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Synthesis And Photoluminescence (Pl) Of Gold (I) And Silver (I) Metal Complexes With 1-Methylbenzimidazole Diphenylphosphine (Mbdp): Potential Sensing Applications For Volatile Organic Compounds, Darkus Elizabeth Jenkins

Dissertations

Volatile organic compound(s), VOC(s), detection have become a highly demanding area of research due to potential harmful effects to the ecosystem. The search for methods of VOC sensor devices has led to the examination of photoluminescence and photoluminescent materials such as metal complexes. Their luminescent properties markedly with phosphine and/or nitrogen based ligands, bridging ligands, have the ability to accommodate metal atoms with short metal – metal distances. It is of great interest to accomplish short metal interactions as the photoluminescent properties can be altered. We show the synthesis and structural characterization of the bridging ligand, 1-methylbenzimidazole diphenylphosphine. We examined …

Evidence Of Things Not Seen, Kim Turner Young

School of Art Graduate Exhibitions, Portfolios, and Theses

No abstract provided.

Thermal And Photochemical Interaction Of Co2 With Biochar, Eneruvie Uyoyou Okinedo

Electronic Theses and Dissertations

With interest in the changes that may occur to the carbonaceous portion of biochar obtain through the pyrolysis of biomass, the simple interaction between CO2 and biochar with water or a mixture of water and ethanol as hydrogen donor resulted in three significant observations. These reactions were carried out thermally at 333K and photochemically by simulating energy from the with a xenon lamp. The photochemical reaction involving biochar, CO2 with water or a mixture of water and ethanol as hydrogen donor led to a decrease in oxygen content of the parent biochar material, as observed by an increase in the …

Geographic And Host-Microbe Symbiotic Influence On Secondary Metabolism, Samuel Hamed Abbas

Electronic Theses and Dissertations

This thesis is composed of studies that regard the advancement to the Arctic region and the importance of host-microbe interactions in natural product discovery. Bioactive metabolites have been reported from a myriad of marine and terrestrial organisms around the world including plants, insects, sponges, tunicates, bacteria, and fungi among others. Many macroorganisms, of which the metabolites are found, depend on the symbiotic relationship of microorganisms for metabolite production. The scope of this work is to investigate secondary metabolism of both marine and terrestrial organisms from different areas of the world as well as search for the importance of host-microbe symbiosis …

Bacterial And Sediment Transport In An Artificial Sand Bed Stream During Unsteady Flow, Mary Alexandra Mccaskill

Electronic Theses and Dissertations

Storms cause a substantial increase in the fecal indicator bacteria (FIB) concentrations in stream water. Causes for this concentration increase include FIB-laden stormwater runoff and the release of bacteria from stream-bottom sediments. Studies were carried out to quantify this second cause of water quality impairment. Coliform bacteria are a group of FIB, indicate the presence of pathogenic microorganisms, and have been shown to be transported in streams far from their source areas, especially during storms. FIB transport is dependent on several factors including water velocity, size and transport rates of bed sediments, and the FIB concentration in bed sediment. The …

Mississippi Breakdown: A New Look At The Mississippi Old Time Fiddle Music Traditions, Joseph Jamison Hollister

Electronic Theses and Dissertations

This is a cultural study that focuses on the fiddle music of Mississippi. It includes both Anglo and African American roots. Also, the white blues fiddle traditions of Mississippi are examined and analyzed.

Virtual Worlds And Conservational Channel Evolution And Pollutant Transport Systems (Concepts), Chenchutta Denaye Jackson

Electronic Theses and Dissertations

Many models exist that predict channel morphology. Channel morphology is defined as the change in geometric parameters of a river. Channel morphology is affected by many factors. Some of these factors are caused either by man or by nature. To combat the adverse effects that man and nature may cause to a water system, scientists and engineers develop stream rehabilitation plans. Stream rehabilitation as defined by Shields et al., states that "restoration is the return from a degraded ecosystem back to a close approximation of its remaining natural potential" [Shields et al., 2003]. Engineers construct plans that will restore streams …

Whole Genome Sequencing Of Mutation Accumulation Lines Reveals A Low Mutation Rate In The Social Amoeba Dictyostelium Discoideum, Gerda Saxer, Paul Havlak, Sara A. Fox, Michael A. Quance, Sharu Gupta, Yuriy Fofanov, Joan E. Strassmann, David C. Queller

