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Fiberoptic Intubation In A Paediatric Patient With Severe Temporomandibular Joint (Tmj) Ankylosis, Ali Asghar, Faisal Shamim, Asiyah Aman

Department of Anaesthesia

Craniofacial abnormalities are associated with mandibular hypoplasia, reduced mandibular space with overcrowding of soft tissues and maxillary hypoplasia. Decreased mouth opening and limitation in jaw protrusion are independent predictors of difficult airway in such patients. The relative difficult problem becomes even graver in the paediatric age group because of their small mouth opening and un-cooperativeness. A child with severe temporomandibular joint (TMJ) ankylosis presented with negligible mouth opening and required surgical correction under general anaesthesia. Successful intubation was performed with endotracheal tube size 5.5 mm using an adult 4.3 mm fiberoptic bronchoscope under inhalational as well as topical anaesthesia.

The Need And Justification For A General Competition-Oriented Compulsory Licensing Regime, Kung-Chung Liu

Research Collection Yong Pung How School Of Law

There seems to be little or no discussion about the need of and justification for a general compulsory licensing that could be applicable to all IP laws. This author has previously argued, by referencing to competition law, in 2008 that it is paramount for the WTO to revise the TRIPS Agreement, so as to include substantive grounds for granting compulsory patent licenses. In so doing, the preservation of competition should be factored in as one of the public policy objectives. As a follow-up study this paper takes an IP-internal approach (therefore will only consult competition law in a very limited …

Sociosexuality, Mate Preferences, And Sex Steroid Hormone Levels Among Breastfeeding Women In Manila, Michelle Escasa

UNLV Theses, Dissertations, Professional Papers, and Capstones

This project investigates the influence of lactation on female sociosexuality and mate preferences in urban Manila, a population with long-term breastfeeding, low contraceptive use, and quick return to ovulatory cycling. Physiological and evolutionary considerations suggest that lactating women face important life history allocation trade-offs between mating and parenting effort that may be manifest in their sociosexual behavior and mate preferences. Breastfeeding (n=155) and control (n=105) women were recruited to provide a saliva sample (for testosterone and estradiol analyses), complete a questionnaire, and complete a face and voice preference task to determine preferences for masculinity. Breastfeeding women reported differences in commitment …

Timeliness Of Electronic And Traditional Laboratory Reporting In Southern Nevada, 1999-2012, Jennifer Anne Lucas

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study compares the timeliness of Electronic Laboratory Reporting (ELR) with traditional reporting. ELR has been implemented in parts of the United States, and is perceived to be faster than traditional reporting. Faster reporting leads to faster public health response to prevent outbreaks, and to reduce the burden of infectious disease in communities. Nevada State law requires that diseases be reported within certain time frames. Timeliness of laboratory reporting at the Southern Nevada Health District (SNHD) from 1999-2012 was assessed by analyzing cases of four common diseases in this retrospective secondary analysis of extant data.

The difference in timeliness regarding …

Molecular Forensic Science Analysis Of Nuclear Materials, Dallas Reilly

UNLV Theses, Dissertations, Professional Papers, and Capstones

Concerns over the proliferation and instances of nuclear material in the environment have increased interest in the expansion of nuclear forensics analysis and attribution programs. A new related field, molecular forensic science (MFS) has helped meet this expansion by applying common scientific analyses to nuclear forensics scenarios. In this work, MFS was applied to three scenarios related to nuclear forensics analysis. In the first, uranium dioxide was synthesized and aged at four sets of static environmental conditions and studied for changes in chemical speciation. The second highlighted the importance of bulk versus particle characterizations by analyzing a heterogeneous industrially prepared …

Quantification Of Mixing In Microchannels, Vijaymaran Manickam

Graduate Theses, Dissertations, and Problem Reports (ETD)

Microchannels are used for delivery of two-or more fluids for multiple purposes, such as drug delivery, where good mixing is desired in a very short time (or distance). For this purpose, many design options are being proposed in the literature. For example herringbone baffles at the bottom of a rectangular channel are commonly proposed to enhance mixing in a drug delivery device. To assess the effectiveness of such devices many experiments need to be performed thus increasing the design cycle time and the cost involved. Computational fluid dynamics (CFD) can and is being used to shorten this design cycle by …

Parkinson Disease And Rehabilitation Administration And Services, Deanna Booker

Research Papers

No abstract provided.

