Digital Commons Network^™

Is Laughter The Best Medicine? An Evaluation Of The Physiological Effects Of Laughter, Annette Dalezman

The Science Journal of the Lander College of Arts and Sciences

Laughter directly affects one’s physiology. Laughter causes various muscle contractions which, in turn, affect body systems. Specifically, the cardiovascular, immune, and respiratory systems are impacted by laughter. Stress levels and pain tolerance thresholds are also directly impacted by laughter. Research has been done on the effects of laughter in patients with cancer, dementia, and atopic dermatitis. Based on the review of multiple experiments, a direct correlation between laughter and multiple body systems and diseases seems to exist.

Benefits Versus Costs Of Statin Drugs, Sara Shilcrat

The Science Journal of the Lander College of Arts and Sciences

Statins have been prescribed to the masses as primary and secondary prevention for coronary disease caused by hypercholesterolemia after their initial discovery in the late 1980s. Their actions in reducing low-density lipoproteins and increasing high-density lipoproteins are well documented; however, many negative effects have been reported related to muscle pathology and kidney function. The goal of this study is to investigate whether the benefits of this class of drugs outweigh the costs. Intense review of the literature was conducted using scholarly articles with original research findings that were located via electronic databases such as Medline, Science Direct, Proquest Medical Library, …

Biological Engineering: Advances And Methods, Joel Schwartz

The Science Journal of the Lander College of Arts and Sciences

The last few decades have seen a tremendous growth in the field of bioengineering. As the need for further treatment and innovation for tissue repair, partial to full organ replication, and gene therapy continues to increase, the field of bioengineering will be tasked with curing and preventing disease and traumatic injuries. The two primary fields currently being focused on in the lab are the way cells interact and communicate to build tissues, and the nature and materials utilized in scaffolding to allow differentiation and migration when cells are seeded. Within those two fields are subsets of different methods, materials that …

A State-Based National Network For Effective Wildlife Conservation, Dale Goble

Articles

State wildlife conservation programs provide a strong foundation for biodiversity conservation in the United States, building on state wildlife action plans. However, states may miss the species that are at the most risk at rangewide scales, and threats such as novel diseases and climate change increasingly act at regional and national levels. Regional collaborations among states and their partners have had impressive successes, and several federal programs now incorporate state priorities. However, regional collaborations are uneven across the country, and no national counterpart exists to support efforts at that scale. A national conservation-support program could fill this gap and could …

Resilience And Water Governance: Adaptive Governance In The Columbia River Basin, Barbara Cosens

Articles

The 1964 Columbia River Treaty between the United States and Canada is currently under review. Under the treaty, the river is jointly operated by the two countries for hydropower and is the largest producer of hydropower in the western hemisphere. In considering the next phase of international river governance, the degree of uncertainty surrounding the drivers of change complicates efforts to predict and manage under traditional approaches that rely on historical ecosystem responses. At the same time, changes in social values have focused attention on ecosystem health, the decline of which has led to the listing of seven salmon and …

New Vertebrate Records And Natural History Notes From Arkansas, M. B. Connior, R. Tumlison, H. W. Robison

Journal of the Arkansas Academy of Science

No abstract provided.

Design And Synthesis Of Antithrombotic Liposomal Protein Conjugate, Hailong Zhang

ETD Archive

Recent advances in the molecular bases of haemostasis have highlighted that endothelial thrombomodulin (TM) plays a critical role in local haemostasis by binding thrombin and subsequently converting protein C to its active form (APC). In addition, the binding of thrombin to TM drastically alters the thrombin's procoagulant activities to anticoagulant activities. The lipid bilayer in which it resides serves as an essential 'cofactor', locally concentrating and coordinating the appropriate alignment of reacting cofactors and substrates for protein C activation. On the other hand, liposomes have been extensively studied as cell membrane model as well as carrier for delivering certain vaccines, …

