Large-Scale Blood Pressure Gwas Accounting For Gene-Depression Interactions In 564,680 Individuals From Diverse Populations, Songmi Lee, Clint L Miller, Amy R Bentley, Michael R Brown, Pavithra Nagarajan, Raymond Noordam, John L Morrison, Karen Schwander, Kenneth Westerman, Minjung Kho, Aldi T Kraja, Paul S De Vries, Farah Ammous, Hughes Aschard, Traci M Bartz, Anh Do, Charles T Dupont, Mary F Feitosa, Valborg Gudmundsdottir, Xiuqing Guo, Sarah E Harris, Keiko Hikino, Zhijie Huang, Christophe Lefevre, Leo-Pekka Lyytikäinen, Yuri Milaneschi, Giuseppe Giovanni Nardone, Aurora Santin, Helena Schmidt, Botong Shen, Tamar Sofer, Quan Sun, Ye An Tan, Jingxian Tang, Sébastien Thériault, Peter J Van Der Most, Erin B Ware, Stefan Weiss, Wang Ya Xing, Chenglong Yu, Wei Zhao, Md Abu Yusuf Ansari, Pramod Anugu, John R Attia, Lydia A Bazzano, Joshua C Bis, Max Breyer, Brian Cade, Guanjie Chen, Stacey Collins, Janie Corley, Gail Davies, Marcus Dörr, Jiawen Du, Todd L Edwards, Tariq Faquih, Jessica D Faul, Alison E Fohner, Amanda M Fretts, Srushti Gangireddy, Adam Gepner, Mariaelisa Graff, Edith Hofer, Georg Homuth, Michelle M Hood, Xu Jie, Mika Kähönen, Sharon L R Kardia, Carrie A Karvonen-Gutierrez, Lenore J Launer, Daniel Levy, Maitreiyi Maheshwari, Lisa W Martin, Koichi Matsuda, John J Mcneil, Ilja M Nolte, Tomo Okochi, Laura M Raffield, Olli T Raitakari, Lorenz Risch, Martin Risch, Ana Diez Roux, Edward A Ruiz-Narvaez, Tom C Russ, Takeo Saito, Pamela J Schreiner, Rodney J Scott, James Shikany, Jennifer A Smith, Harold Snieder, Beatrice Spedicati, E Shyong Tai, Adele M Taylor, Kent D Taylor, Paola Tesolin, Rob M Van Dam, Rujia Wang, Wei Wenbin, Tian Xie, Jie Yao, Kristin L Young, Ruiyuan Zhang, Alan B Zonderman, Biobank Japan Project, Lifelines Cohort Study, Maria Pina Concas, David Conen, Simon R Cox, Michele K Evans, Ervin R Fox, Lisa De Las Fuentes, Ayush Giri, Giorgia Girotto, Hans J Grabe, Charles Gu, Vilmundur Gudnason, Sioban D Harlow, Elizabeth Holliday, Jonas B Jost, Paul Lacaze, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Alanna C Morrison, Kari E North, Brenda W J H Penninx, Patricia A Peyser, Michael M Province, Bruce M Psaty, Susan Redline, Frits R Rosendaal, Charles N Rotimi, Jerome I Rotter, Reinhold Schmidt, Xueling Sim, Chikashi Terao, David R Weir, Xiaofeng Zhu, Nora Franceschini, Jeffrey R O'Connell, Cashell E Jaquish, Heming Wang, Alisa Manning, Patricia B Munroe, Dabeeru C Rao, Han Chen, W James Gauderman, Laura J Bierut, Thomas W Winkler, Myriam Fornage

Faculty, Staff and Student Publications

Gene-environment interactions may enhance our understanding of blood pressure (BP) biology. We conducted a meta-analysis of multi-population genome-wide association studies (GWASs) of BP traits accounting for gene-depressive symptomatology (DEPR) interactions. Our study included 564,680 adults from 67 cohorts and four population backgrounds: African (5%), Asian (7%), European (85%), and Hispanic (3%). We discovered seven previously unreported BP loci showing gene-DEPR interaction. These loci mapped to genes implicated in neurogenesis (TGFA and CASP3), lipid metabolism (ACSL1), neuronal apoptosis (CASP3), and synaptic activity (CNTN6 and DBI). We also showed evidence for gene-DEPR interaction at nine known BP loci, further suggesting links between …

