Digital Commons Network^™

Making Sense Of Intellectual Property Law, Christopher Buccafusco

Cornell Law Review

No abstract provided.

Southern Adventist University Graduate Catalog 2012-2013, Southern Adventist University

Catalog, Graduate

Southern Adventist University's graduate catalog for the academic year 2012-2013.

Muscle Organization In Individuals With And Without Pain And Joint Dysfunction, J. C. Nickel, Y. M. Gonzalez, W. D. Mccall, R. Ohrbach, D. B. Marx, H. Liu, L. R. Iwasaki

Department of Statistics: Faculty Publications

Central nervous system organization of masticatory muscles determines the magnitude of joint and muscle forces. Validated computer-assisted models of neuromuscular organization during biting were used to determine organization in individuals with and without temporomandibular disorders (TMD). Ninety-one individuals (47 women, 44 men) were assigned to one of four diagnostic groups based on the presence (+) or absence (-) of pain (P) and bilateral temporomandibular joint disc displacement (DD). Electromyography and bite-forces were measured during right and left incisor and molar biting. Two three-dimensional models employing neuromuscular objectives of minimization of joint loads (MJL) or muscle effort (MME) simulated biting tasks. …

Learning Interdisciplinary Pedagogies, Alison J. Friedow, Erin E. Blankenship, Jennifer L. Green, Walter Stroup

Department of Statistics: Faculty Publications

Advocates of interdisciplinary teaching and learning in higher education suggest that interdisciplinary courses “promise a wide range of desirable educational outcomes for students” (Newell 1994: 35). These outcomes include enhanced affective and cognitive abilities, increased understanding of multiple perspectives, greater appreciation for ambiguity, and superior capacities for creative thinking, among others (35). Despite claims about the possibilities interdisciplinary learning offers, we have few examples of how faculty from different disciplines work together to create interdisciplinary classroom environments where such outcomes can occur. In short, more examples of how faculty from different disciplines actually develop, engage, and revise interdisciplinary pedagogies with …

Drosophila Melanogaster Selection For Survival Of Bacillus Cereus Infection: Life History Trait Indirect Responses, Junjie Ma, Andrew K. Benson, Stephen D. Kachman, Zhen Hu, Lawrence G. Harshman

Department of Statistics: Faculty Publications

To study evolved resistance/tolerance in an insect model, we carried out an experimental evolution study using D. melanogaster and the opportunistic pathogen B. cereus as the agent of selection. The selected lines evolved a 3.0- to 3.3-log increase in the concentration of spores required for 50% mortality after 18–24 generations of selection. In the absence of any treatment, selected lines evolved an increase in egg production and delayed development time. The latter response could be interpreted as a cost of evolution. Alternatively, delayed development might have been a target of selection resulting in increased adult fat body function including production …

Birds Of New England And Costa Rica: A Science-Based Interdisciplinary Curriculum, Alice M. Ford

Graduate Student Independent Studies

Students are naturally inquisitive scientists, and successful interdisciplinary curricula access this curiosity by shaping academic studies around students' needs as scientists. Therefore, students are scientists who need opportunities to study and observe the world around them. This curriculum, "Birds of New England and Costa Rica: A Science-Based Interdisciplinary Curriculum," is based on children's abilities to observe and question by studying the immediate environment of the students and relating it to another environment. In this way, students compare and contrast relationships in order to construct their own knowledge about birds in New England and in Costa Rica. Through this study, students …

The Statewide Application Of Hydrologic Simulation Program Fortran (Hspf) Models To Support The Business Needs Of The Minnesota Pollution Control Agency, Charles Regan, Timothy Larson

Fifty Years Of Watershed Modeling - Past, Present And Future

No abstract provided.

Improving Watershed Models Through Stakeholder Involvement, Laura Weintraub

Fifty Years Of Watershed Modeling - Past, Present And Future

No abstract provided.

A Distributed Watershed Hydrologic, Sediment, Nutrient Transport And Fate Model, Zhonglong Zhang, Billy E. Johnson, Charles W. Downer

Fifty Years Of Watershed Modeling - Past, Present And Future

No abstract provided.

Summary Of Comments By Panelist William James, Bill James

Fifty Years Of Watershed Modeling - Past, Present And Future

No abstract provided.