Development Of A ‘Clickable’ Non-Natural Nucleotide To Visualize The Replication Of Non-Instructional Dna Lesions, Edward A. Motea, Irene Lee, Anthony J. Berdis

Chemistry Faculty Publications

The misreplication of damaged DNA is an important biological process that produces numerous adverse effects on human health. This report describes the synthesis and characterization of a non-natural nucleotide, designated 3-ethynyl-5-nitroindolyl-2′-deoxyriboside triphosphate (3-Eth-5-NITP), as a novel chemical reagent that can probe and quantify the misreplication of damaged DNA. We demonstrate that this non-natural nucleotide is efficiently inserted opposite an abasic site, a commonly formed and potentially mutagenic non-instructional DNA lesion. The strategic placement of the ethynyl moiety allows the incorporated nucleoside triphosphate to be selectively tagged with an azide-containing fluorophore using ‘click’ chemistry. This reaction provides a facile way to …

Legal Affinities: Explorations In The Legal Form Of Thought, Patrick Mckinley Brennan

Working Paper Series

This is my Introduction to Legal Affinities: Explorations in the Legal Form of Thought (forthcoming 2012) (co-edited with H. Jefferson Powell and Jack Sammons), a volume of essays dedicated to exploring the work of Joseph Vining. The Introduction introduces Vining’s phenomenology of law and surveys the themes and topics developed by the volume’s eight authors: Joseph Vining, Judge John T. Noonan, Jr., Rev. John McCausland, H. Jefferson Powell, Jack Sammons, Steve Smith, James Boyd White, and Patrick Brennan.

Aging Contributes To Inflammation In Upper Extremity Tendons And Declines In Forelimb Agility In A Rat Model Of Upper Extremity Overuse., David M Kietrys, Ann E Barr-Gillespie, Mamta Amin, Christine K Wade, Steve N Popoff, Mary F Barbe

Department of Physical Therapy Faculty Papers

We sought to determine if tendon inflammatory and histopathological responses increase in aged rats compared to young rats performing a voluntary upper extremity repetitive task, and if these changes are associated with motor declines. Ninety-six female Sprague-Dawley rats were used in the rat model of upper extremity overuse: 67 aged and 29 young adult rats. After a training period of 4 weeks, task rats performed a voluntary high repetition low force (HRLF) handle-pulling task for 2 hrs/day, 3 days/wk for up to 12 weeks. Upper extremity motor function was assessed, as were inflammatory and histomorphological changes in flexor digitorum and …

Apo A1 Mimetic Rescues The Diabetic Phenotype Of Ho-2 Knockout Mice Via An Increase In Ho-1 Adiponectin And Lkbi Signaling Pathway, Jian Cao, Nitin Puri, Komal Sodhi, Lars Bellner, Nader G. Abraham, Attallah Kappas

Biochemistry and Microbiology

Insulin resistance, with adipose tissue dysfunction, is one of the hallmarks of metabolic syndrome. We have reported a metabolic syndrome-like phenotype in heme oxygenase (HO)-2 knockout mice, which presented with concurrent HO-1 deficiency and were amenable to rescue by an EET analog. Apo A-I mimetic peptides, such as L-4F, have been shown to induce HO-1 expression and decrease oxidative stress and adiposity. In this study we aimed to characterize alleviatory effects of HO-1 induction (if any) on metabolic imbalance observed in HO-2 KO mice. In this regard, HO-2^(−/−) mice were injected with 2 mg/kg/day L-4F, or vehicle, i.p., for …

General Undergraduate Catalog, 2012-2013, Marshall University

Marshall University Catalogs 2010-2019

Marshall University Undergraduate Course Catalog for the 2012-2013 academic year.

Graduate Catalog, 2012-2013, Marshall University

Marshall University Catalogs 2010-2019

Marshall University Graduate Course Catalog for the 2012-2013 academic year.