Biology Faculty Research

Spontaneous mutations play a central role in evolution. Despite their importance, mutation rates are some of the most elusive parameters to measure in evolutionary biology. The combination of mutation accumulation (MA) experiments and whole-genome sequencing now makes it possible to estimate mutation rates by directly observing new mutations at the molecular level across the whole genome. We performed an MA experiment with the social amoeba Dictyostelium discoideum and sequenced the genomes of three randomly chosen lines using high-throughput sequencing to estimate the spontaneous mutation rate in this model organism. The mitochondrial mutation rate of 6.76×10(-9), with a Poisson confidence interval …

Why Wasp Foundresses Change Nests: Relatedness, Dominance, And Nest Quality, Perttu Seppä, David C. Queller, Joan E. Strassmann

Biology Faculty Research

The costs and benefits of different social options are best understood when individuals can be followed as they make different choices, something that can be difficult in social insects. In this detailed study, we follow overwintered females of the social wasp Polistes carolina through different nesting strategies in a stratified habitat where nest site quality varies with proximity to a foraging area, and genetic relatedness among females is known. Females may initiate nests, join nests temporarily or permanently, or abandon nests. Females can become helpers or egglayers, effectively workers or queens. What they actually do can be predicted by a …

Movement Function Follows Spatial Form: Coordinate System Implications For Online Visual Feedback Control Of The Hand, Justin Brooks

All Theses and Dissertations (ETDs)

Closed loop visual feedback control of the hand is essential for accurate reaching movements. Without visual signals of either the hand or target position, reaches are inaccurate and imprecise; therefore the brain uses a relative positional signal to control movements online. Previous studies suggest that movements are planned and represented in a polar coordinate system and that the dimensions, direction and extent are independently specified and processed. We were interested to find out whether there was behavioral evidence for the independent control of hand direction and extent as a movement unfolded. We asked subjects to make a reaching movement in …

Cardiac Pi3kα Signaling And K+ Channel Regulation In Cardiac Hypertrophy And Heart Failure, Kai-Chien Yang

All Theses and Dissertations (ETDs)

Pathologic biomechanical stresses cause cardiac hypertrophy, which is associated with QT prolongation and increased risk of life-threatening ventricular arrhythmias. Previous studies demonstrated that repolarizing K+ current densities are decreased in pressure overload-induced left ventricular hypertrophy, resulting in action potential and QT prolongation. Cardiac hypertrophy also occurs with exercise training, but this "physiological hypertrophy" is not associated with electrical abnormalities or increased arrhythmia risk, suggesting that repolarizing K+ currents are upregulated, in parallel with the increase in myocyte size, to maintain normal cardiac function. To explore this hypothesis directly, two mouse models of physiological hypertrophy, one produced by chronic exercise: swim-) …

Development Of Kinectᵀᴿ Applications For Assembly Simulation And Ergonomic Analysis, Chinmay Prakash Daphalapurkar

Masters Theses

"Marker-less motion capture technology has been harnessed for several years to track human movements for developing various applications. Recently, with the launch of Microsoft Kinect, researchers have been keenly interested in developing applications using this device. Since Kinect is very inexpensive (only $110 at the time of writing this thesis), it is a low-cost and a promising substitute for the comparatively expensive marker-based motion capture systems. Though it is principally designed for home entertainment, numerous applications can be developed with the capabilities of Kinect. The skeleton data of a human being tracked by a single Kinect device is enough to …

Adrift In Paris: Marc Chagall And The Negotiation Of Identity Through Painting, 1911-1914, Aliya Reich

All Theses and Dissertations (ETDs)

No abstract provided.