The Distribution Of Cadmium And Its Isotopes In The Subarctic Pacific, J. M. Malloy, H. R. Hunt, M. Sieber, S. Takano, H. Obata, T. M. Conway

Making Waves REU

• Cadmium (Cd) is a bioactive trace element that can act as a micronutrient, driving large scale chemical processes like photosynthesis and cellular respiration [1,2].
• The uptake of major nutrients is limited by dissolved iron (Fe) availability in high nutrient low chlorophyll (HNLC) surface regions like the subarctic Pacific [2,4].
• Upwelling of Cd-rich deepwater is a Cd source, in addition to riverine, atmospheric, and anthropogenic inputs [1].
• Dissolved cadmium isotopic compositions (δ114Cd) provide insight into the biogeochemical processes controlling Cd distributions throughout the water column, including biological uptake in surface waters, regeneration, and water mass mixing at depth.
• Here we present …

Proton Versus Photon Radiotherapy For Patients With Oropharyngeal Cancer In The Usa: A Multicentre, Randomised, Open-Label, Non-Inferiority Phase 3 Trial, Steven J Frank, Paul M Busse, J Jack Lee, David I Rosenthal, Mike Hernandez, David M Swanson, Adam S Garden, G Brandon Gunn, Samir H Patel, James W Snider, Daniel J Ma, Jason K Molitoris, Nancy Y Lee, Upendra Parvathaneni, Mark W Mcdonald, Noah S Kalman, Alexander Lin, Nasiruddin Mohammed, Christina Henson, Christian Hyde, Gopal K Bajaj, Sanford R Katz, Roi Dagan, William H Morrison, Jay P Reddy, C David Fuller, Shalin J Shah, Jack Phan, Gregory M Chronowski, Lauren Mayo, Erich M Sturgis, Renata Ferrarotto, Xiaorong R Zhu, Xiaodong Zhang, Li Wang, Katherine A Hutcheson, Adel K El-Naggar, Amy C Moreno, Anna Lee, Michael T Spiotto, Neil D Gross, Stephen Y Lai, Jay J Liao, Jonathan Paly, Zhongxing Liao, Robert L Foote

Faculty, Staff and Student Publications

Background: Radiotherapy is an integral component of treatment for oropharyngeal cancer. Toxicity from the current state-of-the-art photon radiotherapy, intensity-modulated radiation therapy (IMRT), has prompted the search for alternative, less toxic therapies. One such alternative that might de-intensify treatment is proton therapy. In this trial, we aimed to directly compare IMRT with intensity-modulated proton therapy (IMPT), both concurrent with systemic therapy, hypothesising comparable disease control and survival and lower toxicity.

Methods: This randomised, multicentre, open-label, non-inferiority, phase 3 trial was conducted in 21 sites (cancer centres or universities) in the USA. Patients (aged ≥18 years) with stage III or stage IV …

Identification Of Cadm1 As An Immunotherapeutic Target And Evaluation Of A Novel Cadm1-Targeting Antibody-Drug Conjugate In Preclinical Osteosarcoma Models, Yifei Wang, Zhongting Zhang, Caterina Longo, Wendong Zhang, Qi Wang, Amer Najjar, Xiangjun Tian, Rossana N Lazcano Segura, Michael E Roth, Jonathan Gill, Douglas J Harrison, Zhaohui Xu, Yanhua Yi, Xin Zhou, Sylvester Jusu, Timothy M Stearns, Steven B Neuhauser, Carol J Bult, Jing Wang, Alexander J Lazar, Richard Gorlick

