Digital Commons Network^™

Methods For Detecting Or Monitoring Cancer Using Lpe As A Marker, Lian Shan, Lorelei D. Davis, Rebecca Sutphen

USF Patents

A method of detecting a cancer, such as ovarian cancer, in a test subject including (a) determining the amount of a lysophosphatidyl ethanolamine in a sample of a bodily fluid taken from the test subject, and (b) comparing the amount of the lysophosphatidyl ethanolamine in the sample of the bodily fluid taken from the test subject to a range of amounts of the lysophosphatidyl ethanolamine found in samples of the bodily fluid taken from a group of normal subjects of the same species as the test subject and lacking the cancer, such as ovarian cancer, whereby a change in the …

Spartan Daily March 13, 2012, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 138, Issue 24

The Parthenon, March 13, 2012, Crystal Myers

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

Evaluation Of Multiple Protein Docking Structures Using Correctly Predicted Pairwise Subunits., Juan Esquivel-Rodriguez, Daisuke Kihara

Department of Biological Sciences Faculty Publications

Background

Many functionally important proteins in a cell form complexes with multiple chains. Therefore, computational prediction of multiple protein complexes is an important task in bioinformatics. In the development of multiple protein docking methods, it is important to establish a metric for evaluating prediction results in a reasonable and practical fashion. However, since there are only few works done in developing methods for multiple protein docking, there is no study that investigates how accurate structural models of multiple protein complexes should be to allow scientists to gain biological insights.

Methods

We generated a series of predicted models (decoys) of various …

Amino Acid Function And Docking Site Prediction Through Combining Disease Variants, Structure Alignments, Sequence Alignments, And Molecular Dynamics: A Study Of The Hmg Domain, Jeremy W. Prokop, Thomas C. Leeper, Zhong-Hui Duan, Amy Milsted

Biology Faculty Research

Background: The DNA binding domain of HMG proteins is known to be important in many diseases, with the Sox sub-family of HMG proteins of particular significance. Numerous natural variants in HMG proteins are associated with disease phenotypes. Integrating these natural variants, molecular dynamic simulations of DNA interaction and sequence and structure alignments give detailed molecular knowledge of potential amino acid function such as DNA or protein interaction. Results: A total of 33 amino acids in HMG proteins are known to have natural variants in diseases. Eight of these amino acids are normally conserved in human HMG proteins and 27 are …

Indexing And Dialectical Transcendence: Kenneth Burke's Critical Method, David Erland Isaksen

Theses and Dissertations

Kenneth Burke has been described as arguably the most important rhetorician and critical theorist of the twentieth century, and yet an important part of his scholarship has been generally overlooked by the academic community. The pentad has become the most prominent "Burkean" framework for analyzing texts, yet Kenneth Burke himself preferred "a more direct" way of approaching texts which he named "indexing." This thesis recreates this method from the pieces found in his scholarly writing, personal correspondence, and the papers his students produced for the class he taught at Bennington College. Kenneth Burke believed indexing could uncover the "pattern of …

Rhetoric In Dialectical Behavior Therapy: Healing Minds Through Argumentation, Celeste Lloyd Zsembery

Theses and Dissertations

The fields of psychology and rhetoric share the goal of improving human mental health and behavior through persuasion. This thesis traces the history of rhetoric and psychology theory, focusing on the parallel theories of Nienkamp's internal rhetoric and Herman's dialogical self. Both theories model the human mind as having multiple psyches that actively interact to interpret human experience and project human behavior. I conclude with a case study of anorexic patients using ethos, pathos, and logos in dialectical behavior therapy (DBT), arguing that principles of rhetoric can help patients with mental disorders cognitively realign their thinking more effectively than drug …

Effects Of Predation Environment And Food Availability On Somatic Growth In The Livebearing Fish Brachyrhaphis Rhabdophora (Pisces: Poeciliidae), Brittany Herrod Gale

Theses and Dissertations

Variation in somatic growth rates has interested biologists for decades because of the relationship between growth and other fitness-determining traits (i.e. fecundity, survival, and body size), and the corresponding effect of somatic growth on production of organisms humans use for food. The interaction between genetic variation in growth rates and environmentally induced variation in growth rates shows the pattern of growth across multiple environments (i.e. the reaction norm) that clarifies the history and potential future of evolutionary change in growth rates among populations. Theoretical predictions suggest variation in predator-induced mortality rates can influence mean growth rates and the shape of …

Utb/Tsc Admissions Brochure - Knowledge Knows No Boundaries, University Of Texas At Brownsville And Texas Southmost College. Office Of News And Information

UTB/TSC Archives - Factbooks & Brochures

No abstract provided.