Effect Of Catalase And Superoxide Dismutase On Motility, Viability And Acrosomal Integrity Of Canine Spermatozoa During Storage At 5๐c, Khongsak Thiangtum, Tatsuya Hori, Eiichi Kawakami

The Thai Journal of Veterinary Medicine

Preservation of canine spermatozoa at 5๐C is a helpful method for dog breeding management. However, in many species, oxidative damage due to generation of reactive oxygen species (ROS) and long term storage which specifically cause DNA damage, and lipid peroxidation during preservation techniques can cause a decline of sperm motility and fertility capacity. In this study, the effect of antioxidants catalase (CAT) and superoxide dismutase (SOD) on motility, viability and acrosomal integrity of chilled canine semen were investigated. Semen was collected by digital manipulation from 4 dogs (two ejaculates/dog). After removal of seminal plasma, spermatozoa were diluted in egg yolk …

China's Rare Earths Export Quotas: Out Of The China-Raw Materials Gate, But Past The Wto's Finish Line?, Han-Wei Liu, John Maughan

Research Collection Yong Pung How School Of Law

Several recent studies have discussed the ramifications of the China – Raw Materials case for China's rare earths. However, none of these studies has conducted a thorough investigation of China's current export quota regime for rare earths or how it might stand up under WTO rules, assuming that it would be treated the same. This article makes no such assumption, investigating China's export quota regime for rare earths as it stands in early June 2012. The regime is somewhat improved over that applied during the Raw Materials case and could allow a more favourable WTO ruling. However, if General Agreement …

Examining The Forces Associated With Heading In Collegiate Soccer Athletes, Elizabeth A. Tenore

Graduate Theses, Dissertations, and Problem Reports (ETD)

Context: Repetitive sub-concussive impacts have recently been recognized as a contributing factor of long-term cognitive deficits. The potential for this to affect soccer players participating at a high level is great due to the constant intentional use of the unprotected head when playing. Examining the force with which a soccer ball strikes an athlete's head during the act of heading is important to determine if there is a potential risk for long term consequences. Objective: The purpose of this study was to determine how much force is associated with heading in soccer. The variability between goal and corner kicks and …

Strategies To Maximize Feed Quality And Poultry Performance, Kelley G. S. Wamsley

Graduate Theses, Dissertations, and Problem Reports (ETD)

The majority of the research in this dissertation was conducted specifically to benefit a local turkey integrator, Virginia Poultry Grower's Cooperative, which has turkey growers in both West Virginia and Virginia. All of the research presented in this dissertation is applied in nature and may be directly implemented in the commercial poultry industry to improve production. Many commercial feed mills utilize low mixer-added fat (MAF) to increase ingredient binding opportunities and pellet quality, but this technique may decrease feed nutrient digestibility. In Chapter 2, two experiments were conducted in order to determine the best feed manufacture technique (MTECH) to maximize …

Onboard Parameter Identification For A Small Uav, Amanda K. Mcgrail

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the main research focus areas of the WVU Flight Control Systems Laboratory (FCSL) is the increase of flight safety through the implementation of fault tolerant control laws. For some fault tolerant flight control approaches with adaptive control laws, the availability of accurate post failure aircraft models improves performance. While look-up tables of aircraft models can be created for failure conditions, they may fail to account for all possible failure scenarios. Thus, a real-time parameter identification program eliminates the need to have predefined models for all potential failure scenarios. The goal of this research was to identify the dimensional …

Epipathogenesis Of Caries: Analyses Of Family Structure, Fear, And Fatalism Upon World Health Organization Decayed, Missing, And Filled Teeth Severity In Appalachia West Virginia And Pennsylvania, R. Constance Wiener

Graduate Theses, Dissertations, and Problem Reports (ETD)

Appalachian has many social, economic, and biologic factors impacting dental health over the life-course.;Purpose: This study examined dental caries experience and family structure, dental fear, and fatalism in West Virginia and Pennsylvania.;Method: Using a cross-sectional study design, 2002-2009 Center for Oral Health Research in Appalachia data were analyzed utilizing the World Health Organization definitions for caries experience, dichotomized into low and high. Three groups were studied: 1) children, 11-13 years (N=237); 2) adolescents, 14-17 years (N=191); and 3) adults, 18 years and above (N=1125). For multivariable model development, generalized estimating equations with exchangeable working structures accounted for family clusters.;Results. For …

