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2012

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Study Of Dual Angiogenic/Neurogenic Growth Factors Among Saudi Autistic Children And Their Correlation With The Severity Of This Disorder, Faten A. Zakareia, Laila Y. Al-Ayadhi, Abdulmajeed A. Al-Drees Jan 2012

Study Of Dual Angiogenic/Neurogenic Growth Factors Among Saudi Autistic Children And Their Correlation With The Severity Of This Disorder, Faten A. Zakareia, Laila Y. Al-Ayadhi, Abdulmajeed A. Al-Drees

Neurosciences

OBJECTIVE: To investigate the role of 2 angiogenic/neurogenic growth factors, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) in Saudi children with autism. METHODS: The study included a total of 60 children that included 20 controls and 40 patients with a confirmed diagnosis of autism. The study was conducted in the Department of Physiology, Faculty of Medicine, King Saud University, and in the Autism Research and Treatment Center, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between May 2010 and April 2011. Collected blood plasma samples were analyzed for VEGF and PDGF. RESULTS: The levels of VEGF …

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The Role Of Anemia In First Simple Febrile Seizure In Children Aged 6 Months To 5 Years Old, Farhad Heydarian, Hosein Vatankhah Jan 2012

The Role Of Anemia In First Simple Febrile Seizure In Children Aged 6 Months To 5 Years Old, Farhad Heydarian, Hosein Vatankhah

Neurosciences

OBJECTIVE: To assess the relationship between anemia and first simple febrile convulsion in patients 6 months to 5 years old. METHODS: This cross-sectional study was performed on 240 patients aged 6 months to 5 years old from 10 October 2010 to 15 December 2011 at Ghaem Hospital, Imam Reza Hospital, and Dr. Sheikh Hospital, Mashhad, Iran. Patients were divided into 2 groups: the control group who had fever without seizure, and the case group who had first simple febrile seizure. The anemia levels in both groups were evaluated and compared. RESULTS: The mean age of patients was 20.7+/-14.8 months. It …

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Frequency, Severity And Risk Factors For Restless Legs Syndrome In Healthcare Personnel, Selma Civi, Ruhusen Kutlu, Serhat Tokgoz Jan 2012

Frequency, Severity And Risk Factors For Restless Legs Syndrome In Healthcare Personnel, Selma Civi, Ruhusen Kutlu, Serhat Tokgoz

Neurosciences

OBJECTIVE: To evaluate the frequency, severity, and risk factors for restless legs syndrome (RLS) in healthcare personnel. METHODS: This cross-sectional study was performed at the Outpatient Family Medicine Clinic of Meram Medical Faculty in Konya, Turkey and included 354 healthcare personnel who were working at the Meram Medical Faculty Hospital between October 2010 and June 2011. The International RLS (IRLS) rating scale was used to calculate RLS severity. The RLS symptoms positive patients were investigated for neurological examination. RESULTS: Of all the participants, 277 (78.2%) were female. The overall prevalence of RLS according to the 4 essential criteria in the …

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Dynamic Changes In Serum Monocyte Chemoattractant Protein-1, And Regulated Upon Activation, Normal T Cell Expressed And Secreted Levels In Patients With Minor Intracerebral Hemorrhage, Zhendong Li, Shijian Luo, Yuhua Fan, Huabin Sun Jan 2012

Dynamic Changes In Serum Monocyte Chemoattractant Protein-1, And Regulated Upon Activation, Normal T Cell Expressed And Secreted Levels In Patients With Minor Intracerebral Hemorrhage, Zhendong Li, Shijian Luo, Yuhua Fan, Huabin Sun

Neurosciences

OBJECTIVE: To investigate the time expression profile of serum monocyte chemoattractant protein (MCP)-1, and regulated upon activation, normal T cell expressed and secreted (RANTES) after minor intracerebral hemorrhage (ICH). METHODS: This study was carried out in the Department of Neurology in the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China. Fifteen consecutive hospitalized patients with minor ICH were enrolled from July 2008 to December 2008. The patients’ serum levels of MCP-1 and RANTES were measured by enzyme-linked immunosorbent assay (ELISA) on days 1-3, 7, 14, and 30 after the onset of ICH, and compared with that of 10 controls. …

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Images From The Exhibit, Page 2, Allison Marsh Jan 2012

Images From The Exhibit, Page 2, Allison Marsh

Handouts

No abstract provided.

