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Yousef Studies The Physics Of Life And Health, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

The Effect Of E-Cadherin Loss On Melanoma Formation And Metastasis, Lara Rosenbaum

Yale Medicine Thesis Digital Library

Melanoma is the most lethal form of skin cancer and accounts for the majority of skin cancer related mortality. Early metastases are characteristic of melanoma and are an ominous sign, as current therapeutic interventions have little effect on overall survival. The lack of accurate prognostic indicators and effective therapies emphasize the need for a better understanding of the genetic and phenotypic changes in melanoma formation and progression. One such change is the loss of E-cadherin, which normally plays a role in cell-cell adhesion and is thought to be a central feature of epithelial-mesenchymal transition (EMT). Maintenance of E-cadherin in melanoma …

When Whales Became Mammals: The Scientific Journey Of Cetaceans From Fish To Mammals In The History Of Science, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

The Structural Requirements Of Histone Deacetylase (Hdac) Inhibitors: Suberoylanilide Hydroxamic Acid (Saha) Analogues Modified At C3, C6, And C7 Positions Enhance Selectivity, Sun Ea Choi

Wayne State University Dissertations

Histone deacetylase (HDAC) proteins are targets for drug design towards the treatment of cancers since overexpression of HDAC is linked to cancer. Several HDAC inhibitors, including the FDA approved drug suberoylanilide hydroxamic acid (SAHA, Vorinostat), have cleared clinical trials and emerged as anti-cancer drugs. However, SAHA inhibits all of the 11 metal ion-dependent HDAC proteins. Therefore, we synthesized several libraries of small molecule HDAC inhibitors based on SAHA to help understand the structural requirements of inhibitory potency and isoform selectivity.

In previous work, SAHA analogues functionalized at the C2 position (C2-SAHA analogues) near the metal binding hydroxamic acid displayed decreased …

An Investigation Of Cultural Competence In Teachers, Leslie Allison Evola

Wayne State University Dissertations

Using a set of scales to measure cultural competences which have been used in previous research, this study examined the relationships between Cultural Attitudes and Beliefs, Cultural Intelligence (CQ), and Ethnic Identity, as well as the Big Five personality traits and demographic variables, within a sample of 87 high school teachers. Cultural Attitudes and Beliefs predicted Metacognitive CQ, Cognitive CQ, Motivational CQ, and overall CQ above and beyond Openness. Teachers with ten years of experience or less were found to have higher CQ than teachers with more than ten years of experience, which may be attributed to age. Also, teachers …

Bioassay-Guided Isolation Of Cytotoxic Cycloartane Triterpenoid Glycosides From The Traditionally Used Medicinal Plant Leea Indica, Yau Hsiung Wong, Habsah Abdul Kadir, Sui Kiong Ling

Research Publications (2011 to 2015)

Leea indica is a medicinal plant used traditionally to cure cancer. In this study, the cytotoxic compounds of L. indica were isolated using bioassay-guided approach. Two cycloartane triterpenoid glycosides, mollic acid arabinoside (MAA) and mollic acid xyloside (MAX), were firstly isolated from L. indica. They inhibited the growth of Ca Ski cervical cancer cells with IC(50) of 19.21 μM (MAA) and 33.33 μM (MAX). MRC5 normal cell line was used to calculate selectivity index. MAA and MAX were about 8 and 4 times more cytotoxic to Ca Ski cells compared to MRC5. The cytotoxicity of MAA was characterized by both …

Chemical Reporters For Investigating Lipidated Proteins At The Host-Pathogen Interface, Guillaume Charron

Student Theses and Dissertations

Lipidation of proteins regulates many cellular processes such as signaling transduction and membrane sorting by modulating protein localization and proteinprotein interactions. As such, defects in protein lipidation can render host cells more susceptible to microbial infection and are also associated with a variety of human diseases ranging from cancer to neurological disorders. Moreover, viral and bacterial pathogens can exploit and modulate the host lipidation machinery to enhance infection. Robust biochemical methods for characterizing lipidated proteins are therefore important for understanding fundamental physiology and disease mechanisms. In this thesis, I report the development of alkyne-lipid chemical reporters that afford more sensitive …

