Digital Commons Network^™

Clinical And Demographic Correlates Of Depression In Stable Heart Failure, Beth Heaney

Yale School of Nursing Digital Theses

In this secondary analysis of cross sectional data collected from 173 patients with chronic HF the demographic, clinical, and sleep related factors present in patients with stable HF and major depressive disorder (MDD) were explored. Participants were recruited from 5 structured HF disease management programs in the Northeastern US. Measures include the Centers for Epidemiological Studies Depression Scale (CESD), the Charlson Comorbidity Index (CCI), and a sleep diary. Results indicate significant between group differences between patients with MDD and without MDD in age, gender, NYHA, diabetes, chronic fatigue, asthma, past psychiatric history, antidepressant use, anxiolytic use, insomnia, and taking sleeping …

Influence Of Previous Cesarean Section On Clinical Outcome Of Medication Abortion, Lauren Pellegrino

Yale School of Nursing Digital Theses

A retrospective chart review was conducted to assess for a relationship between previous Cesarean section delivery and failure of subsequent medication abortion. Several studies have shown a positive relationship between parity and failure of subsequent medication abortion; however, these studies did not isolate method of delivery (Cotte, Monniez, and Norel 2008; Ashok, Templeton, Wagaarachchi, & Flett, 2002; Niinimäki, Martikainen, and Talvensaari-Mattila, 2004; Bartley, Tong, Everington, & Baird, 2000). The sample was 196 women who underwent medication abortion and returned for a two week follow-up appointment at an urban women's health clinic during 2005-2010. The protocol for medication abortion was 200mg …

Alcohol Use In Inpatient Psychiatric Clinicians, Lauren Fiola

Yale School of Nursing Digital Theses

Employee alcohol use is an important public health problem that has not been adequately studied. This may be due to stigma, privacy, and ethical issues associated with uncovering problematic drinking behavior in the workplace. The present study sought to estimate the current prevalence of self-reported alcohol use in 59 inpatient psychiatric clinicians. Results indicated that 66.1% report current alcohol use, 30.5% report binge drinking episodes, 11.9% report harmful or hazardous alcohol use, and 10.2% report a history of an alcohol problem. In adjusted logistic regression models, non-white ethnicity suggested harmful or hazardous alcohol use (OR = 5.57, 95% CI [0.84, …

Assessing Cardiovascular Disease Risk In Women Newly Diagnosed With Breast Cancer, Ashleigh Kristina Smith

Yale School of Nursing Digital Theses

This prospective, descriptive study was designed to explore the baseline cardiovascular disease (CVD) risk factors of women newly diagnosed with breast cancer prior to receiving treatment with anthracyclines and/or trastuzumab. Women diagnosed with breast cancer are at risk for developing CVD and may experience increased risk factors related to breast cancer diagnoses and treatments. The specific aim was to determine baseline cardiovascular risk through the use of the Framingham General Cardiovascular Risk Assessment Score (FGCVRAS) calculation and heart/vascular age calculation. Subjects included 30 women (mean age 49.97). Mean FGCVRAS was 5.58% (SD 5.68), and mean heart/vascular age was 49.62 years …

Anticholinergic Impact On Cognition In Schizophrenia, Catherine Underwood

Yale School of Nursing Digital Theses

This secondary analysis examined the relationship between the total anticholinergic load and scores on cognitive tests in 94 patients diagnosed with schizophrenia or schizoaffective disorder. Cognitive impairment is a core feature of schizophrenia, and studies have shown that it is a strong predictor of functional outcomes in this population. Anticholinergic medications have been demonstrated to have a negative impact on cognition. Some antipsychotic medications have anticholinergic properties, and anticholinergic medications are often prescribed to patients with schizophrenia to treat or prevent extrapyramidal side effects of antipsychotics. We did not find any significant correlations between anticholinergic load as measured by benztropine …

Medication Administration In Child Care: A Comparison Of State Child Care Center Regulations With National Health And Safety Standards, Sarah Viall

Yale School of Nursing Digital Theses

The purpose of this thesis was to review the 50 state and D.C. child care center regulations (N=51) and compare with medication administration standards in Caring for Our Children (CFOC)- National Health and Safety Performance Standards: Guidelines for Out-of-Home Child Care Programs, 3rd edition (CFOC). A data collection instrument, which included the seven standards directly related to medication administration in early care and education programs (ECE), was developed and reviewed by a team of national experts to measure compliance of state regulations with the standards. None of the states' regulations (N=51) met the criteria for all seven standards. Most of …

