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2012

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The Youngest Ages Can Turn Pages, Geraldine French Jan 2012

The Youngest Ages Can Turn Pages, Geraldine French

Reports

We think of literacy as reading and writing, something children learn at school. But literacy is much more basic than that and begins at birth. Children develop the ability to learn and communicate very early in life from their parents and carers. They learn to listen and to speak before they read and write. Not all parents and carers realise the important role they play in the future development of their children. By helping to develop a child’s literacy levels they can give them a really good start not just in school but in life. Simple things like engaging children …


Trends In The Utilization Of Outpatient Advanced Imaging After The Deficit Reduction Act., David C Levin, Vijay M Rao, Laurence Parker Jan 2012

Trends In The Utilization Of Outpatient Advanced Imaging After The Deficit Reduction Act., David C Levin, Vijay M Rao, Laurence Parker

Department of Radiology Faculty Papers

PURPOSE: After the Deficit Reduction Act (DRA) took effect in 2007, there was concern that private office-based imaging facilities would close, that advanced imaging would shift to less convenient hospital-based facilities, and that access to advanced imaging might be restricted. The aim of this study was to see if these developments occurred during the years after the DRA.

METHODS: Using Medicare data, outpatient CT, MRI, and nuclear medicine trends before and after the DRA were studied. Procedure volumes performed in private offices and hospital outpatient departments (HOPDs) were tabulated separately. Volumes were tracked from 2000 to 2006 (before the DRA) …


"You Got To Be Follow-Worthy Or I Will Unfollow You!” Students’ Voices On Twitter Integration Into Classroom Settings, Tian Luo, Teresa Franklin Jan 2012

"You Got To Be Follow-Worthy Or I Will Unfollow You!” Students’ Voices On Twitter Integration Into Classroom Settings, Tian Luo, Teresa Franklin

STEMPS Faculty Publications

This research centers on a case study where Twitter was integrated in an undergraduate level course. Under the instructor’s specific guidance and ongoing feedback, students actively participate in the course both in and outside of classroom. They perceived the incorporation of Twitter into classroom to be highly engaging and contributive to their learning. During the 10 week course, students’ initiatives in developing self-defined codes of conduct for tweeting, creating user groups, and assisting one another to become proficient in using Twitter, demonstrated a high degree of autonomous social learning in both formal and informal learning environments. Not only were they …


Designing Microblogging-Based Class Activities, Tian Luo, Fei Gao Jan 2012

Designing Microblogging-Based Class Activities, Tian Luo, Fei Gao

STEMPS Faculty Publications

Microblogging tools such as Twitter have been frequently adopted in educational settings to facilitate learning. This study examined how a microblogging tool, Twiducate, was incorporated into a graduate-level class of ten students. During the 1.5 hour lesson, students participated in a series of Twiducate-supported collaborative and reflective activities. The analysis of in-class discussion transcripts, text-based posts on Twiducate and a pre- and post-test survey results revealed that students were highly engaged in classroom collaborative learning and there is a high level of interaction. Students reported the challenges of using microblogging tools, such as the possibility of creating distraction and disorder …


Reconsidering Instructional Design With Web 2.0 Technologies, Fei Gao, Kun Li, Tian Luo, Jamie Smith Jan 2012

Reconsidering Instructional Design With Web 2.0 Technologies, Fei Gao, Kun Li, Tian Luo, Jamie Smith

STEMPS Faculty Publications

Emerging technologies such as Web 2.0 afford interconnections, content creation and remixing, which provide rich opportunities to for more personally meaningful, collaborative, and socially relevant learning (Greenhow, Robelia, & Hudges, 2009). Web 2.0 and other emerging technologies offer new possibilities of designing collaborative activities that engage learners in meaningful learning (Chai & Tan, 2009; Cress & Kimmerle, 2008).