Matching Phosphorylation Response Patterns Of Antigen-Receptor-Stimulated T Cells Via Flow Cytometry, Ariful Azad, Saumyadipta Pyne, Alex Pothen

Department of Computer Science Faculty Publications

Background

When flow cytometric data on mixtures of cell populations are collected from samples under different experimental conditions, computational methods are needed (a) to classify the samples into similar groups, and (b) to characterize the changes within the corresponding populations due to the different conditions. Manual inspection has been used in the past to study such changes, but high-dimensional experiments necessitate developing new computational approaches to this problem. A robust solution to this problem is to construct distinct templates to summarize all samples from a class, and then to compare these templates to study the changes across classes or conditions. …

Surficial Redistribution Of Fallout 131iodine In A Small Temperate Catchment, Joshua D. Landis, Nathan T. Hamm, Carl E. Renshaw, W. Brian Dade, Francis J. Magilligan, John D. Gartner

Dartmouth Scholarship

Isotopes of iodine play significant environmental roles, including a limiting micronutrient (¹²⁷I), an acute radiotoxin (¹³¹I), and a geochemical tracer (¹²⁹I). But the cycling of iodine through terrestrial ecosystems is poorly understood, due to its complex environmental chemistry and low natural abundance. To better understand iodine transport and fate in a terrestrial ecosystem, we traced fallout ¹³¹iodine throughout a small temperate catchment following contamination by the 11 March 2011 failure of the Fukushima Daiichi nuclear power facility. We find that radioiodine fallout is actively and efficiently scavenged by the soil system, where it …

Evaluating Climate Change Effects In Two Contrasting Reservoirs Using Two-Dimensional Water Quality And Hydrodynamic Models, Oliver Obregon

Theses and Dissertations

I analyzed and compared impacts from global climate change (GCC) and land use change to Deer Creek (United States) a temperate reservoir and Aguamilpa (Mexico), a tropical reservoir by using calibrated CE-QUAL-W2 (W2) water quality and hydrodynamic models based on field data over an extended time period. I evaluated and compared the sensitivity to predicted GCC and land use changes. I individually evaluated changes to air temperature (TAIR), inflow rates (Q), and nutrient loads (PO4-P and NO3-NO2-N) followed by analysis of worst case scenarios. I developed analysis methods using indexes to represent the total …

A Methodology For Strategically Designing Physical Products That Are Naturally Resistant To Reverse Engineering, Stephen P. Harston

Theses and Dissertations

Reverse engineering - defined as extracting information about a product from the product itself - is a design tactic commonly used in industry from competitive benchmarking to product imitation. While reverse engineering is a legitimate practice - as long as the product was legally obtained - innovative products are often reverse engineered at the expense of the pioneering company. However, by designing products with built-in barriers to reverse engineering, competitors are no longer able to effectively extract critical information from the product of interest. Enabling the quantification of barriers to reverse engineering, this dissertation presents a set of metrics and …

Montana Kaimin, March 13, 2012, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Vitamin D Status In Lean And Obese Mexican American Children, Nadia H. Agha, Whitney L. Breslin, Brian K. Mcfarlin

International Journal of Exercise Science: Conference Proceedings

Vitamin D deficiency is a worldwide problem amongst adolescents and adults, particularly in minority populations due to high skin melanin content. Melanin blocks the absorption of UVB photons, which limits natural vitamin D accumulation, requiring more dietary intake of vitamin D. Vitamin D deficiency is associated with an increased risk for chronic diseases like cardiovascular disease and diabetes mellitus. Low levels of vitamin D are inversely correlated with systemic inflammation possibly mediating the relationship between vitamin D deficiency and disease. Adequate levels of vitamin D may decrease the risks of chronic diseases, including cardiovascular disease, diabetes mellitus, common cancers, and …

