Digital Commons Network^™

Ykl-40 Genetic Polymorphisms And The Risk Of Liver Disease Progression In Patients With Advanced Fibrosis Due To Chronic Hepatitis C, Herbert L. Bonkovsky

UCHC Articles - Research

Abstract

Background/Aims

The aim of this study was to explore the association of a functional YKL-40 promoter polymorphism (rs4950928) with baseline disease stage, response to antiviral therapy, and risk of liver disease progression in a group of patients with chronic hepatitis C (CHC).

Methods

YKL-40 promoter polymorphisms were determined in 456 HALT-C Trial patients with bridging fibrosis or cirrhosis entering a prerandomization lead-in peginterferon/ribavirin 24-week treatment phase and in 462 patients followed for a mean of 3.8 years after randomization to maintenance peginterferon or observation.

RESULTS

Mean patient age was 49.5 years, 70.4% were male, and 71.2% were Caucasian. The …

Pharmacological And Therapeutic Effects Of A3 Adenosine Receptor (A3ar) Agonists, Bruce T. Liang

UCHC Articles - Research

The G_i-coupled A₃ adenosine receptor (A₃AR) mediates anti-inflammatory, anticancer and anti-ischemic protective effects. The receptor is overexpressed in inflammatory and cancer cells, while low expression is found in normal cells, rendering the A₃AR as a potential therapeutic target. Highly selective A₃AR agonists have been synthesized and molecular recognition in the binding site has been characterized. The present review summarizes preclinical and clinical human studies demonstrating that A₃AR agonists induce specific anti-inflammatory and anticancer effects via a molecular mechanism that entails modulation of the Wnt and the NF-κB signal transduction …

Bevacizumab And Breast Cancer: What Does The Future Hold?, Christina E. Stevenson

UCHC Articles - Research

Breast cancer is a major health concern for many women, but despite the current standard therapies, many women still die of metastatic disease. Angiogenesis has been evaluated as a possible target for therapy and bevacizumab (Avastin^®, Genentech/Roche, CA, USA), a monoclonal antibody against VEGF-A, has been developed to target this. Current clinical trials utilizing bevacizumab have shown an increase in progression-free survival, but this has not translated to an increase in overall survival in breast cancer patients. In this article, we summarize the currently published trials utilizing bevacizumab in the treatment of breast cancer and describe various methods …

Right Flier: Newsletter Of The Aaup-Wsu Volume 12, Number 3, April 2012, American Association Of University Professors-Wright State University

The Right Flier Newsletter

A ten page newsletter created by the Wright State University chapter of the American Association of University Professors. The newsletter discusses topics related to the faculty.

2011-2012 Ugr Bibliography Of Ccu Student Research, Coastal Carolina University

Student Research Bibliographies

No abstract provided.

Lynx Tale, April 2012, Lindenwood University

Lynx Tale

The Lynx Tale was a Lindenwood University-Belleville student centered newspaper that informed students on upcoming events and news on campus.

Structural And Functional Characterization Of Two Alternative Splicing Variants Of Mouse Endothelial Cell-Specific Chemotaxis Regulator (Ecscr), Wen Wu, Chunwei Shi, Fanxin Ma, James Balducci, Hanju Huang, Hong Long Ji, Yongchang Chang, Yao Huang

Translational Neuroscience

Endothelial cells (ECs) that line the lumen of blood vessels are important players in blood vessel formation, and EC migration is a key component of the angiogenic process. Thus, identification of genes that are specifically or preferentially expressed in vascular ECs and in-depth understanding of their biological functions may lead to discovery of new therapeutic targets. We have previously reported molecular characterization of human endothelial cell-specific molecule 2 (ECSM2)/endothelial cell-specific chemotaxis regulator (ECSCR). In the present study, we cloned two mouse full-length cDNAs by RT-PCR, which encode two putative ECSCR isoform precursors with considerable homology to the human ECSCR. Nucleotide …

April 2012 Quicknotes, Southern Adventist University

QuickNotes – Advancement e-Newsletter

QuickNotes is an e-newsletter that comes from Advancement at Southern Adventist University. April 2012 features the article "Retired Nurse Shares her Legacy with Nursing Students at Southern".

Lawrence Today, Volume 92, Number 2, Spring 2012, Lawrence University

Lawrence Today

No abstract provided.

