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2012

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Putting A Bifunctional Motor To Work: Insights Into The Role Of Plant Kch Kinesins, Ram Dixit Feb 2012

Putting A Bifunctional Motor To Work: Insights Into The Role Of Plant Kch Kinesins, Ram Dixit

Biology Faculty Research

Comment on: A novel actin-microtubule cross-linking kinesin, NtKCH, functions in cell expansion and division. [New Phytol. 2012 Feb;193(3):576-89. doi: 10.1111/j.1469-8137.2011.03944.x. ]


Single-Molecule Analysis Of The Microtubule Cross-Linking Protein Map65-1 Reveals A Molecular Mechanism For Contact-Angle-Dependent Microtubule Bundling, Amanda Tulin, Sheri Mcclerklin, Yue Huang, Ram Dixit Feb 2012

Single-Molecule Analysis Of The Microtubule Cross-Linking Protein Map65-1 Reveals A Molecular Mechanism For Contact-Angle-Dependent Microtubule Bundling, Amanda Tulin, Sheri Mcclerklin, Yue Huang, Ram Dixit

Biology Faculty Research

Bundling of microtubules (MTs) is critical for the formation of complex MT arrays. In land plants, the interphase cortical MTs form bundles specifically following shallow-angle encounters between them. To investigate how cells select particular MT contact angles for bundling, we used an in vitro reconstitution approach consisting of dynamic MTs and the MT-cross-linking protein MAP65-1. We found that MAP65-1 binds to MTs as monomers and inherently targets antiparallel MTs for bundling. Dwell-time analysis showed that the affinity of MAP65-1 for antiparallel overlapping MTs is about three times higher than its affinity for single MTs and parallel overlapping MTs. We also …


Volume 49, Number 24: February 01, 2012, University Of North Dakota Feb 2012

Volume 49, Number 24: February 01, 2012, University Of North Dakota

University Letter Archive

No abstract provided.


Emerging Viruses In The Felidae: Shifting Paradigms, Stephen J. O'Brien, Jennifer L. Troyer, Meredith Brown, Warren E. Johnson, Agostinho Antunes, Melody E. Roelke, Jill Pecon-Slattery Feb 2012

Emerging Viruses In The Felidae: Shifting Paradigms, Stephen J. O'Brien, Jennifer L. Troyer, Meredith Brown, Warren E. Johnson, Agostinho Antunes, Melody E. Roelke, Jill Pecon-Slattery

Biology Faculty Articles

The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP) diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV) in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV) mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important …


Remedying Wrongful Execution, Meghan J. Ryan Feb 2012

Remedying Wrongful Execution, Meghan J. Ryan

University of Michigan Journal of Law Reform

The first legal determination of wrongful execution in the United States may very well be in the making in Texas. One of the state's district courts is in the midst of investigating whether Cameron Todd Willingham, who was executed in 2004, was actually innocent. The court's investigation has been interrupted by objections from Texas prosecutors, but if the court proceeds, this may very well become a bona fide case of wrongful execution. Texas, just like other jurisdictions, is ill equipped to provide any relief for such an egregious wrong, however. This Article identifies the difficulties that the heirs, families, and …


Kinship Between The Kingdoms: Quorum Testing, Darrin Schultz, Ben Garfinkel Feb 2012

Kinship Between The Kingdoms: Quorum Testing, Darrin Schultz, Ben Garfinkel

The Synapse: Intercollegiate science magazine

No abstract provided.


Social Evolution In Primates: From Loners To Altruistic Flea-Pickers, Jessica Lamb Feb 2012

Social Evolution In Primates: From Loners To Altruistic Flea-Pickers, Jessica Lamb

The Synapse: Intercollegiate science magazine

No abstract provided.


500 Milligrams For Arachnophobia, 1000 For The Ex-Wife: The Science Of Memory Erasure, Elie Goldberg Feb 2012

500 Milligrams For Arachnophobia, 1000 For The Ex-Wife: The Science Of Memory Erasure, Elie Goldberg

The Synapse: Intercollegiate science magazine

No abstract provided.


An Interview With William Fuchsman: The Life And Work Of Oberlin's Retiring Chemistry Professor, Lizzie Roberts Feb 2012

An Interview With William Fuchsman: The Life And Work Of Oberlin's Retiring Chemistry Professor, Lizzie Roberts

The Synapse: Intercollegiate science magazine

No abstract provided.


Seminar: Stuart Mcdaniel '94: Using Moss Model Systems To Clarify Patterns Of Biodiversity, Sesha Nandyal Feb 2012

Seminar: Stuart Mcdaniel '94: Using Moss Model Systems To Clarify Patterns Of Biodiversity, Sesha Nandyal

The Synapse: Intercollegiate science magazine

No abstract provided.


