Digital Commons Network^™

Robust Computational Tools For Multiple Testing With Genetic Association Studies, William L. Welbourn Jr.

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The mapping of the human genome and the completion of the Human HapMap project over the past decade have significantly altered how research is conducted with respect to the genetic epidemiology of human disease. Study designs and analytic approaches have evolved rapidly from investigations involving relatively few targeted candidate genes to hypothesis-free genome-wide association studies, where thousands – and now even millions – of single molecular mutations are simultaneously analyzed to identify regions of the genome that may influence disease. As laboratory techniques continue to improve and costs decrease, the volume of genetic data will inexorably rise, and robust tools …

Genetic Diversity And Genetic Structuring At Multiple Spatial Scales Across The Range Of The Northern Leopard Frog, Rana Pipiens, Ryan P. O'Donnell

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Genetic diversity is the raw material for evolution: evolution cannot happen without genetic diversity, and the ability of a population to respond to a changing environment depends directly on how diverse its genes are. Understanding the distribution of genetic diversity is important for many reasons, including predicting whether species will be able to adapt to climate change and predicting the spread of invasive species. Information about the distribution of genetic diversity across the range of the Northern Leopard Frog, a declining species, will not only help us to ensure that the species can continue to evolve in response to changing …

A Demographic Evaluation Of Increasing Rates Of Suicide Mortality In Japan And South Korea, Sun Young Jeon

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

According to a World Health Organization report, about one million people die by suicide each year. Fortunately, rates of suicide mortality have been decreasing
among most of the OECD countries, but Japan and South Korea are the only two exceptions to this trend, which has shown increasing suicide rates over the last 25
years. A number of studies have focused on psychological motives and individual-level causes of suicide, such as depression, mental disorder, and disability. However,
as Durkheim pointed out, suicide in a society does not have any obvious relationship to the prevalence of mental disorder. With his theory indicating …

An Investigation Of Trypanosoma Brucei Hexokinases: Localization, Oligomerization, And Inhibition, April Joice

All Dissertations

Trypanosoma brucei is the causative agent of African sleeping sickness in humans and nagana in livestock. The parasite inhabits multiple environmental niches including the bloodstream of the mammalian host and the mid-gut of the tsetse fly vector. While in the bloodstream of its mammalian host, the organism depends solely on glycolysis for production of ATP. My studies focus on the first enzyme in glycolysis, hexokinase.
T. brucei has two hexokinases, TbHK1 and TbHK2 that are 98.5% identical at the nucleotide level. The hexokinases are expressed in the glycosomes of both procyclic form and bloodstream form parasites. Glycosomes are peroxisome-like organelles …

Infiltrating Ductal Carcinoma Of Breast Presenting As Areolar Dermal Lesion, Gulnaz Shafqat, Shaista Khan, Khurram Minhas, Shaista Afzal

Department of Radiology

Infiltrating ductal carcinoma is the most common form of invasive breast cancer. It accounts for 80% of all types of breast cancer. We report an unusual presentation of histologically proven case of infiltrating ductal carcinoma of breast presented clinically as a small palpable areolar dermal lesion. Well defined hypoechoic cystic lesion in areolar dermis was present on ultrasound with a negative mammogram.

Lameness Associated With A Possible Neural Problem In The Lower Spinal Cord Of Chickens, Gallus Gallus, Gurueswar Nagarajan

Graduate Theses and Dissertations

Since the second half of the twentieth century lameness in broiler chickens has been known to be caused by different types of disorders, however the etiology of several type of lameness remain unknown. Because of the intense selection of broilers for rapid growth, some birds are more prone to physiological insults resulting in lameness. This study focuses on possible neural problems in the lower spinal cord associated with lameness in broilers. Broilers were raised in pens with wire floors and provided with food and water ad libitum. Three groups of birds 1) birds displaying a normal gait (Controls), 2) lame …

Whores & More: Selected Stories By Hernán Migoya, Nikki Noreen Settelmeyer

Graduate Theses and Dissertations

This is a collection of short stories written by Hernán Migoya from the books, Todas putas and Putas es poco. The stories have been translated from the original Spanish to English. The selected stories demonstrate the humor, style, and neurosis typical of Migoya's writing.

