Digital Commons Network^™

Michael Norwood V. John Johnson

2012 Decisions

USDC for the District of New Jersey

Enteric Alpha Defensins In Norm And Pathology., Nikolai A Lisitsyn, Yulia A Bukurova, Inna G Nikitina, George S Krasnov, Yuri Sykulev, Sergey F Beresten

Kimmel Cancer Center Faculty Papers

ABSTRACT: Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.

The Guardian, January 11, 2012, Wright State University Student Body

The Guardian Student Newspaper

Twelve page issue of The Guardian, the official student-run newspaper for Wright State University. The Guardian has been published regularly since March of 1965.

It's Not Easy Being Green: Evolving Legal Frameworks To Address The Unanticipated Consequences Of New Environmental Programs, Beth S. Dorris

The Journal of Business, Entrepreneurship & the Law

No abstract provided.

The Impact Of Medimmune, Inc. V. Genentech, Inc. And Its Progeny On Technology Licensing, Michael Donovan

The Journal of Business, Entrepreneurship & the Law

No abstract provided.

Effects Of Weaning Age And Winter Development Environment On Heifer Grazing Distribution, N.L. Hojer, M.B. Hubert, P.S. Johnson, M.H. Price

South Dakota Beef Report, 2012

The objective of this experiment was to determine if early weaning (approximately 125 d) vs. normal weaning (approximately 250 d) and wintering replacement heifers in drylot versus rangeland affected heifer grazing distribution during the subsequent summer. Heifer calves from the 2009 and 2010 calf crop (n = 104 and 73, respectively) were allocated to the 2 weaning treatments and then stratified by age into the 2 winter development treatments. During the summer of yr 1 heifers were allocated to 2 pastures by winter treatment, and in yr 2, all 4 treatment combinations were allocated to separate pastures. A subset of …

Your Worst Animal Nightmare, Harold Herzog

'Animals and Us' Blog Posts

Monster snakes are headed your way...

Lynches Lane Reed & Willow Bed Facility Final Report South Dubin County Council, Liam Mccarton, Sean O'Hogain, Don Mcdonald, Anna Reid

Reports

This final report will present results from a two year study to monitor the performance of a hybrid reed willow bed facility at Lynches Lane, in the administrative area of South Dublin County Council (SDCC). Design specifications for the facility are presented. Monitoring results for a two year period including influent and effluent parameters, rainfall, potential evapotranspiration, and soil classification are also presented and discussed. During the two year monitoring period the system achieved a zero discharge. This report will discuss the potential application of similar systems within South Dublin County Council administrative area. This is in the context of …

Evidence For A Grooming Claw In A North American Adapiform Primate: Implications For Anthropoid Origins, Stephanie Maiolino, Doug M. Boyer, Jonathan I. Bloch, Christopher C. Gilbert, Joseph Groenke

Publications and Research

Among fossil primates, the Eocene adapiforms have been suggested as the closest relatives of living anthropoids (monkeys, apes, and humans). Central to this argument is the form of the second pedal digit. Extant strepsirrhines and tarsiers possess a grooming claw on this digit, while most anthropoids have a nail. While controversial, the possible presence of a nail in certain European adapiforms has been considered evidence for anthropoid affinities. Skeletons preserved well enough to test this idea have been lacking for North American adapiforms. Here, we document and quantitatively analyze, for the first time, a dentally associated skeleton of Notharctus tenebrosus …

Biology And Pathogenesis Of Acanthamoeba., Ruqaiyyah Siddiqui, Naveed Ahmed Khan

Department of Biological & Biomedical Sciences

Acanthamoeba is a free-living protist pathogen, capable of causing a blinding keratitis and fatal granulomatous encephalitis. The factors that contribute to Acanthamoeba infections include parasite biology, genetic diversity, environmental spread and host susceptibility, and are highlighted together with potential therapeutic and preventative measures. The use of Acanthamoeba in the study of cellular differentiation mechanisms, motility and phagocytosis, bacterial pathogenesis and evolutionary processes makes it an attractive model organism. There is a significant emphasis on Acanthamoeba as a Trojan horse of other microbes including viral, bacterial, protists and yeast pathogens.

Aggregative Feeding Behavior In Sea Urchins Leads To Destructive Grazing In A Nova Scotian Kelp Bed, Colette Feehan, R. E. Scheibling, J. S. Lauzon-Guay

Department of Biology Faculty Scholarship and Creative Works

Grazing aggregations of the sea urchin Strongylocentrotus droebachiensis drive the transition between alternative ecosystem states in Nova Scotia, from productive kelp beds to less productive barrens. This transition can be initiated by the formation of gaps within a kelp bed, containing dense aggregations of sea urchins. We examined the importance of local density of sea urchins and pre-existing gaps in a kelp canopy in mediating the formation of destructive grazing aggregations of sea urchins in a kelp bed. We transplanted 14 000 adult sea urchins from a barrens on the Atlantic coast of Nova Scotia into ̃4.5 m 2 plots …

Walking Box Ranch Custodianship Quarterly Progress Report: Period Ending January 10, 2012, Margaret N. Rees

