Digital Commons Network^™

Physiological Notch Signaling Maintains Bone Homeostasis Via Rbpjk And Hey Upstream Of Nfatc1, Xiaolin Tu, Jianquan Chen, Joohyun Lim, Courtney M. Karner, Seung-Yon Lee, Julia Heisig, Cornelia Wiese, Kameswaran Surendran, Raphael Kopan, Manfred Gessler, Fanxin Long

Open Access Publications

No abstract provided.

Ligand-Induced Movements Of Inner Transmembrane Helices Of Glut1 Revealed By Chemical Cross-Linking Of Di-Cysteine Mutants, Mike Mueckler, Carol Makepeace

Open Access Publications

No abstract provided.

Lack Of Evidence From Studies Of Soluble Protein Fragments That Knops Blood Group Polymorphisms In Complement Receptor-Type 1 Are Driven By Malaria, Patience B. Tetteh-Quarcoo, Christoph Q. Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn D T Mertens, Arthur Rowe, John P. Atkinson, Alan F. Cowman, J Alexandra Rowe, Paul N. Barlow

Open Access Publications

No abstract provided.

Psoriasis Patients Are Enriched For Genetic Variants That Protect Against Hiv-1 Disease, Haoyan Chen, Genki Hayashi, Olivia Y. Lai, Alexander Dilthey, Peter J. Kuebler, Tami V. Wong, Maureen P. Martin, Marcelo A. Fernandez Vina, Gil Mcvean, Matthias Wabl, Kieron S. Leslie, Toby Maurer, Jeffrey N. Martin, Steven G. Deeks, Mary Carrington, Anne M. Bowcock, Douglas F. Nixon, Wilson Liao

Open Access Publications

No abstract provided.

Effects Of Doxycycline On Gene Expression In Wolbachia And Brugia Malayi Adult Female Worms In Vivo, Ramakrishna U. Rao, Yuefang Huang, Sahar Abubucker, Michael Heinz, Seth D. Crosby, Makedonka Mitreva, Gary J. Weil

Open Access Publications

No abstract provided.

Genome-Wide Association And Functional Follow-Up Reveals New Loci For Kidney Function, Xiaoyi Gao, Mary Feitosa, Michael Province, Shamika Ketkar, Ingrid Borecki, Et Al.

Open Access Publications

No abstract provided.

Distinct Repeat Motifs At The C-Terminal Region Of Caga Of Helicobacter Pylori Strains Isolated From Diseased Patients And Asymptomatic Individuals In West Bengal, India, Santanu Chattopadhyay, Rajashree Patra, Raghunath Chatterjee, Ronita De, Jawed Alam, T. Ramamurthy, Abhijit Chowdhury, G. Balakrish Nair, Douglas E. Berg, Asish K. Mukhopadhyay

Open Access Publications

No abstract provided.

Differentiation Of The Lateral Compartment Of The Cochlea Requires A Temporally Restricted Fgf20 Signal, Sung-Ho Huh, Jennifer Jones, Mark E. Warchol, David M. Ornitz

Open Access Publications

No abstract provided.

Tbc1d3, A Hominoid-Specific Gene, Delays Irs-1 Degradation And Promotes Insulin Signaling By Modulating P70 S6 Kinase Activity, Marisa J. Wainszelbaum, Jialu Liu, Chen Kong, Priya Srikanth, Dmitri Samovski, Xiong Su, Philip D. Stahl

Open Access Publications

No abstract provided.

Optimizing Read Mapping To Reference Genomes To Determine Composition And Species Prevalence In Microbial Communities, John Martin, Sean Sykes, Sarah Young, Karthik Kota, Ravi Sanka, Nihar Sheth, Joshua Orvis, Erica Sodergren, Zhengyuan Wang, George M. Weinstock, Makedonka Mitreva

Open Access Publications

No abstract provided.

Constitutively Active Canonical Nf-Kb Pathway Induces Severe Bone Loss In Mice, Jesse E. Otero, Tim Chen, Kaihua Zhang, Yousef Abu-Amer

Open Access Publications

No abstract provided.

Network Analysis Of Corticocortical Connections Reveals Ventral And Dorsal Processing Streams In Mouse Visual Cortex, Quanxin Wang, Olaf Sporns, Andreas Burkhalter

Open Access Publications

No abstract provided.

Lack Of Short-Term Effectiveness Of Rotating Treadmill Training On Turning In People With Mild-To-Moderate Parkinson's Disease And Healthy Older Adults: A Randomized, Controlled Study, Marie E. Mcneely, Gammon M. Earhart

Open Access Publications

No abstract provided.

Functional Relationships Between Lipid Metabolism And Liver Regeneration, David A. Rudnick, Nicholas O. Davidson

Open Access Publications

No abstract provided.

Intestinal Adenocarcinoma Arising In Urinary Conduits, Genevieve C. Moyer, Robert L. Grubb Iii, Frank E. Johnson

Open Access Publications

No abstract provided.

Mhc Class I Cross-Presentation By Dendritic Cells Counteracts Viral Immune Evasion, Katrin Nopora, Caroline A. Bernhard, Christine Ried, Alejandro A. Castello, Kenneth M. Murphy, Peggy Marconi, Ulrich Koszinowski, Thomas Brocker

Open Access Publications

No abstract provided.

Three Ontologies To Define Phenotype Measurement Data, Mary Shimoyama, Rajni Nigam, Leslie Sanders Mcintosh, Rakesh Nagarajan, Treva Rice, D. C. Rao, Melinda R. Dwinell

Open Access Publications

No abstract provided.