Effects Of Respiratory Vaccination Timing And Hormonal Growth Implant On Health, Performance, And Immunity Of Newly Received Stocker Calves, Kimberly Denise Poe

Graduate Theses and Dissertations

Stress alters the immune system and vaccination during this time may reduce vaccine response; whereas, growth implants may shift metabolism to enhance tissue deposition in exchange for energy required for immune response during bovine respiratory disease (BRD) challenge. This study was conducted to determine the effects of pentavalent respiratory vaccination timing with or without a hormonal growth implant on arrival (d 0) on health, performance, complete blood count, and vaccine response in high&ndashrisk, newly received stocker calves during a 42&ndashd receiving period. Crossbred bull and steer calves (n = 385) were weighed (initial BW = 202 ± 4.1 kg), stratified …

Anxiety In Children/Youth With Bowel And Bladder Dysfunction And Their Parents: Impact Of Medical, Educational, And Psychosocial Factors, Leslie Cristen Lavergne

Dissertations

Children and youth with special health care needs are impacted both physically and psychologically by their medical condition. Furthermore, parents of children with special health care needs experience increased symptoms of anxiety related to their child’s condition. Literature suggests the negative impact may be lessened by providing psychosocial family-centered supports. This study investigated the anxiety levels of children with bowel and/or bladder dysfunction and their parents, finding the relationships of anxiety among mothers and child/youth, as well as mothers and fathers. No significant relationship was found among fathers and child/youth. Further, it explored the impact of medical, educational, and psychosocial …

Using Archaeological Methods In Cemetery Surveys With Emphasis On The Application Of Lidar, Sarah L. Weitman

College of Graduate Studies: Theses & Dissertations

Cemeteries are important components of history. Surveying cemeteries is a good way to not only keep track of the information that cemeteries contain, but it also can provide a professional, systematic and standardized way of recording information and presenting it to the public. The preservation of cemeteries through recording information from the gravestones remains an important task that needs to be undertaken. Preservation, in this context, refers to having a comprehensive record of the gravestone data and maps of the gravestone locations to aid those who seek to garner information from the cemetery as well as preventing the loss of …

Interaction Of Environmental B. Cenocepacia Strains With Cystic Fibrosis And Non-Cystic Fibrosis Bronchial Epithelial Cells In Vitro., Annamaria Bevivino, Luisa Pirone, Ruth Pilkington, Noemi Cifani, Claudia Dalmastri, Máire Callaghan, Fiorentina Ascenzioni, Siobhan Mcclean

Articles

Burkholderia cenocepacia is an important human pathogen in patients with cystic fibrosis (CF). Non-clinical reservoirs may play a role in the acquisition of infections, so it is important to evaluate the pathogenic potential of environmental B. cenocepacia isolates. In this study, we investigated the interactions of two environmental B. cenocepacia strains (Mex1 and MCII-168) with two bronchial epithelial cell lines,16HBE14o- and CFBE41o-, which have a non-CF and a CF phenotype, respectively.

The environmental strains showed a significantly lower level of invasion into both CF- and non-CF cells in comparison with the clinical B. cenocepacia LMG16656^T strain. Exposure of polarized …

Social And Contextual Factors That Influence Hiv Risk Behaviors Among Indigenous Msm In The Peruvian Amazon, Isaac E. Alva, E. Roberto Orellana

