to article

The Cellular And Molecular Mechanisms Underlying Apoptosis Augmentation Via Cell Cycle Arrest In Human Carcinoma Hct116 Cells By Swietenia Macrophylla King Derived Phytochemicals / Goh Bey Hing, Bey Hing Goh Jan 2012

The Cellular And Molecular Mechanisms Underlying Apoptosis Augmentation Via Cell Cycle Arrest In Human Carcinoma Hct116 Cells By Swietenia Macrophylla King Derived Phytochemicals / Goh Bey Hing, Bey Hing Goh

Student Works (2010-2019)

Swietenia macrophylla King is a large mahogany tree growing in the rainforest of Malaysia. Its seeds have been widely used in traditional medicine to treat various diseases. In this study, anticancer properties of Swietenia macrophylla were examined for the first time. Solvent extraction yielded crude ethanolic extract (SMCE) which exhibited prominent bioactivites towards various cancer cell lines namely, MCF-7, KB, HepG2, CasKi and HCT116. Thus, SMCE was fractionated into hexane (SMHF), ethyl acetate (SMEAF) and water fraction (SMWF) for further cytotoxic evaluation. The SMEAF was found to be most potent in inhibiting the growth of human colorectal carcinoma cell line …

Go to article

Studies On Forensically Important Entomological Specimens Recovered From Monkey Carrion Exposed To Different Ecological Habitats / Chen Chee Dhang, Chee Dhang Chen Jan 2012

Studies On Forensically Important Entomological Specimens Recovered From Monkey Carrion Exposed To Different Ecological Habitats / Chen Chee Dhang, Chee Dhang Chen

Student Works (2010-2019)

Little information was available on the forensically important specimens collected from carcasses in indoor and different ecological habitats in Malaysia. This study was attempted to determine the arthropod succession on carcasses (1) placed in different ecological habitats, such as lowland forested area, coastal area and montane forested area; (2) placed in indoor and outdoor conditions; and (3) carcasses being incinerated, submerged in freshwater river, and treated with insecticide and its effect on post mortem interval (PMI) estimation. Carcasses placed outdoor and indoor underwent 5 decomposition stages namely, fresh, bloating, decay, advanced decay and remains/dry. Decomposition duration on carcasses placed in …

Go to article

Growth And Biochemical Composition Of Selected Algae In Palm Oil Mill Effluent / Lalitha A/P Maniam, Lalitha Maniam Jan 2012

Growth And Biochemical Composition Of Selected Algae In Palm Oil Mill Effluent / Lalitha A/P Maniam, Lalitha Maniam

Student Works (2010-2019)

The palm oil industry in Malaysia is one of the largest producers of agroindustrial wastewater known as Palm Oil Mill Effluent (POME). POME is highly organic in content which is acidic, thick, dark in colour, with high levels of chemical oxygen demand, ammonical nitrogen, orthophosphate, nitrate, nitrite, total suspended solids, and total solids. Due to high organic load, the raw POME has to be digested anaerobically to reduce the pollutant level, in order to meet the effluent discharge standard for palm oil mills. The objective of the present study is to investigate the potential of selected microalgae to grow in …

Go to article

Effect Of 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine (Dppe)-Peg2000 And 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine (Dppe)-Peg5000 On Fatty Acid Nanoliposomes And Their Langmuir Monolayer / Teo Yin Yin, Yin Yin Teo Jan 2012

Effect Of 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine (Dppe)-Peg2000 And 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine (Dppe)-Peg5000 On Fatty Acid Nanoliposomes And Their Langmuir Monolayer / Teo Yin Yin, Yin Yin Teo

Student Works (2010-2019)

Liposome is an artificial colloidal particle that formed from convolution of bilayer structure from amphiphilic molecules into a spherical particle. At certain pH, the presence of both ionized and non-ionized fatty acid molecules in the solution leads to the formation of dimers that can be an analog to the double chain phospholipids. Fatty acid liposomes provide both hydrophilic and hydrophobic compartments that make them suitable candidates as a carrier for water soluble and liposoluble substances that have potential for medicinal or cosmetic applications. Unmodified fatty acid liposome suspensions are normally unstable and it needs to be addressed so that it …

Go to article

Somatic Embryogenesis And Regeneration Of Polianthes Tuberosa L. / Sakinah Binti Abdullah, Sakinah Abdullah Jan 2012