Retinal Optical Coherence Tomography Manifestations Of Intraocular Lymphoma., Tin Yan Alvin Liu, Mohamed Ibrahim, Millena Bittencourt, Yasir J. Sepah, Diana V. Do, Quan Dong Nguyen

Journal Articles: Ophthalmology

PURPOSE: Primary central nervous system lymphoma (PCNSL) is a rare disease. The index report describes a patient with intraocular lymphoma secondary to recurrent PCNSL and corresponding retinal findings on spectral domain optical coherence tomography (SD-OCT).

METHODS: Case report.

RESULTS: OCT changes were documented and correlated with the clinical course of intraocular lymphoma progression in the index patient. The OCT changes, manifested as hyperreflective material accumulation in the intraretinal and subretinal pigment epithelial spaces, were caused by lymphomatous infiltration.

CONCLUSION: SD-OCT can be useful in diagnosing and monitoring the progression or regression of intraocular lymphoma with retinal involvement.

New Fusion Transcripts Identified In Normal Karyotype Acute Myeloid Leukemia, Hongxiu Wen, Yongjin Li, Sami N. Malek, Yeong C. Kim, Jia Xu, Pei Xian Chen, Fengxia Xiao, Xin Huang, Xianzheng Zhou, Zhenyu Xuan, Shiva Mankala, Guihua Hou, Janet D. Rowley, Michael Q. Zhang, San Ming Wang

Journal Articles: Genetics, Cell Biology & Anatomy

Genetic aberrations contribute to acute myeloid leukemia (AML). However, half of AML cases do not contain the well-known aberrations detectable mostly by cytogenetic analysis, and these cases are classified as normal karyotype AML. Different outcomes of normal karyotype AML suggest that this subgroup of AML could be genetically heterogeneous. But lack of genetic markers makes it difficult to further study this subgroup of AML. Using paired-end RNAseq method, we performed a transcriptome analysis in 45 AML cases including 29 normal karyotype AML, 8 abnormal karyotype AML and 8 AML without karyotype informaiton. Our study identified 134 fusion transcripts, all of …

Public Land Management Values: A Delphi Study Of Austrian And Pacific Northwest United States Recreation Resource Managers, Jessie Meybin

Graduate Theses, Dissertations, and Problem Reports (ETD)

There is a continuing global increase in recreational visitor use of public land. This rise in visitation can be a good thing if a proactive management plan utilizing strong methodology to anticipate impacts to an area and sustain its natural and social resources is in place. Although a wide spectrum of issues is presented to each management, few of the concepts are new to any of the administrators. With increasing duties, newly emerging concerns, and decreasing time, there is little room or patience for error concerning the implementation of any management derivatives or techniques. If the existing research on all …

Switchgrass Potential On Reclaimed Surface Mines For Biofuel Production In West Virginia, Michael A. Marra

Graduate Theses, Dissertations, and Problem Reports (ETD)

The high cost and environmental risks associated with non-renewable energy sources has caused an increased interest in, and development of renewable biofuels. Switchgrass (Panicum virgatum L.), a warm season perennial grass, has been investigated as a source of biofuel feedstock due to its high biomass production on marginal soils, its tolerance of harsh growing conditions, and its ability to provide habitat for wildlife and soil conservation cover. West Virginia contains vast expanses of reclaimed surface mine lands and could potentially benefit from the production of switchgrass as a biofuel feedstock. Furthermore, switchgrass production could satisfy Surface Mining Reclamation and Control …

Decentralized Synergetic Control Of Power Systems, Taoridi Ademoye

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this dissertation is to design decentralized controllers to enhance the transient stability of power systems. Due to the nonlinearities and complexities of the system, nonlinear control design techniques are required to improve its dynamic performance. In this dissertation a synergetic control technique is being proposed to design supplementary controller that is added to the exciter of the generation unit of the system. Although this method has been previously applied to a Single Infinite Machine Bus (SMIB) system with high degree of success, it has not been employed to systems with multi machine. Also, the method has good …