Role Of Hoga And Sskb Protein Kinases In Mycotoxin Production In The Filamentous Fungus Aspergillus Nidulans, Lauren Jurkowski

Honors Capstones

Aspergillus nidulans is a filamentous fungus that is often used as a model organism in genetics and molecular biology studies. The species has a well- characterized life-cycle and its genome has been sequenced. Aspergillus species are commonly found in the environment. Some species can cause health problems in humans. Some Aspergillus species produce aflatoxin, a toxic compound that causes acute necrosis, cirrhosis, and carcinoma of the liver in some animal species and can potentially cause similar symptoms in humans (Center for Integrated Fungal Research, 2005). A. nidulans produces the carcinogenic mycotoxin sterigmatocystin (ST), a precursor in the aflatoxin biosynthetic pathway …

Design, Synthesis, And Biological Evaluation Of Indole-Based 1,4-Disubstituted Piperazines As Cytotoxic Agents, Meri̇ç Köksal Akkoç, Mi̇ne Yarim Yüksel, İrem Durmaz, Rengül Çeti̇n Atalay

Turkish Journal of Chemistry

A series of 3-[(4-substitutedpiperazin-1-yl)methyl]-1H-indole derivatives were synthesized, and their structures were confirmed by spectral analysis. All the compounds were tested for their cytotoxic activity in vitro against 3 human tumor cell lines: human liver (HUH7), breast (MCF7), and colon (HCT116). Among the designed derivatives, most of the compounds showed significant cytotoxicity against liver and colon cancer cell lines with lower IC_{50} concentrations than the standard drug 5-fluorouracil. Compound 3s, with 3,4-dichlorophenyl substituent on the piperazine ring, was the most active in suppressing the growth of all screened cancer cells.

The Cell Collective: Toward An Open And Collaborative Approach To Systems Biology, Tomáš Helikar, Bryan Kowal, Sean Mcclenathan, Mitchell Bruckner, Thaine Rowley, Alex Madrahimov, Ben Wicks, Manish Shrestha, Kahani Limbu, Jim A. Rogers

Department of Biochemistry: Faculty Publications

Background: Despite decades of new discoveries in biomedical research, the overwhelming complexity of cells has been a significant barrier to a fundamental understanding of how cells work as a whole. As such, the holistic study of biochemical pathways requires computer modeling. Due to the complexity of cells, it is not feasible for one person or group to model the cell in its entirety.

Results: The Cell Collective is a platform that allows the world-wide scientific community to create these models collectively. Its interface enables users to build and use models without specifying any mathematical equations or computer code - addressing …

Unraveling The Chicago/Harvard Antitrust Double Helix: Applying Evolutionary Theory To Guard Competitors And Revive Antitrust Jury Trials, Thomas J. Horton

University of Baltimore Law Review

No abstract provided.

Gaining Insight Into The Physics Of Dynamic Atomic Force Microscopy In Complex Environments Using The Veda Simulator, Daniel Kiracofe, John Melcher, Arvind Raman

Birck and NCN Publications

Dynamic atomic force microscopy (dAFM) continues to grow in popularity among scientists in many different fields, and research on new methods and operating modes continues to expand the resolution, capabilities, and types of samples that can be studied. But many promising increases in capability are accompanied by increases in complexity. Indeed, interpreting modern dAFM data can be challenging, especially on complicated material systems, or in liquid environments where the behavior is often contrary to what is known in air or vacuum environments. Mathematical simulations have proven to be an effective tool in providing physical insight into these non-intuitive systems. In …

Examining Chronic Non-Cancer Pain Among A Sample Of Individuals In Opioid Treatment Programs, Erin Stevenson

Theses and Dissertations--Social Work

National rates of chronic non-cancer pain (CNCP) are rising alongside increasing reports of prescription opioid abuse and mortality. Associations between the rise in CNCP and in opioid abuse seem logical, yet research on CNCP among individuals with opioid dependence is currently limited due to the complicated nature of comorbid conditions in research and treatment. This study aims to expand the CNCP knowledge base by responding to the question: Do individuals with CNCP participating in an opiate treatment program have better or worse treatment outcomes than individuals without CNCP?