Evaluation Of A Vivo-Morpholino Delivery Method To The Brain And The Affect On Physical Activity, David P. Ferguson, Emily E. Schmitt, Dr.Timothy Lightfoot

International Journal of Exercise Science: Conference Proceedings

Evaluation of a Vivo-Morpholino Delivery Method to the Brain and the Affect on Physical Activity

*David P. Ferguson MS, Emily E. Schmitt MS, J. Timothy Lightfoot PhD FACSM

Biology of Physical Activity Lab, Texas A&M University, College Station, TX, 77843

*To be judged in the doctoral category

Physical inactivity has been shown to be correlated to various disease and conditions. Therefore, there is interest in the genetic mechanisms that control daily physical activity. Vivo-morpholinos are a new molecular biology tool that allows for the transient silencing of specific genes in an animal model, thereby allowing for a systematic method to …

The Correlation Of Physical Activity And Body Composition In Inbred Mice, Analisa M. Jimenez, David P. Ferguson, Dr.Timothy Lightfoot

International Journal of Exercise Science: Conference Proceedings

The Correlation of Physical Activity and Body Composition in Inbred Mice.

Analisa .M Jimenez*; David .P Ferguson MS RCEP; J. Timothy Lightfoot, PhD FACSM RCEPCES

I would like to participate in the undergraduate category.

Biology of Physical Activity Lab, Texas A&M University, College Station TX, 77843-4243

Obesity is a growing epidemic related to physical inactivity, cardiovascular disease, and Type II diabetes. In smaller mouse cohorts, there has been no association reported between physical activity and body composition indices. The purpose of this experiment was to determine if there was a correlation between the physical activity level and body composition in …

Effects Of Voluntary Resistance Exercise Training During Recovery From Hindlimb Unloading On Rat Gastrocnemius Muscle, Jacqueline I. Perticone, Kevin L. Shimkus, Yasaman Shirazi-Fard, Harry A. Hogan, James D. Fluckey

International Journal of Exercise Science: Conference Proceedings

As research continues to examine the deleterious impact of long-duration spaceflight on human muscle mass and function, there remain gaps in our knowledge of muscle physiology, especially in examining how muscle’s ability to recover or rehabilitate from unloading may alter the results of multiple exposures to microgravity followed by 1g recovery. The purpose of this study was to analyze the effects of resistance exercise training of gastrocnemius muscle mass and anabolism during the initial recovery period immediately following a bout of unloading, as well as to examine the role that exercise may have on a subsequent period of weightlessness. This …

Influence Of A Short-Term Increase In Intraluminal Pressure, With And Without Recovery, On Ach-Induced Dilation In Senescent Skeletal Muscle Feed Arteries., John W. Seawright, Christopher R. Woodman

International Journal of Exercise Science: Conference Proceedings

Influence of a short-term increase in intraluminal pressure, with and without recovery, on ACh-induced dilation in senescent skeletal muscle feed arteries.

John W. Seawright¹ and Christopher R. Woodman^1,2

1. Vascular Biology Laboratory, Dept. of Health and Kinesiology, Texas A&M University, College Station, TX 77843

2. Dept of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843

We tested the hypothesis that a short-term increase in intraluminal pressure, to mimic a 1 h bout of exercise, would attenuate or reverse age-induced impairments in acetylcholine (ACh)-induced dilation in soleus muscle feed arteries (SFA). In addition, we hypothesized that …

Exercise Ameliorates Disruption Of The Dystrophin-Associated Glycoprotein Complex And Fibrosis In The Aging Rat Heart, Yang Lee, Jeffrey M. Hord, Hyo-Bum Kwak, Jong-Hee Kim, John M. Lawler

International Journal of Exercise Science: Conference Proceedings

The dystrophin-glycoprotein complex (DGC) is localized and integrated into the cell membrane. The DGC provides a mechanical link between the cellular cytoskeleton and the extracellular matrix (ECM). In cardiac muscle, disruption of DGC might be involved in mediating cardiac remodeling that occurs with aging, cardiomyopathy, and heart failure through transforming growth factor-beta (TGF-ß). Decorin is a small leucine-rich proteoglycan closely related to the DGC component that binds to collagen. Decorin reduces fibrosis via inhibition of TGF-ß and myofibroblast formation. PURPOSE: To test the hypothesis that exercise training (ET) would alleviate age-related disruption of localization in DGC proteins (dystrophin, α-syntrophin, and …