Retention Of Knowledge By Nurses After An Online Ecg Monitoring Course, Hui Wu

Yale School of Nursing Digital Theses

This thesis is a sub-study of the large study PULSE Trial. Nurses need to have sufficient knowledge to carry out high quality patient care and to produce good patient outcome. Preliminary study of the PULSE Trial has shown that nurses' ECG monitoring knowledge can improve after taking the online ECG course. This study aims to determine the retention of knowledge 1-2 years after the course and to identify factors associated with better knowledge retention. The sample of the study consists of the nurses who participated in all the three phases of the PULSE Trial. This includes 504 individual nurses, with …

Redefining Onyx Hd 500 In The Flow Diversion Era., Richard Tyler Dalyai, Ciro Randazzo, George Ghobrial, L Fernando Gonzalez, Stavropoula I Tjoumakaris, Aaron S Dumont, Robert H Rosenwasser, Pascal Jabbour

Department of Neurosurgery Faculty Papers

We report the largest US case series results using Onyx HD-500 (EV3), a new liquid embolic agent, in the successful treatment of 21 patients with wide-neck intracranial aneurysms (mean size 4.5 mm), which are at increased risk of incomplete occlusion or recanalization with standard endovascular intervention utilizing detachable platinum coils. All aneurysms were located in the anterior circulation, and three aneurysms presented as acute subarachnoid hemorrhages. Complete aneurysm occlusion was present in 19 of 21 patients (90%). On six-month followup, one patient with an initially small residual neck progressed to total occlusion. Aneurysm recanalization was not detected in any patients …

Emerging Microbial And Viral Infections Of The Central Nervous System, Brian J. Balin, Christine J. Hammond

PCOM Scholarly Works

This review focuses on emerging viral and bacterial infections in the human central nervous system (CNS) that are responsible for significant global morbidity and mortality. These infections include those responsible for acute neurological disease such as meningitis and encephalitis as well those associated with chronic neurodegenerative conditions. Recent changes in climate conditions and pollution have been precipitating factors leading to the emergence of many of these pathogenic organisms. In addition, increased urbanization, global travel, life span, and exposure to new vectors have promoted the organisms’ spread across the globe. Categorization of many of these organisms includes identification of new species, …

Curcumin Nanoformulations: A Future Nanomedicine For Cancer, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

Curcumin, a natural diphenolic compound derived from turmeric Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion, apoptosis and cell death, revealing its anticancer potential. In this review, we focus on the design and development of nanoparticles, self-assemblies, nanogels, liposomes and complex fabrication for sustained and efficient curcumin delivery. We also discuss the anticancer applications and clinical benefits of nanocurcumin formulations. Only a few novel multifunctional and composite nanosystem strategies offer simultaneous therapy as well as imaging characteristics. We also summarize the challenges to developing curcumin delivery platforms and …

Green Transportation For A Green Earth, Petros J. Katsioloudis, Mildred V. Jones

STEMPS Faculty Publications

Transportation is one of the biggest contributors to the destruction of the environment. Results from environmental research and pursuant governmental regulations are changing the way companies do business and how transportation systems address the future. The Environmental Protection Agency (EPA) has been at the forefront in leading environmental research and instituting policies and regulations to fight the issues impacting the environment. The transportation industry and consumers alike are concerned about the environment, energy resources, efficiencies, and economics. In this article, the authors suggest that it is vital that people promote the protection of the environment and strengthen the laws that …

Temperature Mapping Study Of United States Distribution Systems, Ken Silverman

Theses

The purpose of this one-year temperature mapping study was to determine the extreme temperatures and respective durations commercial pharmaceutical products are expected to be exposed to during routine ambient distribution within the continental United States. Extreme temperature conditions may affect the safety and efficacy of pharmaceutical products during distribution. Knowing the value and duration of the extreme temperatures that products are likely to experience in the ambient (uncontrolled) distribution environment allows for improved product degradation testing, optimized thermal package design and scientifically based determination as to when logistical and environmental controls should be used. Before this study, testing was performed …