Graduate Catalog, Fall 2010, Marshall University

Marshall University Catalogs 2010-2019

Marshall University Graduate Course Catalog for the Fall 2010 academic year.

Et Cetera, Marshall University

Et Cetera

Founded in 1953, Et Cetera is an annual literary magazine that publishes the creative writing and artwork of Marshall University students and affiliates. Et Cetera is free to the Marshall University community.

Et Cetera welcomes submissions in literary and film criticism, poetry, short stories, drama, all types of creative non-fiction, photography, and art.

George W. Bush, The American Press, And The Initial Framing Of The War On Terror After 9/11, Stephen D. Cooper, Jim A. Kuypers, Matthew T. Althouse

Communications Faculty Research

President George W. Bush's speech to the General Assembly of the United Nations on November I 0, 200 I, marks an important moment in the history of the War on Terror. 1 It followed closely upon the joint U.S.-Northern Alliance military capture of Mazari Sarif, Afghanistan, which significantly disrupted the Taliban's operations and arguably marked the official beginning of America's War on Terror. As President Bush stated, "The time for sympathy has now passed; the time for action has now arrived."2 In some ways, the speech offered nothing new. It reiterated words and ideas that the president frequently used to …

Consumption Of High Ω-3 Fatty Acid Diet Suppressed Prostate Tumorigenesis In C3(1) Tag Mice, Juliana A. Akinsete, Gabriela Ion, Theodore R. Witte, W. Elaine Hardman

Biochemistry and Microbiology

Prostate cancer incidence and mortality are high in the Western world and high ω-6/ω-3 PUFA in the Western diet may be a contributing factor. We investigated whether changing from a diet that approximates ω-6 fat content of the Western diet to a high ω-3 fat diet at adulthood might reduce prostate cancer risk. Female SV 129 mice that had consumed a high ω-6 diet containing corn oil for 2 weeks were bred with homozygous C3(1)Tag transgenic male mice. All male offspring were weaned to the corn oil diet (CO) until postpuberty when half of the male offspring were transferred to …

Nitrogen Partitioning And Transport Through A Subalpine Lake Measured With An Isotope Tracer, Dave M. Epstein, Wayne A. Wurtsbaugh, Michelle A. Baker

Watershed Sciences Faculty Publications

We used a stable isotope tracer to measure nitrogen (N) assimilation and transfer through Bull Trout Lake, a 0.3-km2 mountain lake in Idaho, specifically to explore the relative importance of pelagic and benthic producers. was added into the inflow stream above the lake during spring runoff and the resulting mass of tracer was measured within the various ecosystem compartments, including the outflow stream. Although a portion of the moved through the lake quickly due to a low hydraulic residence time during the addition, the tracer was also assimilated rapidly by seston in the water column and at a slower rate …

Effect Of Varying Exercise Intensities On Gdnf Expression And Neuromuscular Junction Morphology, Amy Morrison Gyorkos, Monica J. Mccullough, John Spitsbergen

Biological Sciences Faculty and Graduate Student Research

Glial cell-line derived neurotrophic factor (GDNF) supports and maintains the neuromuscular system during development and through adulthood by promoting neuroplasticity. The aim of this study was to determine if different intensities of exercise can promote changes in GDNF expression and neuromuscular junction (NMJ) morphology in slow- and fast-twitch muscles. Rats were randomly assigned to a low intensity run-training (run group), higher intensity swim-training (swim group), or control group. GDNF protein content increased in both soleus (SOL) and extensor digitorum longus (EDL) following run-training and in EDL following swim-training determined by enzyme-linked immunosorbent assay. NMJ morphology was analyzed by measuring α-bungarotoxin …

The Role Of Medications In Predicting Activity Restriction Due To A Fear Of Falling, Dawn M. Guthrie, Paula C. Fletcher, Evelyn Williams, Nicole Boumans, John P. Hirdes