Specializing Interfaces For Citizen Science Segmentation Of Volumetric Data, Michelle Vaughan, Cindy Grimm, Ruth Sowell, Robert Pless, Stephen Kobourov

All Computer Science and Engineering Research

Segmentation of 3D and time-varying volumetric (4D) image data is considered a time and resource intensive bottleneck in scientific endeavors. Automatic methods are becoming more reliable, but many data sets still require manual intervention. This can mainly be attributed to the characteristics of the image data not being amenable to automated methods, the existence of variations in or poor image quality, or the need for an expert to review and edit results from an automatic technique. Manually segmenting volumetric data is a challenge even for those more experienced. Understanding the 3D nature of the data and navigating through the 3D …

Rapid Development Environments For Therapy Games: Looking Glass Therapy Games For Cerebral Palsy Treatment Utilizing The Kinect, Melynda Eden

All Computer Science and Engineering Research

Cerebral palsy is a group of neurological disorders that impair body movement, muscle coordination, hearing, vision, and cognitive function. Symptoms vary but can include muscle weakness, muscle and joint tightness, abnormal or unsteady gait, seizures, learning disabilities, speech problems, as well as hearing or vision problems [1]. Although cerebral palsy cannot be cured, treatments such as physical and occupational therapy can greatly help affected children develop motor skills needed to increase mobility and foster independence [2]. Computer based therapy games have shown promise in helping stroke survivors recover from stroke [3]. Initially, stroke therapy games developed in Looking Glass utilized …

Molecular Dissection Of Ia Channels In Cortical Pyramidal Neurons, Aaron Norris

All Theses and Dissertations (ETDs)

The rapidly activating and inactivating voltage-gated K+: Kv) current, I _A, is broadly expressed in neurons and is a key regulator of action potential repolarization, repetitive firing, back propagation: into dendrites) of action potentials, and responses to synaptic inputs. Interestingly, results from previous studies on a number of neuronal cell types, including hippocampal, cortical and spinal neurons, suggest that macroscopic I _A is composed of multiple components and that each component is likely encoded by distinct Kv channel α-subunits. The goals of the experiments presented here were to test this hypothesis and to determine the molecular identities of the …

Identification Of Viral Determinants Of Murine Norovirus Pathogenesis, David Strong

All Theses and Dissertations (ETDs)

Human noroviruses are responsible for the majority of cases of epidemic non-bacterial gastroenteritis. Despite their importance as human pathogens, knowledge of the viral life cycle and host pathogenesis is limited due to the lack of practical models to study. In contrast, murine norovirus: MNV) has been a critical surrogate for the study of human noroviruses as it is the only member of this genus that establishes infection in a small animal model, can be grown in cell culture, and has a reverse genetics system. Noroviruses are divided into genogroups which can contain many viral strains. These viral strains can display …

Developing High-Density Diffuse Optical Tomography For Neuroimaging, Brian White

All Theses and Dissertations (ETDs)

Clinicians who care for brain-injured patients and premature infants desire a bedside monitor of brain function. A decade ago, there was hope that optical imaging would be able to fill this role, as it combined fMRI's ability to construct cortical maps with EEG's portable, cap-based systems. However, early optical systems had poor imaging performance, and the momentum for the technique slowed. In our lab, we develop diffuse optical tomography: DOT), which is a more advanced method of performing optical imaging. My research has been to pioneer the in vivo use of DOT for advanced neuroimaging by: 1) quantifying the advantages …

Measuring Equity In Disability And Healthcare Utilization In Afghanistan, Jean-Francois Trani, Cecile Barbou Des Rosieres

Brown School Faculty Publications

This paper analyses equity in health and healthcare utilization in Afghanistan based on a representative national household survey. Equitable access is a cornerstone of the Afghan health policy. We measured socioeconomic-related equity in access to public health care, using disability– because people with disabilities are poorer and more likely to use health care – and a concentration index (CI) and its decomposition. The socioeconomicrelated equity in healthcare utilization was measured using a probit model and compared with an OLS model providing the horizontal inequity index (HI). We found low rate of healthcare facilities utilization (25%). Disabled persons are using more …

The Identity Of A Plantation Structure: The Preliminary Analysis Of An Early Structure At Mont Repose Plantation, St. Luke's Parish, Jasper County, South Carolina, Heather R. Amaral

College of Graduate Studies: Theses & Dissertations

During the 2000 Archeology Field School, Georgia Southern University began an investigation of a nineteenth century plantation structure near Ridgeland, South Carolina. The plantation, Mont Repose, is an example of an inland rice plantation operated in this region during the eighteenth and nineteenth centuries. The structure was initially believed to be a kitchen for this plantation but more recent fieldwork has suggested that this designation may need to be re-examined. Recent excavations have yielded specific artifacts suggesting that the structure may have sheltered a variety of daily functions in addition to specific kitchen activities. Preliminary Mean Ceramic Dating suggests a …