Treadmill Running And Tower Climbing Resistance Exercise Mitigate Disuse Bone Loss In Mice Equally Well, Ramon Boudreaux, Corinne Metzger, Tiphaine Cecchini, Kaleigh A. Camp, Evelyn Yuen, Brandon R. Macias, Yasaman Shirazi-Fard, Harry A. Hogan, Susan Bloomfield

International Journal of Exercise Science: Conference Proceedings

Ground-Based Model for Lunar Disuse Bone Loss

During spaceflight, astronauts are susceptible to decrements in bone mineral density. This suscetibility leaves astronauts at an increased risk of fracture and compromises their likelihood of repeat missions. Our ground-based Lunar model simulates disuse bone loss. Through our novel exercise regimens, we were able to mitigate losses seen by group members not exercised.

Influence Of Fitness And Adiposity On Melanocortin-1 And Melanocortin-3 Receptors On Monocytes., Matthew Unthank, Jonathan Woodson, Jason Butler, Gregory Bratton, James Barbee, Michael Chumley, Dennis Cheek, Joel Mitchell, Melody Phillips

International Journal of Exercise Science: Conference Proceedings

Purpose: While it is known that exercise improves health by reducing systemic inflammation, potential mechanisms remain to be elucidated. The purpose of this study is to examine the influence of fitness and adiposity on the anti-inflammatory melanocortin system as a potential mechanism by which exercise reduces inflammation. Methods: Forty-one men and women (35-55yr), who were free from cardiovascular disease, inflammatory disorders, and not taking medications that affect inflammation, were recruited. Participants were questioned about exercise habits and medical history; then completed testing for body composition and aerobic fitness (VO₂max). Subjects were classified as lean/fit (LF, n=14), overweight/fit (OF, …

Response Of Immune System After Ultra Endurance Event: Relation Between Magnesium And Immunological Response, Marcos Bürger-Mendonça

International Journal of Exercise Science: Conference Proceedings

Magnesium (Mg) is one of the most important micronutrients, and therefore its role in biological system has been extensively investigated. Particularly, Mg has a strong regulatory role in the immune system. The aim of this study was to investigate the behavior of plasma magnesium and the immune response after half-ironman triathlon. Blood samples from six athletes were collected before and immediately after the triathlon competition. Magnesium plasma concentration and immune parameters were analyzed (total white blood cells (WBC), neutrophils, (NE), lymphocytes (LY), eosinophils (EO) monocytes (MO) and basophils (BA)). Pre and post race values were compared by paired t-tests. Pearson's …

Reproducibility Of A Vo2max Protocol For Runners Using Treadmill, Thiago Fernando Lourenço, Lucas Samuel Tessuti, Luis Eduardo Barreto Martins, René Brenzikofer

International Journal of Exercise Science: Conference Proceedings

Test protocols applied to runners should reproduce the real training, outdoor race and should be able to unequivocally determine the submaximal parameters such as ventilatory threshold (VT) and respiratory compensation point (RCP). However, classical VO2max protocols are still used for athletes, mainly due to familiarity, and most of them differ in methodological characteristics, such as stage duration and increment size. Other difficulty found is the lack of reliability, which can affect the precision assessment of the athlete’s performance. The aim of this study was to verify the reproducibility of an incremental protocol for the treadmill based on metabolic concepts. Eleven …

Reliability Of The Electrocardiogram In Normal Rats, Renato Buscariolli De Oliveira, Denise Vaz De Macedo, Gustavo Barbosa Santos, Miguel Arcanjo Areas

International Journal of Exercise Science: Conference Proceedings

Several electrocardiogram (ECG) indexes are used to identify cardiac abnormalities in rats. However, there are few studies about the reliability of this tool. The aim of this study was to verify the reliability of a computerized electrocardiography (Heart Ware System) adapted for rats. The ECG was registered under intramuscular anesthesia (Zoletil®, 25mg/kg body weight) in the supine position, using four inserted electrodes in the subcutaneous layer of the animals’ paws (n=11). Three records per day were performed in an interval of fifteen minutes in three distinct days. Six standard leads were obtained (I, II, III, aVR, aVL and aVF) and …