Despite the enthusiasm of integrating Web 2.0 technologies into learning environment design, researchers found that few instructors know the pedagogies that could lead to productive innovation (Collis & Moonen, 2008). This symposium consists of one theoretical paper and three case studies that …


The Regulation Of Insulin-Like Growth Factor 1 By Growth Hormone Via Stat5b, Tiffany Morrison Jan 2012

The Regulation Of Insulin-Like Growth Factor 1 By Growth Hormone Via Stat5b, Tiffany Morrison

University Honors Theses

The growth hormone (GH) and insulin-like factor 1 (IGF-1) growth axis is integral to growth, metabolism and tissue repair. This pathway involves binding of GH to the GH receptor and activation of the transcription factor, Stat5b, leading to nuclear transclocation, interaction with DNA binding sites in chromatin and stimulation of IGF-1 transcription. Stat5b binding sites have been determined experimentally by previous research but are all found far from the IGF-1 promoters and the mechanism by which Stat5b binding initiates IGF-1 gene transcription is currently unknown. Since no system for studying this process currently exists, the goal of this project is …


Men In Black, Martin Munoz Jan 2012

Men In Black, Martin Munoz

Jesuit Higher Education: A Journal

At almost every Catholic university you will undoubtedly find old photographs of a sepia colored world, grainy artifacts steeped in tradition with narratives all but forgotten, like clouds passing in a blue sky. These photographs are but a moment in time, only the instruments that captured these moments may exist, a reminder of how science has permanence in a world ruled by the machine while stories pass on like ghostly figures in an indifferent province. The stories within these photos that once were filled with hope, promise and faith are now silent; only the reverberations of their memory remain.


New Tools In Improvised Music Performance., Seán Mac Erlaine Jan 2012

New Tools In Improvised Music Performance., Seán Mac Erlaine

Articles

This paper looks at the synthesis of computer technology and instrumental practice in improvised music performance. The emerging field of performers who use real-time signal processing as a technological extension of their instrument is discussed. How do new tools affect musical practice? Does the use of computers impose an associated aesthetic?

A number of key players are scrutinised including Evan Parker, La Monte Young, Terry Riley, Jon Hassell, Miles Davis, Pauline Oliveros, David Behrman. The research provides a historical context to these practices and explores how pre- and post-digital technologies have shaped their work.

This article identifies an innovative and …


The End Game Of Deregulation: Myopic Risk Management And The Next Catastrophe, Thomas O. Mcgarity, Rena I. Steinzor Jan 2012

The End Game Of Deregulation: Myopic Risk Management And The Next Catastrophe, Thomas O. Mcgarity, Rena I. Steinzor

Faculty Scholarship

On December 22, 2008, the contents of an enormous impoundment containing coal-ash slurry from the Tennessee Valley Authority’s (TVA) Kingston Fossil Fuel Plant poured into the Emory River. The proximate cause of the spill was the bursting of a poorly reinforced dike holding back a pit of sludge that towered 80 feet above the river and 40 feet above an adjacent road. The volume and force of the spill were so large that 1.1 billion gallons of the inky mess flowed across the river, inundating 300 acres of land in a layer four to five feet deep, uprooting trees, destroying …


Portraying Migrants’ Experiences In Irish Documentary Film, Agnes Kakasi Jan 2012

Portraying Migrants’ Experiences In Irish Documentary Film, Agnes Kakasi

Conference Papers

Portraying Migrants’ Experiences in Irish Documentary Film

In this presentation I critically analyse the types of narratives and formal characteristics, as well as the variety of social issues that filmmakers in the Republic of Ireland have engaged in, in creating stories about transnational migration and the immigrant subject in recent Irish documentary film. As a result of the Celtic Tiger economy from the mid-90s until 2008, Ireland has experienced a major transformation in its ethnoscape (Appadurai, 1996) by becoming a ‘country of immigrants’, with an estimated 12% of the population born outside the country. Through the analysis of such documentary …


What Are The Visible And Invisible Archaeologies Of Conflict In The Irish Landscape Of Donegal And How May These Be Contextualised And Represented Through Arts Practice, Mhairi Sutherland Jan 2012

What Are The Visible And Invisible Archaeologies Of Conflict In The Irish Landscape Of Donegal And How May These Be Contextualised And Represented Through Arts Practice, Mhairi Sutherland

Doctoral

The research question - "What are the visible and invisible archaeologies of conflict in the Irish landscape of Donegal and how may these be contextualised and represented through arts practice?" has been addressed through textual and historical research and through arts practice, using lens-based media in the exploration of an historic series of military circumstances, in the contemporary Irish landscape of County Donegal. The research undertaken and the resulting outcomes are presented as a textual narrative and as visual arts practice. The thesis material is composed of five chapters, each of which discusses selected arguments in the fields of, respectively; …


Icts In Education: An Evaluation Of The Dublin Inner City Schools' Computerization (Disc) And Hp Managed Learning Environment (Mle) Projects, Elizabeth Quinn Jan 2012