Cell Signaling Components Of The Drosophila Circadian Pacemaker, Laura B. Duvall

All Theses and Dissertations (ETDs)

Daily rhythms in physiology are conserved throughout evolution. The molecular oscillations that underlie rhythms have been well characterized and are required in a specific set of pacemaker cells in the Drosophila brain for locomotor rhythms. These cells are divided into distinct subgroups and evidence suggests that subgroups of pacemaker cells may control distinct components of circadian behavior although these assignments are not rigid, and depend critically upon environmental conditions. Plasticity in the neural circuits controlling circadian behavior allow the animal flexibility in responding to fluctuations in environmental inputs, for example changing day length over seasons.

Intercellular communication between diverse clock …

The Role Of The Intestinal Microbiota In Inflammatory Bowel Disease, Seth Bloom

All Theses and Dissertations (ETDs)

Inflammatory bowel disease: IBD) arises from complex interactions of genetic, environmental, and microbial factors. The intestinal microbiota is crucial for IBD induction and complex shifts in microbiota composition occur in IBD, but disease has not been consistently associated with presence or absence of a specific microbe. It is thus controversial whether fulfilling Koch's postulates for individual bacterial species is relevant to IBD and whether disease-associated alterations in microbial colonization are predictive of underlying etiology. Resolving these controversies has been challenging due to paucity of animal models with rapid disease onset, experimental reliance on gnotobiotic animals, and difficulty specifically isolating many …

Finite Element Analysis Of Blade-Formation Interactions In Excavation, Osei Brown

Masters Theses

"The efficiency and costs of mining operations greatly depend on the efficient design and use of excavators. The performance of these capital-intensive excavators requires thorough understanding of the physical and design factors that affect the formation-cutting tool interaction process. The current body of knowledge, based on experimental and analytical methods, provides limited understanding of these factors, which limits the accurate design and performance of excavators. The soil constitutive equations used in most of the available finite element (FE) models also fail to adequately capture the elastic and plastic behaviors of soil formations. This research initiative uses FE techniques to model …

Depth Profiling Of Pahs Treated With Activated Carbon Using In-Situ Spme, Ryan D. Stringer

Masters Theses

"Novel and efficient methods to measure the bioavailability of hydrophobic organic contaminants (HOCs) in contaminated sediments will play an important role in the acceptance of alternative sediment remediation strategies. In this project, solid phase microextraction (SPME) fibers, protected in perforated steel tubes, were used as in situ passive samplers to measure the treatment of activated carbon (AC) in polycyclic aromatic hydrocarbon (PAH) contaminated sediment. Contaminated sediment was treated with two modes of AC waterjet amendment. In the first treatment, a single 2-min injection was shot into the center of a test vessel and in the second treatment, multiple 7-sec injections …

Training Teachers For A Virtual School System: A Call To Action, Michael Barbour

Education Faculty Publications

Online learning at the K-12 level is growing exponentially. Students learning in supplemental virtual schools and full-time cyber schools, using a variety of delivery models that include and sometimes combine independent, asynchronous, and synchronous instruction, in almost every state in the US. In some instances the knowledge, skills, and abilities required by teachers in this technology-mediated environment is consistent with what they learned about face-to-face teaching in their teacher education programs, while in many instances, the two are quite different. Presently the lack of empirical research into effective K-12 online teaching limits teacher education programs. However, teacher education programs still …

Optimization Of Process Planning For Focused Ion Beam Machine In Nano-Manufacturing, Sushrut Shekhar Naik

Masters Theses

"The current revolution witnessed by nanotechnology is facing several challenges such as manufacturing of nano sized devices economically on a large scale. Focused ion beam (FIB) technology is one of the widely used approaches for nano-manufacturing due to its versatile nature. It provides accurate machining and process repeatability and has a range of applications. Major challenges for the current FIB process are the tradeoffs between quality, the processing time, and the long planning time. This research provides a pathway to eliminate the current problems facing nanotechnology. Using MATLAB and the Helios 600 FIB/SEM instrument available, modeling and analyses are carried …

Effects Of Coal Comminution In Relation To Waterjet And Selected Feed Properties, Yaqing Li

Masters Theses

"The necessity to develop a viable alternative to oil means that the development of coal-water fuels (CWF) has become increasingly important. However, the existing methods of comminution to prepare ultrafine particles for CWF are very inefficient. Consequently, a number of novel methods of comminution have been investigated in order to increase the efficiency of the process.