Biodegradation And Mushroom Cultivation Studies On Peanut Shells And Corn Stalks By Pleurotus Ostreatus Under Solid State Fermentation Conditions, Mansuru Usif

Theses

Peanut shells (PS) and corn stalks (CS) are abundant agro-industrial wastes that are mainly disposed of by burning or soil incorporation. The biodegradation of PS and CS in various substrate combinations (SCs) was studied under solid state fermentation with Pleurotus ostreatus. A two factorial experiment in a completely randomized design (CRD) was used in this study. The abilities of the selected SCs to support fruit body yield was also investigated as a one factorial experiment in a CRD. Analysis of variance (ANOVA) was used to determine significant differences at 5% level of significance. The results from the biodegradation studies showed …

Development Of Emotional Health Monitoring And Feedback System Based On Facial Expression Recognition,Traditional Chinese Medicine Theory, And Regional Agriculture, Franshaun Latrice Hardy

Theses

An individual’s emotional, as well as physical state plays a valuable role in their overall productivity. If one has a balance of physical and emotional well being, the likelihood of their performance will increase towards their daily tasks and assignments. One’s nutritional diet plays a vital role in creating and producing balance into their lives. Studies have shown that the foods you eat have a significant effect on your physical, mental and emotional state.The objective of this research was to develop a system that will enable more research for emotion monitoring and feedback with the long term goal of developing …

Identification Of Pan-Ligands For Peroxisome Proliferator-Activated Receptors (Ppar) Using Computational Virtual Screening With Molecular Docking, Hamid Dafalla Ismail

Theses

Peroxisome Proliferator-activated Receptors (PPARs) are ligand-activated nuclear receptors known for their major role in metabolic syndrome (MS). Abdominal obesity, high blood pressure, increased glucose levels and low concentrations of high-density lipoprotein characterize MS. Numerous studies proposed developing pan-agonists as potent drug candidates for the treatment and control of metabolic syndrome. The objective of this study was to use virtual screening with molecular docking to identify potential pan-PPAR ligands from the ZINC database. The 3D structural files of the receptor ligand binding domains (LBD), obtained from the Protein Data Bank (PDB), were energetically minimized and the binding pockets on each LBD …

A Study On Thermal Stability Of Palladiumcomposite Membrane Fabricated By Surfactant Induced Electroless Plating (Siep), Syed Zahadul Islam

Theses

Thermal stability of the palladium membrane is a major challenge in hydrogen separation from mixture of gases at high temperature. To study the long term thermal stability of palladium membrane, thin, dense, and defect free Pd composite membranes on microporous stainless steel (MPSS) substrate were prepared by surfactant induced electroless plating (SIEP). Dodecyl trimethyl ammonium bromide (DTAB), a cationic surfactant was used in the Pd EP-bath. Permeability tests were carried out with hydrogen and nitrogen at temperatures and pressures in the range of 523 - 823 K and 20 - 100 psi respectively. The membranes showed good hydrogen flux and …

Cellular Analysis Of Hepg2 Cells On Gastrin Releasing Peptide (Grp) Nanostructure, Karshak Kosaraju

Theses

Artificial juxtacrine stimulation arises from the covalent attachment of growth factors onto biomaterials. Incorporation of growth factors onto cell culture substrates has been found to enhance the functionality of cells in vitro. In this study, we describe how the immobilization of Gastrin Releasing Peptide (GRP) enhances the viability of hepatocarcinoma cell line, HepG2 up to 4 days. The biomaterial for immobilization of GRP was prepared using indium tin oxide (ITO) sputtered on polyethylene terephthalate (PET). A self-assembled monolayer (SAM) of 3-aminopropyl triethoxysilane (3-APTES) on ITO was covalently attached to GRP. Characterization of the substrates before and after immobilization of GRP …

Soil And Water Remediation Using Controlled Release Polymer, Jerrine Theresa Foster

Theses

Water and soil treatment for the eradication of pathogens are important today and will forever be of importance in the future. It has been noted that poor water quality poses major threat to human health and is responsible for the deaths of 1.8 million people annually worldwide, with over 90% (1.6 million) of the reported cases being children under the age of five (United Nations International Children's Emergency Fund, 2005). Fresh water can be accessed for personal use and recreation through fresh water sources, such as rivers, lakes, groundwater and springs. These sources, especially surface water sources, are exposed to …

(1s, 3s)-3-Amino-4-Difluoromethylenyl-1-Cyclopentanoic Acid (Cpp-115), A Potent Gamma-Aminobutyric Acid Aminotransferase Inactivator For The Treatment Of Cocaine Addiction, Y. Pan, M. R. Gerasimov, T. Kvist, P. Wellendorph, K. K. Madsen, E. Pera, H. Lee, A. Schousboe, S. L. Dewey, R. B. Silverman, +6 Additional Authors

Journal Articles

No abstract provided.

University Of Southern Maine Graduate Catalog 2012-2013, University Of Southern Maine

Course Catalogs

No abstract provided.