On Academic Freedom, St. Norbert College

Pix Media

Patrick McCormick, of Gonzaga University, speaks to the relationship between theologians and the Church, in a lecture at St. Norbert College as featured in the Spring 2012 issue of SNC Magazine and captured as a part of a digital preservation project by Mulva Archives in Summer 2019.

Medicine + Health, Spring 2012, George Washington University, School Of Medicine And Health Sciences, Office Of Communications And Marketing

Medicine + Health Magazine

No abstract provided.

Com Outlook Spring 2012, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Nota Bene: News From The Yale Library, Yale University Library

Nota Bene

Nota Bene is published during the academic year to acquaint the Yale community and others with the resources of the Yale Library.

Plasma Persistence Of 2-Aminothiazoline-4-Carboxylic Acid In Rat System Determined By Liquid Chromatography Tandem Mass Spectrometry, Ilona Petrikovics, Jorn C.C. Yu, David E. Thompson, Prashanth Jayanna, Brian A. Logue, Jessica Nasr, Raj K. Bhandari, Steven I. Baskin, Gary Rockwood

Chemistry and Biochemistry Faculty Publications

2-Aminothiazoline-4-carboxylic acid (ATCA) was intravenously injected to rats in order to investigate its plasma distribution. ATCA was extracted from plasma samples by solid phase extraction (SPE) and molecularly imprinted polymer stir bar sorption extraction (MIP-SBSE). Detection and quantification of ATCA were achieved by using liquid chromatography–tandem mass spectrometry (LC–MS/MS). It was found that the intravenously injected ATCA concentration quickly decreased to half within 2.5 h in the rat system. However, after 2.5 h, the concentration of ATCA in plasma stayed constant at least 5 folds above the endogenous ATCA level for more then 48 h. This finding can be used …

New Frontiers 2011-2012, University Of Nebraska At Kearney Office Of Graduate Studies And Research

New Frontiers

New Frontiers 2011 Features:

• Batman - Keith Geluso
• Passion for Proust - Herbert Craig
• Molten Master - Chad Fonfara
• Fruits of a Family Tree - Sylvia Asay
• Shared Minds With A Global Impact - Teara Archwamety and Max McFarland
• Law And Order In the Wild West - Mark Ellis

Cloning And Characterization Of The Cell Wall Acting Enzyme Cd1034 From The Pathogen Clostridium Difficile, Zachary Suter

Honors Projects in Science and Technology

The manifestation of multidrug resistance in bacteria over the past several decades has resulted in one of the foremost challenges in the management of infectious diseases. The question arises, “How do we address this growing problem?” One solution to stem the growing rise in antimicrobial resistance is to investigate new targets, while another approach is to re-examine classical antibacterial targets with a fresh perspective. The aim of this paper is to begin the process of antibacterial development for the pathogen Clostridium difficile by characterizing the cell wall acting glucosaminidase CD1034. It is inunderstanding how CD1034 functions biochemically that it can …

Qualitative Study Of The Relationship Between The Employee Engagement Of Certain Employees And The Emotional Intelligence Of Their Respective Leaders, Ann Kulow

Professional Projects

The purpose of this ethnographic qualitative study was to explore the relationships between an employee’s engagement and the emotional and social intelligence of the employee’s manager. The participants were certain employees of a Midwest manufacturer who were chosen by purposeful, criterion sampling. Direct reports of the chosen and consenting leaders were asked to complete a survey designed to measure the employee’s assessment of the social and emotional intelligence of their leaders. A total of 42 reports and 21 managers participated in this portion of the study. The emotional intelligence survey results were coded, reviewed and compared with the engagement survey …

High-Frequency Ultrasound M-Mode Imaging For Identifying Lesion And Bubble Activity During High-Intensity Focused Ultrasound Ablation, Ronald Kumon, Madhu Sudhan Reddy Gudur, Yun Zhou

Physics Publications

Effective real-time monitoring of high-intensity focused ultrasound (HIFU) ablation is important for application of HIFU technology in interventional electrophysiology. This study investigated rapid, high-frequency M-mode ultrasound imaging for monitoring spatiotemporal changes during HIFU application. HIFU (4.33 MHz, 1 kHz PRF, 50% duty cycle, 1 s, 2600 – 6100 W/cm2 ) was applied to ex-vivo porcine cardiac tissue specimens with a confocally and perpendicularly aligned high-frequency imaging system (Visualsonics Vevo 770, 55 MHz center frequency). Radiofrequency (RF) data from M-mode imaging (1 kHz PRF, 2 s × 7 mm) was acquired before, during, and after HIFU treatment (n = 12). Among …

Brazen (Spring 2012), Hollins University

Brazen - Gender & Women's Studies Department Newsletters

No abstract provided.

