Digital Commons Network^™

The Mechanical Properties Of Epoxy Composites Filled With Rubbery Copolymer Grafted Sio2, Jianing Gao, Junting Li, Brian C. Benicewicz, Su Zhao, Henrik Hillborg, Linda S. Schadler

Faculty Publications

This study demonstrated a method for toughening a highly crosslinked anhydride cured DGEBA epoxy using rubbery block copolymer grafted SiO2 nanoparticles. The particles were synthesized by a sequential reversible addition-fragmentation chain transfer (RAFT) polymerization. The inner rubbery block poly(n-hexyl methacrylate) (PHMA) had a glass transition temperature below room temperature. The outer block poly(glycidyl methacrylate) (PGMA) was matrix compatible. A rubbery interlayer thickness of 100% and 200% of the particle core radius was achieved by grafting a 20 kg/mol and a 40 kg/mol PHMA at a graft density of 0.7 chains/nm² from the SiO₂ surface. The 20 kg/mol rubbery …

Emerging Issue: Coastal And Marine Spatial Planning:Found In The Wind: The Value Of Early Consultation And Collaboration With Other Ocean Users For Successful Offshore Wind Development, David E. Frulla, George M. Hagerman Jr., Michele G. Hallowell

Roger Williams University Law Review

No abstract provided.

A Comparative Review Of “How To” Books For Parents Of Adhd Children And “How To” Books For Parents Of Typical Children, Bora Pajo, Paul H. Stuart Dr.

All Faculty and Staff Scholarship

Although an increasing number of children are diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) and take medications to control their behaviors, a well-publicized controversy persists about whether ADHD refers to a common neurobehavioral disorder of childhood or to various medicalized temperamental, educational, and cultural differences and difficulties of children. Moreover, behaviors indicative of ADHD are commonly found among all children—although with different frequencies. This paper aims to identify and compare the type of information provided to parents of ADHD and non-ADHD diagnosed children through readily available self-help books. Searches using popular online bookstores were conducted to rank and select the …

The Nucleus 2011-2012, Rosalie A. Richards

Science Education Center

No abstract provided.

Deafdigest: Gold Edition, January 15, 2012, Barry Strassler

DeafDigest Gold 2012

No abstract provided.

High Altitude Diving In River Otters: Coping With Combined Hypoxic Stresses, Jamie R. Crait, Henry D. Prange, Noah A. Marshall, Henry J. Harlow, Clark Cotton, Merav Ben-David

Biology Faculty Publications

River otters (Lontra canadensis) are highly active, semi-aquatic mammals indigenous to a range of elevations and represent an appropriate model for assessing the physiological responses to diving at altitude. In this study, we performed blood gas analyses and compared blood chemistry of river otters from a high-elevation (2357 m) population at Yellowstone Lake with a sea-level population along the Pacific coast. Comparisons of oxygen dissociation curves (ODC) revealed no significant difference in hemoglobin-oxygen (Hb-O₂) binding affinity between the two populations - potentially because of demands for tissue oxygenation. Instead, high-elevation otters had greater Hb concentrations (18.7 …

Eng 2001-001: Creative Writing Nonfiction, Lania Knight

Spring 2012

No abstract provided.

Orai1 Deficiency Leads To Heart Failure And Skeletal Myopathy In Zebrafish., Mirko Völkers, Nima Dolatabadi, Natalie Gude, Patrick Most, Mark A Sussman, David Hassel

Center for Translational Medicine Faculty Papers

Mutations in the store-operated Ca²⁺ entry pore protein ORAI1 have been reported to cause myopathies in human patients but the mechanism involved is not known. Cardiomyocytes express ORAI1 but its role in heart function is also unknown. Using reverse genetics in zebrafish, we demonstrated that inactivation of the highly conserved zebrafish orthologue of ORAI1 resulted in severe heart failure, reduced ventricular systolic function, bradycardia and skeletal muscle weakness. Electron microscopy of Orai1-deficient myocytes revealed progressive skeletal muscle instability with loss of myofiber integrity and ultrastructural abnormalities of the z-disc in both skeletal and cardiac muscle. Isolated Orai1-deficient cardiomyocytes showed loss …

Discernible But Limited Introgression Has Occurred Where Trichinella Nativa And The T6 Genotype Occur In Sympatry, Detiger B. Dunams-Morel, Mason V. Reichard, Luigi Torretti, Dante S. Zarlenga, Benjamin Rosenthal