Rethinking The “Apprenticeship Of Liberty”: The Case For Academic Programs In Community Engagement In Higher Education, Dan W. Butin Feb 2012

Rethinking The “Apprenticeship Of Liberty”: The Case For Academic Programs In Community Engagement In Higher Education, Dan W. Butin

Education Faculty Publications

This article articulates a model for the “engaged campus” through academic programs focused on community engagement, broadly construed. Such academic programs—usually coalesced in certificate programs, minors, and majors—provide a complementary vision for the deep institutionalization of civic and community engagement in the academy that can revitalize an “apprenticeship of liberty” for students, faculty, and academic staff.


In Vitro Complex, Anna Druzcz Feb 2012

In Vitro Complex, Anna Druzcz

Theses

Contemporary technological developments allow for greater manipulation of the natural world than ever before. While the increasing variety of synthetic materials, techniques, and equipment employed in horticulture and urban development are reshaping the land, sophisticated digital imaging tools, ranging from computer-generated graphics to 3D modeling and rendering software, are changing the way we design and represent landscapes. Through technology, we are continually imitating, reconstructing, and perfecting the natural environment. As a result, the physical and conceptual borders between the organic and synthetic elements, the "born" and the "made," in our physical environments are becoming progressively obscured, as are the lines …


Decorin-Mediated Inhibition Of Colorectal Cancer Growth And Migration Is Associated With E-Cadherin In Vitro And In Mice., Xiuli Bi, Nicole M Pohl, Zhibin Qian, George R Yang, Yuan Gou, Grace Guzman, Andre Kajdacsy-Balla, Renato V Iozzo, Wancai Yang Feb 2012

Decorin-Mediated Inhibition Of Colorectal Cancer Growth And Migration Is Associated With E-Cadherin In Vitro And In Mice., Xiuli Bi, Nicole M Pohl, Zhibin Qian, George R Yang, Yuan Gou, Grace Guzman, Andre Kajdacsy-Balla, Renato V Iozzo, Wancai Yang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a downregulation of p21, p27(kip1) and E-cadherin and an upregulation of β-catenin signaling [Bi,X. et al. (2008) Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis, 29, 1435-1440]. However, the regulation of E-cadherin by decorin and its implication in cancer formation and metastasis is largely unknown. Using a decorin knockout mouse model (Dcn(-/-) mice) and manipulated expression of decorin …


L-Tetrahydropalamatine: A Potential New Medication For The Treatment Of Cocaine Addiction, Jia Bei Wang​, John R. Mantsch Feb 2012

L-Tetrahydropalamatine: A Potential New Medication For The Treatment Of Cocaine Addiction, Jia Bei Wang​, John R. Mantsch

Biomedical Sciences Faculty Research and Publications

Levo-tetrahydropalmatine (l-THP) is an active constituent of herbal preparations containing plant species of the genera Stephania and Corydalis and has been approved and used in China for a number of clinical indications under the drug name Rotundine. The pharmacological profile of l-THP, which includes antagonism of dopamine D1 and D2 receptors and actions at dopamine D3, α adrenergic and serotonin receptors, suggests that it may have utility for treating cocaine addiction. In this review, we provide an overview of the pharmacological properties of l-THP and the evidence supporting its development as an anti-addiction medication. The results …


Artificial Modifications Of The Coast In Response To The Deepwater Horizon Oil Spill: Quick Solutions Or Long-Term Liabilities?, M. Luisa Martinez, Rusty A. Feagin, Kevin M. Yeager, John W. Day, Robert Costanza, Jim A. Harris, Richard J. Hobbs, Jorge López-Portillo, Ian J. Walker, Eric Higgs, Patricia Moreno-Casasola, Julio Sheinbaum, Alejandro Yáñez-Arancibia Feb 2012

Artificial Modifications Of The Coast In Response To The Deepwater Horizon Oil Spill: Quick Solutions Or Long-Term Liabilities?, M. Luisa Martinez, Rusty A. Feagin, Kevin M. Yeager, John W. Day, Robert Costanza, Jim A. Harris, Richard J. Hobbs, Jorge López-Portillo, Ian J. Walker, Eric Higgs, Patricia Moreno-Casasola, Julio Sheinbaum, Alejandro Yáñez-Arancibia

Institute for Sustainable Solutions Publications and Presentations

The Deepwater Horizon oil spill threatened many coastal ecosystems in the Gulf of Mexico during the spring and summer of 2010. Mitigation strategies included the construction of barrier sand berms, the restriction or blocking of inlets, and the diversion of freshwater from rivers to the coastal marshes and into the ocean, in order to flush away the oil, on the premise that these measures could reduce the quantity of oil reaching sensitive coastal environments such as wetlands or estuaries. These projects result in changes to the ecosystems that they were intended to protect. Long-term effects include alterations of the hydrological …


The Impact Of The Extension Service On Minority-Owned Small Farm Operations, Renita W. Marshall Feb 2012

The Impact Of The Extension Service On Minority-Owned Small Farm Operations, Renita W. Marshall

Journal of Extension

Reaching and serving minority populations will require greater consideration in the future. However, this mission can only be accomplished when Extension makes a commitment to provide better coordination and administration of internal and external outreach programs. There is a necessity for Extension professionals to facilitate interactions between limited resource minority farmers and USDA agencies. This will in turn promote opportunities for these farmers to participate in various programs sponsored by eligible USDA and other participating agencies. The creation of minority outreach programs by Extension clearly demonstrates a commitment to this mission. Yet there is so much more to be done.