This study used a secondary dataset including 483 adults from Kentucky’s Opiate …

Acute Oral Toxicity Evaluations Of Some Zinc(Ii) Complexes Derived From 1-(2-Salicylaldiminoethyl)Piperazine Schiff Bases In Rats, Muhammad Saleh Salga, Hapipah Mohd Ali, Mahmood Ameen Abdulla, Siddig Ibrahim Abdelwahab

Research Publications (2011 to 2015)

The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, H-1 NMR, C-13 NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days. The serum level of aspartate (AST), alanine aminotransferases (ALT), alkaline phosphate (ALP), triglyceride, high density lipoprotein (HDL), immunoglobulins (GAM) and the C-reactive proteins did not …

Aflibercept In The Treatment Of Metastatic Colorectal Cancer, Tzu-Fei Wang, Albert Craig Lockhart

Open Access Publications

No abstract provided.

Comparative Studies Of Six Populations Of Isoetes Panchganiensis From India, Brij Bhan Yadav, Sarvesh Kumar Singh, Manju Srivastava, Gopal Krishan Srivastava

Turkish Journal of Botany

Six populations of Isoetes panchganiensis G.K.Srivast., D.D.Pant & P.K.Shukla growing in different environmental conditions of the Western Ghats have been studied to determine the range of variation within the species. The present investigation does not show any variation in habitat (aquatic), rhizomorph (trilobed), velum (fenestra), and presence or absence of peripheral strands; however, there is a subtle variation in the length of plants, number of leaves, size of megasporangia, and size and ornamentation of the megaspores. The basic organisation of the megaspores of all the populations is almost same, but the finer details of the ornamentation of the megaspores exhibit …

Design, Synthesis, And Biological Evaluation Of Novel Polyamine Transport System Probes And Their Application To Human Cancers, Aaron Muth

Electronic Theses and Dissertations

The mammalian polyamine transport system (PTS) has been of interest due to its roles in cancer and maintaining cellular homeostasis. Polyamines are essential growth factors which are tightly controlled via a balance of biosynthesis, metabolism, import, and export. This work focused on the development and biological testing of polyamine transport probes to help understand the molecular requirements of the PTS. This was mediated through the use of a CHO (PTS active) and CHO-MG* (PTS deficient) screen, where compounds demonstrating high toxicity in CHO and low toxicity in CHO-MG* were considered PTS selective. The first chapter focused on the development of …

Gamma-Ray Attenuation Coefficients Of Carbon Steel Plates Using Iridium-192 / Siti Madiha Muhammad Amir, Muhammad Amir Siti Madiha

Student Works (2010-2019)

Measurement of gamma radiation attenuation coefficients on carbon steel using gamma radiation beam from Iridium-192 has been made to permit their use for precision measurement, material studies and in various industrial radiographic techniques. The material examined is carbon steel plates with various thicknesses ranging from 2 mm to 13 mm. There are two aspects in this study; determination of the attenuation coefficient using theoretical method, and from experiments. Two types of detectors are used; the film radiography and ion chamber. The gamma ray source is the polychromatic radionuclide Iridium-192. Cross section of the incoherent scattering of every element in the …

Effect Of Selected Bacteria On The Antibacterial And Antioxidant Activities Of Centella Asiatica / Arash Rafat, Arash Rafat

Student Works (2010-2019)

The role of selected naturally distributed bacteria on the antibacterial and antioxidant activities and production of phenolic compounds in one of the most important Asian medicinal plants namely Centella asiatica was investigated based on the effects of beneficial and pathogenic bacteria on the metabolic pathways of plants as reported in literature. Firstly, antibacterial and antioxidant properties and production of phenolic compounds of two subspecies of C. asiatica which are commonly used in Malaysia (University of Malaya Herbarium Voucher Specimens: KLU047364 and KLU047552) were evaluated and the most potent of them was chosen for the rest of the study. Different antioxidant …

Synthesis, Characterization And Fluorescence Properties Of Selected Amino Derivatives Of Quinoline / Zainal Abidin Hasan, Hasan Zainal Abidin