Faculty, Staff and Student Publications

Due to the paucity of validated cell surface osteosarcoma-specific targets, patients with this condition have long been excluded from the benefits of antibody-drug conjugate (ADC) therapy observed in patients with several solid and hematologic malignancies. Our comprehensive surfaceome profiling approach previously identified osteosarcoma-specific cell-surface antigens that are highly expressed in osteosarcomas but minimally expressed in normal tissues. As a result, one such antigen, CADM1, was selected for the generation of an ADC. We tested a CADM1-targeting ADC with a tesirine payload (SG3249) in vitro in osteosarcoma, rhabdomyosarcoma, and neuroblastoma patient-derived xenograft cell lines. In vivo, we tested six CADM1-expressing osteosarcoma …

Flipi24: A Modern Prognostic Model And Clinical Trial Enrichment Tool For Newly Diagnosed Follicular Lymphoma, Matthew J Maurer, Vit K Prochazka, Tarec Christoffer El-Galaly, Christopher R Flowers, Diego Villa, Emmanuel Bachy, Elliot J Cahn, Marguerite Fournier, Melissa C Larson, Caroline E Dietrich, Lasse Hjort Jakobsen, Hervé Ghesquières, Robert Kridel, Maher K Gandhi, Chan Y Cheah, Eliza A Hawkes, John F Seymour, Ciara L Freeman, Michael R Clausen, Björn E Wahlin, Jonathan W Friedberg, Carla Casulo, Thomas M Habermann, Yucai Wang, Loretta J Nastoupil, Peter De Nully Brown, David Belada, Andrea Janíková, Heidi Mocikova, Tomáš Fürst, Pierre Feugier, Hervé Tilly, Corinne Haioun, Andrew J Davies, Guillaume Cartron, Richard Burack, Dai Chihara, Peter Martin, Jonathon B Cohen, Izidore S Lossos, Brad S Kahl, Laurie H Sehn, Karin E Smedby, Gilles Salles, Marek Trneny, Brian K Link, Franck Morschhauser, James R Cerhan

Faculty, Staff and Student Publications

Purpose: Although most patients with follicular lymphoma (FL) can expect an indolent course, progressive lymphoma remains the primary cause of death during the first decade after diagnosis. Progression of disease within 24 months (POD24) of starting first-line (1L) immunochemotherapy defines a high-risk population with poor survival, but better risk stratification at diagnosis is needed.

Methods: The FLIPI24 model was developed and internally validated to predict 24-month event rates using individual data from 4,485 patients treated with 1L immunochemotherapy from 10 observational cohorts of FL. Overall and cause-specific survival was further evaluated in FLIPI24 risk groups. External validation in the 1L …

The Computationally Designed Tri2-2 Miniprotein Inhibitor Protects Against Multiple Sars-Cov-2 Omicron Variants, Jimin Lee, James Brett Case, Young-Jun Park, Rashmi Ravichandran, Daniel Asarnow, M Alejandra Tortorici, Jack T Brown, Shilpa Sanapala, Lauren Carter, David Baker, Michael S Diamond, David Veesler

2020-Current year OA Pubs

The continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has compromised neutralizing antibody responses elicited by prior infection or vaccination and abolished the utility of most monoclonal antibody therapeutics. We previously described a computationally-designed, homotrimeric miniprotein inhibitor, designated TRI2-2, that protects mice against pre-Omicron SARS-CoV-2 variants. Here, we show that TRI2-2 exhibits broadly neutralizing activity of SARS-CoV-2 variants and protects mice against BQ.1.1, XBB.1.5 and BA.2.86 challenge when administered intranasally post-exposure. The resistance of TRI2-2 to viral escape by most variants and the ability to deliver it directly to the upper airways highlight the potential of the multivalent …

Antibacterial Peptides From Soybean (Glycine Max (L.) Merr.) With In Silico Study Against Escherichia Coli Bacteria, Dian Riana Ningsih, Ely Setiawan, Purwati Purwati, Zusfahair Zusfahair, Anita Hindayanti Rukmana