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

The genetic diversity within and among parasite populations provides clues to their evolutionary history. Here, we sought to determine whether mitochondrial and microsatellite DNA variation could be used to evaluate the extent of differentiation, gene flow and historical reproductive isolation among the freeze resistant parasites Trichinella nativa and the Trichinella T6 genotype infecting wolverines (Gulo gulo) in Nunavut, Canada. To this end, we genotyped Trichinella isolates derived from the diaphragms of 39 wol- verines from this locale to reference strains of T. nativa and the Trichinella T6 genotype. Results showed that among a subset of 13 isolates examined, individuals resembled …

Superarmed Glycosyl Donors In Chemical Glycosylation, Hemali Deepthika Premathilake

Dissertations

Only recently has the tremendous biological significance and therapeutic potential of carbohydrates and conjugates thereof (glycoproteins, glycolipids, proteoglycans, etc.) begun to emerge. As the appreciation for the biological roles of carbohydrates a growing demand for efficient and scalable methods towards the synthesis of these challenging molecules has become even more imperative. This has led to the development of a variety of expeditious strategies for oligosaccharide assembly. Amongst these strategies, the so-called armed-disarmed strategy introduced by Fraser-Reid is of particular attractiveness as it allows for chemoselective oligosaccharide synthesis. Recently, the conformational changes as well as the strategic placement of common protecting …

What Fescue Toxicosis Is Really Doing Inside Your Animals, Glen E. Aiken

Forage Symposium at the Kentucky Cattlemen’s Convention

Eighty years have passed since Dr. F.N. Fergus collected seed of tall fescue from that hillside at the Suiter Farm in Menifee County that led to the commercial release of the cultivar ‘Kentucky 31’. Fescue provided an opportunity to replace the briar and weed patches that dominated the rocky hillsides of Kentucky with productive forage. Plantings of tall fescue were numerous in the state during the 1940s and 1950s, and its hardiness and adaptability resulted in the grass spreading over much of the middle and upper southeastern USA, eventually covering a region we now call the “fescue belt”. It did …

War Crimes Prosecution – Lessons Learned From Bosnia And Herzegovina, Iva Vukusic

Conflict, Memory, and Reconciliation: Bridging past, present, and future

Since the war ended fifteen years ago, war crimes prosecution has been the dominant tool of addressing war crimes committed during the four-year-long conflict in Bosnia and Herzegovina (1992-1995). The prosecution has been conducted at the International Criminal Tribunal for the former Yugoslavia (ICTY), the national institutions (Court of BiH, Sarajevo) and the local courts (cantonal and district in Republika Srpska, the Federation of BiH and the Brcko District – all entities established as a result of the Dayton Peace Accords). All these institutions have been criticized by various individuals in different capacities, for different reasons – some of these …

The Role Of Mitochondrial Dysfunction In Neurodegenerative Proteinopathies And Aging., Alejandro Ocampo

Open Access Dissertations

Age-related neurodegenerative proteinophaties, including polyglutamine (polyQ) diseases such as Huntington’s disease, are a group of disorders in which a single protein or a set of proteins misfold and aggregate resulting in a progressive and selective loss of anatomically or physiologically related neuronal systems. Despite evidence showing a clear relationship between mitochondrial dysfunction, aging and neurodegenerative proteinophaties, the extent of the mitochondrial respiratory chain deficits, the involvement of mitochondrial dysfunction and the mechanisms responsible for these processes are largely unknown. Using yeast models of cellular aging and polyQ disorders we show that mitochondrial dysfunction is an important contributor to the process …

Library Impact Statement For Bio 553 Regulatory Processes In Eucaryotic Cells, Michael A. Cerbo Ii

Library Impact Statements

Library Impact Statement for BIO 553 Regulatory Processes in Eucaryotic Cells new course proposal. No new library resources are needed to support this course. Responding library faculty member: Michael A. Cerbo II. Requesting faculty member: Joanna Norris.