Photonic Crystal Fiber Interferometer For Dew Detection, Jinesh Mathew, Yuliya Semenova, Gerald Farrell

Articles

A novel method for dew detection based on photonic crystal fiber (PCF) interferometer that operates in reflection mode is presented in this paper. The fabrication of the sensor head is simple since it only involves cleaving and fusion splicing. The sensor shows good sensitivity to dew formation with a large wavelength peak shift of the interference pattern at the onset of dew formation. The device’s response to ambient humidity and temperature are also studied and reported in this paper. From our experiment it is also concluded that by attaching a thermoelectric cooler with temperature feedback, the sensor head demonstrated can …

Securing Our Community Through The Emergency Medical Services Sector, Michael Linehan

Master in Management for Public Safety and Homeland Security Professionals Master's Projects

Keeping the nation resilient; that is a nation able to withstand any threat or catastrophe is a primary goal of the United States Government. Ever since 9-11 our nation has had to face the reality that we can be vulnerable to threats from forces outside our control. We have had to re-examine the threats that we face and how we can better deal with them in the best way possible.

The following project will explore the many facets connected to making a resilient society. My area of expertise within the emergency services management gives me the unique perspective as a …

Human Dignity And The Logic Of Caritas:The Source And Direction Of Economic Justice, Bruce Baker

Verbum Incarnatum: An Academic Journal of Social Justice

No abstract provided.

Insulin Resistance, Ceramide Accumulation, And Endoplasmic Reticulum Stress In Human Chronic Alcohol-Related Liver Disease, Lisa Longato, Kelsey Ripp, Mashiko Setshedi, Miroslav Dostalek, Fatemeh Akhlaghi, Mark Branda, Jack R. Wands, Suzanne M. De La Monte

Biomedical and Pharmaceutical Sciences Faculty Publications

Background. Chronic alcohol-related liver disease (ALD) is mediated by insulin resistance, mitochondrial dysfunction, inflammation, oxidative stress, and DNA damage. Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic insulin resistance and may cause steatohepatitis to progress. Objective. We examined the degree to which hepatic insulin resistance in advanced human ALD is correlated with ER stress, dysregulated lipid metabolism, and ceramide accumulation. Methods. We assessed the integrity of insulin signaling through the Akt pathway and measured proceramide and ER stress gene expression, ER stress signaling proteins, and ceramide profiles in …

Community Annotation And Bioinformatics Workforce Development In Concert—Little Skate Genome Annotation Workshops And Jamborees, Qinghua Wang, Cecilia N. Arighi, Benjamin L. King, Shawn W. Polson, James Vincent, Chumching Chen, Hongzhan Huang, Brewster F. Kingham, Shallee T. Page, Marc Farnum Rendino, William Kelley Thomas, Daniel W. Udwary, Cathy H. Wu

Biomedical and Pharmaceutical Sciences Faculty Publications

Recent advances in high-throughput DNA sequencing technologies have equipped biologists with a powerful new set of tools for advancing research goals. The resulting flood of sequence data has made it critically important to train the next generation of scientists to handle the inherent bioinformatic challenges. The North East Bioinformatics Collaborative (NEBC) is undertaking the genome sequencing and annotation of the little skate (Leucoraja erinacea) to promote advancement of bioinformatics infrastructure in our region, with an emphasis on practical education to create a critical mass of informatically savvy life scientists. In support of the Little Skate Genome Project, the …

One-Pot Regioselective Synthesis Of Tetrahydroindazolones And Evaluation Of Their Antiproliferative And Src Kinase Inhibitory Activities, V. Kameshwara Rao, Bhupender S. Chhikara, Rakesh Tiwari, Amir Nasrolahi Shirazi, Keykavous Parang, Anil Kumar

Biomedical and Pharmaceutical Sciences Faculty Publications

A number of 2-substituted tetrahydroindazolones were synthesized by three-component condensation reaction of 1,3-diketones, substituted hydrazines, benzaldehydes, and Yb(OTf)₃ as a catalyst in [bmim][BF₄] ionic liquid using a simple, efficient, and economical one-pot method. The synthesized tetrahydroindazolones were evaluated for inhibition of cell proliferation of human colon carcinoma (HT-29), human ovarian adenocarcinoma (SK-OV-3), and c-Src kinase activity. 3,4-Dichlorophenyl tetrahydroindazolone derivative (15) inhibited the cell proliferation of HT-29 and SK-OV-3 cells by 62% and 58%, respectively. 2,3-Diphenylsubstituted tetrahydroindazolone derivatives, 19, 25, and 33, inhibited the cell proliferation of HT-29 cells by 65–72% at a …

Antiamoebic Properties Of The Actinomycete Metabolites Echinomycin A And Tirandamycin A, Avelina Espinosa, Aaron M. Socha, Erica Ryke, David C. Rowley