Reference Change Values Of Some Current Blood Parameters In Sports Science In Physically Active Subjects, Lázaro Alessandro Soares Nunes, René Brenzikofer, Denise Vaz De Macedo

International Journal of Exercise Science: Conference Proceedings

The training monitoring by blood analysis and performance tests may be useful to improve performance. However, effective interpretation of data should take in account the inherent biological and analytical variation. To verify if the difference between two serial results is significant and biologically relevant it can be calculated the Reference Change Value (RCV) from the following formula: RCV = (2)½ * Zp*(CVA2 + CV I 2)1/2, where: 21/2=to verify difference between 2 moments, Zp=Z score (probability 95% =1.96), CVA=analytical coefficient of variation and CVI=intra-individual coefficient of variation. The difference between two consecutive results compared to a calculated RCV make possible …

Low And Moderate Intensity Strength Exercise Affects More Beneficially The Lipid Profile Than High Intensity Strength Exercise, Fábio Santos Lira, Alex Shimura Yamashita, Marco Carlos Uchida, Nelo Eidy Zanchi

International Journal of Exercise Science: Conference Proceedings

This study aimed to compare the time-course effects of four different intensities of strength exercise (bench press) bouts on the blood lipid profile. Thirty-five Brazilian Army male soldiers were allocated randomly into five groups based at different percentages of one repetition maximum, in previous test (1-RM): 50%-1RM, 75%-1RM, 90%-1RM, 110%-1RM (this executing only eccentric phase), and control group. The total volume (sets x reps x load) of the exercise was equalized. The lipid profile (Triglycerides, VLDL, HDL-cholesterol, LDL-cholesterol, HDL-c/Total Cholesterol ratio and Total cholesterol) was determined at rest and after 1, 24, 48 and 72 h of the strength exercise. …

Interpreting Data Of A Repeated Sprint Test, Rafael Alkmin Reis, Denise Vaz De Macedo, René Brenzikofer

International Journal of Exercise Science: Conference Proceedings

Alterations in performance are often quantified through physical tests. However, although frequently used there are a few discussions about the reliability and interpretation of their results. The purpose of this study was to verify the reliability of a new method to access the repeated sprint ability denominated Labex-Test (LT) as well as analyzing the effect of 10 weeks of systematized training in soccer players' performance. LT consists of an uncertain number of sprints of 30m until a fall of performance of 10% is observed in relation to its initial speed. All the sprints are intercalated with 20 seconds of active …

Effects Of A Training Season Of Master Runners On Maximal And Sub-Maximal Prescription Parameters, Lucas Samuel Tessutti, Lúcio Muramatsu, Danilo Lopes Ferrucci, Charles Ricardo Lopes

International Journal of Exercise Science: Conference Proceedings

Maximal oxygen uptake (VO2max) is considered an important physiological parameter to determinate cardiorespiratory capacity and has been used to predict the performance in middle and long-distance running athletes. Also the ventilatory threshold speed (sVT) and respiratory compensation point speed (sRCP) are important tools to predict performance and for training prescription. The aim of the present study was to demonstrate the changes in sVO2max, sVT, sRCP and running performance during the 2008 training season. Seven master runners (50.4 ± 8.4 years), six men and one woman, with more than five years experience running training were selected. The training period was divided …

Exercise In Colon Cancer Modulation: An Experimental Approach, Marcelo M. P. Demarzo, Sérgio B. Garcia, Sérgio E. A. Perez

International Journal of Exercise Science: Conference Proceedings

Carcinogenesis is a complex process best characterized as an accumulation of alterations in genes regulating cellular homeostasis. The whole process can be divided into three main stages: initiation, promotion, and progression. It has been observed that moderate and regular physical activity (PA) may prevent cancer, mainly colon cancer (CC), up to 50% in humans. The evidence that PA protects against colon cancer is convincing. Also, PA probably protects against postmenopausal breast cancer and cancer of the endometrium. On the other hand, exhaustive exercise increases free radical DNA oxidative damage, inflammation and depresses immune function, events also related to the increased …