Somatic Embryogenesis And Regeneration Of Polianthes Tuberosa L. / Sakinah Binti Abdullah, Sakinah Abdullah

Student Works (2010-2019)

An efficient protocol was developed for rapid propagation and regeneration of the Polianthes tuberosa L. plantlets via somatic embryogenesis pathway using leaf, stem and flower bud as explants. Explants were cultured on MS media supplemented with various combinations and concentrations of BAP and NAA to induce callus formation. Leaf explants cultured on MS media supplemented with 2.0 mg/l NAA was the best to produce optimum callus. Within 5 months the percentage of explant produce callus was 100.00 ± 0.00%. Stem explants started to produce callus earlier (4 weeks) than other explants. 100.0±0.00 % of stem explant produced callus in MS …

Go to article

Proteomic Analysis Of Urinary Proteins From Patients With Ovarian Cancer And Cervical Cancer / Siti Suhana Binti Abdullah Soheimi, Siti Suhana Abdullah Soheimi Jan 2012

Proteomic Analysis Of Urinary Proteins From Patients With Ovarian Cancer And Cervical Cancer / Siti Suhana Binti Abdullah Soheimi, Siti Suhana Abdullah Soheimi

Student Works (2010-2019)

Diagnosis of ovarian carcinoma is in urgent need for new complementary biomarkers for early stage detection. In order to find an alternative procedure to replace an uncomfortable conventional method in detecting cervical cancer, a proteomic approach in screening the urinary proteins were employed. Proteins that are aberrantly excreted in the urine of cancer patients are excellent biomarker candidates for development of new non-invasive protocol for early diagnosis and screening purposes. In the present study, urine samples from patients with ovarian carcinoma and cervical cancer were analysed by two-dimensional gel electrophoresis (2-DE) and the profiles generated were compared to those similarly …

Go to article

Isolation And Characterisation Of Carotenoid And Genes Involved In The Carotenoid Biosynthetic Pathway From Ipomoea Leaves / Hue Seow Mun, Seow Mun Hue Jan 2012

Isolation And Characterisation Of Carotenoid And Genes Involved In The Carotenoid Biosynthetic Pathway From Ipomoea Leaves / Hue Seow Mun, Seow Mun Hue

Student Works (2010-2019)

This study focussed on the extraction and characterisation of carotenoid pigments and genes from the carotenoid biosynthetic pathway in I. batatas leaves. Six different local I. batatas varieties were studied namely, I. batatas var. Batu Kelantan (BK), I. batatas var. Batu Biasa (BB), I. batatas var. Oren (Oren), I. batatas var. Indon (Indon), I. batatas var. Vitato (Vitato) and I. batatas var. Biru Putih (BP). The different I. batatas varieties were distinguished based on the morphological variations in their leaves and storage roots. General screening of the β-carotene and lutein levels conducted across the different developmental stages among the different …

Go to article

Pelaksanaan Pendidikan Islam Di Indonesia (1947-2009): Kajian Di Desa Koto Dian Pulau Tengah, Kerinci, Jambi / Erlina Andestuti, Abdullah Erlina Andestuti Jan 2012

Pelaksanaan Pendidikan Islam Di Indonesia (1947-2009): Kajian Di Desa Koto Dian Pulau Tengah, Kerinci, Jambi / Erlina Andestuti, Abdullah Erlina Andestuti

Student Works (2010-2019)

Kajian ini dilakukan untuk melihat pelaksanaan pendidikan Islam di Desa Koto Dian Pulau Tengah dari tahun 1947–2009. Sekiranya pelaksanaan itu sesuai, dapat diteruskan namun sekiranya terdapat sebarang masalah, pelaksanaan ini boleh diperbaiki melalui penyelidikan yang sesuai untuk manfaat generasi hadapan. Pendidikan yang dilaksanakan merangkumi pendidikan formal dan tidak formal. Kajian ini membincangkan tentang sejarah masyarakat Islam di Desa Koto Dian dan ciri-ciri khasnya, kaedah pelaksanaan pendidikan Islam, masalah-masalah yang dihadapi semasa proses pengajaran dan pembelajaran pendidikan Islam dan pencapaian pendidikan Islam. Metodologi kajian berbentuk kajian perpustakaan dan kajian lapangan. Dalam kajian lapangan, data diperolehi melalui metode dokumentasi, metode historis dan …

Go to article

Shamsiah Fakeh (1924-2008) : Kajian Terhadap Perjuangan Wanita Islam Di Tanah Melayu / Aisyah Binti Ab Rahim, Aisyah Ab Rahim Jan 2012