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Morphological Investigations Of Microdrile Oligochaetes (Annelida, Clitellata) Using Scanning Electron Microscopy, Carlos Caramelo, Enrique Martinez Ansemil Jan 2012

Morphological Investigations Of Microdrile Oligochaetes (Annelida, Clitellata) Using Scanning Electron Microscopy, Carlos Caramelo, Enrique Martinez Ansemil

Turkish Journal of Zoology

Over the past several years, the authors of this work have investigated external structures of microdrile oligochaetes using scanning electron microscopy (SEM). Both published and still-unpublished data have revealed new structures of interest, especially those associated with mating, ciliate sense receptors, chaetae, and dorsal pores. Mating systems can be classified in 3 categories: grasping, coupling, and embracing. Ciliate sense receptors can be classified as poorly defined (unelevated), sensory buds, or papillae, and are provided with blunt cilia and/or sharp cilia. They are present along the whole body (including clitellum, budding, and regeneration zones), scattered on the prostomium, peristomium, and pygidium, …

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Distribution And Diversity Of Aquatic Oligochaeta In Small Streams Of The Middle Taiga, Maria Baturina Jan 2012

Distribution And Diversity Of Aquatic Oligochaeta In Small Streams Of The Middle Taiga, Maria Baturina

Turkish Journal of Zoology

The goal of the present study was to describe the fauna, community structure, distribution, diversity, abundance, and ecology of Oligochaeta in small streams of the Komi Republic. The work was performed in 13 streams located in the Vychegda River basin during the month of July, 2005-2008. During the study, 48 taxa from 7 families were collected. The habitat of each study stream was determined with respect to chemical water composition (Na^+, Mg^{2+}, Ca^{2+}, Cl^-, and total phosphorus (P^{tot}), among others) and some environmental factors: bottom structure (hard or soft), water temperature, depth, flow velocity, moss or algae cover, etc. The …

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Spatial And Temporal Variation Of Echinoderm Assemblages From Soft Bottoms Of The Çanakkale Strait (Turkish Strait System) With A Taxonomic Key Of The Genus Amphiura (Echinodermata: Ophiuroidea), Herdem Aslan Ci̇hangi̇r, Maria Antonietta Pancucci-Papadopoulou Jan 2012

Spatial And Temporal Variation Of Echinoderm Assemblages From Soft Bottoms Of The Çanakkale Strait (Turkish Strait System) With A Taxonomic Key Of The Genus Amphiura (Echinodermata: Ophiuroidea), Herdem Aslan Ci̇hangi̇r, Maria Antonietta Pancucci-Papadopoulou

Turkish Journal of Zoology

This study deals with the structure of echinoderm assemblages and their relationships with the biotic and abiotic conditions in the Çanakkale Strait in 2006 and 2007. A total of 25 echinoderm species were found, 4 species of which [Amphiura securigera (Düben & Koren, 1846); Amphiura lacazei Guille, 1976; Amphiura cherbonnieri Guille, 1972; and Thyone fusus (O.F. Müller, 1776)] were new records for Turkish fauna; 1 species [Ophiopsila annulosa (M. Sars, 1859)] was new for the Turkish Strait System; and 22 species were first reports for the Çanakkale Strait. Echinocyamus pusillus (O.F. Müller, 1776), Amphipholis squamata (Delle Chiaje, 1829), and Ophiothrix …

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Parasitic Hymenoptera Reared From The Insects On Heracleum Platytaenium Boiss. (Apiaceae) With New Faunistic And Biological Records, Erhan Koçak, Mustafa Özdemi̇r Jan 2012

Parasitic Hymenoptera Reared From The Insects On Heracleum Platytaenium Boiss. (Apiaceae) With New Faunistic And Biological Records, Erhan Koçak, Mustafa Özdemi̇r

Turkish Journal of Zoology

Some parasitic hymenopterans were reared from their host insects found on the stems and branches of Heracleum platytaenium Boiss., which contains furanocoumarins that are insect repellents and suppress growth in some species. Plant materials with insects were collected from the vicinity of Kızılcahamam in Ankara Province in July-September 2008. The parasitoids (Hymenoptera) and their hosts were Didyctium brunnea (Belizin) (Eucolidae) from puparia of Lasiambia albidipennis (Strobl) (Diptera: Chloropidae), Pronotalia carlinarum (Szelenyi & Erdos) (Eulophidae) and Homoporus febriculosus (Girault) (Pteromalidae) from puparia of Melanagromyza heracleana Zlobin (Diptera: Agromyzidae), and Baryscapus crassicornis (Erdos) (Eulophidae) from larvae, pupae, and adults of Lixus nordmanni …