Structural Properties Of Thermoresponsive Poly(N-Isopropylacrylamide)-Poly(Ethyleneglycol) Microgels, J. Clara-Rahola, A. Fernandez-Nieves, B. Sierra-Martin, A. B. South, L. Andrew Lyon, J. Kohlbrecher, A. F. Barbero

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The application of RNA interference to treat disease is an important yet challenging concept in modern medicine. In particular, small interfering RNA (siRNA) have shown tremendous promise in the treatment of cancer. However, siRNA show poor pharmacological properties, which presents a major hurdle for effective disease treatment especially through intravenous delivery routes. In response to these shortcomings, a variety of nanoparticle carriers have emerged, which are designed to encapsulate, protect, and transport siRNA into diseased cells. To be effective as carrier vehicles, nanoparticles must overcome a series of biological hurdles throughout the course of delivery. As a result, one promising …

An In Vitro Comparative Study Of Intracanal Fluid Motion And Wall Shear Stress Induced By Ultrasonic And Polymer Rotary Finishing Files In A Simulated Root Canal Model, Jon Koch, John Borg, Abby Mattson, Kris Olsen, James Bahcall

Mechanical Engineering Faculty Research and Publications

Objective. This in vitro study compared the flow pattern and shear stress of an irrigant induced by ultrasonic and polymer rotary finishing file activation in an acrylic root canal model. Flow visualization analysis was performed using an acrylic canal filled with a mixture of distilled water and rheoscopic fluid. The ultrasonic and polymer rotary finishing file were separately tested in the canal and activated in a static position and in a cyclical axial motion (up and down). Particle movement in the fluid was captured using a high-speed digital camera and DaVis 7.1 software. The fluid shear stress analysis was …

A Critical Review Of The Mandatory Reporting Protocol, Elayne M. Tanner

Theses and Dissertations (Comprehensive)

Mandatory reporting, although originally enacted to serve the single purpose of protecting vulnerable children from abuse, has been considered for ever expanding purposes. As a policy stance, mandatory reporting is frequently considered to support those socially sanctioned behavioural standards developed to regulate social institutions such as marriage, child rearing, aging and work. Although always embracing an inherent element of protection, a careful balance must be negotiated because mandatory reporting obligations also risk compromising the very rights that are the cornerstones of the social work profession, those of autonomy, confidentiality and self-determination. This research explored the mandatory reporting protocol specifically questioning …

Nsu Center For Psychological Studies: Master's Programs In Counseling: Policies And Procedures Handbook 2012–2013, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.

Enhancing Elementary School Prevention Program Implementation Through Influential Contextual Factors, Alice Schmidt Hanbidge

Theses and Dissertations (Comprehensive)

A current gap in the literature exists with regard to formulating a holistic view of contextual factors involved in school-based prevention programming implementation. The purpose of this grounded theory study is to further explore how multilevel ecological and cross-system factors influence prevention program implementation. This study builds on development of a theory to guide the practices for preventive program implementation with fidelity. The Integrated Program (IP) conceptual framework, initiated in an earlier paper (Schmidt Hanbidge, 2009) identified key program contextual and motivational factors that critically influence prevention program implementation. Taken from an ecological perspective, the IP framework incorporates multi-levels of …

Vibrio Parahaemolyticus In Rhode Island Coastal Ponds And The Estuarine Environment Of Narragansett Bay, Annie M. Cox, Marta Gomez-Chiarri

Graduate School of Oceanography Faculty Publications

Quantification of the abundance of Vibrio parahaemolyticus in water and oysters from Rhode Island showed the presence of environmental strains and low levels of potentially pathogenic strains when water temperatures were ≥18°C, with peak levels in late July to early August. A higher abundance of the trh gene than of the tdh gene was observed.