Kinesiology and Physical Education Faculty Publications

Objectives: To examine the role of medication use and other factors in predicting activity restriction due to a fear of falling (AR/FF). Methods: Older adults were assessed twice with the interRAI Community Health Assessment and the Berg Balance Scale (BBS). The main outcome was limiting going outdoors due to an AR/FF. Medications were recorded by trained assessors. Results: Participants (n=441) had a mean age of 80.3 (sd=7.1) years, most were aged 65+ (96.8%) and 29.3% reported activity restriction. Taking nervous system active or cardiovascular medications was associated with AR/FF. In a multivariate model, the main predictors were having 3+ comorbid …

Nordp News 2.2, National Organization Of Research Development Professionals, Jeffrey M. Anderson (Ed.)

Research Development Repository

This is an upload of a past issue of the NORDP News Newsletter. The table of contents includes:

• New ERA of Transatlantic Research Collaborations

• President’s Corner

• Stay out of the Hazards: What do NIH and Golf have in Common?

• Social Scientists and Research Development

• What to Say—and Not Say—to Program Officers

• Upcoming Research Development Conferences

• Research Development Jobs Sampler

2012 Complete Digest, Department Of English

Gleanings: Department of English Blog Archive

No abstract provided.

The Role Of Larval Dispersal In Metapopulation Gene Flow: Local Population Dynamics Matter, Daphne M. Munroe, John .. Klinck, Eileen E. Hofmann, Eric N. Powell

Journal of Marine Research

The degree of genetic connectivity among populations in a metapopulation has direct consequences for species evolution, development of disease resistance, and capacity of a metapopulation to adapt to climate change. This study used a metapopulation model that integrates population dynamics, dispersal, and genetics within an individual-based model framework to examine the mechanisms and dynamics of genetic connectivity within a metapopulation. The model was parameterized to simulate four populations of oysters (Crassostrea virginica) from Delaware Bay on the mid-Atlantic coast of the United States. Differences among the four populations include a strong spatial gradient in mortality, a spatial gradient …

Oyster Food Supply In Delaware Bay: Estimation From A Hydrodynamic Model And Interaction With The Oyster Population, Eric N. Powell, Danielle A. Kreeger, Jason M. Morson, Dale B. Haidvogel, Zhiren Wang, Roger Thomas, Jennifer E. Gius

Journal of Marine Research

To evaluate oyster food supply, water samples were collected at fifteen sites in Delaware Bay nearmonthly in 2009 and 2010. Food was estimated as the sum of particulate protein, labile carbohydrate, and lipid. Delaware Bay shows a typical spring bloom, centered in March and April, with declining food supply thereafter into early fall, followed sporadically by a minor fall bloom. The geographic and temporal structure of food was more predictable in summer to early fall, and considerably less predictable in spring. Five variables each based on temperature and the spatial and temporal variability of temperature were significant contributors to a …

Evidence Of Vertical Coupling Between The Kuroshio Extension And Topographically Controlled Deep Eddies, Andrew D. Greene, D. Randolph Watts, Georgi G. Sutyrin, Hideharu Sasaki

Journal of Marine Research

Strong energy in the 30–60 day band was observed using 39 deep pressure and current records from the Kuroshio Extension System Study (KESS). Energy in this band accounted for 25–50% of the total deep-pressure variance and was strongest under the Kuroshio Extension jet axis. Often, deep-pressure anomalies propagated into the region from the north-northeast and locally intensified as they passed under and interacted with the Kuroshio Extension. The topographically controlled deep-pressure anomalies translate nearly along lines of constant f/H. Statistically significant coherence between 30–60 day upper- and deep-ocean streamfunction anomalies demonstrated that there was strong vertical coupling in that …

Adjustment Of A Wind-Driven Two-Layer System With Mid-Basin Topography, Magdalena Andres, Jiayan Yang, Young-Oh Kwon

