Digital Commons Network^™

Methods For Evaluating Prediction Performance Of Biomarkers And Tests, Margaret Pepe, Holly Janes

UW Biostatistics Working Paper Series

This chapter describes and critiques methods for evaluating the performance of markers to predict risk of a current or future clinical outcome. We consider three criteria that are important for evaluating a risk model: calibration, benefit for decision making and accurate classification. We also describe and discuss a variety of summary measures in common use for quantifying predictive information such as the area under the ROC curve and R-squared. The roles and problems with recently proposed risk reclassification approaches are discussed in detail.

We Are...Marshall, October 17, 2012, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

The Winonan, Winona State University

The Winonan - 2010s

No abstract provided.

Glibenclamide Induces Collagen Iv Catabolism In High Glucose-Stimulated Mesangial Cells, Liping Zhu, Pedro Cortes, Clare Hassett, David W. Taube, Jerry Yee

Nephrology Articles

We have shown the full prevention of mesangial expansion in insulin-deficient diabetic rats by treatment with clinically-relevant dosages of glibenclamide (Glib). Studies in mesangial cells (MCs) also demonstrated reduction in the high glucose (HG)-induced accumulation of collagens, proposing that this was due to increased catabolism. In the present study, we investigated the signaling pathways that may be implicated in Glib action. Rat primary MCs were exposed to HG for 8 weeks with or without Glib in therapeutic (0.01 μM) or supratherapeutic (1.0 μM) concentrations. We found that HG increased collagen IV protein accumulation and PAI-1 mRNA and protein expression, in …

De Geus V. De Geus Respondent's Brief Dckt. 39931

Idaho Supreme Court Records & Briefs, All

No abstract provided.

The Bg News October 17, 2012, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. October 17, 2012. Volume 103-Issue 26.

Registration, Attendance, And Reality: African-Americans Engaged In Sat Preparation, Don Coleman

Theses and Dissertations

There is limited research into the persistence, participation, and efforts of African American students in their preparation for college admission exams (SAT, ACT). Registration, attendance, and the experienced reality of African American students who voluntarily enrolled in an SAT prep program as well as perceptions of African American instructors were the foci of this mixed methods action research. This study examined the development of a Saturday SAT preparation program over an 18 month period. Theoretical frameworks of Stereotype Threat (STT) (Steele, 1992; Steele & Aronson, 1995) and schooling effects (Diamond, 2007; Kao & Thompson, 2003; Ladson-Billings 1995, 1997; Starratt, 2003; …

Whalesong 2012-10-17, N/A N/A

Whalesong

No abstract provided.

Bio-Logic Builder: A Non-Technical Tool For Building Dynamical, Qualitative Models, Tomáš Helikar, Brian Kowal, Alex Madrahimov, Manish Shrestha, Jay Pedersen, Kahani Limbu, Ishwor Thapa, Thaine Rowley, Rahul Satalkar, Naomi Kochi, John Konvalina, Jim A. Rogers

Mathematics Faculty Publications

Computational modeling of biological processes is a promising tool in biomedical research. While a large part of its potential lies in the ability to integrate it with laboratory research, modeling currently generally requires a high degree of training in mathematics and/or computer science. To help address this issue, we have developed a web-based tool, Bio-Logic Builder, that enables laboratory scientists to define mathematical representations (based on a discrete formalism) of biological regulatory mechanisms in a modular and non-technical fashion. As part of the user interface, generalized “bio-logic” modules have been defined to provide users with the building blocks for many …

Volume 50, Number 9: October 17, 2012, University Of North Dakota

University Letter Archive

No abstract provided.

Development Of A Ground Based Remote Sensing Approach For Direct Evaluation Of Aerosol-Cloud Interaction, Bomidi Lakshmi Madhavan, Yuzhe He, Yonghua Wu, Barry Gross, Fred Moshary, Samir Ahmed

Publications and Research

The possible interaction and modification of cloud properties due to aerosols is one of the most poorly understood mechanisms within climate studies, resulting in the most significant uncertainty as regards radiation budgeting. In this study, we explore direct ground based remote sensing methods to assess the Aerosol-Cloud Indirect Effect directly, as space-borne retrievals are not directly suitable for simultaneous aerosol/cloud retrievals. To illustrate some of these difficulties, a statistical assessment of existing multispectral imagers on geostationary (e.g., GOES)/Moderate Resolution Imaging Spectroradiometer (MODIS) satellite retrievals of the Cloud Droplet Effective Radius (Reff) showed significant biases especially at larger solar zenith angles, …

The Parthenon, October 17, 2012, Shane Arrington

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern University STEM Institute Names Affiliates
• Religious Scholar to Present on Faiths of Postwar Presidents at Georgia Southern University

Spectrum, Volume 30, Issue 5, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Parking Causes Problems -- Voting In Presidential Election -- WWE Wrestler Gives Presentation at SHU -- Students are sleepless at SHU -- Is technology taking over the way we live our lives? -- Editorials