A Selective Force Favoring Increased G+C Content In Bacterial Genes, Rahul Raghavan, Yogeshwar D. Kelkar, Howard Ochman

Biology Faculty Publications and Presentations

Bacteria display considerable variation in their overall base compositions, which range from 13% to over 75% G+C. This variation in genomic base compositions has long been considered to be a strictly neutral character, due solely to differences in the mutational process; however, recent sequence comparisons indicate that mutational input alone cannot produce the observed base compositions, implying a role for natural selection. Because bacterial genomes have high gene content, forces that operate on the base composition of individual genes could help shape the overall genomic base composition. To explore this possibility, we tested whether genes that encode the same protein …

Psychological Evaluation Of Parenting Capacity In Child Welfare Proceedings, Katherine L. Rosenblum, Joshua B. Kay

Articles

In the child welfare context, courts, attorneys, and child protection agencies often turn to psychologists to evaluate parenting capacity. As evaluators in child protection cases, psychologists may be asked to evaluate different parties for different purposes, acting as agents of the court, the child protection agency, or directly retained by the parents or the lawyer guardian ad litem. In this article we focus specifically on psychological evaluations addressing issues pertaining to parenting capacity (in contrast to, for example, assessments that focus solely on child psychological well-being or developmental status). These types of assessments may help to inform dispositional decisions, including …

Do Boumediene Rights Expire?, Andrew Kent

Faculty Scholarship

In 2008, Guantanamo detainees won a landmark victory in Boumediene v. Bush, which held that the Congress and the President could not prevent the detainees from accessing the courts to seek release via habeas corpus. The Court decided that persons claiming to be innocent civilians deserved a day in court, even though they were noncitizens held by the U.S. military as enemy combatants on foreign territory. The Court applied a fact-specific test that granted habeas rights to noncitizens outside the United States only when a balance of factors — including citizenship, enemy status, the nature of status review procedures, the …

An Epidemiological Model Of Rift Valley Fever With Spatial Dynamics, Tianchan Niu, Holly D. Gaff, Yiannis E. Papelis, David M. Hartley

Biological Sciences Faculty Publications

As a category A agent in the Center for Disease Control bioterrorism list, Rift Valley fever (RVF) is considered a major threat to the United States (USA). Should the pathogen be intentionally or unintentionally introduced to the continental USA, there is tremendous potential for economic damages due to loss of livestock, trade restrictions, and subsequent food supply chain disruptions. We have incorporated the effects of space into a mathematical model of RVF in order to study the dynamics of the pathogen spread as affected by the movement of humans, livestock, and mosquitoes. The model accounts for the horizontal transmission of …

Proteomic Analysis Of The Highly Detergent Resistant Radial Component Of Myelin, Vatsal M. Patel

Theses and Dissertations (Comprehensive)

The wrapping of multiple layers of myelin membrane sheets around an axon plays an important role in normal neuronal function. In the central nervous system (CNS), oligodendrocytes are responsible for forming multiple myelin internodes which consist of lipids and proteins. Within these regions, there are various membrane microdomains including the radial component/tight junctions. The radial component is a junctional complex believed to stabilize the myelin membranes in the CNS myelin. In this study, the radial component from bovine and mouse myelin was isolated using differential detergent extraction. A highly detergent resistant fraction, containing previously identified proteins of the radial component …

Atr-Ftir Studies On The Kinetics Of Dimethylarsinic Acid (Dma) Surface Complexation With Iron(Oxyhydr)Oxides, Julia Tofan-Lazar Miss

Theses and Dissertations (Comprehensive)

Dimethylarsinic acid (DMA) is an organoarsenical compound that, along with monomethylarsonic acid, poses a health and an environmental risk, and a challenge to the energy industry. Little is known about the surface chemistry of DMA at the molecular level with materials relevant to geochemical environments and industrial sectors. The surface chemistry of phosphorus and arsenic compounds in their organic and inorganic forms is of great interest due to its role in controlling their transport, bioaccessibility and speciation. This thesis reports the first in-situ and surface-sensitive rapid kinetic studies on the adsorption and desorption of DMA to and from Fe-(oxyhydr)oxide films …

In Vitro Propagation Of Candidatus Rickettsia Andeanae Isolated From Amblyomma Maculatum, Alison Luce-Fedrow, Chelsea Wright, Holly D. Gaff, Daniel E. Sonenshine, Wayne L. Hynes, Allen L. Richards

Biological Sciences Faculty Publications

Candidatus Rickettsia andeanae was identified during an investigation of a febrile outbreak in northwestern Peru (2002). DNA sequencing from two ticks (Amblyomma maculatum, Ixodes boliviensis) collected during the investigation revealed a novel Rickettsia agent with similarity to the spotted fever group rickettsiae. Since then, Candidatus R. similar to andeanae has been detected in A. maculatum ticks collected in the southeastern and southcentral United States, Argentina, and Peru. To date, Candidatus R. andeanae has not been successfully cultivated in the laboratory. We present evidence for the continuous cultivation in three cell lines of Candidatus R. similar to …