Biomedical and Pharmaceutical Sciences Faculty Publications

Entamoeba histolytica infects 50 million people per year, causing 100,000 deaths worldwide. The primary treatment for amoebiasis is metronidazole. However, increased pathogen resistance combined with the drug’s toxic side effects encourages a search for alternative therapeutic agents. Secondary metabolites from marine bacteria are a promising resource for antiprotozoan drug discovery. In this study, extracts from a collection of marine-derived actinomycetes were screened for antiamoebic properties, and the activities of antibiotics echinomycin A and tirandamycin A are shown. Both antibiotics inhibited the in vitro growth of a E. histolytica laboratory strain (HM-1:IMSS) and a clinical isolate (Colombia, Col) at 30- to …

Dec1 Binding To The Proximal Promoter Of Cyp3a4 Ascribes To The Downregulation Of Cyp3a4 Expression By Il-6 In Primary Human Hepatocytes, Zhao Mao, Xiaofei Luan, Gang Cao, Wei Liu, Jing Xiong, Gang Hu, Ruini Chen, Rui Ning, Wei Shang, Jian Yang, Bingfang Yan

Biomedical and Pharmaceutical Sciences Faculty Publications

In this study, we provided molecular evidences that interleukin-6 (IL-6) contributed to the decreased capacity of oxidative biotransformation in human liver by suppressing the expression of cytochrome P450 3A4 (CYP3A4). After human hepatocytes were treated with IL-6, differentially expressed in chondrocytes 1 (DEC1) expression rapidly increased, and subsequently, the CYP3A4 expression decreased continuously. Furthermore, the repression of CYP3A4 by IL-6 occurred after the increase of DEC1 in primary human hepatocytes. In HepG2 cells, knockdown of DEC1 increased the CYP3A4 expression and its enzymatic activity. In addition, it partially abolished the decreased CYP3A4 expression as well as its enzymatic activity induced …

False Justice And The “True” Prosecutor: A Memoir, Tribute, And Commentary, Mark A. Godsey

Faculty Articles and Other Publications

This article is a review of False Justice: Eight Myths that Convict the Innocent by Jim and Nancy Petro. But this article is also a memoir, in that I tell the story, from my own perspective as Director of the Ohio Innocence Project, of how I have watched Jim Petro go from prosecutor and elected Attorney General of Ohio to a leading champion of the wrongfully convicted across the nation. The article is also a commentary in that, along the way, I address what makes Jim Petro so different from many prosecutors in this country. In this respect, I discuss …

Rna-Seq Analysis Implicates Dysregulation Of The Immune System In Schizophrenia, Junzhe Xu, Jingchun Sun, Jingchun Chen, Lily Wang, Anna Li, Matthew Helm, Steven L. Dubovsky, Silviu-Alin Bacanu, Zhongming Zhao, Xiangning Chen

Psychiatry Publications

Background While genome-wide association studies identified some promising candidates for schizophrenia, the majority of risk genes remained unknown. We were interested in testing whether integration gene expression and other functional information could facilitate the identification of susceptibility genes and related biological pathways.

Results We conducted high throughput sequencing analyses to evaluate mRNA expression in blood samples isolated from 3 schizophrenia patients and 3 healthy controls. We also conducted pooled sequencing of 10 schizophrenic patients and matched controls. Differentially expressed genes were identified by t-test. In the individually sequenced dataset, we identified 198 genes differentially expressed between cases and controls, of …

Design Of An Implantable Device For Ocular Drug Delivery, Jae Hwan Lee, Ramana M. Pidiparti, Gary M. Atkinson, Ramana S. Moorthy

Mechanical and Nuclear Engineering Publications

Ocular diseases, such as, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa require drug management in order to prevent blindness and affecting million of adults in USA and worldwide. There is an increasing need to develop devices for drug delivery to address ocular diseases. This study focuses on the design, simulation, and development of an implantable ocular drug delivery device consisting of micro-/nanochannels embedded between top and bottom covers with a drug reservoir made from polydimethylsiloxane (PDMS) which is silicon-based organic and biodegradable polymer. Several simulations were carried out with six different micro-channel configurations in order to see …

Identification And Structural Characterization Of A New Three-Finger Toxin Hemachatoxin From Hemachatus Haemachatus Venom, Vallerinteavide Mavelli Girish, Sundramurthy Kumar, Lissa Joseph, Chacko Jobichen, R. Manjunatha Kini, J. Sivaraman

Biochemistry and Molecular Biology Publications

Snake venoms are rich sources of biologically active proteins and polypeptides. Three-finger toxins are non-enzymatic proteins present in elapid (cobras, kraits, mambas and sea snakes) and colubrid venoms. These proteins contain four conserved disulfide bonds in the core to maintain the three-finger folds. Although all three-finger toxins have similar fold, their biological activities are different. A new three-finger toxin (hemachatoxin) was isolated from Hemachatus haemachatus (Ringhals cobra) venom. Its amino acid sequence was elucidated, and crystal structure was determined at 2.43 Å resolution. The overall fold is similar to other three-finger toxins. The structure and sequence analysis revealed that the …