A New Green's Function Formulation For Modeling Homogeneous Objects In Layered Medium, Yongpin P. Chen, Weng Cho Chew, Lijun Jiang

Electrical and Computer Engineering Faculty Research & Creative Works

A new Green's function formulation is developed systematically for modeling general homogeneous (dielectric or magnetic) objects in a layered medium. The dyadic form of the Green's function is first derived based on the pilot vector potential approach. The matrix representation in the moment method implementation is then derived by applying integration by parts and vector identities. The line integral issue in the matrix representation is investigated, based on the continuity property of the propagation factor and the consistency of the primary term and the secondary term. The extinction theorem is then revisited in the inhomogeneous background and a surface integral …

Correlated Variability Of Upwelling And Tracers Near The Tropical Tropopause, Marta Abalos

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

Tropical upwelling should exert strong influence on temperatures and on tracers with large vertical gradients in the lower stratosphere. We test this behavior by comparing three upwelling estimates calculated from ERA‐Interim reanalysis data with observed temperatures in the tropical lower stratosphere, and with measurements of ozone and carbon monoxide (CO) from the Aura Microwave Limb Sounder (MLS) satellite instrument. Time series of temperature, ozone and CO are well correlated in the tropical lower stratosphere, and we quantify the influence of tropical upwelling on this joint variability. Strong coherent annual cycles observed in each quantity are found to reflect the seasonal …

Comparison Between Microphysical Model Simulation And Observed Cirrus Clouds Formation Within A Volcanic Aerosol Layer In The Tropical Tropopause Layer, Mayuko Sakurai

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

In order to know the formation process of cirrus clouds in tropical tropopause layer, we used a microphysical numerical model to calculate nucleation and growing process of cirrus cloud particles, and compared the results of the model simulations with observed results. The observations compared had been performed at Biak, Indonesia in January 2011. Formation of cirrus clouds was observed by lidar in an aerosol layer at the altitude from 17.5 to 19 km. The backscatter coefficient of cirrus clouds was 10^-8~10^-7/m/str and number concentration was estimated less than 10⁵/m³. Calculated results by …

Dehydration In The Ttl Estimated From The Water Vapor Match, Yoichi Inai

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

The match method is applied to the quantification of the dehydration process in the tropical tropopause layer (TTL) over the western Pacific. The match pairs are sought from the Soundings of Ozone and Water in the Equatorial Region (SOWER) campaign network observations with the use of isentropic trajectories. For those pairs identified, extensive screening procedures are performed to verify the representativeness of the air parcel and the validity of the isentropic treatment and to check possible water injection by deep convection, consistency between the sonde data and analysis field, and conservation of the ozone content. Among those pairs remaining, we …

Development Of A Balloon-Born Peltier-Based Chilled-Mirror Hygrometer For The Troposphere And The Lower Stratosphere, Takuji Sugidachi

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

We have developed a new balloon-borne hygrometer, which is based on a chilled-mirror principle and uses a two stage Peltier cooler. In January 2012, we have conducted flight tests at Biak, Indonesia (1.18⁰S, 136.11⁰E) to evaluate the performances of this sensor. The result showed that this hygrometer has the ability to measure atmospheric water vapor from the surface to the lower stratosphere. It is considered that our hygrometer is helpful for TTL observation campaigns because of its ease-in-handling.

Diurnal Variability Of Total Ozone, Nitrogen Dioxide And Sulfurdioxide Columns Over, Wiwiek Setyawati

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

Atmospheric ozone plays important role in preserving living things on Earth from harmful solar ultraviolet radiation. Atmospheric nitrogen dioxide (NO2) and sulfur dioxide (SO2) act as very important substances as precursor and destructor of atmospheric ozone. Knowing the importance of these substances therefore LAPAN has conducted observations of total ozone, NO2 and SO2 columns in Bandung since 2007 using brewer spectrophotometer. Bandung is an urban area and a capital city of West Java province where rapid development of trading, tourism and industrial activities has declined its air quality. Diurnal variability of total ozone column showed its minimum around 11:00 AM …

Atmospheric Temperature Tides In The Tropical Upper Troposphere And Lower Stratosphere, Takatoshi Sakazaki

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

Atmospheric thermal tides are global-scale waves with periods that are harmonics of a solar day, mainly excited by diurnally varying diabatic heating in the troposphere and the stratosphere. Some recent studies suggested that the tidal temperature variations in the TTL might affect the appearance of cirrus clouds and, thus, the dehydration process. It should be noted, however, that the global pattern of diurnal temperature variations in the TTL still remains unclear. In this study, we aim at revealing the 3D structure of diurnal temperature variations around the TTL, including its seasonal variations, by using data from global reanalyses for the …

Intraseasonal To Interannual Variations Of The Temperature Structure Around The Tropical Tropopause And Their Relationships With Convective Activities, Eriko Nishimoto