Karbala International Journal of Modern Science

Bioactive peptides are produced from soy milk protein hydrolysis using trypsin. The research began with the preparation and separation of soy milk protein, followed by fractionation using ammonium sulphate, protein hydrolysis, and SDS-PAGE analysis of protein hydrolysates. Fractions exhibiting the highest degree of hydrolysis were further fractionated by SPE and tested to determine the antibacterial activity Staphylococcus aureus and Escherichia coli. The peptide sequence of the active peptide as an antibacterial was identified, employing LC-HRMS. The mode of action between active peptides and bacterial membran was analysed using molecular dynamics (MD) simulation. The findings displayed that F15 contained the highest …

The Archon, 1950 Edition, Zeta Phi Beta Sorority Incorporated

Josie Green Washington Papers

A 1950 edition pamphlet called The Archon, an official organ of the Zeta Phi Beta Sorority.

(((Qpie))) How To Read Qpie If You Are Trained In Physics, Teddy Burroughs

Defensive Publications Series

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The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPIE)))How to Read QPIE If You Are Trained in Physics

How to Read QPIE If You Are Trained in Physics

A Technical Orientation Guide for Physicists, Information Scientists, and Systems Theorists

0. One-Paragraph Orientation (Read This First)

QPIE (Quantum Perspective Is Everything) is not a competing physical theory, nor a modification of quantum mechanics. It is a meta-scientific operator …

Orthodontic Space Closure And Third Molar Uprighting For Simultaneous Maxillary And Mandibular Molar Loss On The Same Side, Chun-Yi Huang, Yuan-Hou Chen, Ching-Yu Yang, Jian-Hong Yu

Taiwanese Journal of Orthodontics

This case report describes the successful non-surgical orthodontic management of a complex Class I malocclusion characterized by unilateral posterior tooth loss and functionally induced facial asymmetry. A 28-year-old male patient presented with a non-restorable maxillary first molar (#26) and a missing mandibular second molar (#37). The resulting occlusal discrepancy contributed to a mandibular functional shift and facial asymmetry. The patient declined prosthetic and surgical options, prompting a conservative orthodontic approach.

The treatment plan incorporated third molar protraction and upright to substitute for the missing second molar, combined with occlusal rehabilitation to correct the asymmetry. Space closure was achieved using elastic …

Survey Of Mainehealth Cancer Care Network Providers On Cannabis Use: Preparation For Studies Sponsored By The National Cancer Institute, Jill M Prescott, Jamie G Saunders, Leslie S Bradford, Scot C Remick

Journal of Maine Medical Center

Introduction: Cannabis and cannabinoid use in patients with cancer has rapidly scaled up over the past decade and is a topic of considerable clinical, research, and public health interest.

Methods: We conducted a cannabis landscape survey among front-line providers in the MaineHealth Cancer Care Network (MHCCN) before applying and participating in National Cancer Institute (NCI)-sponsored studies on cannabis use in patients with cancer. The results of the survey can better inform participation in national studies and provide a departure point for provider educational activities focused on cannabis use in the cancer care setting.

Results: Notable observations from our survey included …

Metabolic Phenotyping And Therapeutic Hierarchy For Dyslipidemia In Saudi Type 2 Diabetes, Ahmed A. Almohammadi, Mohammed W. Azuny, Abdulmannan A. Alem, Sarah F. Alsobhi, Muath H. Alqayidi, Rami O. Alharbi, Salem S. Alhubayshi, Duha W. Azouni

University of Bisha Journal for Basic and Applied Sciences

Aims: Dyslipidemia represents a critical cardiovascular risk factor in type 2 diabetes mellitus (T2DM), yet distinct metabolic phenotypes and their therapeutic implications remain inadequately characterized in Saudi populations. This study aimed to identify dyslipidemia phenotypes, establish therapeutic hierarchies, and examine metabolic determinants in Saudi T2DM patients.