School of Social Work Faculty Publications and Presentations

Men who have sex with men (MSM) face a significantly higher risk of HIV infection than the general population around the globe. In Peru, HIV prevalence among MSM range from 14% to 23%, with Lima, the capital, and port cities in the Amazonian region being the most affected. Recent studies found that indigenous MSM who leave their villages for cities along the Amazon River and its tributaries, engage in high risk behaviors such as high alcohol consumption and unprotected sex with mestizo (non- indigenous) MSM. This study examined social and contextual factors associated with risky behaviors among indigenous MSM in …

A Multiple Streams Approach To Bioterrorism Policy, Craig Reeder

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Bioterrorism is not a new phenomenon and the issues that surround bioterrorism are complex. This paper focuses on the history of bioterrorism, its current threat in public view, and then applying a theory in which explains how those problems became issues in government. The paper starts by examining a historical account of bioterrorism. The history serves a purpose to discuss the ongoing developments and struggles of drafting legislation for an ongoing problem.

After a discussion of bioterrorism from a historical perspective, the paper examines the current threat or state of bioterrorism. This will lead into a discussion about John Kingdon’s …

The Traditional Roles Of Caring For Elders: Views From First Nations Elders Regarding Health, Violence, And Elder Abuse, Eileen A. Owen-Williams

Theses and Dissertations (ETD)

This study sought to respectfully understand Northern British Columbia First Nations Elders' views regarding health of communities, intergenerational relationships, Elder roles, and violence towards Elders. Injuries, both intentional and unintentional, are a leading cause of death for First Nations Peoples. Information regarding Elder abuse in First Nations communities is lacking, though family violence has been identified as a problem within First Nations communities. The goal of this research was to understand the point of view and Elders' reality through the creation of a dialogue with Elders, and to discern the interface between Traditional First Nations' belief systems, healing methods, and …

The Delivery System Design Of A Community Mental Health Center And Provision Of Quality: Cardiometabolic Screening For Persons With A Severe Mental Illness Prescribed Atypical Antipsychotic Medication, Dawn Marie Vanderhoef

Theses and Dissertations (ETD)

Background: Persons with a severe mental illness (SMI) prematurely lose up to 25 years of life when compared to the general population. This patient population has increased morbidity and mortality due to higher than normal rates of obesity, hypertension, diabetes, and cardiovascular disease. Treatment of SMI often includes the use of atypical antipsychotic (AA) medication which has been associated with the development of cardiometabolic illnesses. In response to the higher rates of co-morbid, chronic physical illness, monitoring guidelines for cardiometabolic illness have been published. Despite these guidelines, screening rates for cardiometabolic illness in this population remain low. Neither community mental …

Clam (Corbicula Fluminea) As A Potential Sentinel Of Human Norovirus Contamination In Freshwater, Xunyan Ye

Dissertations

The purpose of this study was to evaluate and validate the use of the clam Corbicula fluminea as a sentinel of human noroviruses (HuNoV) contamination in freshwater. The first specific aim was to develop a new method to extract HuNoV RNA from contaminated bivalves (e.g. oysters, clams) that would be much faster than existing methods. The procedure developed includes an initial total RNA extraction using TRI Reagent, followed by HuNoV RNA concentration and purification using biotinylated probe-capture technology. HuNoV RNA is finally detected by real-time RT-PCR. Using bivalve homogenates spiked with HuNoV, 100 PCR detection units of the virus was …

India's Efforts In Open Access Publishing, Bhaskar Mukherjee, Bidyut Kumar Mal

Library Philosophy and Practice (e-journal)

Introduction

For a long time, India has been generating a great deal of scholarly resources in all disciplines. After independence, there was a lot of investment in science and technology, and S&T were used to leverage development efforts and to improve the standard of living. However, one in four Indians still lives below the poverty line. There is a considerable research effort in a wide variety of areas including science, technology, medicine, humanities and social sciences. Research is performed essentially in three sectors: (1) higher educational institutions, such as universities and deemed universities (2) laboratories under different government agencies such …