Walking Box Ranch

• UNLV provides stewardship of Walking Box Ranch (WBR) by providing a caretaker who oversees the property, facilitating use of the property by researchers and educators, developing a use and research policy for the property, and coordinating these activities with BLM and in accordance with TNC restrictions.
• UNLV currently addresses security issues for the property through the presence of the caretaker and two Metro Officers who reside on the property in two recreational vehicles.
• UNLV is working with new BLM employees Glen Marsh and Audrey Asselin to address continuing deterioration of the ranch house. UNLV has suggested to BLM that they …

Walking Box Ranch Planning And Design Quarterly Progress Report: Period Ending January 10, 2012, Margaret N. Rees

Walking Box Ranch

• UNLV’s President Smatresk has reiterated his commitment to the WBR project and has further committed full funding for IT and security costs.
• UNLV participated in a one-half day meeting with BLM to discuss the future WBR operating agreement between BLM and UNLV; UNLV participated in a 1.5 day meeting to review the 100% Design drawings.
• UNLV continues to wait on BLM for direction on how to mitigate the continuing deterioration of the ranch house.
• Weather station research continues and has produced the following this past quarter. 1) Ground-source heat pump (GSHP) Vs Photovoltaic (PV) technology: A detailed analysis comparing these …

Use Of Building Information Modelling In Responding To Low Carbon Construction Innovations: An Irish Perspective, Alan V. Hore

Conference papers

At present the Irish construction industry is facing one of its most uncertain and challenging periods and will see major cuts in all areas of the economy in 2012. Despite this, Ireland pushes forward in sustainability initiatives with the Government ruling that environmentally-friendly policies are to get priority in competing for State contracts worth up to €16 billion a year. This and further initiatives are in place, so as to reduce greenhouse gas emissions by up to 20% by the year 2020. By the end of 2018 the public sector must own or rent only buildings with high energy-saving standards …

Transcriptome-Based Differentiation Of Closely-Related Miscanthus Lines, Philippe Chouvarine, Shane C. Burgess, Daniel G. Peterson

CVM Publications

No abstract provided.

Method For Producing Biocomposite Comprising Collagen And Polymer, Edward Turos, Thomas J. Koob, Kerriann Robyn Greenhalgh

USF Patents

The present invention concerns a biocomposite useful in artificial tissue replacement, methods for its production, and methods of use. The biocomposite can be implanted into humans or animals as an artificial tissue for treatment of a tissue defect. The biocomposite can be formed or manipulated into a desired shape for implantation.

Computer Systems And Methods For Selecting Subjects For Clinical Trials, William S. Dalton, Timothy Yeatman

USF Patents

Computers, computer program products, and methods for identifying a plurality of subjects for a clinical trial are provided. A candidate set of molecular profiles in a stored plurality of molecular profiles are identified. Each such profile has measurements for a discriminating set of cellular constituents that match the measurements of corresponding cellular constituents in a responder set of biological samples, thereby identifying the plurality of subjects for the trial from those subjects from which the candidate set of molecular profiles were derived. Each respective molecular profile in the stored plurality of profiles has measurements of a plurality of cellular constituents …

The Daily Gamecock, Tuesday, January 10, 2012, University Of South Carolina, Office Of Student Media

January

No abstract provided.

Usp8 Promotes Smoothened Signaling By Preventing Its Ubiquitination And Changing Its Subcellular Localization, Ruohan Xia, Hongge Jia, Junkai Fan, Yajuan Liu, Jianhang Jia

Molecular and Cellular Biochemistry Faculty Publications

The seven transmembrane protein Smoothened (Smo) is a critical component of the Hedgehog (Hh) signaling pathway and is regulated by phosphorylation, dimerization, and cell-surface accumulation upon Hh stimulation. However, it is not clear how Hh regulates Smo accumulation on the cell surface or how Hh regulates the intracellular trafficking of Smo. In addition, little is known about whether ubiquitination is involved in Smo regulation. In this study, we demonstrate that Smo is multi-monoubiquitinated and that Smo ubiquitination is inhibited by Hh and by phosphorylation. Using an in vivo RNAi screen, we identified ubiquitin-specific protease 8 (USP8) as a deubiquitinase that …

Tumor Suppression By Cell Competition Through Regulation Of The Hippo Pathway, Chiao-Lin Chen, Molly C. Schroeder, Madhuri Kango-Singh, Chunyao Tao, Georg Halder

Biology Faculty Publications

Homeostatic mechanisms can eliminate abnormal cells to prevent diseases such as cancer. However, the underlying mechanisms of this surveillance are poorly understood. Here we investigated how clones of cells mutant for the neoplastic tumor suppressor gene scribble (scrib) are eliminated from Drosophila imaginal discs. When all cells in imaginal discs are mutant for scrib, they hyperactivate the Hippo pathway effector Yorkie (Yki), which drives growth of the discs into large neoplastic masses. Strikingly, when discs also contain normal cells, the scrib− cells do not overproliferate and eventually undergo apoptosis through JNK-dependent mechanisms. However, induction of apoptosis does …