Methods: A cross-sectional study enrolled 406 T2DM patients at Madinah Diabetic Center, Saudi Arabia (August-December 2024). Comprehensive sociodemographic, clinical, lifestyle, and laboratory data were collected. Statistical analyses included cluster analysis for phenotype identification, multivariate linear regression for lipid determinants, and chi-square tests for categorical associations. Ethical approval was obtained from IRB-Madinah (H-03-M-84).

Results: Dyslipidemia …

Pyruvate Kinase M2: Function, Regulation And Targeting Therapeutics In Cancer, Nada M. Ali

University of Bisha Journal for Basic and Applied Sciences

Pyruvate kinase M2 (PKM2) is a pivotal enzyme in glycolysis, catalyzing the conversion of phosphoenolpyruvate (PEP) into pyruvate while generating ATP through substrate-level phosphorylation. Unlike other pyruvate kinase isoforms, PKM2 exhibits unique regulatory properties that allow it to switch between active tetrameric and less-active dimeric states, influencing both energy metabolism and biosynthetic pathways. PKM2 is widely expressed in tumors, where it plays a central role in metabolic reprogramming and cancer progression. Beyond its metabolic function, recent studies have identified non-canonical roles for PKM2, including its nuclear translocation and protein kinase activity, which influence gene expression, cell cycle regulation, and tumor …

Ud In The News Jan. 3-9, University Of Dayton

News Releases

The Point in Gambia, OtherWords, POLITICO, The Scientist, TrainsPRO, Alabama Catholic Radio and cleveland.com are among the news outlets tapping UD faculty expertise the first full week of the new year.

Repair Techniques For Acute Rupture Of The Patellar Tendon: A Systematic Review, Gaston Davis, Harrison S. Fellheimer, Christian Mccormick, Kevin B. Freedman

Rothman Institute Papers

BACKGROUND: Multiple techniques exist to repair acute tears of the patellar tendon. Surgical repair is required to reestablish full function of the extensor mechanism of the knee, and optimal results typically occur when the tear is repaired acutely.

PURPOSE: To systematically review the literature to evaluate treatment outcomes and complication rates after acute surgical repair of patellar tendon ruptures using suture anchor repair, transosseous repair, and end-to-end repair.

STUDY DESIGN: Scoping review; Level of evidence, 4.

METHODS: A systematic review was performed to analyze outcomes after patellar tendon repair in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews …

Atlantic Goliath Grouper (Epinephelus Itajara) Neurocranium, Sierra Rafacz, Rileigh Gonzalez, Ema Nagel, Nicholas Burchett, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Fish In An Aquaponics System, Amy M. Shambach, Rebecca M. Ward, J. Stuart Carlton, Kwamena K. Quagrainie, Tomas O. Höök

Supplementary Content for Aquaponics: Farming Fish and Growing Greens for Grades 9–12

This PowerPoint slide provides readers with information on fish in an aquaponics system. This book was published by the Purdue University Press. Copyright 2026.

Permission: Illinois-Indiana Sea Grant

Introduction To The Nitrogen Cycle, Amy M. Shambach, Rebecca M. Ward, J. Stuart Carlton, Kwamena K. Quagrainie, Tomas O. Höök

Supplementary Content for Aquaponics: Farming Fish and Growing Greens for Grades 9–12

This PowerPoint slide provides readers with an introduction to the Nitrogen cycle. This book was published by the Purdue University Press. Copyright 2026.

Permission: Illinois-Indiana Sea Grant

Information On Building An Aquaponics Business, Amy M. Shambach, Rebecca M. Ward, J. Stuart Carlton, Kwamena K. Quagrainie, Tomas O. Höök

Supplementary Content for Aquaponics: Farming Fish and Growing Greens for Grades 9–12

This PowerPoint slide provides readers with information on building an aquaponics business. This book was published by the Purdue University Press. Copyright 2026.

Permission: Illinois-Indiana Sea Grant

Anatomy Of An Aquaponics System, Amy M. Shambach, Rebecca M. Ward, J. Stuart Carlton, Kwamena K. Quagrainie, Tomas O. Höök

Supplementary Content for Aquaponics: Farming Fish and Growing Greens for Grades 9–12

This PowerPoint slide describes the anatomy of an aquaponics system. This book was published by the Purdue University Press. Copyright 2026.