Icts In Education: An Evaluation Of The Dublin Inner City Schools' Computerization (Disc) And Hp Managed Learning Environment (Mle) Projects, Elizabeth Quinn

Masters

The Dublin Inner-City Schools Computerization (DISC) Projects initiative was established with the aim of achieving equality of access, opportunity and training in Information and Communication Technology (ICT) in thirty-eight inner-city schools and innovative use of ICT in the classroom. This report seeks to evaluate the project to include the ICT projects Initiative and a pilot Managed Learning Environment (MLE) called LearningNI (LNI) currently being run by C2k in Northern Ireland (NI). This report finds that while the DISC project overall has been broadly welcomed by many schools, some schools are not engaging with the programme and the objective of integrating …


Co-Operatives As Social Innovation – How Older Models Of Social Enterprise Are More Relevant Than Ever, Gerard Doyle Jan 2012

Co-Operatives As Social Innovation – How Older Models Of Social Enterprise Are More Relevant Than Ever, Gerard Doyle

Articles

Ireland faces a number of socio-economic issues, including, an over-reliance on fossil fuels, inequality, unsustainable approaches to urban regeneration and unbalanced regional development. This chapter will demonstrate how social enterprise can lead to the implementation of socially innovative responses to addressing these issues.


Increased Susceptibility Of Arterial Tissue To Wire Perforation With The Application Of High Frequency Mechanical Vibrations, Mark Wylie, Garrett Mcguinness, Graham Gavin Jan 2012

Increased Susceptibility Of Arterial Tissue To Wire Perforation With The Application Of High Frequency Mechanical Vibrations, Mark Wylie, Garrett Mcguinness, Graham Gavin

Articles

High frequency mechanical vibrations (20–50 kHz), delivered via small diameter flexible wire waveguides represent a minimally invasive technology for the treatment of chronic total occlusions (CTOs) and in other tissue ablation applications. Tissue disruption is reported to be caused by repetitive mechanical contact and cavitation. This work focuses on the effects of vibrating wire waveguides in contact with arterial tissue. An apparatus with clinically relevant parameters was used, characterized as operating at 22.5 kHz and delivering amplitudes of vibration of 17.8 - 34.3 µm (acoustic intensity, ISATA: 1.03 - 3.83 W/cm2) via 1.0 mm diameter waveguides. …


Iterative Orthology Prediction Uncovers New Mitochondrial Proteins And Identifies C12orf62 As The Human Ortholog Of Cox14, A Protein Involved In The Assembly Of Cytochrome C Oxidase, R Szklarczyk, Bfj Wanschers, Td Cuypers, Jj Esseling, Et Al Jan 2012

Iterative Orthology Prediction Uncovers New Mitochondrial Proteins And Identifies C12orf62 As The Human Ortholog Of Cox14, A Protein Involved In The Assembly Of Cytochrome C Oxidase, R Szklarczyk, Bfj Wanschers, Td Cuypers, Jj Esseling, Et Al

School of Biomedical Sciences

BACKGROUND: Orthology is a central tenet of comparative genomics and ortholog identification is instrumental to protein function prediction. Major advances have been made to determine orthology relations among a set of homologous proteins. However, they depend on the comparison of individual sequences and do not take into account divergent orthologs. RESULTS: We have developed an iterative orthology prediction method, Ortho-Profile, that uses reciprocal best hits at the level of sequence profiles to infer orthology. It increases ortholog detection by 20% compared to sequence-to-sequence comparisons. Ortho-Profile predicts 598 human orthologs of mitochondrial proteins from Saccharomyces cerevisiae and Schizosaccharomyces pombe with 94% …


Crisis And Policy Change: The Role Of The Political Entrepreneur, John Hogan, Sharon Feeney Jan 2012

Crisis And Policy Change: The Role Of The Political Entrepreneur, John Hogan, Sharon Feeney

Articles

This paper seeks to investigate the inner mechanics of policy change. It aims to discover how ideas enter the political arena, and how endogenous forces within the policy making environment transform ideas into new policies. The central hypothesis is that in times of crisis, new ideas emanate from a number of change agents, but in order for any of these ideas to enter the institutional environment, one specific agent of change must be present: the political entrepreneur. Without political entrepreneurs, ideational change, and subsequent policy change, would not occur. The paper sets out a framework for identifying and explaining the …