Shamsiah Fakeh (1924-2008) : Kajian Terhadap Perjuangan Wanita Islam Di Tanah Melayu / Aisyah Binti Ab Rahim, Aisyah Ab Rahim

Student Works (2010-2019)

Kajian ini adalah mengenai seorang tokoh pejuang negara bernama Shamsiah Fakeh. Walaubagaimanapun ramai yang mengenalinya sebagai seorang tali barut komunis dan digelar sebagai Wanita Besi Parti Komunis Malaya. Beliau merupakan antara tokoh terawal yang membentuk peranan wanita yang bersifat progresif di Malaya. Beliau berani mencabar budaya konservatif pada masa itu yang menganggap peranan wanita sebagai kurang penting dan terhad kepada peranan di dapur sahaja. Sepanjang kajian ini, kita dapat mempelajari bahawa sehingga ke akhir hayatnya, beliau merupakan seorang nasionalis sejati dan anti-British yang tegar. Terdapat beberapa persoalan yang ingin diketengahkan oleh penulis dalam kajian ilmiah ini. Antaranya seperti latar belakang …

Go to article

Konsep Sejarah Menurut Syed Muhammad Naquib Al-Attas : Kajian Terhadap Karya-Karya Terpilih / Siti Nor Aisyah Binti Ngadiran, Siti Nor Aisyah Ngadiran Jan 2012

Konsep Sejarah Menurut Syed Muhammad Naquib Al-Attas : Kajian Terhadap Karya-Karya Terpilih / Siti Nor Aisyah Binti Ngadiran, Siti Nor Aisyah Ngadiran

Student Works (2010-2019)

Kajian ini dilakukan bagi menganalisis dengan lebih mendalam dan menyeluruh mengenai konsep sejarah daripada pandangan Syed Muhammad Naquib al-Attas. Kajian ini telah dikhususkan kepada karya-karya terpilih beliau yang melibatkan sebanyak 15 buah karya secara keseluruhan. Fokus utama kajian ini iaitu konsep sejarah adalah merupakan suatu kajian pemikiran atau kerangka falsafah al-Attas mengenai pandangan beliau tentang sejarah. Oleh itu, ia mestilah merangkumi subjek-subjek tertentu yang membentuk kerangka pemikiran tersebut seperti definisi, objektif, sumber, prinsip, dan metodologi tertentu yang digunakan oleh al-Attas dalam kajian serta penulisan sejarahnya. Manakala al-Attas pula dipilih sebagai subjek kajian berdasarkan keautoritian beliau dalam bidang falsafah dan sumbangan …

Go to article

Peranan Institusi Perguruan Diniyah Puteri Padang Panjang, Sumatera Barat Dalam Pendidikan Wanita / Syaifullah Chaidir, Syaifullah Chaidir Jan 2012

Peranan Institusi Perguruan Diniyah Puteri Padang Panjang, Sumatera Barat Dalam Pendidikan Wanita / Syaifullah Chaidir, Syaifullah Chaidir

Student Works (2010-2019)

Disertasi ini membincangkan Perguruan Diniyah Puteri Padang Panjang dari aspek peranannya dalam pendidikan wanita, berserta kaitannya dengan sejarah perkembangan dan peranannya dalam memajukan pendidikan di Padang Panjang dari masa penubuhannya sehingga tahun 1969. Untuk mencapai matlamat kajian ini, penyelidik telah menyandarkan pengumpulan data kepada kajian perpustakaan (library research) dan kajian lapangan (field research), di mana kedua-dua kaedah ini mencakupi kajian sejarah, dokumentasi dan temu bual. Setelah berjaya mengumpul data yang mencukupi mengenai sejarah dan perkembangan Diniyah Puteri, yang boleh dianggap sebagai benar-benar tepat dan bernilai dari segi objektif dan kesahihan, penyelidik menjalankan analisis yang menyeluruh terhadap data dan sumber tersebut, …

Go to article

Kaedah Psikoterapi Berasaskan Konsep Maqamat : Kajian Terhadap Kitab Qut Al-Qulub Abu Talib Al-Makki / Sharifah Basirah Binti Syed Muhsin, Sharifah Basirah Syed Muhsin Jan 2012

Kaedah Psikoterapi Berasaskan Konsep Maqamat : Kajian Terhadap Kitab Qut Al-Qulub Abu Talib Al-Makki / Sharifah Basirah Binti Syed Muhsin, Sharifah Basirah Syed Muhsin

