Digital Commons Network^™

Diversity Awards, Nancy Lavin

The Good 5 Cent Cigar Articles

Article reporting on the 14th annual URI Diversity Awards Banquet

Care Seeking For Neonatal Illness In Low- And Middle-Income Countries: A Systematic Review, Hadley K. Herbert, Anne C. C. Lee, Aruna Chandran, Igor Rudan, Abdullah H. Baqui

Surgery Publications

Background

Despite recent achievements to reduce child mortality, neonatal deaths continue to remain high, accounting for 41% of all deaths in children under five years of age worldwide, of which over 90% occur in low- and middle-income countries (LMICs). Infections are a leading cause of death and limitations in care seeking for ill neonates contribute to high mortality rates. As estimates for care-seeking behaviors in LMICs have not been studied, this review describes care seeking for neonatal illnesses in LMICs, with particular attention to type of care sought.

Methods and Findings

We conducted a systematic literature review of studies that …

Non-Alcoholic Fatty Liver Disease: The Bile Acid-Activated Farnesoid X Receptor As An Emerging Treatment Target, Michael Fuchs

Internal Medicine Publications

Non-alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver disease worldwide. It may progress to liver cirrhosis and liver cancer and is poised to represent the most common indication for liver transplantation in the near future. The pathogenesis of NAFLD is multifactorial and not fully understood, but it represents an insulin resistance state characterized by a cluster of cardiovascular risk factors including obesity, dyslipidemia, hyperglycemia, and hypertension. Importantly, NAFLD also has evolved as independent risk factor for cardiovascular disease. Unfortunately thus far no established treatment does exist for NAFLD. The bile acid-activated nuclear farnesoid X receptor …

Posttransplant Metabolic Syndrome, M. Shadab Siddiqui, Richard K. Sterling

Internal Medicine Publications

Metabolic syndrome (MS) is a cluster of metabolic derangements associated with insulin resistance and an increased risk of cardiovascular mortality. MS has become a major health concern worldwide and is considered to be the etiology of the current epidemic of diabetes and cardiovascular disease. In addition to cardiovascular disease, the presence of MS is also closely associated with other comorbidities including nonalcoholic fatty liver disease (NAFLD). The prevalence of MS in patients with cirrhosis and end-stage liver disease is not well established and difficult to ascertain. Following liver transplant, the prevalence of MS is estimated to be 44–58%. The main …

Metabolomic Profiling To Identify Predictors Of Response To Vitamin E For Non-Alcoholic Steatohepatitis (Nash), Jianfeng Cheng, Andrew Joyce, Katherine Yates, Bradley Aouizerat, Arun J. Sanyal

Internal Medicine Publications

Vitamin E was recently shown to improve hepatic histology in a randomized controlled trial of pioglitazone or vitamin E for nonalcoholic steatohepatitis (PIVENS). The current study utilized samples collected in the PIVENS trial to identify: (1) baseline metabolomic profiles that could identify who would respond to vitamin E treatment and (2) end of treatment metabolomic profiles reflective of histologic improvement. A comprehensive analysis of metabolomics profiles (n = 547) quantified by mass spectrometry was performed in vitamin E responders (n = 16), vitamin E non-responders (n = 15), and placebo responders (n = 15). At baseline, phenyl-propionic acid (Odds ratio: …

Catheter Related Bloodstream Infection (Cr-Bsi) In Icu Patients: Making The Decision To Remove Or Not To Remove The Central Venous Catheter, Rodrigo O. Deliberato, Alexandre R. Marra, Thiago D. Correa, Marines D. V. Martino, Luci Correa, Oscar Fernando Pavao Dos Santos, Michael B. Edmond

Internal Medicine Publications

Background

Approximately 150 million central venous catheters (CVC) are used each year in the United States. Catheter-related bloodstream infections (CR-BSI) are one of the most important complications of the central venous catheters (CVCs). Our objective was to compare the in-hospital mortality when the catheter is removed or not removed in patients with CR-BSI.

Methods

We reviewed all episodes of CR-BSI that occurred in our intensive care unit (ICU) from January 2000 to December 2008. The standard method was defined as a patient with a CVC and at least one positive blood culture obtained from a peripheral vein and a positive …

Elastogenic Characterization Of Rat Bm-Msc-Derived Smcs Towards Use In Soft Tissue Engineering, Sahithya Wintrich

ETD Archive

No abstract provided.