Association Of The 5-Htt Gene-Linked Promoter Region (5-Httlpr) Polymorphism With Psychiatric Disorders: Review Of Psychopathology And Pharmacotherapy, George A. Kenna, Nick Roder-Hanna, Lorenzo Leggio, William H. Zywiak, James Clifford, Steven Edwards, John A. Kenna, Jessica Shoaff, Robert M. Swift

College of Nursing Faculty Publications

Serotonin (5-HT) regulates important biological and psychological processes including mood, and may be associated with the development of several psychiatric disorders. An association between psychopathology and genes that regulate 5-HT neurotransmission is a robust area of research. Identification of the genes responsible for the predisposition, development, and pharmacological response of various psychiatric disorders is crucial to the advancement of our understanding of their underlying neurobiology. This review highlights research investigating 5-HT transporter (5-HTTLPR) polymorphism, because studies investigating the impact of the 5-HTTLPR polymorphism have demonstrated significant associations with many psychiatric disorders. Decreased transcriptional activity of the S allele (“risk allele”) …

Structural Basis For Activation Of Calcineurin By Calmodulin, Julie Rumi-Masante, Farai I. Rusinga, Terrence E. Lester, Tori B. Dunlap, Todd D. Williams, A. Keith Dunker, David D. Weis, Trevor P. Creamer

Center for Structural Biology Faculty Publications

The highly conserved phosphatase calcineurin (CaN) plays vital roles in numerous processes including T-cell activation, development and function of the central nervous system, and cardiac growth. It is activated by the calcium sensor calmodulin (CaM). CaM binds to a regulatory domain (RD) within CaN, causing a conformational change that displaces an autoinhibitory domain (AID) from the active site, resulting in activation of the phosphatase. This is the same general mechanism by which CaM activates CaM-dependent protein kinases. Previously published data have hinted that the RD of CaN is intrinsically disordered. In this work, we demonstrate that the RD is unstructured …

God Has No Grandchildren, Steve Case

180 Symposium Publications

Biological births create second and third generations. A spiritual birth creates a child of God regardless of that person’s age or relationship to other biological generations. That’s why God has no grandchildren; only children. The second birth may lack obvious, tangible markers. Those who grow up with religious parents might not be able to name a date or place for their own spiritual re-birth. New environments seem more conducive for new-birth experiences. We need additional markers. Complications, misunderstanding, and power plays may arise when the first, second and third generations flatten into one generation called “Children of God.”

Uterine Dysfunction In Biglycan And Decorin Deficient Mice Leads To Dystocia During Parturition., Zhiping Wu, Abraham W Aron, Elyse E Macksoud, Renato V Iozzo, Chi-Ming Hai, Beatrice E Lechner

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Cesarean birth rates are rising. Uterine dysfunction, the exact mechanism of which is unknown, is a common indication for Cesarean delivery. Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of reproductive tissues and muscle. Mice deficient in biglycan display a mild muscular dystrophy, and, along with mice deficient in decorin, are models of Ehlers-Danlos Syndrome, a connective tissue anomaly associated with uterine rupture. As a variant of Ehlers-Danlos Syndrome is caused by a genetic mutation resulting in abnormal biglycan and decorin secretion, we hypothesized that biglycan and decorin play a role in uterine function. Thus, …

Altering Iron Oxide Nanoparticle Surface Properties Induce Cortical Neuron Cytotoxicity, Christopher J. Rivet, Yuan Yuan, Diana Andra Borca-Tasciuc, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

Superparamagnetic iron oxide nanoparticles, with diameters in the range of a few tens of nanometers, display the ability to cross the blood-brain barrier and are envisioned as diagnostic and therapeutic tools in neuro-medicine. However, despite the numerous applications being explored, insufficient information is available on their potential toxic effect on neurons. While iron oxide has been shown to pose a decreased risk of toxicity, surface functionalization, often employed for targeted delivery, can significantly alter the biological response. This aspect is addressed in the present study, which investigates the response of primary cortical neurons to iron oxide nanoparticles with coatings frequently …

Volume Cxxix, Number 10, January 13, 2012, Lawrence University

The Lawrentian

No abstract provided.

Chimes: January 13, 2012, Calvin College

Chimes

Kill-a-Watt charges up campus mindset by Allysa Metzner

Board of Trustees recommends Le Roy for Calvin president by Joseph Matheson & Andrew Steiner

Microsoft poised over mobile market by Jonathan Hielkema

'Jane by Design' wanders by Samantha Wade

Men's basketball team makes weak show in Pacific Northwest by Mark Zylstra

Women, still undefeated, beat Dutch by Jess Koster

Case Report Of Dramatic Resolution Of Psychotic Symptoms During Cross-Over To Clozapine, Leo Sher M.D., Alan Mendelowitz M.D.