Serotonin 1a Receptor-Mediated Signaling Through Erk And Pkcα Is Essential For Normal Synaptogenesis In Neonatal Mouse Hippocampus, A. Mogha, Sara R. Guariglia, Priya Ranjan Debata, Guang Y. Wen, Probal Banerjee

Publications and Research

Aberrant expression of the presynaptic serotonin 1A receptor (5-HT_1A-R) because of a polymorphism in the 5-HT_1A-R gene is associated with severe depression in human, whereas its absence up to postnatal day 21 (P21) in the forebrain of mice results in heightened anxiety in adulthood. These observations collectively indicate that the 5-HT1A-R has a crucial role in brain development. To understand the mechanistic underpinnings of this phenomenon, we used organotypic slice cultures of hippocampi from C57BL6 mice (C57) at P15, which coincides with the peak of neonatal synaptogenesis. Stimulation of the hippocampal 5-HT1A-R caused a dramatic increase …

Derivation Of A Novel Efficient Supervised Learning Algorithm From Cortical-Subcortical Loops, Ashok Chandrashekar, Richard Granger

Dartmouth Scholarship

Although brain circuits presumably carry out powerful perceptual algorithms, few instances of derived biological methods have been found to compete favorably against algorithms that have been engineered for specific applications. We forward a novel analysis of a subset of functions of cortical-subcortical loops, which constitute more than 80% of the human brain, thus likely underlying a broad range of cognitive functions. We describe a family of operations performed by the derived method, including a non-standard method for supervised classification, which may underlie some forms of cortically dependent associative learning. The novel supervised classifier is compared against widely used algorithms for …

Enhancing Thermal Tolerance By Eliminating The Pejus Range: A Comparative Study With Three Decapod Crustaceans, Jennifer A. Jost, Stephanie M. Podolski, Markus Frederich

Marine Sciences Faculty Publications

Marine invertebrates in the intertidal and subtidal zones are often exposed to highly variable environmental conditions, especially rapid changes in temperature. The ability to survive at different temperatures has previously been described using an extended version of Shelford’s law of tolerance, with optimum, pejus (Latin: ‘turning worse’), and pessimum ranges, and the respective thresholds, critical (Tc) and pejus (Tp) temperatures, that mark the transition from one range into the next. The width of the pejus range, in which the scope for activity gradually declines, varies among species. We tested the hypothesis that the width of the …

Aquaporin 4 Is A Ubiquitously Expressed Isoform In The Dogfish (Squalus Acanthias) Shark, Christopher P. Cutler, Bryce Maciver, Gordon Cramb, Mark L. Zeidel

Biology: Faculty Publications

The dogfish ortholog of aquaporin 4 (AQP4) was amplified from cDNA using degenerate PCR followed by cloning and sequencing. The complete coding region was then obtained using 5′ and 3′ RACE techniques. Alignment of the sequence with AQP4 amino acid sequences from other species showed that dogfish AQP4 has high levels (up to 65.3%) of homology with higher vertebrate sequences but lower levels of homology to Agnathan (38.2%) or teleost (57.5%) fish sequences. Northern blotting indicated that the dogfish mRNA was approximately 3.2 kb and was highly expressed in the rectal gland (a shark fluid secretory organ). Semi-quantitative PCR further …

Identification And Quantification Of Protein Carbonylation By Mass Spectrometry, Qingyuan Liu

Theses and Dissertations

Accumulated evidence indicates oxidative stress plays important roles in disease and aging. Under oxidative stress, lipid peroxidation (LPO) leads to reactive carbonyl species (RCS) that can modify a wide range of biomolecules including protein, DNA and carbohydrate. In this dissertation, we investigate the modification of two model proteins, human serum albumin (HSA) and aconitase (ACO), by the LPO-relevant a, b-unsaturated aldehydes, acrolein (ACR) and 4-hydroxy-2-nonenal (HNE). The investigation is focused on the characterization and quantification ACR and HNE addition to the model proteins. A correlation between HNE modification and ACO activity is also determined. These results provide insights into the …

Furman, Lucy Salome, 1869-1958 (Sc 564), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid and scan (Click on "additional files" below) for Manuscripts Small Collection 564. Chiefly letters, 1914-1938, written by Lucy Furman, author and educator, who taught and worked at Hindman Settlement School, Hindman, Knott County, Kentucky. Twenty-one of the letters, to Julia Neal, Auburn, Logan County, Kentucky, are collected in a separate subfolder. Miss Neal wrote her 1933 master’s thesis on Miss Furman. Also includes other letters and printed materials used in Miss Neal’s thesis.

Crow's Nest, January 9, 2012, Crow's Nest Staff

Crow's Nest

The January 9, 2012, issue of the Crow's Nest.

Daily Eastern News: January 09, 2012, Eastern Illinois University

January

No abstract provided.

V49no1_Compiled, Sarah King Steiner

Georgia Library Quarterly

No abstract provided.

News - Northwest Georgia Regional Library System, Nick Fogarty

Georgia Library Quarterly

No abstract provided.