The Metal Ion-Dependent Adhesion Site Motif Of The Enterococcus Faecalis Ebpa Pilin Mediates Pilus Function In Catheter-Associated Urinary Tract Infection, Hailyn V. Nielsen, Pascale S. Guiton, Kimberly A. Kline, Gary C. Port, Jerome S. Pinkner, Fabrice Neiers, Staffan Normark, Birgitta Henriques-Normark, Michael G. Caparon, Scott J. Hultgren

Open Access Publications

No abstract provided.

A Glycosylphosphatidylinositol Anchor Is Required For Membrane Localization But Dispensable For Cell Wall Association Of Chitin Deacetylase 2 In Cryptococcus Neoformans, Nicole M. Gilbert, Lorina G. Baker, Charles A. Specht, Jennifer K. Lodge

Open Access Publications

No abstract provided.

Isolated Short Femur Length On Second-Trimester Sonography: A Marker For Fetal Growth Restriction And Other Adverse Perinatal Outcomes, Katherine R. Goetzinger, Alison G. Cahill, George A. Macones, Anthony O. Odibo

Open Access Publications

No abstract provided.

Identifying Genomic And Metabolic Features That Can Underlie Early Successional And Opportunistic Lifestyles Of Human Gut Symbionts, Catherine Lozupone, Karoline Faust, Jeroen Raes, Jeremiah J. Faith, Daniel N. Frank, Jesse Zaneveld, Jeffrey I. Gordon, Rob Knight

Open Access Publications

No abstract provided.

Varscan 2: Somatic Mutation And Copy Number Alteration Discovery In Cancer By Exome Sequencing, Daniel C. Koboldt, Qunyuan Zhang, David E. Larson, Dong Shen, Michael D. Mclellan, Ling Lin, Christopher A. Miller, Elaine R. Mardis, Li Ding, Richard K. Wilson

Open Access Publications

No abstract provided.

Actin Cap Associated Focal Adhesions And Their Distinct Role In Cellular Mechanosensing, Dong-Hwee Kim, Shyam B. Khatau, Yunfeng Feng, Sam Walcott, Sean X. Sun, Gregory D. Longmore, Denis Wirtz

Open Access Publications

No abstract provided.

Genome-Wide Meta-Analyses Of Smoking Behaviors In African Americans, Y. J. Sung, D. C. Rao, Et Al

Open Access Publications

No abstract provided.

Deciphering A Global Network Of Functionally Associated Post-Translational Modifications, Pablo Minguez, Luca Parca, Francesca Diella, Daniel R. Mende, Runjun Kumar, Manuela Helmer-Citterich, Anne-Claude Gavin, Vera Van Noort, Peer Bork

Open Access Publications

No abstract provided.

Ubiquitination And Degradation Of The Hominoid- Specific Oncoprotein Tbc1d3 Is Mediated By Cul7 E3 Ligase, Chen Kong, Dmitri Samovski, Priya Srikanth, Marisa J. Wainszelbaum, Audra J. Charron, Jialiu Liu, Jeffrey J. Lange, Pin-I Chen, Zhen-Qiang Pan, Xiong Su, Philip D. Stahl

Open Access Publications

No abstract provided.

Mouse Transgenesis In A Single Locus With Independent Regulation For Multiple Fluorophores, Joseph D. Dougherty, Juliet Zhang, Huifen Feng, Shiaoching Gong, Nathaniel Heintz

Open Access Publications

No abstract provided.

Determination Of The Molecular Mechanisms Of Hyperglycemia-Induced Changes In Cav3.2 Calcium Channel Properties, Ginny Marie Keeling

Master's Theses

Hyperglycemia can cause altered excitability due to increased CaV3.2 T-type calcium channel function, bestowing diabetics an increased neuropathy risk. The objective of this study was to understand the molecular mechanisms of increased CaV3.2 function during hyperglycemia in vitro, which leads to a 58% increase in current density and increased channel open probability (PO), among other changes. Two major findings are reported in this study:

1) The enzymatic elimination of extracellular N-acetylneuraminic acid (NANA) moieties reversed the increase in current density and the shift in PO, showing that hyper-glycosylation alters channel function in disease.

2) Treatment with GM1 (a ganglioside highly …

Pteridine Cleavage Facilitates Dna Photocleavage By Ru(Ii) Polypyridyl Compounds, Benjamin R. Williams, Shannon R. Dalton, Meredith Skiba, Sung Eun Kim, Allison Shatz, Patrick J. Carroll, Sharon J. Nieter Burgmayer

Chemistry Faculty Research and Scholarship

The synthesis, characterization, binding to calf thymus DNA, and plasmid DNA photocleavage studies of two ruthenium(II) pteridinylphenanthroline complexes are reported where the new pteridinylphenantholine ligands in these complexes are additions to a larger family designed to resemble DNA bases. [Ru(bpy)₂(L-keto)](PF₆)₂1 is synthesized from ligand substitution of Ru(bpy)₂Cl₂ by 4-keto-pteridino[6,7-f]phenanthroline (L-keto). Increasing the reaction temperature during synthesis of 1 causes a ring scission of the L-keto ligand within the pyrimidine ring yielding a second Ru complex, [Ru(bpy)₂(L-aap)](PF₆)₂2 where L-aap is 2-amino-3-amidopyrazino[5,6-f]phenanthroline. The …

Sigma-2 Ligands Induce Tumour Cell Death By Multiple Signalling Pathways, Chenbo Zeng, Justin M. Rothfuss, Jun Zhang, Wenhua Chu, Suwanna Vangveravong, Zhude Tu, Fenghui Pan, Katherine Chang, Richard S. Hotchkiss, Robert H. Mach

Open Access Publications

No abstract provided.