In this research, a new method of comminution using a high-pressure waterjet has been tested to produce ultrafine particle sizes necessary for efficient CWF process. To establish the fundamental performance of the waterjet mill, the influence of the operational pressure, standoff distance, feed size, …

Mfa12 (Mfa 2012), Sam Fox School Of Design & Visual Arts, Mildred Lane Kemper Art Museum, Buzz Spector, Patricia Olynyk, Ifeoma Ugonnwa Anyaeji, Je Baker, Natalie Baldeon, E. Thurston Belmer, Lauren Cardenas, Megan Sue Collins, Adrian Cox, Maya Durham, Erin Falker, Jieun Kim, Howard Krohn, Robert Long, Marie Bannerot Mcinerney, Nikki Mcmahan, Michael T. Meier, Katie Millitzer, Reid G. Norris, Kathleen Perniciaro, Emily Squires, Jamie Presson Wells, Whitney Lorene Wood, Andrew Woodard, Kelly K. Wright

Books and Monographs

Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum May 4-Aug. 6, 2012. Contents include Introduction / Buzz Spector -- Think, make, show and tell / Patricia Olynyk -- Ifeoma Ugonnwa Anyaeji -- J.E. Baker / Elissa Yukiko Weichbrodt -- Natalie Baldeon / Emily Hanson -- As in a turning gear : E. Thurston Belmer / Rickey Laurentiis -- Lauren Cardenas / Nicholas Tamarkin -- Megan Sue Collins / Catherine Chiodo -- Adrian Cox -- Maya Durham / Dolly Laninga -- Erin Falker / Melissa Olson -- St. Louis dreamscape : Jieun Kim / Caitlin …

Evaluation Of Novel Sigma Receptor Antagonists Against Meth-Induced Neurotoxicity: In Vivo And In Vitro Studies, Nidhi Kaushal

Graduate Theses, Dissertations, and Problem Reports (ETD)

Methamphetamine (METH) is a highly addictive psychostimulant drug of abuse, causing hyperthermia and neurotoxicity at high doses. Currently, there is no clinically proven pharmacotherapy to treat these effects of METH, necessitating identification of potential novel therapeutic targets. Earlier studies showed that METH binds to sigma receptors in the brain at physiologically relevant concentrations, where it acts in part as an agonist. AC927 (1-(2-phenethyl)piperidine oxalate), CM156 (3-(4-(4-cyclohexylpiperazin-1-yl)butyl)benzo[d]thiazole-2(3H)-thione) and SN79 (6-acetyl-3-(4-(4-(4-florophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one) were synthesized as putative sigma receptor antagonists with nanomolar affinity and selectivity for sigma receptors over 29-80 other binding sites. AC927, CM156 and SN79 pretreatment afforded protection against METH-induced hyperthermia and …

The Role Of Src-Homology 2 Domain-Containing Tyrosine Phosphatase 2 In Signaling And Tumorigenesis Of Basal Type/Triple Negative Breast Cancer, Fatimah Kh. Matalkah

Graduate Theses, Dissertations, and Problem Reports (ETD)

Basal type/triple negative breast cancer (BTBC) represents a distinct tumor group that is characterized by an aggressive disease phenotype and poor clinical outcome. Patients with this subtype cannot benefit from the available anti-hormone and anti-HER2 targeted therapies (e.g. tamoxifen and herceptin). Therefore, characterizing potential therapeutic targets is urgently needed. We reasoned that the Src-homology 2 domain-containing tyrosine phosphatase 2 (SHP2) could serve as a therapeutic target in BTBC, because of its critical regulation of epidermal growth factor receptor (EGFR) which is overexpressed in BTBC. Here, we demonstrated that SHP2 knockdown in BTBC cell lines suppressed cell proliferation, migration, and transformation. …