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The Seasonality Of Group Size And Group Composition Of Sand Partridge (Ammoperdix Heyi Heyi Temminck, 1825) In The Ibex Reserve, Saudi Arabia, Torsten Wronski Jan 2012

The Seasonality Of Group Size And Group Composition Of Sand Partridge (Ammoperdix Heyi Heyi Temminck, 1825) In The Ibex Reserve, Saudi Arabia, Torsten Wronski

Turkish Journal of Zoology

The seasonality of group size and composition in sand partridges was studied at the Ibex Reserve in central Saudi Arabia. Mean group size and flock encounter rate were significantly related to rainfall and temperature. During winter and the breeding season (March to April), the encounter rate on the valley floors was distinctly lower than that observed during summer. Although encounter rates did not differ significantly between valleys, sand partridges were more likely to be encountered in narrow, stony valleys. Correcting for valley width, encounter rates did not differ between valleys. Male and female encounter rates were constant throughout the reserve, …

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A New Species Of Tephritis Latreille (Diptera: Tephritidae) From Turkey, Murat Kütük, Nesli̇han Bayrak, Rüstem Hayat Jan 2012

A New Species Of Tephritis Latreille (Diptera: Tephritidae) From Turkey, Murat Kütük, Nesli̇han Bayrak, Rüstem Hayat

Turkish Journal of Zoology

Tephritis ozaslani sp. nov. is described from Artvin Province of Turkey and placed in the T. pulchra species group. The key to the T. pulchra group is provided, which includes 9 species. The main characters that distinguish the new species from the closely resembling Palaearctic species, T. cometa israilis Freidberg, T. acanthiophilopsis Hering, T. erdemlii Kütük, T. divisa Rondani, T. recurrens Loew, T. merzi Freidberg & Kütük, and T. hurvitzi Freidberg, are discussed. In addition, Inula oculus christi L. (Asteraceae) is determined as a host plant of the new species.

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Acute Toxicity Of Nickel To Fresh Water Prawns, Ravi Shanker Verma Jan 2012

Acute Toxicity Of Nickel To Fresh Water Prawns, Ravi Shanker Verma

Turkish Journal of Zoology

In the present study, the LC_{50} of nickel and its impact on the behaviour of 2 species of freshwater prawns, Macrobrachium lamarrei (H. Milne Edwards) and Macrobrachium dayanum (Henderson) was evaluated. An inverse relationship between LC_{50} values and exposure duration was obtained. Nickel was found to be 6.33 times more toxic to M. lamarrei than to M. dayanum. Nickel exposure increased aggression and loss of balance in both species of prawns in a concentration-dependent manner with both parameters being higher in M. dayanum (416.47 mg/L) than in M. lamarrei (65.77 mg/L). All behavioural parameters decreased with increase in exposure duration …

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An Alternative Storage Method For Entomopathogenic Nematodes, Bariş Gülcü, Selçuk Hazir Jan 2012

An Alternative Storage Method For Entomopathogenic Nematodes, Bariş Gülcü, Selçuk Hazir

Turkish Journal of Zoology

Tetra Pak containers were evaluated as an alternative to tissue culture flasks for nematode storage. Our data showed that Tetra Pak containers were an excellent alternative to tissue culture flasks for storage of H. bacteriophora and will more than likely be useful for other entomopathogenic nematode species.

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Effect Of Food Plants On Nutritional Ecology Of Two Acridids (Orthoptera: Acrididae) To Provide Alternative Protein Supplement For Poultry, Mousumi Das, Arijit Ganguly, Parimalendu Haldar Jan 2012

Effect Of Food Plants On Nutritional Ecology Of Two Acridids (Orthoptera: Acrididae) To Provide Alternative Protein Supplement For Poultry, Mousumi Das, Arijit Ganguly, Parimalendu Haldar

Turkish Journal of Zoology

A large annual acridid biomass should be produced on acridid farms to manufacture high-quality, low-cost feed for the poultry industry. A laboratory experiment was conducted to measure the nymphal mortality, nymphal developmental period, growth indices, and adult life span of 2 common acridids (Oxya hyla hyla and Spathosternum prasiniferum prasiniferum) on 3 food plants (Dactyloctenium aegyptium, Cynodon dactylon, and Brachiaria mutica). Among the 3 food plants, D. aegyptium was suitable only for 1st and 2nd instars of O. hyla hyla, and B. mutica was suitable for the remaining instars and the adult stages of O. hyla hyla and for all …