Lesbian Friendships: An Exploration Of Lesbian Social Support Networks, Suzanne Degges-White

Adultspan Journal

No abstract provided.

Aging Our Way: Lessons For Living From 85 And Beyond, Meghan R. Lehembre

Adultspan Journal

No abstract provided.

Mussel Inspired Protein-Mediated Surface Modification To Electrospun Fibers And Their Potential Biomedical Applications, Jingwei Xie, Praveesuda Lorwattanapongsa Michael, Shaoping Zhong, Bing Ma, Matthew R. Macewan, Chwee Teck Lim

MIIR Faculty Research

Mussel inspired proteins have been demonstrated to serve as a versatile biologic adhesive with numerous applications. The present study illustrates the use of such Mussel inspired proteins (polydopamine) in the fabrication of functionalized bio-inspired nanomaterials capable of both improving cell response and sustained delivery of model probes. X-ray photoelectron spectroscopy analysis confirmed the ability of dopamine to polymerize on the surface of plasma-treated, electrospun poly(ε-caprolactone) (PCL) fiber mats to form polydopamine coating. Transmission electron microscopy images demonstrated that self-polymerization of dopamine was induced by pH shift and that the thickness of polydopamine coating was readily modulated by adjusting the concentration …

Regulation Of Iron-Related Molecules In The Rat Hippocampus: Sex- And Age-Associated Differences, Srinivasarao Thulluri, Miaozong Wu, Eric R. Blough, Nandini D.P.K. Manne, Ashley B. Litchfield, Bin Wang

MIIR Faculty Research

Iron accumulation, especially that of free oxidized ferrous iron, has been shown to induce tissue oxidative damage and contribute to brain aging and the development of neurodegenerative disease. Here we examine whether sex and advanced age affect the expression of iron-related molecules that participate in regulating free iron levels (heme oxygenase I (HOI), iron-regulatory protein I (IRPI), and ferritin heavy chain (FTH)) and whether changes in the expression of these molecules are associated with differences in the expression of alpha-synuclein (ASN) which is thought to be a critical regulator in the pathogenesis of neurodegeneration. Using a well-established aging animal model, …

Chronic Paracetamol Treatment Influences Indices Of Reactive Oxygen Species Accumulation In The Aging Fischer 344 X Brown Norway Rat Aorta, Kevin M. Rice, Sarath Meduru, Sunil K. Kakarla, Anjaiah Katta, Sriram P. Mupparaju, Brent Kidd, Lynne J. Goebel, Eric R. Blough

MIIR Faculty Research

Previous reports have demonstrated that increased levels of reactive oxygen species (ROS) and alterations in cell signaling characterize aging in the Fischer 344 X Brown Norway (FBN) rat aorta. Other work has suggested that increases in ROS may be related to vascular wall thickening and the development of hypertension. Paracetamol (acetaminophen) is a potent antioxidant that has been found to diminish free radicals in ischemia-reperfusion studies. However, it remains unclear whether chronic paracetamol administration influences signaling or ROS accumulation in the aging aorta. FBN rats (27 months old; n=8) were subjected to 6 months of treatment with a therapeutic dose …

Marshall Magazine Spring 2012, Marshall University

Marshall Magazine

No abstract provided.

Spring 2012 Newsletter, Malena Hernández, Jaime Barajas Hernandez, Luis Xacon, Robert M. Gutierrez, Raúl Navarro, Isidoro Guzman, Roberto Reyna, Maribel Gómez, Tenoch Ortiz, Juan Carlos Jáuregui, Felipe Ponce, Isidro Zaragoza, Juan Pablo Mercado, José García

XGC: Xicana/o Graduate Council Newsletter

No abstract provided.

Forensic Science Forum, San Jose State University

Forensic Science Forum (Justice Studies)

No abstract provided.

Engineering At San Jose State University, Spring 2012, San Jose State University, Charles W. Davidson College Of Engineering

Engineering at San Jose State University

No abstract provided.

Together, No. 2, San Jose State University, College Of Social Sciences

Together (College of Social Sciences)

No abstract provided.

Sjsu Erfa News, Spring 2012, San Jose State University, Emeritus And Retired Faculty Association

Emeritus and Retired Faculty Association (ERFA) Newsletter

Volume 25, Number 3