Student Works (2010-2019)

Kajian ini yang berlandaskan kaedah penyelidikan perpustakaan menggunakan analisis kualitatif deskriptif adalah bertujuan membina kaedah psikoterapi Islam berasaskan perbahasan maqamat seorang tokoh sufi terkenal, Abu Talib al-Makki (m. 386H/966M) dalam karyanya yang terkenal, Qut al-Qulub. Secara khususnya, ia membincangkan latar belakang penulisan Qut al-Qulub dan idea-idea utamanya, dengan pemfokusan kepada al-maqamat dan kemudiannya merumuskan satu kaedah psikoterapi Islam. Bagi mencapai objektif tersebut, kajian ini dibahagi kepada enam bab iaitu bab pendahuluan, bab pertama mengenai latar belakang tokoh tasawuf Abu Talib al-Makki serta pengenalan kitab Qut al-Qulub, bab kedua membincangkan mengenai konsep maqamat dalam tasawuf dan hubungannya dengan psikoterapi Islam secara …

Go to article

Generic Structure Of Introductions In Entrepreneurship Research Articles / Fatemeh Naderi Osat, Osat Fatemeh Naderi Jan 2012

Generic Structure Of Introductions In Entrepreneurship Research Articles / Fatemeh Naderi Osat, Osat Fatemeh Naderi

Student Works (2010-2019)

The purpose of the present study is twofold. Firstly it seeks to find the generic structures that are inherent in the introduction sections of entrepreneurship research articles and secondly it investigates the role of experiential metafunction and its distribution in realization of obligatory generic elements that are found in the data. The approach applied is a combination of Halliday and Hasan’s (1989) model of genre analysis to find the generic structure potential (GSP) of the introduction sections as well as Halliday’s (1994) model of transitivity analysis to find the typicality of the process types and their contribution in the realization …

Go to article

An Artificial Co-Stimulation Classifier For Malicious Api Calls Classification In Portable Executable Malwares / Saman Mirza Abdulla, Saman Mirza Abdulla Jan 2012

An Artificial Co-Stimulation Classifier For Malicious Api Calls Classification In Portable Executable Malwares / Saman Mirza Abdulla, Saman Mirza Abdulla

Student Works (2010-2019)

Recently, most researchers have employed behaviour based detection systems to classify Portable Executable (PE) malwares. They usually tried to identify malicious Application Programming Interface (API) calls among the sequence of calls that made by a suspected application. They depended mostly on measuring the similarity or the distance between the suspected API calls with a set of predefined calls that collected from normal and malware applications. However, malwares always tried to keep their normality through hiding their malicious activities. Within such behaviours, calls that made by PE malwares become more similar to normal, which in turn, challenging most distinguishing models. Even …

Go to article

Investigating Information Seeking Anxiety Among Postgraduate Students : Development And Validation Of A Multidimensional Scale / Mohammadamin Erfanmanesh, Mohammadamin Erfanmanesh Jan 2012

Investigating Information Seeking Anxiety Among Postgraduate Students : Development And Validation Of A Multidimensional Scale / Mohammadamin Erfanmanesh, Mohammadamin Erfanmanesh

Student Works (2010-2019)

The current study aims to determine whether a valid and reliable instrument could be developed and validated to measure levels of anxiety experienced by postgraduate students during the information seeking process. It also attempts to determine the prevalence and correlates of the information seeking anxiety among postgraduate students at a research intensive university in Kuala Lumpur, Malaysia. Results of the study indicated that the newly developed scale, the Information Seeking Anxiety Scale (ISAS), had satisfactory face, content, and construct validity as well as internal reliability. The Information Seeking Anxiety Scale (ISAS) contains thirty-eight (38) 5-point Likert-format items that measures seven …

Go to article

Development, Expression And Characterization Of Humanized Anti-C2 Monoclonal Antibody / Suba Dharshanan A/L Panja Bernam, Panja Bernam Suba Dharshanan Jan 2012

Development, Expression And Characterization Of Humanized Anti-C2 Monoclonal Antibody / Suba Dharshanan A/L Panja Bernam, Panja Bernam Suba Dharshanan

Student Works (2010-2019)