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Contributions To The Limoniidae (Insecta, Diptera) Fauna From Inner Western Anatolia, Okan Özgül, Hasan Koç Jan 2012

Contributions To The Limoniidae (Insecta, Diptera) Fauna From Inner Western Anatolia, Okan Özgül, Hasan Koç

Turkish Journal of Zoology

The study was carried out between 2009 and 2011 in the inner part of western Anatolia (Afyonkarahisar, Kütahya, and Uşak), and 18 species were recorded for the first time for the Turkish Limoniidae fauna. The taxa are Ellipteroides (s.str.) lateralis (Macquart, 1835), Erioconopa diuturna (Walker, 1848), E. interposita Stary, 1976, Gonempeda flava (Schummel, 1829), Gonomyia (s.str.) recta Tonnoir, 1920, G. (Paralipophleps) bifida Tonnoir, 1920, Hoplolabis (Parilisia) longior Stary, 2006, Idiocera (s.str.) alexanderiana (Lackschewitz, 1940), Ilisia inermis Mendl, 1979, Molophilus (s.str.) appendiculatus (Staeger, 1840), M. (s.str.) niger Goetghebuer, 1920, Tasiocera (Dasymolophilus) murina (Meigen, 1818), Euphylidorea phaeostigma (Schummel, 1829), Pilaria scutellata (Staeger, …

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Season- And Locality-Related Changes In The Diet Of Asiatic Jackal (Canis Aureus) In Potohar, Pakistan, Muhammad Sajid Nadeem, Ruqqya Naz, Syed Israr Shah, Mirza Azhar Beg, Amjad Rashid Kayani, Muhammad Mushtaq, Tariq Mahmood Jan 2012

Season- And Locality-Related Changes In The Diet Of Asiatic Jackal (Canis Aureus) In Potohar, Pakistan, Muhammad Sajid Nadeem, Ruqqya Naz, Syed Israr Shah, Mirza Azhar Beg, Amjad Rashid Kayani, Muhammad Mushtaq, Tariq Mahmood

Turkish Journal of Zoology

Feeding habits of the Asiatic jackal were studied through 98 scats collected between January 2009 and March 2010 from different sites in Potohar, Pakistan. The overall frequency of occurrence of plant items was 54.0%; the animal prey item frequency was 46.2%. Among the plant foods, Ziziphus was eaten year round, whereas wild olive, grasses, and wheat grains were the chief components of the diet during all seasons except summer. Among the animal food items, livestock carcasses were consumed year round; the highest consumption was observed during the summer and autumn seasons and the lowest in winter. Small mammals, particularly rodents, …

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Karyological Characteristics, Morphological Peculiarities, And A New Distribution Locality For Talpa Davidiana (Mammalia: Soricomorpha) In Turkey, Mustafa Sözen, Ferhat Matur, Faruk Çolak, Sercan Irmak Jan 2012

Karyological Characteristics, Morphological Peculiarities, And A New Distribution Locality For Talpa Davidiana (Mammalia: Soricomorpha) In Turkey, Mustafa Sözen, Ferhat Matur, Faruk Çolak, Sercan Irmak

Turkish Journal of Zoology

Talpa davidiana is the least known species of the genus Talpa, and the karyotype of this species is still unknown. Its distribution records are also very scattered. The karyological, cranial, and pelvic characteristics of 2 samples from Kızıldağ in Adana Province were analyzed for the first time. It was determined that T. davidiana has 2n = 34, NF = 66, and NFa = 62. The X chromosome was large and metacentric and the Y chromosome was dot-like acrocentric. The 2 samples are different from each other, and from previous T. davidiana records, in terms of their lower incisor and premolar …

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New Record Of Lynx Lynx (L., 1758) In Turkey (Mammalia: Carnivora), İrfan Albayrak Jan 2012

New Record Of Lynx Lynx (L., 1758) In Turkey (Mammalia: Carnivora), İrfan Albayrak

Turkish Journal of Zoology

This paper reports the morphological characteristics of a subadult lynx, Lynx lynx, collected in 2005 from Ardanuç in Artvin Province. Pelage color, hair structure, and some cranial measurements of this specimen and other recent records of Turkish lynxes are given, including that from Beyaz Dağ in Şırnak Province in the southeastern part of Turkey collected during field work and a skin from an unknown locality in Isparta. It was concluded that Turkish lynxes are likely to represent the subspecies L. lynx dinniki based on a comparison of morphometric values given in the literature.