Young Men Consuming Newspaper Prostitution: A Discourse Analysis Of Responses To Irish Newspaper Coverage Of Prostitution., Joseph Fitzgerald, Brendan O'Rourke Jan 2012

Young Men Consuming Newspaper Prostitution: A Discourse Analysis Of Responses To Irish Newspaper Coverage Of Prostitution., Joseph Fitzgerald, Brendan O'Rourke

Articles

In this article we look at how young men consume coverage of prostitution in Irish newspapers. This is important for a number of reasons. Firstly, because the media, and newspapers in particular, seem to be an important source of information for people (Meade, 2008). This is especially true in the case of prostitution, as the only contact the citizenry generally have with sex-workers is through the media (Hallgrimsdottir, Phillips and Benoit, 2006). In many Western countries consuming media is one of the main activities that people, particularly young people, engage in and therefore is the prism through which they view …


Airlift Column Photobioreactors For Porphyridium Sp. Culturing: Part Ii. Verification Of Dynamic Growth Rate Model For Reactor Performance Evaluation, Hu Ping Luo, Muthanna H. Al-Dahhan Jan 2012

Airlift Column Photobioreactors For Porphyridium Sp. Culturing: Part Ii. Verification Of Dynamic Growth Rate Model For Reactor Performance Evaluation, Hu Ping Luo, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Dynamic Growth Rate Model Has Been Developed to Quantify the Impact of Hydrodynamics on the Growth of Photosynthetic Microorganisms and to Predict the Photobioreactor Performance. Rigorous Verification of Such Reactor Models, However, is Rare in the Literature. in This Part of Work, Verification of a Dynamic Growth Rate Model Developed in Luo and Al-Dahhan (2004) [Biotech Bioeng 85(4): 382-393.] Was Attempted using the Experimental Results Reported in Part I of This Work and Results from Literature. the Irradiance Distribution Inside the Studied Reactor Was Also Measured at Different Optical Densities and Successfully Correlated by the Lambert-Beer Law. When Reliable Hydrodynamic …


Separation And Liquid Chromatography Using A Single Carbon Nanotube, Riju Singhal, Vadym Mochalin, Maria R. Lukatskaya, Gary Friedman, Yury G. Gogotsi Jan 2012

Separation And Liquid Chromatography Using A Single Carbon Nanotube, Riju Singhal, Vadym Mochalin, Maria R. Lukatskaya, Gary Friedman, Yury G. Gogotsi

Chemistry Faculty Research & Creative Works

Use of a single template-grown carbon nanotube as a separation column to separate attoliter volumes of binary mixtures of fluorescent dyes has been demonstrated. The cylindrical nanotube walls are used as stationary phase and the surface area is increased by growing smaller multi-walled carbon nanotubes within the larger nanotube column. Liquid-liquid extraction is performed to separate selectively soluble solutes in a solvent, and chromatographic separation is demonstrated using thin, long nanotubes coated inside with iron oxide nanoparticles. The setup is also used to determine the diffusion coefficient of a solute at the sub-micrometer scale. This study opens avenues for analytical …


Serdar Somuncu: Reframing Integration Through A Transnational Politics Of Satire, Kathrin M. Bower Jan 2012

Serdar Somuncu: Reframing Integration Through A Transnational Politics Of Satire, Kathrin M. Bower

Languages, Literatures, and Cultures Faculty Publications

Founded by Şinasi Dikmen and Muhsin Omurcu in Ulm in 1985, Knobi-Bonbon is widely recognized as the first Turkish German cabaret in the Federal Republic. Dikmen and Omurcu focused on ethnic stereotypes, integration, and coexistence in their early programs, with an emphasis on the German misunderstanding of integration as cultural assimilation (Boran 202, 219). With a run of successful performances, Knobi-Bonbon established a momentum that has carried through to the present day, making Turkish German comedy a fixture on the German stage. Responding to the wave of nationalism and xenophobia that followed in the wake of unification, Knobi-Bonbon’s shows became …


Enhancing The Mechanical Properties Of A Hydroxyapatite-Collagen Bone Surrogate, Richard Franz Banglmaier Jan 2012

Enhancing The Mechanical Properties Of A Hydroxyapatite-Collagen Bone Surrogate, Richard Franz Banglmaier