Adenovirus-36 Is Associated With Obesity In Children And Adults In Sweden As Determined By Rapid Elisa, Malin Almgren, Richard Atkinson, Jia He, Agenta Hilding, Emilia Hagman, Alicia Wolk, Anders Thorell, Claude Marcus, Erik Naslund, Claes-Goren Ostenson, Martin Schalling, Catherina Lavebratt

Pathology Publications

Background

Experimental and natural human adenovirus-36 (Adv36) infection of multiple animal species results in obesity through increasing adipogenesis and lipid accumulation in adipocytes. Presence of Adv36 antibodies detected by serum neutralization assay has previously been associated with obesity in children and adults living in the USA, South Korea and Italy, whereas no association with adult obesity was detected in Belgium/the Netherlands nor among USA military personnel. Adv36 infection has also been shown to reduce blood lipid levels, increase glucose uptake by adipose tissue and skeletal muscle biopsies, and to associate with improved glycemic control in non-diabetic individuals.

Principal Findings

Using …

Cardiorespiratory Fitness, Alcohol Intake, And Metabolic Syndrome Incidence In Men, Kerem Shuval, Carrie E. Finley, Karen G. Chartier, Bijal A. Balasubramanian, Kelley Pettee Gabriel, Carolyn E. Barlow

Social Work Publications

Purpose

To prospectively examine the independent and joint effects of alcohol consumption and cardiorespiratory fitness on the incidence of metabolic syndrome in a cohort of men.

Methods

A prospective examination of 3,411 apparently healthy men at baseline, who came to the Cooper Clinic (Dallas, Texas) for at least 2 preventive visits (1979–2010). Primary exposure variables were cardiorespiratory fitness and alcohol intake; the outcome measure was metabolic syndrome (MetS) and the components thereof. Cox proportional hazard models were computed to assess the relationship between the exposure variables and the incidence of MetS while adjusting for confounders.

Results

Over a mean follow-up …

Binge Eating Disorder Mediates Links Between Symptoms Of Depression, Anxiety, And Caloric Intake In Overweight And Obese Women, Roseann E. Peterson, Shawn J. Latendresse, Lindsay T. Bartholome, Cortney S. Warren, Nancy C. Raymond

Human and Molecular Genetics Publications

Despite considerable comorbidity between mood disorders, binge eating disorder (BED), and obesity, the underlying mechanisms remain unresolved. Therefore, the purpose of this study was to examine models by which internalizing behaviors of depression and anxiety influence food intake in overweight/obese women. Thirty-two women (15 BED, 17 controls) participated in a laboratory eating-episode and completed questionnaires assessing symptoms of anxiety and depression. Path analysis was used to test mediation and moderation models to determine the mechanisms by which internalizing symptoms influenced kilocalorie (kcal) intake. The BED group endorsed significantly more symptoms of depression (10.1 versus 4.8, 𝑃 = 0 . 0 …

Otx But Not Mitf Transcription Factors Are Required For Zebrafish Retinal Pigment Epithelium Development, Brandon M. Lane, James A. Lister

Human and Molecular Genetics Publications

Otx and Mitf transcription factors have been implicated in the development of the retinal pigmented epithelium (RPE), but the relationship between these factors and their specific roles in the development of the RPE have not been fully defined. The role of the three Otx transcription factors (Otx1a, Otx1b, and Otx2) and two Mitf transcription factors (Mitfa and Mitfb) in the development of the zebrafish RPE was explored in these experiments. The loss of Otx activity through morpholino knockdown produced variable eye defects, ranging from delayed RPE pigmentation to severe coloboma, depending on the combination of Otx factors that were targeted. …

A Preliminary Study On The Potential Of Manuka Honey And Platelet-Rich Plasma In Wound Healing, Scott A. Sell, Patricia Wolfe, Andrew J. Spence, Isaac Rodriguez, Jennifer M. Mccool, Rebecca L. Petrella, Koyal Garg, Jeffery J. Ericksen, Gary L. Bowlin

Biomedical Engineering Publications

Aim. The purpose of this study was to determine the in vitro response of cells critical to the wound healing process in culture media supplemented with a lyophilized preparation rich in growth factors (PRGF) and Manuka honey. Materials and Methods. This study utilized cell culture media supplemented with PRGF, as well as whole Manuka honey and the medical-grade Medihoney (MH), a Manuka honey product. The response of human fibroblasts (hDF), macrophages, and endothelial cells (hPMEC) was evaluated, with respect to cell proliferation, chemotaxis, collagen matrix production, and angiogenic potential, when subjected to culture with media containing PRGF, MH, Manuka honey, …

Racial Differences In Symptom Management Approaches Among Persons With Radiographic Knee Osteoarthritis, Shibing Yang, Rachel Jawahar, Timothy Mcalindon, Charles B. Eaton, Kate L. Lapane

Family Medicine and Population Health Publications

Background

The extent to which racial differences exist in use of treatments for osteoarthritis (OA) is debatable. The purpose of this study was to describe the differences between African Americans (AA) and Caucasian Americans (CA) in using treatment approaches to manage symptoms among individuals with radiographic-confirmed knee OA.