Assessing The Surface Water Quality Impacts Of Marcellus Shale Development In Whiteday Creek Watershed, West Virginia, D. Aaron Streets

Graduate Theses, Dissertations, and Problem Reports (ETD)

Shale gas development in Central Appalachia will likely increase economic activity and help meet future energy needs; however, there are concerns over potential impacts to water resources. This research assessed impacts of drilling for gas in the Marcellus shale in the White Day Creek watershed in northern West Virginia. A total of eight stream sites, located both upstream and downstream of three permitted gas wells, were monitored. Two of the permitted wells were in the development phase while the third was actively being drilled. Water samples were collected during the bi-weekly sampling and analyzed at the National Research Center of …

The Ozark Historical Review, V. 41, 2012 Entire_Issue

The Ozark Historical Review

No abstract provided.

N200 And P300 Evoked By Stimuli Straddling Category Boundary In Lexical Context, Ji Young Lee

Theses and Dissertations (ETD)

Background and Objectives: Event-related potentials (ERPs) like N200 and P300 have been reported to reflect the categorical perception of speech. The purpose of the present study is to explore whether these ERP components reflect the influence of lexical context on categorical perception. Findings may provide evidence for bottom-up or top-down processing of speech. Methods: On a seven step series of the /bi/-/pi/ continuum, a two-forced choice labeling test was administered in two conditions: /bi/ context (e.g. bee sting) and /pi/ context (e.g. pea soup). From the labeling results, Stimulus 1which is a prototypical /bi/ was selected for standard stimuli, and …

Hematopoietic Stem Cell Threshold Sensing Controls Regulatory Pathways Facilitating Clinically Relevant Ex Vivo Expansion For Stem Cell Transplantation, Andrew D. Lasiter

Theses and Dissertations (ETD)

The ex vivo expansion of hematopoietic stem cells (HSCs) for transplantation has threefold importance: 1.) First, because of the rarity of stem cells there often isn’t a sufficient supply obtainable from common sources for larger children and adults. 2.) Secondly, patient morbidity and time to hematopoietic reconstitution following myeloablative preconditioning is improved by administering a larger pool of HSCs. 3.) Lastly, gene therapies for hematological diseases still require a robust supply of HSCs to offset varying degrees of inefficiency in vector mediated transfection protocols. These reasons, and others, have been an impetus for many discoveries made within four primary subdivisions …

In Vitro Staining Of Denture Liners And Potential For Color Correction Using Commonly Available Denture Cleansers, Russell D. Morrell

Theses and Dissertations (ETD)

Background: Denture liners are routinely used as part of immediate denture therapy, following surgery involving edentulous tissues, and to improve the function and stability of existing removable prostheses. Appropriate application of denture liners can facilitate patient comfort during prolonged therapy and prior to placement of definitive restorations. However, concern has been raised regarding the susceptibility of common denture liners to agent-induced color change which, in turn, adversely impacts the esthetic appeal of the associated removable prosthesis.

Objective: The purpose of the study was to evaluate the color stability of denture liners exposed to commonly encountered food stains and commonly used …

Mrp4 Is A Crucial Regulator Of Testosterone Biosynthesis, Jessica Ann Morgan

Theses and Dissertations (ETD)

The physiological role of multidrug resistance protein 4 (Mrp4) in the testes is unknown. It was discovered that Mrp4 is expressed primarily in mouse and human Leydig cells; however, there is no current evidence that Mrp4 regulates testosterone biosynthesis. The role of Mrp4 was investigated in Leydig cells where testosterone production is regulated by cAMP, an intracellular second messenger formed when the luteinizing hormone (LH) receptor (Lhr) is activated. As Mrp4 regulates cAMP, we compared testosterone levels in our Mrp4 WT and KO mice. Prepubertal KO mice had significantly reduced testicular testosterone, impaired gametogenesis, and disrupted cAMP homeostasis, resulting in …

Effect Of Compression Force On Agglomeration Of Micronized Active Pharmaceutical Ingredients: Techniques To Prevent Api Agglomeration During Compression, Suresh Potharaju

Theses and Dissertations (ETD)

Micronization is one of the common processes for size reduction to increase surface area of poorly soluble Active Pharmaceutical Ingredient’s (API). This size reduction improves the dissolution rate and permeability thereby increasing the bioavailability for hydrophobic API’s.