Student Works (2010-2019)

ii ABSTRACT 2-N-(3-methyl)piperidinoquinoline (25), 2-N-(4-methyl)piperidinoquinoline (26), 2-N-anilinoquinoline (28), 2-N- (m-methyl)anilinoquinoline (30), 2-N-(p-methyl)anilinoquinoline (32), 2-N-(m-ethyl)anilinoquinoline (34), 2-N-(p-ethyl)anilinoquinoline (36), 2-N-methylanilinoquinoline (38), 2-N-ethylanilinoquinoline (40), 2-N-(m-methoxy)anilinoquinoline (42), 2-N-(p-methoxy)anilinoquinoline (44), 2-N-(m-chloro)anilinoquinoline (46), and 2-N-(p-chloro)anilinoquinoline (48) were prepared by reacting 2-chloroquinoline (22) with 3-methylpiperidine (23), 4-methylpiperidine (24), aniline (27), m-toluidine (29), p-toluidine (31), m-ethylaniline (33), p-ethylaniline (35), N-methylaniline (37), N-ethylaniline (39), m-anisidine (41), p-anisidine (43), m-chloroaniline (45) and p-chloroaniline (47) respectively. The structure of these compounds were confirmed using 1H NMR, 13C NMR, infra-red and GCMS. The fluorescence properties were recorded using Luminescence Spectrophotometer. Almost all compounds prepared showed highest fluorescence intensity in less polar solvents …

Synthesis Of Chalcone-Based Six And Seven Membered Heterocyclic Compounds And Their Biological Activities Against H1n1 Virus / Marzieh Yaeghoobi, Marzieh Yaeghoobi

Student Works (2010-2019)

This thesis describes the synthesis of a library of chalcones and several flavanones and 1,5-benzothiazepines derived from chalcones and some biological studies of these compounds against neuraminidase (NA). The environmentally benign one-pot method using PMA/SiO2 in ethanol has successfully been applied toward the preparation of flavanone analogues from 2¢- hydroxychalcones, 2¢-aminochalcones and 2¢-mercaptochalcones in reasonable yields. Reactions were screened in a variety of parameters, including solvents, temperatures, reaction time and amount of catalyst used. The nature of the solvent played a key role in the reaction where the reaction performed well in a polar protic solvent such as ethanol and …

Generic Structure Of Introductions In Entrepreneurship Research Articles / Fatemeh Naderi Osat, Osat Fatemeh Naderi

Student Works (2010-2019)

The purpose of the present study is twofold. Firstly it seeks to find the generic structures that are inherent in the introduction sections of entrepreneurship research articles and secondly it investigates the role of experiential metafunction and its distribution in realization of obligatory generic elements that are found in the data. The approach applied is a combination of Halliday and Hasan’s (1989) model of genre analysis to find the generic structure potential (GSP) of the introduction sections as well as Halliday’s (1994) model of transitivity analysis to find the typicality of the process types and their contribution in the realization …

Isospora Species (I. Canaria, Isospora Sp.) In Canaries (Serinus Canarius, Linnaeus), Cem Ecmel Şaki̇, Edi̇p Özer

Turkish Journal of Veterinary & Animal Sciences

Of 64 canaries with diarrhea in Elazığ Province between May 2002 and May 2006, 18 (28.1%) had Isospora oocysts in their feces. It was determined that the oocysts, examined morphologically before and after sporulating, were Isospora canaria and Isospora sp. Among the infected animals, 8 (44.4%) were concurrently infected with both species. Total numbers of I. canaria oocysts were greater than those of Isospora sp. A total of 2 canaries showing severe clinical signs were necropsied. Liver, spleen, and lung preparations and peripheral blood smears of the necropsied animals were examined for Atoxoplasma, and no development forms were seen. For …

Phytochemical Studies On The Medicinal Plant Sutherlandia Frutescens, Xiang Fu

Electronic Theses and Dissertations

Sutherlandia frutescens (L.) R. Br (Fabaceae) is a multipurpose medicinal plant with diverse biological activities, and has been widely used for the treatment of cancer, AIDS, diabetes, and infectious diseases in southern Africa. The primary goal of this study was to investigate the chemical constituents of S. frutescens and develop an analytical method to analyze this plant and the dietary supplements derived from this plant. The dissertation is composed of six chapters. Chapter 1 introduces the general background of S. frutescens, including traditional uses and chemical and biological studies on the plant. Chapter 2 describes the phytochemical studies that have …