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The Importance Of Moral Construal: Moral Versus Non-Moral Construal Elicits Faster, More Extreme, Universal Evaluations Of The Same Actions, Jay J. Van Bavel, Dominic J. Packer, Ingrid J. Haas, William A. Cunningham Jan 2012

The Importance Of Moral Construal: Moral Versus Non-Moral Construal Elicits Faster, More Extreme, Universal Evaluations Of The Same Actions, Jay J. Van Bavel, Dominic J. Packer, Ingrid J. Haas, William A. Cunningham

Department of Political Science: Faculty Publications

Over the past decade, intuitionist models of morality have challenged the view that moral reasoning is the sole or even primary means by which moral judgments are made. Rather, intuitionist models posit that certain situations automatically elicit moral intuitions, which guide moral judgments. We present three experiments showing that evaluations are also susceptible to the influence of moral versus non-moral construal. We had participants make moral evaluations (rating whether actions were morally good or bad) or non-moral evaluations (rating whether actions were pragmatically or hedonically good or bad) of a wide variety of actions. As predicted, moral evaluations were faster, …

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How Indeterminism Shapes Ecologists’ Contributions To Managing Socio-Ecological Systems, Sarah Michaels, Andrew Tyre Jan 2012

How Indeterminism Shapes Ecologists’ Contributions To Managing Socio-Ecological Systems, Sarah Michaels, Andrew Tyre

Department of Political Science: Faculty Publications

To make a difference in policy making about socio-ecological systems, ecologists must grasp when decision makers are amenable to acting on ecological expertise and when they are not. To enable them to do so we present a matrix for classifying a socio-ecological system by the extent of what we don’t know about its natural components and the social interactions that affects them. We use four examples, Midcontinent Mallards, Laysan Ducks, Pallid Sturgeon, and Rocky Mountain Grey Wolves to illustrate how the combination of natural and social source of indeterminism matters. Where social indeterminism is high, ecologists can expand the range …

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Models Of Justice To Protect Innocent Persons, Tim Bakken Jan 2012

Models Of Justice To Protect Innocent Persons, Tim Bakken

NYLS Law Review

No abstract provided.

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Longwood University Catalog 2012-2013, Longwood University Jan 2012

Longwood University Catalog 2012-2013, Longwood University

Undergraduate Catalogs

No abstract provided.

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Tennessee Ag Insider, A Guide The The State's Farms, Food, And Forestry, 2012 Edition, Tennessee. Department Of Agriculture. Jan 2012

Tennessee Ag Insider, A Guide The The State's Farms, Food, And Forestry, 2012 Edition, Tennessee. Department Of Agriculture.

Tennessee Ag Insider

No abstract provided.

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The Status Of Five State-Listed Tidal Plant Species In New Hampshire With Emphasis On Potential Impacts Of Sea Level Rise, Lauren A. Kras Jan 2012

The Status Of Five State-Listed Tidal Plant Species In New Hampshire With Emphasis On Potential Impacts Of Sea Level Rise, Lauren A. Kras

Master's Theses and Capstones

Tidal habitat in New Hampshire is restricted to 162 miles along coasts and estuaries. Limited area combined with anthropogenic impacts has caused 27 tidal plant species to be listed as threatened or endangered. In 2009 and 2010, the status of four threatened species: Eleocharis parvula, Samolus valerandi, Lilaeopsis chinensis , and Agalinis maritima and one endangered species Salicornia bigelovii was examined. To guide management and conservation, the historic and current distributions were compared and habitat features were determined. All five species were stable; however, S. valerandi and L. chinensis appear threatened by sea level rise and coastal squeeze as they …

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Child Fatalities In Tennessee 2010, Tennessee. Department Of Health. Jan 2012

Child Fatalities In Tennessee 2010, Tennessee. Department Of Health.

Child Fatalities in Tennessee Report

No abstract provided.