Tablets and capsules are the most marketed and easy to manufacture solid dosage forms. During manufacturing of tablets, high compression forces are applied uniaxially on the powder bed to get a coherent consolidated compact with good tensile strength. So, diluents are required to mix with API’s and compress into tablets. When this mixture is compressed into tablets, there is a possibility of agglomeration …

The Health Of Rural Grandparents Raising Grandchildren, Kimberly Y. Robitaille

Theses and Dissertations (ETD)

Introduction: Grandparents are becoming increasingly responsible for raising their grandchildren. Previous studies have noted physical and mental health limitations for custodial grandparents. Grandparents face numerous challenges in raising grandchildren and consequently, experience high stress levels. However, coping and social support have been found to mediate grandparent stress. Rural custodial grandparents have been an understudied population. Using the Stress Process Model, this study extends the knowledge of rural grandparents raising grandchildren by describing the relationships among physical and mental health, stressors, coping, and social supports for custodial grandparents living in Western Kentucky.

Methods: A mixed methods approach was used to examine …

The Role Of Bip Nucleotide Exchange Factor Sil1 In Immunoglobulin Biosynthesis, Tyler Sanford

Theses and Dissertations (ETD)

BiP is an essential endoplasmic reticulum resident molecular chaperone of the HSP70 family that binds exposed hydrophobic regions of unfolded proteins. Substrates bound by BiP are protected from dangerous non-specific interaction with other unfolded proteins via their aggregation prone exposed hydrophobic regions, which are normally buried in the native state, and act as BiP binding targets. For these substrates to mature into the native state, BiP must be released. Like all HSP70 family members, cycles of BiP binding and release are nucleotide dependent and facilitated by two genres of cochaperones, HSP40s, and nucleotide exchange factors (NEFs). HSP40s function in stimulating …

An Innovative Testing Protocol To Study Foot And Ankle Kinetics During Early Stance Phase Of Gait, Thomas E. Stewart

Theses and Dissertations (ETD)

The objective of this study was to improve upon existing testing platform limitations with respect to foot and ankle mechanics in the sagittal plane during dorsiflexion and plantar flexion. The intent was to develop a multi-loading protocol that simulated aspects of early stance phase of walking gait. This data were used to evaluate the influence an Achilles load has on the kinematic profile of the ankle complex. Also, resulting kinematic profile data can be used to evaluate ligament/tendon effects, ankle arthroplasty, and various surgical techniques.

A pair of cadaveric human feet, from the same donor, 50 years of age were …

Verification Of The Accuracy Of Electronic Mandibular Movement Recording Devices: : An In Vitro Investigation, Joshua Heath Balch

Theses and Dissertations (ETD)

One goal of restorative dentistry is to truly capture maxillomandibular relationships that accurately reproduce mandibular border movements and that would prescribe the best occlusal interface. Registration of horizontal and sagittal movements of the patient allows maximum cusp height and fossae depth with proper placement of occlusal ridges and grooves. The goal is to develop an occlusion that is interference free and entails the concepts of organic occlusion. Methods to transfer patient information to a highly adjustable articulator include mechanical recorders, mechano-electronic recorders and optoelectronic recorders. The purpose of this study is to verify the accuracy of electronic mandibular movement recording …

Nanotherapies For Treating Prostate Cancer, Michael Danquah

Theses and Dissertations (ETD)

Current prostate cancer treatment remains ineffective primarily due to ineffectual therapeutic strategies and numerous tumor-associated physiological barriers which hinder efficacy of anticancer agents. Therefore, the focus of this study was to investigate a new combination therapy approach for treating prostate cancer and develop polymeric nanocarriers to facilitate anticancer drug and nucleic acid delivery.

It was hypothesized that simultaneously targeting androgen-androgen receptor (AR) and X-linked inhibitor of apoptosis protein (XIAP) signaling pathways would be effective in treating prostate cancer. The effect of bicalutamide (antiandrogen) and embelin (XIAP inhibitor) on the growth of prostate cancer cells in vitro and in vivo was …