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

Space-time variability in the tropical tropopause temperatures and its relationship with convective activities are examined by using the ERA40/ERA-interim re-analysis and NOAA/OLR data sets. Low temperatures around the tropical tropopause generally occur over the equator and extend northwestward and southwestward in the subtropics to form the horseshoe-shaped structure. This structure resembles a stationary wave response known as the Matsuno-Gill pattern, which is a superposition of the Rossby and Kelvin responses. Because of this, the two preliminary indices are first defined to represent the two responses. The horseshoe-shaped structure index is then calculated from the two indices. The seasonal and interannual …

The Dehydration Process In The Tropical Tropopause Layer, Moe Yamaki

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

Water vapor contributes to the radiation budget of earth and the photochemistry of ozone. Therefore, it is important to understand the variation of water vapor in the research of global warming and ozone depletion. Noting that the saturation water vapor mixing ratio in the Cold-Point Tropopause (CPT) is not always a good estimate of water amount entering the stratosphere, Selkirk et al. (2010) defined the Tropopause Saturation Layer (TSL) using the cryogenic frostpoint hygrometer data taken in the tropical eastern Pacific during Northern Hemisphere summer. In the present study, the effectiveness of TSL is examined by using the SOWER data …

Testing The Role Of Radiation In Determining Tropical Cloud Top Temperature, Bryce Harrop

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

Tropical anvil clouds that detrain near the mixing barrier near 13km in the tropics have a strong effect on the longwave and shortwave energy budgets of Earth. A cloud-resolving model is used to test the Fixed Anvil Temperature (FAT) Hypothesis proposed by Hartmann and Larson (2002). Results show that the radiative cooling, primarily due to water vapor, is the strongest control of the anvil cloud detrainment temperature. Water vapor concentrations are largely controlled by temperature, so, following the FAT hypothesis, the cloud detrainment should follow a fixed temperature. The results also show, however, that ozone contributes a significant heating rate …

Cirrus And Water Vapor Transport In The Tropical Tropopause Layer: A Modeling Study, Tra Dinh

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

In simulations of tropical-tropopause-layer (TTL) cirrus forced by a large-scale equatorial Kelvin wave, we show that the radiatively induced mesoscale dynamics in these clouds actively contributes to vertical transport of water vapor. In a typical TTL cirrus, the heating that results from absorption of radiation by ice crystals induces a mesoscale circulation. Advection of water vapor by the radiatively induced circulation leads to upward advection of the cloudy air. Upward advection of the cloudy air is equivalent to upward transport of water vapor when the air above the cloud is drier than the cloudy air. On the other hand, ice …

Analysis Of The Tropical Tropopause Layer Using The Global Nonhydrostatic Atmospheric Model, Hiroyasu Kubokawa

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

No abstract provided.

Analysis Of The Ttl Cirrus And Their Convective Origin - A Water Perspective, Tao Wang, Andrew Dessler

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

Two mechanisms are thought to be primarily responsible for the formation of cirrus in the Tropical Tropopause Layer (TTL): detrainment from deep convective anvils and in situ initiation. By analyzing water vapor measurements from the Aura Microwave Limb Sounder (MLS) and ice water content measurements from the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO), we identify TTL cirrus that contain too much ice to have been formed in situ—and therefore must be of convective origin. Analyzing 3 years of CALIPSO measurements (2008–2010), we found three maxima in the occurrence of convective cirrus: equatorial Africa, the tropical western Pacific, and …

The Representation Of The Ttl In A Tropical Channel Version Of Wrf Model, Stephanie Evan

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

In this study, the Weather Research Forecast (WRF) model is used to investigate key physical processes controlling the Tropical Tropopause Layer (TTL) temperature and water vapor distributions in December-January-February (DJF) 2006. The model domain is configured as a tropical channel with a horizontal grid-spacing of 37 km, a vertical grid-spacing of 500 m and a top at 0.1 hPa. Initial and boundary conditions are set using European Centre for Medium-Range Weather Forecasts (ECMWF) Reanalysis Interim data. An ozone distribution computed from satellite and ozonesonde measurements is used for radiative forcing calculations.

The modelʼs ability to replicate observed TTL temperature variability …

Water Vapor And Cloud Formation In The Ttl: Simulation Results Vs. Satellite Observations, Tao Wang, Andrew Dessler, Mark Schoeberl

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

Driven by analyzed winds and temperature, domain-filling forward trajectory calculations are used to reproduce water vapor and cloud formations in the tropical tropopause layer (TTL). As with most Lagrangian models of this type, excess water vapor is instantaneously removed from the parcel to keep the relative humidity with respect to ice from exceeding a specified (super) saturation level. The dehydration occurrences serve as an indication of where and when cloud forms. Convective moistening through ice lofting and gravity waves are also included in our simulations as mechanisms that could affect water vapor abundances and cloud formations in the TTL. Our …

Constraining Middle Atmospheric Mositure In Geos-5 Using Eos-Mls Observations, Jianjun Jin

U.S. - Japan Bilateral Workshop on the Tropical Tropopause Layer: State of the Current Science and Future Observational Needs

No abstract provided.