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Artemis And Metnase Mediated Processing Of 3΄-Blocked Dna Lesions: Role In Radio/Chemoresistance And Dna Repair, Susovan Mohapatra Jan 2012

Artemis And Metnase Mediated Processing Of 3΄-Blocked Dna Lesions: Role In Radio/Chemoresistance And Dna Repair, Susovan Mohapatra

Theses and Dissertations

DNA double-strand breaks (DSB) with chemically modified end-termini are the most significant lesions resulting from radio/chemotherapeutic intervention of cancer and non homologous end-joining (NHEJ) factor Artemis nuclease has been implicated in the repair of such breaks. To examine whether the resolution of terminally blocked DNA DSBs is the biologically relevant function of Artemis, Artemis deficient fibroblasts were stably complemented with wild type or an endonuclease deficient D165N mutant Artemis. Physiological levels of wild type (WT) Artemis completely restored DSB repair proficiency and resistance to γ-radiation, bleomycin, and neocarzinostatin. Cells expressing the D165N mutants remained as chemo/radiosensitive and as repair deficient …

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Biobehavioral Correlates In Fibromyalgia, Ann Trivigno Mcnallen Jan 2012

Biobehavioral Correlates In Fibromyalgia, Ann Trivigno Mcnallen

Theses and Dissertations

Introduction: Fibromyalgia (FMS) is a chronic pain syndrome characterized by non-restorative sleep, and fatigue. Over 75% of individuals with FMS complain of poor sleep quality and fatigue. These have been ranked by patients with FMS as having great impact on quality of life. A literature review suggested that poor sleep quality may be a predictor of increased stress and FMS symptom onset in those affected. However, no experimental studies have demonstrated a causal relationship between poor sleep and stress in people with FMS. Methods: Using a single stage cross-sectional design, the primary study aim was to compare 25 women with …

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The Role Of Fyn And B-Cell Expressed Adam10 In Early B Cell Development, Germinal Center Formation And Terminal B Cell Differentiation, Natalia Chaimowitz Jan 2012

The Role Of Fyn And B-Cell Expressed Adam10 In Early B Cell Development, Germinal Center Formation And Terminal B Cell Differentiation, Natalia Chaimowitz

Theses and Dissertations

In these studies we sought to determine the role of Fyn kinase and ADAM10 in B cell biology. A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple transmembrane receptors and ligands. In particular, ADAM10 has been identified as a key regulator of lymphocyte development. Here we report that ADAM10 is dispensable for early B cell development within the bone marrow. However, deletion of ADAM10 from all peripheral B cells or in post-switch cells leads to severe …

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The Role Of High Affinity Nicotinic Acetylcholine Receptors On Anxiety-Like Behavior: A Study In Female Mice, Jessicka Hall Jan 2012

The Role Of High Affinity Nicotinic Acetylcholine Receptors On Anxiety-Like Behavior: A Study In Female Mice, Jessicka Hall

Theses and Dissertations

Tobacco dependence is high in women who suffer from anxiety disorders yet little is known about the contributions of nicotinic acetylcholine receptors (nAChRs) on anxiety-like behavior. β2*nAChRs (*denotes assembly with other subunits) are the most abundantly expressed nAChRs in the brain yet little is known about the contributions of β2*nAChRs on anxiety-like behavior in female mice. In this study, antagonism and nicotine effects on anxiety-like behavior was investigated across the life span in 6, 12 and 24-month-old drug-naïve knockout (KO), heterozygous (HET) and a gain of function α6L9S mice and wild type (WT). HET mice showed increased sensitivity to di-hydrobeta-erythroidine …

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Non-Canonical Roles For Stat1 And Stat2 In Mitochondrial Biogenesis And Fasting Homeostasis., Jennifer Sisler Jan 2012

Non-Canonical Roles For Stat1 And Stat2 In Mitochondrial Biogenesis And Fasting Homeostasis., Jennifer Sisler

Theses and Dissertations

The signal transducer and activator of transcription 1 (STAT1) and 2 (STAT2) are primarily activated by interferons and play a central role in orchestrating responses to a variety of pathogens by activating the transcription of nuclear encoded genes that mediate antiviral, antigrowth and immune surveillance responses. In addition to their nuclear effects, we report that STAT1 and STAT2 inhibit the expression of mitochondrial encoded mRNAs by activating type I interferons (IFNβ) under basal conditions. STAT1-/- livers also exhibit elevated levels of nuclear encoded components of the electron transport chain (ETC). Treatment of wild-type mice with IFNβ inhibits both mitochondrial and …

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