Permission: Illinois-Indiana Sea Grant

How To Measure The Level Of Nitrogen In An Aquaponics System, Amy M. Shambach, Rebecca M. Ward, J. Stuart Carlton, Kwamena K. Quagrainie, Tomas O. Höök

Supplementary Content for Aquaponics: Farming Fish and Growing Greens for Grades 9–12

This PowerPoint slide shows readers how to measure the level of Nitrogen in an aquaponics system. This book was published by the Purdue University Press. Copyright 2026.

Permission: Illinois-Indiana Sea Grant

Plants In An Aquaponics System, Amy M. Shambach, Rebecca M. Ward, J. Stuart Carlton, Kwamena K. Quagrainie, Tomas O. Höök

Supplementary Content for Aquaponics: Farming Fish and Growing Greens for Grades 9–12

This PowerPoint slide provides readers with information on plants in an aquaponics system. This book was published by the Purdue University Press. Copyright 2026.

Permission: Illinois-Indiana Sea Grant

Additional Information About The Nitrogen Cycle And Population Dynamics, Amy M. Shambach, Rebecca M. Ward, J. Stuart Carlton, Kwamena K. Quagrainie, Tomas O. Höök

Supplementary Content for Aquaponics: Farming Fish and Growing Greens for Grades 9–12

This PowerPoint slide provides readers with additional information about the Nitrogen cycle and population dynamics. This book was published by the Purdue University Press. Copyright 2026.

Permission: Illinois-Indiana Sea Grant

Introduction To Aquaponics, Amy M. Shambach, Rebecca M. Ward, J. Stuart Carlton, Kwamena K. Quagrainie, Tomas O. Höök

Supplementary Content for Aquaponics: Farming Fish and Growing Greens for Grades 9–12

This PowerPoint slide provides readers with an introduction to aquaponics. This book was published by the Purdue University Press. Copyright 2026.

Permission: Illinois-Indiana Sea Grant

Maternal Immunization With Vp8* Mrna Vaccine Yields Superior Passive Transfer Of Rotavirus-Neutralizing Antibodies To Foals, Karin E R Borba, Rebecca M Legere, Nathan M Canaday, Jill W Skrobarczyk, Zachary W T Arnold, Elena Cotton-Betteridge, Cristina Poveda, Michael F Criscitiello, Angela I Bordin, Luc R Berghman, Jeroen B K Pollet, Noah D Cohen

Faculty, Staff and Students Publications

Background: Despite the availability of a killed whole-virus (KV) vaccine, diarrhea caused by equine rotavirus group A (ERVA) remains a significant health concern for foals in the United States. The vaccine is administered to pregnant mares, with foals protected by passive transfer of colostral antibodies. However, KV-induced immunity is only partially protective and maternal antibody levels in foals are often low and wane rapidly. To address these limitations, we developed a mRNA-based ERVA vaccine encoding the highly conserved VP8* protein to evaluate whether it can provide improved immune protection.

Methods: Pregnant mares (n = 12 per group) were …

Lung Epithelial And Alveolar Macrophage-Like Cell Interactions Significantly Modify Innate Responses To Bacterial Endotoxin With The Involvement Of Direct Cellular Contacts, Tnf-Α, Icam1 And Mcp-1, Connor Wood, Shagun Khera, Minjeong Woo, Vikram Sharma, Justyna Lopatecka, Frederic Coulon, Zaheer Nasir, Vincent Delorme, Simon K. Jackson, György Fejer

School of Biomedical Sciences

Introduction: Lung alveolar macrophages (AMs) and epithelial cells form the first line of defense against inhaled pathogens. Their interactions strongly influence innate immune responses in the lung, yet the mechanisms underlying this cross-talk remain incompletely understood. Methods: In this study, we established a co-culture system using a primary model of AMs (MPI alveolar macrophage-like cells) and MLE-12 alveolar epithelial cells to investigate innate responses and cellular interactions during bacterial lipopolysaccharide (LPS)-induced TLR4 activation. Results: Cytokine and chemokine profiling revealed that co-cultures exhibited significantly enhanced proinflammatory responses to both LPS and TLR2 ligands—including IL-6, TNF-a, and MCP-1 secretion—compared with mono-cultures. Strikingly, …