Humanized monoclonal antibodies (mAbs) are widely used for diagnosis and treatment of cancer due to their reduced immunogenicity and high specificity. In this project, we aimed to develop procedures to produce, with high efficiency in terms continuity of production, lowered cost and increased speed, humanized mAbs against C2-antigen (hum-C2 mAbs), a marker specifically expressed in colorectal and ovarian cancer, from mAb of mouse origin. The resulting hum-C2 mAbs must still retain their original specificity and functionality, but possess reduced immunogenicity. Two methods of humanization were compared to identify potential immunogenic mouse amino acids in the variable regions: a deimmunization method …

Go to article

Disruption Of Mammalian Dream Complexes By Human Papilomavirus E7 Proteins / Nurshamimi Nor Rashid, Rashid Nurshamimi Nor Jan 2012

Disruption Of Mammalian Dream Complexes By Human Papilomavirus E7 Proteins / Nurshamimi Nor Rashid, Rashid Nurshamimi Nor

Student Works (2010-2019)

Human papillomaviruses have been identified as the major aetiological factor in cervical cancer. Constitutive expression of the high risk HPV E6 and E7 oncoproteins are important for malignant transformation in infected keratinocytes. In particular, E6 and E7 bind to and inactivate the cellular tumor suppressors p53 and pRB, respectively, thus delaying differentiation and inducing proliferation in suprabasal keratinocytes to enable HPV replication. One member of the pRB family, p130 appears to be an important target for E7 in promoting S-phase entry. Recently, it has been discovered that p130 is part of a large protein complex termed DREAM. The composition of …

Go to article

A Study Of Micro Rna Profiles In Ischaemic Stroke And Its Risk Factor In Development Of The Novel Biomarker Of Young Stroke Patients / Gan Chye Sheng, Chye Sheng Gan Jan 2012

A Study Of Micro Rna Profiles In Ischaemic Stroke And Its Risk Factor In Development Of The Novel Biomarker Of Young Stroke Patients / Gan Chye Sheng, Chye Sheng Gan

Student Works (2010-2019)

Recent global stroke surveillance conducted by World Health Organization (WHO) has reported 15 million people suffer from stroke per annum. Approximately one-third of the stroke causes mortality placing it as the second leading cause of death after cardiac arrest. Knowledge pertaining stroke has been valuable and utmost desired in order to deliver effective education, prevention, diagnosis/classification and management. Emergence of microRNA expression level delivering promising biomarker has driven diligent researches in developing novel biomarkers for stroke. MicroRNA is a class of ~22 nucleotide-long non-coding RNAs, which is shown to orchestrate protein expression at posttranscriptional levels, hence earlier detection prior manifestation. …

Go to article

Rational Discovery Of Dengue Type 2 Non-Competitive Inhibitors / Heh Choon Han, Choon Han Heh Jan 2012

Rational Discovery Of Dengue Type 2 Non-Competitive Inhibitors / Heh Choon Han, Choon Han Heh

Student Works (2010-2019)

Pelbagai kajian telah dijalankan dalam pembangunan terapeutik terhadap jangkitan dengue. Malah, kini, vaksin mahupun ejen anti-dengue yang berkesan masih belum ditemui. Dalam kajian ini, kami memberi tumpuan pada penemuan drug yang rasional terhadap ejen anti-dengue yang berpotensi dengan merujuk pada perencatan protease DEN-2 NS2B-NS3 yang tidak kompetitif. Sebuah model homologi, DH-1, untuk DEN-2 NS2B-NS3 (yang menggunakan kompleks protease West Nile Virus NS2B-NS3, 2FP7, sebagai rujukan) telah digunakan sebagai reseptor sasaran untuk reka bentuk tersebut. Pinostrobin, suatu flavanone, telah digunakan sebagai ligan piawai dalam kajian ini. Sejumlah 13,341 sebatian kecil, berstruktur yang mengandungi tulang belakang chalcone, flavanone and flavone, yang terdapat …

Go to article

Quorum Sensing And Quorum Quenching Studies In Clinical Acinetobacter Isolates From Ummc / Deepa Anbazhagan, Deepa Anbazhagan Jan 2012

Quorum Sensing And Quorum Quenching Studies In Clinical Acinetobacter Isolates From Ummc / Deepa Anbazhagan, Deepa Anbazhagan

Student Works (2010-2019)