Wayne State University Dissertations

The synthesis of biomimetic hydroxyapatite-collagen composites is desirable from the perspective of graft elimination and load-bearing support when treating damaged or diseased bone. Bone is an organized network of carbonated hydroxyapatite mineralized collagen, whose strength and toughness is dependent on the organized array of mineralized collagen fibers that align with applied physiologic stresses. The apatitic calcium phosphate phase, hydroxyapatite, is promising for the biomimetic mineralization of collagen. Hydroxyapatite-collagen composites are osteoconductive and resorbable. However, the mechanical properties of these composites are one or more orders of magnitude less than bone. The aim of this study was to produce a bone-like …


Longitudinal Outcomes Of Distortion Product Otoacoustic Emissions And Wideband Reflectance In Infants, Virginia Ramachandran Jan 2012

Longitudinal Outcomes Of Distortion Product Otoacoustic Emissions And Wideband Reflectance In Infants, Virginia Ramachandran

Wayne State University Dissertations

Clinical practice has shown that some infants are born with, or develop a temporary conductive hearing loss characterized by the absence of measurable otoacoustic emissions (OAEs) but normal sensorineural hearing. This transient situation interferes with the process of universal newborn hearing screening and identification.

The purpose of this prospective, longitudinal study was to describe outcomes of distortion product OAE (DPOAE) screening in infants at birth, and one, four, eight, and twelve weeks of age. In addition, wideband reflectance (WBR) measures, which have the potential to help characterize outer-ear canal and middle-ear function, were examined to determine their potential utility in …


Hdm2 Small-Molecule Inhibitors For Therapeutic Intervention In B-Cell Lymphoma, Angela Sosin Jan 2012

Hdm2 Small-Molecule Inhibitors For Therapeutic Intervention In B-Cell Lymphoma, Angela Sosin

Wayne State University Dissertations

Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, compromising p53 activity. Therefore, lymphoma is a suitable model for studying therapeutic value of disrupting HDM2-p53 association by small-molecule inhibitors (SMIs). HDM2 SMIs have been developed and are currently under various stages of preclinical and clinical investigation. This study examined various molecular mechanisms associated and biological effects of two different classes of HDM2 SMIs: the spiro-oxindoles (MI-219) and cis-imidazoline (Nutlin-3) in lymphoma cell lines and patient-derived B-lymphoma cells. Surprisingly, results revealed significant quantitative and qualitative differences between these two agents. At the molecular level, effect of Nutlin-3 was generally more …


Characterization Of The Lone Extracytoplasmic Function Sigma Factor, Ós, And Its Role In The Staphylococcus Aureus Virulence And Stress Responses, Halie Kay Miller Jan 2012

Characterization Of The Lone Extracytoplasmic Function Sigma Factor, Ós, And Its Role In The Staphylococcus Aureus Virulence And Stress Responses, Halie Kay Miller

USF Tampa Graduate Theses and Dissertations

Previously our laboratory had identified a novel component of the Staphylococcus aureus regulatory network, an extracytoplasmic function ó factor, óS, involved in stress response and disease causation. Here we present additional characterization of óS, demonstrating a role for it in protection against DNA damage, cell wall disruption and interaction with components of the innate immune system. Promoter mapping reveals the existence of four unique sigS start sites, one of which appears to be subject to auto-regulation. Transcriptional profiling revealed that sigS expression remains low in a number of S. aureus wild-types, but is upregulated in the highly mutated strain RN4220. …


Neuron To Microglia Communication; A Study Of Cx3cl1 Signaling Implications In Cognitive Function, Inflammation, And Neurodegeneration, Joshua M. Morganti Jan 2012

Neuron To Microglia Communication; A Study Of Cx3cl1 Signaling Implications In Cognitive Function, Inflammation, And Neurodegeneration, Joshua M. Morganti

USF Tampa Graduate Theses and Dissertations

As a consequence of aging, the brain is subject to chronic neuroinflammatory conditions. The resident immune cells of the brain, microglia, act similarly to peripheral macrophages to protect the brain from insults, infection, and physical trauma. However, without proper regulation of their respective host defense mechanisms, these actions can become neurotoxic. In the healthy brain neurons have several signaling systems that directly interact with microglia in order to maintain a calming influence upon their actions, one of particular interest is the chemokine CX3CL1. This chemokine is found predominantly on neurons, while its cognate receptor CX3CR1 is found exclusively on microglia. …


Encapsulation Of High Temperature Phase Change Materials For Thermal Energy Storage, Rupa Nath Jan 2012