Differences In Quality Environmental Rating Subscales Between Family Child Care Homes And Facilities In West Virginia, Kaitlin J. Buchanan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Quality of family child care homes and facilities in the state of West Virginia was investigated for differences in quality and provider education and training. Data was collected through the West Virginia Department of Health and Human Resources grant titled, "Quality Rating and Improvement for West Virginia Child Care." Quality was measured using the Family Child Care Environmental Rating Scale (FCCERS), which has 38 items across 7 subscales including aspects specific to the family child care setting. Twenty-nine family child care facilities and 55 family child care homes participated in the study. Family child care homes scored lower than facilities …

War And Terrorism Risk Insurance, Helen M. Benzie

Journal of Civil Rights and Economic Development

No abstract provided.

New York Public Health Law § 2500-F: The Hand That Robbed The Cradle Of Privacy, Gina A. Angelletta

Journal of Civil Rights and Economic Development

No abstract provided.

War And Medicine At The Canadian War Museum, Andrew Burtch, Tim Cook

Canadian Military History

War and Medicine is the Canadian War Museum’s major summer exhibition. War and Medicine provides an unflinching look at the relationship between medical practice and military operations over the past 150 years. It comprises more than 300 artifacts, images, and works of art from the Museum’s National Collection and 50 lenders in Europe and North America. The exhibition is open until 13 November 2011.

Development Stage-Specific Proteomic Profiling Uncovers Small, Lineage Specific Proteins Most Abundant In The Aspergillus Fumigatus Conidial Proteome, Moo-Jin Suh, Natalie D. Fedorova, Steven E. Cagas, Susan Hastings, Robert D. Fleischmann, Scott N. Peterson, David S. Perlin, William C. Nierman, Rembert Pieper, Michelle Momany

Biochemistry and Molecular Medicine Faculty Publications

Background

The pathogenic mold Aspergillus fumigatus is the most frequent infectious cause of death in severely immunocompromised individuals such as leukemia and bone marrow transplant patients. Germination of inhaled conidia (asexual spores) in the host is critical for the initiation of infection, but little is known about the underlying mechanisms of this process.

Results

To gain insights into early germination events and facilitate the identification of potential stage-specific biomarkers and vaccine candidates, we have used quantitative shotgun proteomics to elucidate patterns of protein abundance changes during early fungal development. Four different stages were examined: dormant conidia, isotropically expanding conidia, hyphae …

Engineering Of Polyamidoamine (Pamam) Dendrimers For Gene And Drug Delivery, Quan Yuan

Theses and Dissertations

Dendrimers are a class of polymers with a highly branched, three-dimensional architecture composed of an initiator core, several interior layers of repeating units and multiple surface groups. They have been recognized as the most versatile compositionally and structurally controlled nanoscale building blocks throughout the fields of engineering, materials science, chemistry, and biology, and they have been widely investigated for drug and gene delivery. Polyamidoamine (PAMAM) dendrimers have inherent properties for gene delivery because of their high buffering capacity, polycationic surface and numerous surface groups for biofunctionlization. This dissertation is organized into four independent sections. The first section investigates a series …

Activation Of An Nlrp3 Inflammasome Restricts Mycobacterium Kansasii Infection, Chang-Chieh Chen, Sheng-Hui Tsai, Chia-Chen Lu, Shiau-Ting Hu, Ting-Shu Wu, Tsung-Teng Huang, Najwane Saïd-Sadier, David M. Ojcius, Hsin-Chih Lai

All Dugoni School of Dentistry Faculty Articles

Mycobacterium kansasii has emerged as an important nontuberculous mycobacterium pathogen, whose incidence and prevalence have been increasing in the last decade. M. kansasii can cause pulmonary tuberculosis clinically and radiographically indistinguishable from that caused by Mycobacterium tuberculosis infection. Unlike the widely-studied M. tuberculosis, little is known about the innate immune response against M. kansasii infection. Although inflammasome activation plays an important role in host defense against bacterial infection, its role against atypical mycobacteria remains poorly understood. In this report, the role of inflammasome activity in THP-1 macrophages against M. kansasii infection was studied. Results indicated that viable, but not heat-killed, …