Jefferson Journal of Psychiatry

Clozapine is the first antipsychotic drug with proven superiority over conventional antipsychotics in the management of treatment-resistant patients. We describe a case of tratment-resistant schizoaffective disorder in a young woman who improved rapidly on clozapine. The patient was started on a low dose of clozapine while fluphenazine was decreased. She improved significantly during the first several days of treatment. This improvement took place well before the expected effect of clozapine. Possible explanations for this unusual response include: 1) the placebo effect; 2) fluphenazine dose-response curve; 3) acute clozapine neurochemical mechanisms; 4) inaccurate original diagnosis. Better understanding of the mechanisms of …

Case Report: Failure Of Group Therapy With Elderly Russian-Jewish Immigrants (An Exploratory Analysis), Gennady Berezkin M.D.

Jefferson Journal of Psychiatry

This paper is a description of an unsuccessful attempt to carry out group therapy with elderly Russian-Jewish immigrants.

An attempt was made to conduct group therapy following general principals of traditional psychotherapy with geriatric populations.

In the final analysis, we conclude that culturally based preconceptions toward psychotherapy, culturally based stereotypes of interpersonal relationships and culturally-based transference to the therapist were the primary reasons for the development of negative transference and resistance which culminated in the ultimate failure of group psychotherapy with this group of elderly immigrants.

Cal Poly To Offer Compost Training In April, Public Affairs Office

Press Releases

No abstract provided.

Eastern Progress - 12 Jan 2012, Eastern Kentucky University

Eastern Progress 2011-2012

No abstract provided.

Lanthorn, Vol. 46, No. 33, January 12, 2012, Grand Valley State University

Volume 46, July 14, 2011 - June 18, 2012

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present. This issue is misnumbered as Vol. 46, No. 32.

Relationship Between Fat Content And Ne Values For Some Ethanol Byproducts, R. Pritchard, E. Loe, T. Milton

South Dakota Beef Report, 2012

A finishing phase study was conducted to measure the impact of the fat content of ethanol byproducts on the relative Net Energy values for these feedstuffs. The three feedstuffs with varying crude fat content used included a commercially available corn gluten feed corn distillers grains blend (CGD); a corn wet distillers grains without solubles (WDG); and corn wet distillers grains plus solubles (WDGS). Byproducts were incorporated as 40% of the finishing diets (DM basis) replacing corn and SBM components of the control (CO) diet. There were 6 pens of 7 or 8 yearling steers on each treatment during the 130 …

Curriculum Subcommittee Minutes, January 12, 2012, Utah State University

Educational Policies Committee

Utah State University (Student Services)

• Course Prefix Change

Department of Theatre Arts

• Prerequisite Change

Department of Health, Physical Education and Recreation

• New Course

Department of Psychology

• Grade Mode Change

Department of Mechanical and Aerospace Engineering

• Prerequisite Change

Department of Languages, Philosophy and Speech Communication

• New Course

Department of Wildland Resources

• New Course

Department of Biology

• Prerequisite Change

Department of Geology

• New Course
• Prerequisite Change, Course Description Change
• Title Change, Credit Hour Change, Add Multiple List

Other

• Creating a Hospitality and Tourism Management Minor
• Discontinuing the PhD in Recreation Resource Management

Graduate Faculty Committee, Wku Graduate Council

Graduate School

Membership of Graduate Committee.

A High Density Snp Array For The Domestic Horse And Extant Perissodactyla: Utility For Association Mapping, Genetic Diversity, And Phylogeny Studies, Molly E. Mccue, Danika L. Bannasch, Jessica L. Petersen, Jessica Gurr, Ernie Bailey, Matthew M. Binns, Ottmar Distl, Gérard Guérin, Telhisa Hasegawa, Emmeline W. Hill, Tosso Leeb, Gabriella Lindgren, M Cecilia T. Penedo, Knut H. Røed, Oliver A. Ryder, June E. Swinburne, Teruaki Tozaki, Stephanie J. Valberg, Mark Vaudin, Kerstin Lindblad-Toh, Claire M. Wade, James R. Mickelson

Veterinary Science Faculty Publications

An equine SNP genotyping array was developed and evaluated on a panel of samples representing 14 domestic horse breeds and 18 evolutionarily related species. More than 54,000 polymorphic SNPs provided an average inter-SNP spacing of ∼43 kb. The mean minor allele frequency across domestic horse breeds was 0.23, and the number of polymorphic SNPs within breeds ranged from 43,287 to 52,085. Genome-wide linkage disequilibrium (LD) in most breeds declined rapidly over the first 50-100 kb and reached background levels within 1-2 Mb. The extent of LD and the level of inbreeding were highest in the Thoroughbred and lowest in the …