Toward The History Of Study Of Symbiogenesis: On The English Translation Of B. M. Kozo-Polyansky’S A New Principle Of Biology (1924), Victor Fet

Biological Sciences Faculty Research

We reproduce the text by Victor Fet, which was read on 6 October 2011 at the Moscow Society of Naturalists during the presentation of new book translation (B.M. Kozo- Polyansky. Symbiogenesis: A New Principle of Evolution / transl. by Victor Fet; ed. by Victor Fet & Lynn Margulis. Cambridge, Mass.: Harvard University Press, 2010. 138 p.) This half- forgotten book by Boris M. Kozo-Polyansky was known only by name to Western biologists. Victor Fet gives a brief history of this new translation, enthusiastically initiated and supported by Lynn Margulis (1938–2011), a famous naturalist who was always eager to gave credit …

Mechanism Of Inhibition Of The Glua2 Receptors By N-3 Derivatives Of 2,3-Benzodiazepines With C-4 Methyl Group, Congzhou Wang

Legacy Theses & Dissertations (2009 - 2024)

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are one of the three subtypes of ionotropic glutamate receptors. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system (CNS). Over-activation of calcium permeable AMPA receptors causes intracellular calcium overload, which leads to neurodegeneration and cell death. As such, AMPA receptors have been implicated in a number of neurological disorders and diseases, such as epilepsy, amyotrophic lateral sclerosis (ALS), and Parkinson's disease. 2,3-Benzodiazepine derivatives (or GYKI compounds) are a group of structurally similar compounds synthesized as inhibitors of AMPA receptors, and they have been used as potential drug candidates for the treatment of various …

Diversity And Ecology Of Diatoms From Felent Creek (Sakarya River Basin), Turkey, Cüneyd Nadi̇r Solak, Sophia Barinova, Eva Acs, Hayri̇ Dayioğlu

Turkish Journal of Botany

Diatoms are an important group of aquatic ecosystems. To date, there have been many important algological studies in different river basins in Turkey. However, the use of diatoms in biomonitoring (according to diatom indices, Watanabe's or Van Dam's systems) is relatively new in Turkey. In the present study, 41 samples of epilithic diatoms were collected from 5 stations along Felent creek between June 2006 and February 2007 and a total of 117 diatom taxa were identified. The bio-indication (autoecology and abundance scores in the communities) of Felent creek was investigated and, as a result, the organic pollution indicators of Watanabe's …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Reproduction Of The Root Vole (Microtus Oeconomus) At The Edge Of Its Distribution Range, Linas Balciauskas, Laima Balciauskiene, Agne Janonyte

Turkish Journal of Zoology

Data on the reproduction of the root vole (Microtus oeconomus) in Lithuania, the margin of its geographic range, are presented in the context of litter size analysis. In Lithuania, the breeding season lasts from April until the end of October. The average litter size was 5.93 ± 0.11 (2-14), decreasing from a mean of 8.0 embryos in June to 4.3 in October, with 2-3 litters per year. The average body mass of breeding females was 40.4 ± 0.6 (16.5-77.0) g. However, 6.25% of females start breeding with a body mass of under 25 g. Litter size was found to increase …

Isolation, Structure Elucidation And Biological Evaluation Of Natural Products From Plants And Fungi, Xiaoning Wang

Electronic Theses and Dissertations

Natural products have provided considerable value for drug discovery over the past half-century. Nearly four fifth of drugs were natural products or inspired by natural compounds. Bioactive secondary metabolites isolated from natural source, either fungal or terrestrial, are relatively safer for human health and the environment and can serve as drug or as drug leads for the development of synthetic or semi-synthetic analogs. Natural products have also been successfully used in agriculture as plant growth regulators, signal transductions, fungicides, herbicides and tranquilizers. In our continued efforts to identify bioactive compounds, seventy-seven plant and fungal extracts were evaluated using a direct-bioautography …