Encapsulation Of High Temperature Phase Change Materials For Thermal Energy Storage, Rupa Nath

USF Tampa Graduate Theses and Dissertations

Thermal energy storage is a major contributor to bridge the gap between energy demand (consumption) and energy production (supply) by concentrating solar power. The utilization of high latent heat storage capability of phase change materials is one of the keys to an efficient way to store thermal energy. However, some of the limitations of the existing technology are the high volumetric expansion and low thermal conductivity of phase change materials (PCMs), low energy density, low operation temperatures and high cost. The present work deals with encapsulated PCM system, which operates at temperatures above 500°C and takes advantage of the heat …


Mangroves, Mudbanks And Seawalls: Political Ecology Of Adaptation To Sea Level Rise In Suriname, Ravic Nijbroek Jan 2012

Mangroves, Mudbanks And Seawalls: Political Ecology Of Adaptation To Sea Level Rise In Suriname, Ravic Nijbroek

USF Tampa Graduate Theses and Dissertations

This study seeks to understand how global discourses of sea level rise (SLR) and mangrove ecology influence national climate change adaptation policy to reduce coastal vulnerability in Suriname. A majority of the Surinamese population lives along the low elevation coastal zone and is highly exposed to projected SLR. Failure by the international community to reach agreement on climate change mitigation means that vulnerable coastal communities must adapt. The Suriname coast is predominantly shaped by mudbanks and mangroves which together provide protection against coastal erosion and trap sediments resulting in coastal accretion. Knowledge claims of mangrove ecology and utility in SLR …


Maternal Immune Dysregulation In The Pathogenesis Of Neurodevelopmental Disorders: Interleukin-6 As A Central Mechanism And Therapeutic Target Of Flavonoids, Ellisa Carla Parker-Athill Jan 2012

Maternal Immune Dysregulation In The Pathogenesis Of Neurodevelopmental Disorders: Interleukin-6 As A Central Mechanism And Therapeutic Target Of Flavonoids, Ellisa Carla Parker-Athill

USF Tampa Graduate Theses and Dissertations

Activation of the maternal immune system and resultant maternal cytokine expression due to prenatal infection has been implicated as a significant contributor to the pathology of neuropsychiatric and neurodevelopmental disorders such as schizophrenia and Autism Spectrum Disorder (ASD). Increased maternal interleukin-6 (IL-6) expression, observed clinically and in animal models of prenatal infection, and resultant activation of key signaling pathways, has been shown to be a biological indicator of pathology, and a central component of the pathological mechanism. In animal models of prenatal infection and clinically in pregnancy disorders hallmarked by immunological irregularities and increased IL-6 expression, inhibition of IL-6 has …


Four English Language Learners' Experiences And Strategy Use In Learning Environments Of Multiliteracies, Ho Ryong Park Jan 2012

Four English Language Learners' Experiences And Strategy Use In Learning Environments Of Multiliteracies, Ho Ryong Park

USF Tampa Graduate Theses and Dissertations

English language learners (ELLs) develop their reading by engaging in diverse literacy activities in the learning contexts of multiliteracies. I investigated ELLs' experiences and their use of strategies when they read computer-based texts at home and in school. In addition, I identified a variety of influential factors that affected the ELLs' use of reading strategies when they read computer-based texts in both research contexts.

This research was conducted at homes and at three public elementary schools. Participants were two fourth-grade and two fifth-grade ELLs, four parents, and five classroom teachers. The study included observations, interviews, verbal reports, documents, field notes, …


Cell Adhesion And Migration On Ndga Cross-Linked Fibrillar Collagen Matrices For Tendon Tissue Engineering, Ana Ysabel Rioja Jan 2012

Cell Adhesion And Migration On Ndga Cross-Linked Fibrillar Collagen Matrices For Tendon Tissue Engineering, Ana Ysabel Rioja

USF Tampa Graduate Theses and Dissertations

Tendons, essential tissues that connect muscles to bones, are susceptible to rupture/degeneration due to their continuous use for enabling movement. Often surgical intervention is required to repair the tendon; relieving the pain and fixing the limited mobility that occurs from the damage. Unfortunately, post-surgery immobilization techniques required to restore tendon properties frequently lead to scar formation and reduced tendon range of motion. Our ultimate goal is to create an optimal tendon prosthetic that can stabilize the damaged muscle-bone connection and then be remodeled by resident cells from the surrounding tissues over time to ensure long-term function. To achieve this, we …