Journal of Marine Research

A linear primitive equations model is used to simulate spin-up of a two-layer ocean bisected by a meridional ridge. The ocean is forced with steady zonal winds east of the ridge. When wind-driven barotropic planetary Rossby waves propagate across the ridge, barotropic and baroclinic anomalies are generated as the barotropic flow adjusts. These ridge-generated anomalies propagate westward from the ridge as planetary Rossby waves and their arrival along the basin's western boundary modulates the western boundary current (WBC) transport and vertical structure. Model results suggest that at short (<1 year) and long (>10 years) delay relative to a …

Reproducibility Of Exercise Testing In Patients With Pulmonary Arteriovenous Malformations, Bolin Niu

Yale Medicine Thesis Digital Library

Patients with pulmonary arteriovenous malformations (PAVMs) are at risk for complications, hemorrhagic and neurological, and therefore require close follow-up.

The primary hypothesis of this project poses that the exercise stress test (EST) and 6-minute walk test (6MWT) are reproducible and reliable in patients with PAVMs. Secondarily, if these tests are shown to be reproducible, they may become a surrogate follow-up tool for patients with PAVMs after quantification with non-contrast CT and may replace contrast echocardiography in asymptomatic children under age 12.

Twenty-two patients with PAVMs, most of whom had hereditary hemorrhagic telangiectasia (HHT), participated in a Human Investigations Committee-approved protocol. …

The Effect Of E-Cadherin Loss On Melanoma Formation And Metastasis, Lara Rosenbaum

Yale Medicine Thesis Digital Library

Melanoma is the most lethal form of skin cancer and accounts for the majority of skin cancer related mortality. Early metastases are characteristic of melanoma and are an ominous sign, as current therapeutic interventions have little effect on overall survival. The lack of accurate prognostic indicators and effective therapies emphasize the need for a better understanding of the genetic and phenotypic changes in melanoma formation and progression. One such change is the loss of E-cadherin, which normally plays a role in cell-cell adhesion and is thought to be a central feature of epithelial-mesenchymal transition (EMT). Maintenance of E-cadherin in melanoma …

Volume 20, Nos. 1 & 2

Thinking: The Journal of Philosophy for Children

Cassidy, Claire. “Questioning Children.” 62­-68.

Ferreira, Louise Brandes Moura. “Philosophy for Children in Science Class: Children Learning Basic Science Process Skills through Narrative.” 73-­81.

Karaba, Robert. “Reconceptualizing the Aims in Philosophy for Children,” 50­-54.

Kennedy, David. “I Must Change My Life: Review of A Life Teaching Thinking by Matthew Lipman.” 11­-21.

Küçük, Nimet. “The Education of Thinking Course: Innovation in Turkish Schools.” 69­72.

Moriyón, Félix García. “Matthew Lipman: An Intellectual Biography.” 22­-32.

-----­­­­­ “Review: Discussions in Science.” 94-­96.

Murris, Karrin. “Review of Talking about Feelings and Values with Children by Michael Schleiffer with Cynthia Martiny.” 88­-90.

Naji, Saeed and Ghazinezhad, …

Forelimb Kinematics During Swimming In The Pig-Nosed Turtle, Carettochelys Insculpta, Compared With Other Turtle Taxa: Rowing Versus Flapping, Convergenceversus Intermediacy, Angela R.V. Rivera, Gabriel Rivera, Richard W. Blob

Publications

Animals that swim using appendages do so by way of rowing and/or flapping motions. Often considered discrete categories, rowing and flapping are more appropriately regarded as points along a continuum. The pig-nosed turtle, Carettochelys insculpta, is unusual in that it is the only freshwater turtle to have limbs modified into flippers and swim via synchronous forelimb motions that resemble dorsoventral flapping, traits that evolved independently from their presence in sea turtles. We used high-speed videography to quantify forelimb kinematics in C. insculpta and a closely related, highly aquatic rower (Apalone ferox). Comparisons of our new data with those previously collected …