An Integrated Single-Cell And Spatial Transcriptomic Atlas Of Thyroid Cancer Progression Identifies Prognostic Fibroblast Subpopulations, Matthew A Loberg, George J Xu, Sheau-Chiann Chen, Hua-Chang Chen, Claudia C Wahoski, Kailey P Caroland, Megan L Tigue, Heather A Hartmann, Jean-Nicolas Gallant, Courtney J Phifer, Andres A Ocampo, Dayle K Wang, Reilly G Fankhauser, Kirti A Karunakaran, Chia-Chin Wu, Maxime Tarabichi, Sophia M Shaddy, James L Netterville, Sarah L Rohde, Carmen C Solórzano, Lindsay A Bischoff, Naira Baregamian, Barbara A Murphy, Jennifer H Choe, Jennifer R Wang, Eric C Huang, Quanhu Sheng, Luciane T Kagohara, Elizabeth M Jaffee, Ryan H Belcher, Ken S Lau, Fei Ye, Ethan Lee, Vivian L Weiss

Faculty, Staff and Student Publications

Although well-differentiated thyroid carcinoma (WDTC) is characterized by a robust treatment response, aggressive subtypes, such as anaplastic thyroid carcinoma (ATC), remain highly lethal. To understand thyroid cancer evolution in both children and adults, we analyzed single-cell transcriptomes of 423,733 cells from 81 samples and spatially resolved key tumor and microenvironment populations across 28 tumors with spatial transcriptomics, including rare and unique composite WDTC/ATC tumors and pediatric diffuse sclerosing thyroid carcinomas. Additionally, we identified gene signatures of stromal cell populations in 5 large thyroid cancer bulk RNA-sequencing cohorts. Through this multi-institutional effort, we defined a population of POSTN+ myofibroblast cancer-associated fibroblasts …

Daily Locomotor Activity Declines With Tumor Growth And Disease Progression In Glioblastoma, Maria F Gonzalez-Aponte, Sofia V Salvatore, Anna R. Damato, Ruth Gn Katumba, Grayson R. Talcott, Omar H. Butt, Jian L. Campian, Jingqin Luo, Joshua B. Rubin, Olivia J. Walch, Erik D. Herzog

2020-Current year OA Pubs

Glioblastoma (GBM) is an aggressive brain tumor that often progresses despite resection and treatment. Timely and continuous assessment of GBM progression is critical to expedite secondary surgery or enrollment in clinical trials. However, current progression detection requires costly and specialized MRI examinations, which, in the absence of new symptoms or signs, are usually scheduled every 2-3 months. Here, we hypothesized that changes in daily activity are associated with GBM growth and disease progression. We found that wheel-running activity in GBM-bearing mice declined as tumors grew and preceded weight loss and circadian breakdown by over a week. Temozolomide treatment in the …

The Yeh Pilus Adhesin Is Equipped With An Α-Helical Flap Motif, Which Contributes To Pectin Adherence, Kevin O Tamadonfar, Roger D Klein, Edward D B Lopatto, Maxwell I Zimmerman, Philippe N Azimzadeh, Denise A Sanick, Justin R Porter, Jesus Bazan Villicana, Jerome S Pinkner, Bo Huey Chiang, Nathaniel C Gualberto, Karen W Dodson, Michael L Patnode, George M H Et Al., Gregory R Bowman, Scott J Hultgren

2020-Current year OA Pubs

The Yeh chaperone-usher pathway (CUP) pilus adhesin is encoded in one-half of all

A Prescription For Ineffective Notice In Mhealth, Tatyana Norman-Webler

Akron Law Review

No abstract provided.