The Effect Of Cadmium Exposure On Repeat Swimming Performance And Recovery In Rainbow Trout (Oncorhynchus Mykiss), Brown Trout (Salmo Trutta) And Lake Whitefish (Coregonus Clupeaformis), Jessie L. Cunningham

Theses and Dissertations (Comprehensive)

Swim performance provides a measure of the integrated metabolic costs of sub-lethal exposure to stressors, including Cd. While the impacts to sustained swimming performance in Cd exposed fish have already been characterised, effects to repeat swimming ability have not. This thesis identifies the effects of sub-lethal waterborne Cd exposure on ionoregulatory function, repeat swimming ability, anaerobic metabolism and stress response in rainbow trout (Oncorhynchus mykiss), brown trout (Salmo trutta) and lake whitefish (Coregonus clupeaformis).

Repeat swim trials included an initial swim to 85% of the U_crit of control fish and a recovery period …

The Effects Of 17Α-Ethynylestradiol (Ee2) On Gonadal Development And Differentiation In The Estuarine Killifish, Fundulus Heteroclitus, Ibrahim Chehade

Theses and Dissertations (Comprehensive)

Endocrine disrupting substances (EDSs) comprise a wide variety of chemicals that perturb normal endocrine function including developmental and reproductive processes in vertebrates. The synthetic estrogen 17α-ethynylestradiol (EE₂) is a commonly-used model EDS because of its environmental relevance and its effects on the reproductive endocrine system. Early life-stage exposure of fish to estrogenic EDSs causes effects such as intersex (ovotestes in males) and feminization. This study aims to confirm the period of gonadal differentiation in the estuarine killifish or mummichog (Fundulus heteroclitus) and to determine the sensitivity of gonadal development to EE₂. Artificially-regressed mummichog were spawned, and …

Effects Of 17Α-Ethinylestradiol (Ee2) On Reproductive Endocrine Status In Mummichog (Fundulus Heteroclitus) Under Differing Salinity And Temperature Conditions, Esteban Gillio Meina

Theses and Dissertations (Comprehensive)

Waterborne exposure to 17α-ethinylestradiol (EE₂), a synthetic estrogen, has previously been shown to decrease reproductive endocrine status in the estuarine killifish or mummichog (Fundulus heteroclitus macrolepidotus; northern subspecies). To evaluate if variations in salinity or temperature holding conditions modify the effects of EE₂ on gonad size, plasma reproductive steroid levels, and gonadal steroidogenesis, mummichog were exposed in vivo for 14 days to 0, 50 and 250 ng/L EE₂ in 0, 16 and 32 ppt salinity at 18°C and to 0 and 250 ng/L EE₂ at 10, 18 and 26°C at 16 ppt salinity. …

Poetry As The Handmaid Of Piety: Hymns As A Catalyst For Human Development In Early Methodism, Brian Yeich

The Asbury Journal

In the preface to the 1780 edition o f Hymns for the People Called Methodist, John Wesley stated, 'When Poetry thus keeps its place, as the handmaid of Piety, it shall attain, not a poor perishable 'Wreath, but a crown that fadeth not away."l While John Wesley may have never used the term ''human development," a student of Wesley would quickly observe that Wesley and the early Methodists were focused on the transformation of individual human lives as well as the society in which they lived. This paper explores the connection between the hynmody of early Methodism and …

The Chronic Toxicity Of Titanium Dioxide Nanoparticles To The Freshwater Amphipod Hyalella Azteca, Gurkirpal S. Malhi

Theses and Dissertations (Comprehensive)

There has been an increased use of metal-oxide nanoparticles in both commercial and consumer products. The use of these products and waste generated during manufacture may ultimately be released into the aquatic environment and the potential for these contaminants to cause impacts must be assessed. This study examines the effect of titanium dioxide (TiO₂) nanoparticles (NPs) on Hyalella azteca. Chronic toxicity exposures were conducted in 400mL of spiked test solution and contained 20 neonates. Samples collected for characterization of Ti in TiO₂ NP exposure solutions were digested using ammonium persulfate as an oxidizing agent and dissolved …