Quorum sensing is a term that describes an environmental sensing system that allows bacteria to monitor their own population density. Many gram negative bacteria use N-acyl-homoserine lactones (AHLs) as autoinducing quorum sensing signal molecules. This cell-density dependent regulation of gene expression contributes significantly to the size and development of the biofilm. Acinetobacter spp. are now emerging as important nosocomoial pathogens and it has been shown that they form biofilms with enhanced antibiotic resistance. In this study, we sought to find out if the biofilm formation among clinical isolates of Acinetobacter spp. is under the control of autoinducing quorum sensing molecules. …

Go to article

Gender Differences In The Reactivity Of Normoglycemic And Diabetic Rat Aorta And The Effects Of Quercetin And 17Β-Estradiol / Aloysius Umelo Iguegbe, Umelo Iguegbe Aloysius Jan 2012

Gender Differences In The Reactivity Of Normoglycemic And Diabetic Rat Aorta And The Effects Of Quercetin And 17Β-Estradiol / Aloysius Umelo Iguegbe, Umelo Iguegbe Aloysius

Student Works (2010-2019)

Background & objectives: Diabetes is a stronger risk factor in the development of cardiovascular diseases in the female than the male gender. Diabetes-induced reactive oxygen species (ROS) alters the function of endogenous vasoconstrictors for which the antioxidant, quercetin, has been shown to restore in diabetic male rats, which has not been proven in the female. The female hormone, estradiol (a potent antioxidant), combined with quercetin may offer greater protection against diabetes/ROS-induced vascular reactivity. Therefore, the influence of gender on the response of normoglycemic/diabetic aorta to vasoconstrictors in the presence/absence of quercetin/estradiol, including mechanisms underlying any differences in tissue responses was …

Go to article

Studies On Antidiabetic And Other Biological Activities Of Centratherum Anthelminticum / Aditya Arya, Aditya Arya Jan 2012

Studies On Antidiabetic And Other Biological Activities Of Centratherum Anthelminticum / Aditya Arya, Aditya Arya

Student Works (2010-2019)

In search of phytomedicine for diabetes, this preliminary screening was conducted on twelve (12) different plants for hypoglycemic activity and antioxidant potential in the in vitro and in vivo study models. Amongst all, Centratherum anthelminticum seeds demonstrated maximum hypoglycemic and antioxidant potential. Therefore, the defatted crude methanolic fraction of the Centratherum anthelminticum seeds (CAMFs) was selected for detailed antidiabetic activity on the in vitro cell-based biological studies on mouse pancreatic cells, β-TC6 and on type 1 and type 2 diabetic rats for 4-weeks. The results of this study indicate that CAMFs showed potential antidiabetic effect on β-TC6 cells and confirmed …

Go to article

Virtual Screening And Biological Assay Of Compound Libraries For Anticholinesterase Activity / Sri Devi D/O Sukumaran, Sri Devi Sukumaran Jan 2012

Virtual Screening And Biological Assay Of Compound Libraries For Anticholinesterase Activity / Sri Devi D/O Sukumaran, Sri Devi Sukumaran

Student Works (2010-2019)

The current research was aimed at finding peripheral anionic site (PAS) binding acetylcholinesterase (AChE) inhibitors to be used in the treatment of Alzheimer’s disease (AD). The crystal structure of human acetylcholinesterase (hAChE) in complex with fasciculin II (2.76 Ǻ) (PDB ID: 1b41) was found to be the most suitable protein for identifying PAS binding ligands in docking studies and was used for virtual screening of about 830 unknown ligands. Twenty-one compounds with a lowest binding energy ranging from -8.7 kcal/mol to -5.6 kcal/mol were selected for testing for AChE inhibitory activity. Four of these compounds were found to inhibit AChE …

Go to article

The Role Of Gelam Honey In Modulating The Immune Reponse Of Sepsis In Animal Model / Mustafa Kassim, Mustafa Kassim Jan 2012

The Role Of Gelam Honey In Modulating The Immune Reponse Of Sepsis In Animal Model / Mustafa Kassim, Mustafa Kassim

Student Works (2010-2019)

Persistent systemic inflammatory response syndrome is a serious health condition that may lead to multiple organ dysfunction, organ failure, and ultimately death. It leads to both acute inflammation, caused by either infective (microbes or lipopolysaccharide [LPS]) or non-infective (chemicals) sources, and sepsis, an infection caused by a lethal dose of LPS (endotoxemia). These conditions have similar inflammatory mediators such as cytokines, nitric oxide (NO), high-mobility group box-1 (HMGB1), and heme oxygenase-1 (HO-1), suggesting that they may result from similar pathogenic mechanisms. Previous studies have investigated the applications of natural products in targeting these inflammatory mediators. Honey, for example, is used …