Methods

A cross-sectional study was conducted. Using data from the Osteoarthritis Initiative, we identified 508 AA and 2,075 CA with radiographic tibiofemoral OA in at least one knee. Trained interviewers asked questions relating to current OA treatments including seven CAM therapy categories—alternative medical systems, mind-body interventions, manipulation and body-based methods, energy therapies, …

Treatment For Schistosoma Japonicum, Reduction Of Intestinal Parasite Load, And Cognitive Test Score Improvements In School-Aged Children, Amara E. Ezeamama, Stephen T. Mcgarvey, Joseph Hogan, Kate L. Lapane, David C. Bellinger, Luz P. Acosta, Tjalling Leenstra, Remigio M. Olveda, Jonathan D. Kurtis, Jennifer F. Friedman

Family Medicine and Population Health Publications

Background

To determine whether treatment of intestinal parasitic infections improves cognitive function in school-aged children, we examined changes in cognitive testscores over 18 months in relation to: (i) treatment-related Schistosoma japonicum intensity decline, (ii) spontaneous reduction of single soil-transmitted helminth (STH) species, and (iii) ≥2 STH infections among 253 S. japonicum-infected children.

Methodology

Helminth infections were assessed at baseline and quarterly by the Kato-Katz method. S. japonicum infection was treated at baseline using praziquantel. An intensity-based indicator of lower vs. no change/higher infection was defined separately for each helminth species and joint intensity declines of ≥2 STH species. In …

Tennessee Deaths 2011, Tennessee. Department Of Health, Division Of Health Statistics

Tennessee Deaths

Tennessee’s death data provides information on 2011 final mortality data for state residents. Resident data include events which occurred to residents of the state irrespective of where the events took place. Certificates filed with the Office of Vital Records supplied the data for this report.

Single Audit Report, For The Year Ended June 30, 2012, Tennessee. Department Of Audit, Tennessee. Comptroller Of The Treasury

Single Audit Reports

This report from the Division of State Audit shows the expenditures from the fiscal year.

Annual Report Of The Officers, Trustees, Boards, Committees And Agents For The Town Of Nottingham, New Hampshire For The Year Ending December 31, 2011., Nottingham Town Representatives

Nottingham, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

“Injustice Anywhere Is A Threat To Justice Everywhere” Internal Vs. International Armed Conflicts: Should The Distinction Be Eliminated?, Laura Chafey

University of Baltimore Journal of International Law

This article discusses international humanitarian law, particularly the Geneva Conventions and its Additional Protocols. It analyzes the rights of protected persons under the Geneva Conventions, such as prisoners of war and civilians, as well as the obligations of States during armed conflicts. Furthermore, the article points out the flaws in the Geneva Conventions, such as the discrepancy between the obligations of States during an international armed conflict vs. during an internal armed conflicts. It argues that this distinction between international and internal armed conflicts should be eliminated and that States’ obligations should be the same for both conflicts.

Superweeds And Suspect Seeds: Does The Genetically-Engineered Crop Deregulation Process Put American Agriculture At Risk?, Margaret Sova Mccabe

University of Baltimore Journal of Land and Development

No abstract provided.

Medical School Watercooler Newsletter - January 1, 2012, Lindsey Lyle

Watercooler Newsletter

This is the January 1, 2012 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• New Poll Demonstrates Importance of Health Research, Development
• January Med School Café - 'Starting Your Year off Right: Making Resolutions a Reality'
• USA College of Medicine Welcomes Dr. Charles Eric McCathran
• Next Week's DSS - Dr. Richard Cone
• Dr. Fortwendel Awarded Research Grant

Fueling Sport Performance: Increasing Awareness In Female Collegiate Vegetarian Athletes, Rachael Irene Marie Sofie

Theses, Dissertations and Capstones

Vegetarian diets, when well-planned out, have been shown to meet the needs of female athletes. Although the lifestyle provides many benefits, it does not come without risk. Women athletes, in particular, are of the greatest concern. Energy restriction is common among female collegiate athletes. Because athletes are already converting to and practicing a vegetarian lifestyle, it is necessary that athletes and related sport professionals become aware of the risks and benefits of a vegetarian lifestyle. By increasing knowledge among related personnel, athletes can use vegetarianism as a performance enhancer. Outlining possible implications of the lifestyle will allow female collegiate athletes …

The Storm After The Storm: A Comparative Framing Analysis Of Governmental And News Reporting On Hurricane Katrina, Evan T. Zuverink

Theses, Dissertations and Capstones

Hurricane Katrina is widely regarded as the greatest natural disaster to ever befall the United States. Following the storm’s devastation of the Gulf Coast region, a media firestorm unleashed, seeking to ascribe responsibility to governmental actors for the “failed” response effort. Through a comparative framing analysis, this study sought to investigate how major news outlets, the White House, and the Federal Emergency Management Agency framed the response efforts that followed Hurricane Katrina.