Microbiological Profile Of Neonatal Septicemia, Sinan Abdulrazzaq Ibrahim

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND : Neonatal septicemia is a major cause of morbidity and mortality in developing countries. OBJECTIVE: The study is to determine the prevalence , the pattern of organisms and the mortality of neonatal septicemia in a neonatal care unit. PATIENTS AND METHODS: All the cases of neonatal septicemia diagnosed and treated in the neonatal care unit at al-kadimiya teaching hospital for the period january-june 2010 were included in this study. The collected data were : Gender, Birth weight, Gestational age, Onset of sepsis, Place of delivery and Outcome of disease. RESULTS: Out of 589 newborns admitted, 73(12.4%) were confirmed …

Association Of Helicobacter Pylori And Nasal Polyposis, Abbasi, Ahmed Muhamad Ai

Iraqi Postgraduate Medical Journal

ABSTRACT : BACKGROUND: Helicobacter pylori is recognized as an important human pathogen by virtue of its association with peptic ulcer disease , gastric cancer , gastric lymphoma and high prevalence of infection worldwide. Recently this organism was detected in tonsil and adenoid tissue after adenotonsillectomy , as well as in mucosa of patients with chronic rhinosinusitis , but its association with simple nasal polyposis has not been investigated yet in our country . OBJECTIVE: To investigate a possible contribution of Helicobacter pylori (H.pylori) in the etiopathogenesis of simple nasal polyps . Study Design: Prospective clinico –pathological investigation. METHODS : Twenty …

The Seroprevalence Of Igm Among Iraqi Aborted Women Infected With Human Cytomegalovirus, Maysara S.Khalf

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Fetal loss and abortion are responsible for significant emotional distress for couples desiring children. There are many documents which support the role of some certain asymptomatic infections such as Cytomegalovirus (CMV) in spontaneous abortion. OBJECTIVE: This study was aimed to evaluate the prevalence of seropositivity of specific IgM antibody for CMV by ELISA in the sera of (108) women with recurrent abortion associated with obstetric complications. METHODS: This study was carried out in two central hospital in Baghdad (Al-Elwea& Baghdad teaching hospitals )during (2009-2010).A number of (108) women with definite diagnosis of previous abortion ,35women with recurrent abortion …

The Study Of Antibacterial Activity Of Plantago Major And Ceratonia Siliqua, Basma Monjd Abd Razik

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Antibiotics are generally beneficial in treating susceptible microbial infections but such beneficial effects are counter balanced by rampant irrational use. In fact, the misuse of antibiotics leads to the emergence of antibiotic-resistant bacteria. On the other hand, the consumption of foods contaminated with some pathogenic microorganisms represents a serious health risk to humans. OBJECTIVE: Therefore the present study describes the comparison of antibacterial activity between two plants which are known traditionally by their biological activities and used in Iraqi folk medicine as antidiarrheal. METHODS: Agar – well diffusion method tested antibacterial activities of methanolic crud extracts with different …

Incidence Of Bronchiolitis In Breast Fed Infants Below 2, Haider Nadhim Abd

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Acute viral bronchiolitis is a common respiratory infectious disease of children. OBJECTIVE: To study the relationship between bronchiolitis and breastfeeding in children below 2 years of age. MATERIAL AND METHODS: A prospective study was carried out with100 child aged up to 24 months to evaluate their breastfeeding status as possible risk factors for unfavourable evolution in department of pediatric in AL-Kahdimiya Teaching Hospital during the period from first of October 2008 to the end of March 2009. RESULTS: Hundred cases of bronchiolitis were included in this study. Most of them ( 78 %) were below one year. Male …

Stop Federalism Before It Kills Again: Reflections On Hurricane Katrina, Stephen M. Griffin

Journal of Civil Rights and Economic Development

No abstract provided.