Go to article

Adherence To Highly Active Anti-Retroviral Treatment (Haart) And Its Associated Factors Among Hiv-Positive Patients In Sungai Buloh Hospital, Malaysia / Umar Yagoub Mohammed Yousif, Umar Yagoub Mohammed Yousif Jan 2012

Adherence To Highly Active Anti-Retroviral Treatment (Haart) And Its Associated Factors Among Hiv-Positive Patients In Sungai Buloh Hospital, Malaysia / Umar Yagoub Mohammed Yousif, Umar Yagoub Mohammed Yousif

Student Works (2010-2019)

HIV/AIDS is one of the most destructive health diseases of modern times, affecting approximately 45.5 million people worldwide. But the advent of the Highly Active Antiretroviral Therapy (HAART) in 1996 has significantly reduced HIV/AIDS-related mortality and morbidity and it has allowed many previously bed-ridden patients to live healthier and more productive lives. In order for the treatments to be successful, a very high level of adherence to HAART is required. It is estimated that at least 95% adherence to antiretroviral treatment is essential to reduce the replication of the virus and prevent the development of resistance to treatment. Generally, adherence …

Go to article

Exploration Of Mothers' Experiences Of Having A Child With Down's Syndrome And Their Quality Of Life : A Mixed Method Study / Chan Kim Geok, Kim Geok Chan Jan 2012

Exploration Of Mothers' Experiences Of Having A Child With Down's Syndrome And Their Quality Of Life : A Mixed Method Study / Chan Kim Geok, Kim Geok Chan

Student Works (2010-2019)

Mothers of child with the unexpected diagnosis of Down’s syndrome (DS) were reported to be dealing with an on-going, chronic situation in supporting their child’s various needs throughout their life. They were reported to perceive lower quality of life. There are little published studies related to experiences of mothers in Malaysia, particularly in the Borneo state of Sarawak with its diverse socio-economic, cultural and geographical background. The effects of having a child with DS on the quality of life (QOL) of mothers are little known. The purpose of the study is to understand the experiences of mothers having a child …

Go to article

Very Short-Lived Halocarbons In The Malaysian Atmosphere And Their Possible Sources / Mohd Shahrul Mohd Nadzir, Mohd Nadzir Mohd Shahrul Jan 2012

Very Short-Lived Halocarbons In The Malaysian Atmosphere And Their Possible Sources / Mohd Shahrul Mohd Nadzir, Mohd Nadzir Mohd Shahrul

Student Works (2010-2019)

This doctoral thesis investigates biogenic emissions of selected Very Short-lived Species (VSLS) bromocarbons like bromoform (CHBr3), dibromomethane (CH2Br2), dibromochloromethane (CHBr2Cl) and selected chlorocarbons like chloroform (CHCl3) and tetrechloroethylene (C2Cl4) from different environments through ground and a shipborne field campaign. Brominated halocarbon is an atmospheric trace gas and a major source of atmospheric bromine. Recent estimates of brominated halocarbon sources and sinks indicate anthropogenic sources to be negligible. The major source of atmospheric brominated compounds is believed to be from marine especially coastal area. The production pathways of brominated compounds in the ocean are, however, poorly understood. Measurements were made using …

Go to article

Evaluation And Application Of Scar Markers On Bap-Induced Dwarf Off-Types Of Musa Acuminata Cv. Berangan / Arifurrahman Bin Rusman, Arifurrahman Rusman Jan 2012

Evaluation And Application Of Scar Markers On Bap-Induced Dwarf Off-Types Of Musa Acuminata Cv. Berangan / Arifurrahman Bin Rusman, Arifurrahman Rusman

Student Works (2010-2019)

Micropropagation has been widely used to produce better crops at a rapid rate. Plant growth regulators are used to increase shoot proliferation, with benzylaminopurine (BAP) being the most commonly used cytokinin. However, various studies have shown that BAP concentration affects the frequency of abnormality in banana micropropagation. For this study, the effects of BAP concentrations on in vitro cultures of Musa acuminata cv. “Berangan” were investigated and it was found that on Murashige and Skoog (MS) media supplemented with concentrations of 9mgL-1 and 12mgL-1 BAP, cultures took a longer time to regenerate as compared to concentrations of 3mgL-1 and 6mgL-1. …

Go to article

First Prev Next Last