Invited Editorial: African Pygmies, What's Behind A Name?, Paul Verdu, Giovanni Destro-Bisol Feb 2012

Invited Editorial: African Pygmies, What's Behind A Name?, Paul Verdu, Giovanni Destro-Bisol

Human Biology Open Access Pre-Prints

No abstract provided.


Censorship And Holocaust Film In The Hollywood Studio System, Nancy Copeland Halbgewachs Feb 2012

Censorship And Holocaust Film In The Hollywood Studio System, Nancy Copeland Halbgewachs

Sociology ETDs

Following the end of World War II in 1945 to 1969, Hollywood films remained silent about the extermination camps, the sites of the murders and incineration of European Jews by Nazi Germany that came to be known as the Holocaust. The Hollywood studio system produced very few Holocaust motion pictures before 1980. This research provides evidence from the files of the Hays Commission in the Margaret Herrick Library of the Academy of Motion Pictures Arts and Sciences to support the hypothesis that censorship was a major social cause of this silence. The correspondence between members of the Hays Commission, the …


The Influence Of Women's Status On Economic Development: A Pooled Time Series Cross-Sectional Analysis Of 126 Countries, 1980-2005, Lynzie Rowland Feb 2012

The Influence Of Women's Status On Economic Development: A Pooled Time Series Cross-Sectional Analysis Of 126 Countries, 1980-2005, Lynzie Rowland

Sociology ETDs

The role of women in development has generated countless studies devoted to illuminating distinct aspects of womens lives and experiences. Several theories, developmentalism and social feminism, were created as a response to modernization theory's inattention to the roles of women in the process of development. Developmentalism has focused on the influence of the improved status of women on economic development. This study examines this association from the developmentalist perspective for 126 countries every five years between 1980 and 2005. Additionally, this paper investigates the linking mechanisms of women's status to economic development. Secondary data acquired from the World Bank website …


Biosorption Of Uranium And Its Effect On Uranium Transport In Groundewater, Jeanette Leavitt Feb 2012

Biosorption Of Uranium And Its Effect On Uranium Transport In Groundewater, Jeanette Leavitt

Civil Engineering ETDs

In past years, microbial reduction has been explored as a remediation method for uranium-contaminated groundwater at U.S. Department of Energy sites with promising results. Although transport models have been improved to include variations in geochemical concentrations, reductive microbial processes, and adsorption of uranium to minerals, they do not incorporate the presence of microorganisms as sorption sites that may influence the overall transport of uranium. The main objective of this research was to determine the effects of uranium biosorption on the overall transport of uranium by understanding the solution chemical equilibrium and its effects on modeling sorption. This was done by …


Selective Fluoride Removal By Aluminum Precipitation & Membrane Filtration, Emily Kowalchuk Feb 2012

Selective Fluoride Removal By Aluminum Precipitation & Membrane Filtration, Emily Kowalchuk

Civil Engineering ETDs

Fluoride is an anionic constituent of most natural surface and ground waters. At low concentrations it has the beneficial effect of improving dental health, but at high concentrations it causes skeletal and other problems. The drinking water standard for fluoride is 4.0 mg/L, but even at this level approximately 10% of exposed children will develop dental enamel fluorosis. Several small communities in New Mexico have source waters with fluoride concentrations higher than 4.0 mg/L. No commercial technologies selectively remove fluoride from drinking water in part because it is relatively non-reactive in aqueous solution and also because its chemistry is similar …


Global Change, Global Trade, And The Next Wave Of Plant Invasions., Bethany A. Bradley, Dana M. Blumenthal, Regan Early, Edwin D. Grosholz, Joshua J. Lawler, Luke P. Miller, Cascade Jb Sorte, Carla M. D'Antonio, Jeffrey M. Diez, Jeffrey S. Dukes, Ines Ibanez, Julian D. Olden Feb 2012

Global Change, Global Trade, And The Next Wave Of Plant Invasions., Bethany A. Bradley, Dana M. Blumenthal, Regan Early, Edwin D. Grosholz, Joshua J. Lawler, Luke P. Miller, Cascade Jb Sorte, Carla M. D'Antonio, Jeffrey M. Diez, Jeffrey S. Dukes, Ines Ibanez, Julian D. Olden