Visualization Of The Passive Sink Phenomenon In Nonexercising Lower Extremity Muscle Using Two Sampling Sites: Consequences For Assessment And Training, Michelle Elyse Copolo

Theses, Dissertations and Capstones

In the past, interest in the application of human performance and testing values has been limited to exercise professionals and those who participate in physical activity at high levels. One common method exercise physiologists employ to determine performance is the assessment of blood lactate concentration [La - ] through sampling. Blood lactate has been studied extensively; however, selection of an optimal sample site for drawing blood lactate is still an ongoing concern for exercise physiologists. Site selection can impact the values of blood [La - ] being reported, which can in turn impact the development of the training prescription. Studies …

It Is Time To Talk About It: Designing A Health Communication Program For Eating Disorder Recovery In An Appalachian University, Erica Lynn Clites

Theses, Dissertations and Capstones

The purpose of this thesis was to evaluate the treatments used in current eating disorder programs and to develop a more effective model using two relevant communication theories: the Transtheoretical Model of Change and Social Networking Theory. Further, the thesis explored the need for greater mental health literacy on Appalachian college and university campuses as it relates to the three major eating disorders defined by the DSMIV-TR: anorexia nervosa, bulimia nervosa, and binge eating disorders. The analysis of current treatment revealed an overemphasis on physical health and quantitative medical progress. Applying both the Transtheoretical Model of Change and Social Networking …

The Role Of Ptip In Breast Cancer, Lina Niu

Theses, Dissertations and Capstones

In the U.S., breast cancer comprises about 30% of all cancer cases (excluding skin cancer) in women. Such a high incidence makes breast cancer a significant health concern, but our understanding of the molecular and cellular mechanisms of this disease is still limited. Growing evidence suggests that the development of human breast cancer may involve epigenetics, which attributes changes in phenotype to mechanisms other than changes in the DNA sequence itself. Histones as the chief proteins of chromatin work on gene expression, and methylation of histone 3 lysine 4 (H3K4) results in transcriptional activation. Lately, Paired box (Pax) trans-activation domain-interacting …

Extraskeletal Effects Of Vitamin D: Potential Impact On Wv Disease Morbidity And Mortality, Franklin D. Shuler, Dana Lycans, Elias Salloum

Orthopaedics

Vitamin D is an essential nutrient and a secosteroid hormone that regulates many physiologic processes beyond calcium and bone homeostasis. These "extraskeletal" effects are impacted by the circulating levels of the storage form of vitamin D, 25-hydroxyvitamin D3. Levels of vitamin D can be detected after completing a simple 25(OH)D blood test. Vitamin D deficiency (< 30 ng/mL) is associated with a higher risk of many chronic diseases including, but not limited to, fourteen types of cancers, type 1 and 2 diabetes mellitus, obesity, cardiovascular disease, hypertension, stroke, and asthma. This article explores the association between vitamin D deficiency and the burden of chronic diseases in West Virginia.

2012 Cancer Care Annual Report, Children's Mercy Hospital

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center.

Food Security And Smallholder Coffee Production: Current Issues And Future Directions, Martha Caswell, V. Ernesto Méndez,, Christopher M. Bacon

Environmental Studies and Sciences

In recent years, there has been growing discussion within the specialty coffee industry about the preva- lence of seasonal food insecurity in coffee growing communities. The idea that coffee producers lack re- sources to feed themselves and their families flies in the face of Fair Trade and other sustainable coffee ini- tiatives, which were designed to ensure a viable livelihood and improved conditions for small-scale coffee farmers around the world. Though these certifications represent an important step toward delivering better prices to farmers, they are inadequate tools to stand alone against the formidable and entrenched barriers faced by this population. …

Neglected Tropical Diseases As Hidden Causes Of Cardiovascular Disease, Yasmin Moolani, Gene Bukhman, Peter J. Hotez

Microbiology, Immunology, and Tropical Medicine Faculty Publications

No abstract provided.

Undergraduate Symposia Abstract Papers

Journal of the Minnesota Academy of Science

No abstract provided.