Department of Forestry & Natural Resources Faculty Publications

Many non-native plants in the US have become problematic invaders of native and managed ecosystems, but a new generation of invasive species may be at our doorstep. Here, we review trends in the horticultural trade and invasion patterns of previously introduced species and show that novel species introductions from emerging horticultural trade partners are likely to rapidly increase invasion risk. At the same time, climate change and water restrictions are increasing demand for new types of species adapted to warm and dry environments. This confluence of forces could expose the US to a range of new invasive species, including many …


Improving Water Supply Systems For Domestic Uses In Urban Togo: The Case Of A Suburb In Lomé, Laurent Ahiablame, Bernard Engel, Taisha Venort Feb 2012

Improving Water Supply Systems For Domestic Uses In Urban Togo: The Case Of A Suburb In Lomé, Laurent Ahiablame, Bernard Engel, Taisha Venort

School of Agricultural & Biological Engineering Faculty Publications

The rapid urbanization facing developing countries is increasing pressure on public institutions to provide adequate supplies of clean water to populations. In most developing countries, the general public is not involved in strategies and policies regarding enhancement, conservation, and management of water supply systems. To assist governments and decision makers in providing potable water to meet the increasing demand due to the rapid urbanization, this study sought to characterize existing water supply systems and obtain public opinion for identifying a community water supply system model for households in a residential neighborhood in Lomé, Togo. Existing water supply systems in the …


The Other Vanishing American: Disappearing Farmers In American Literature, 1887-1939., Carolyn Kuchera Feb 2012

The Other Vanishing American: Disappearing Farmers In American Literature, 1887-1939., Carolyn Kuchera

English Language and Literature ETDs

Beginning in the late nineteenth century, literary depictions of farmers borrow from the established trope of the Vanishing American' Indian to portray farmers as disappearing before the forces of modern civilization. I argue that writing about farmers from this era ought to be approached as a type of extinction discourse: the rhetoric surrounding the decline of a race or culture. Extinction discourse, whether applied to the American Indian or to farmers, fuses mourning over a passing way of life with celebration of civilization's progress. Farmers are portrayed as primitive figures, as fundamentally incompatible with modern civilization, in all of the …


Bet You Missed It: Press Clippings -- In The News -- Carefully Selected By Your Crack Team Of News Sleuths, Bruce Strauch Feb 2012

Bet You Missed It: Press Clippings -- In The News -- Carefully Selected By Your Crack Team Of News Sleuths, Bruce Strauch

Against the Grain

No abstract provided.


I Hear The Train A Comin' -- The Research Works Act, Greg Tananbaum Feb 2012

I Hear The Train A Comin' -- The Research Works Act, Greg Tananbaum

Against the Grain

No abstract provided.


Collectiing To The Core -- Physics, Michael Fosmire, Debra Kolah, Anne Doherty Feb 2012

Collectiing To The Core -- Physics, Michael Fosmire, Debra Kolah, Anne Doherty

Against the Grain

No abstract provided.


Little Red Herring -- Mene, Mene, Tekel, Upharsin, Mark Y. Herring Feb 2012

Little Red Herring -- Mene, Mene, Tekel, Upharsin, Mark Y. Herring

Against the Grain

No abstract provided.


Full Page Ads Feb 2012

Full Page Ads

Against the Grain

No abstract provided.


Mir-25 Targets Tnf-Related Apoptosis Inducing Ligand (Trail) Death Receptor-4 And Promotes Apoptosis Resistance In Cholangiocarcinoma., Nataliya Razumilava, Steve F. Bronk, Rory L. Smoot, Christian D. Fingas, Nathan W. Werneburg, Lewis R. Roberts, Justin L. Mott Feb 2012

Mir-25 Targets Tnf-Related Apoptosis Inducing Ligand (Trail) Death Receptor-4 And Promotes Apoptosis Resistance In Cholangiocarcinoma., Nataliya Razumilava, Steve F. Bronk, Rory L. Smoot, Christian D. Fingas, Nathan W. Werneburg, Lewis R. Roberts, Justin L. Mott

Journal Articles: Biochemistry & Molecular Biology

It has been established that microRNA expression and function contribute to phenotypic features of malignant cells, including resistance to apoptosis. Although targets and functional roles for a number of microRNAs have been described in cholangiocarcinoma, many additional microRNAs dysregulated in this tumor have not been assigned functional roles. In this study, we identify elevated miR-25 expression in malignant cholangiocarcinoma cell lines as well as patient samples. In cultured cells, treatment with the Smoothened inhibitor, cyclopamine, reduced miR-25 expression, suggesting Hedgehog signaling stimulates miR-25 production. Functionally, miR-25 was shown to protect cells against TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Correspondingly, antagonism of …