Digital Commons Network^™

Method And Apparatus For In Vivo Surveillance Of Circulating Biological Components, Dave S B Hoon, Bret Tabeck, Samuel Shaolian

Technology Transfer - Patents

The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis.

Scholarly Inbreeding In Latin American Academically Managed Journals, Erwin Krauskopf

Higher Learning Research Communications

From a bibliometric perspective, scholarly inbreeding has been identified in journals through the excessive use of both author and journal self-citations. However, editorial bias toward researchers from the same institution as the editorial management team has seldom been considered. According to the Spanish Foundation for Science and Technology, this occurs when a journal publishes more than 20% of documents authored by researchers affiliated with the same institution as the editorial management team. The purpose of this study is to establish the extent to which 81 Latin American journals managed by universities publish intramural documents (defined as those published by its …

The Zfx Gene Is Expressed In Human Gliomas And Is Important In The Proliferation And Apoptosis Of The Human Malignant Glioma Cell Line U251, Youxin Zhou, Zuopeng Su, Yulun Huang, Ting Sun, Sansong Chen, Tingfeng Wu, Guilin Chen, Xueshun Xie, Bin Li, Ziwei Du

Faculty Publications

Background: Zfx is a zinc finger protein of the Zfy family, whose members are highly conserved in vertebrates. Zfx is a shared transcriptional regulator of both embryonic stem cells (ESC) and hematopoietic stem cells (HSC), which suggests a common genetic basis of self-renewal in embryonic and adult stem cells. The level of Zfx expression correlates with aggressiveness and severity in many cancer types, including prostate cancer, breast cancer, and leukemia. However, the importance of Zfx in human glioma is largely unknown. In the present study, we examined the role of Zfx in human glioma. Methods. We detected expression levels of …

Interstaple Dithiol Cross-Linking In Au 25(Sr) 18 Nanomolecules: A Combined Mass Spectrometric And Computational Study, Vijay Reddy Jupally, Rajesh Kota, Eric Van Dornshuld, Daniell L. Mattern, Gregory S. Tschumper, De En Jiang, Amala Dass

Chemistry Faculty Research & Creative Works

A systematic study of cross-linking chemistry of the Au 25(SR) 18 nanomolecule by dithiols of varying chain length, HS-(CH₂)_n-SH where n = 2, 3, 4, 5, and 6, is presented here. Monothiolated Au₂₅ has six [RSAuSRAuSR] staple motifs on its surface, and MALDI mass spectrometry data of the ligand exchanged clusters show that propane (C3) and butane (C4) dithiols have ideal chain lengths for interstaple cross-linking and that up to six C3 or C4 dithiols can be facilely exchanged onto the cluster surface. Propanedithiol predominately exchanges with two monothiols at a time, making cross-linking bridges, …

Why Animal Ethics Committees Don't Work, Denise Russell

Between the Species

Abstract

Animal ethics committees have been set up in many countries as a way to scrutinize animal experimentation and to assure the public that if animals are used in research then it is for a worthwhile cause and suffering is kept to a minimum. The ideals of Refinement, Reduction and Replacement are commonly upheld. However while refinement and reduction receive much attention in animal ethics committees the replacement of animals is much more difficult to incorporate into the committees’ deliberations. At least in Australia there are certain structural reasons for this but it is likely that most of the reasons …

Microglial P38Α Mapk Is Critical For Lps-Induced Neuron Degeneration, Through A Mechanism Involving Tnfα, Bin Xing, Adam D. Bachstetter, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: The p38α MAPK isoform is a well-established therapeutic target in peripheral inflammatory diseases, but the importance of this kinase in pathological microglial activation and detrimental inflammation in CNS disorders is less well understood. To test the role of the p38α MAPK isoform in microglia-dependent neuron damage, we used primary microglia from wild-type (WT) or p38α MAPK conditional knockout (KO) mice in co-culture with WT cortical neurons, and measured neuron damage after LPS insult.

RESULTS: We found that neurons in co-culture with p38α-deficient microglia were protected against LPS-induced synaptic loss, neurite degeneration, and neuronal death. The involvement of the proinflammatory …

A New Smart Car?

News Releases

No abstract provided.

Methods And Products For Biasing Cellular Development, Kiminobu Sugaya, Angel Alvarez, Amelia Marutle

UCF Patents

Proper cellular functionand development depends on intrinsic signals and extracellular environmental cues. The interplay of these environmental influences and intracellular dynamics determine cellular ectivity including migration, differentiation and the manner in whihc it interacts with surrounding cells. An object of this invention invloves a way to mofigy cellular activity by gene insertion. Another object of this invention is the application of specially modified cells for therapeutic and research applications. Through gene insertion by means of a delivery system such as transfection we can create specialized cell types from various stem cells including adults these cells can be either be used …

Rice Consumption Contributes To Arsenic Exposure In Us Women, Diane Gilbert-Diamond, Kathryn L. Cottingham, Joann F. Gruber, Tracy Punshon, Vicki Sayarath, A. Jay Gandolfi, Emily R. Baker, Brian P. Jackson, Carol L. Folt, Margaret R. Karagas

Dartmouth Scholarship

Emerging data indicate that rice consumption may lead to potentially harmful arsenic exposure. However, few human data are available, and virtually none exist for vulnerable periods such as pregnancy. Here we document a positive association between rice consumption and urinary arsenic excretion, a biomarker of recent arsenic exposure, in 229 pregnant women. At a 6-mo prenatal visit, we collected a urine sample and 3-d dietary record for water, fish/seafood, and rice. We also tested women's home tap water for arsenic, which we combined with tap water consumption to estimate arsenic exposure through water. Women who reported rice intake (n …

Reverse Protection Assay: A Tool To Analyze Transcriptional Rates From Individual Promoters, Yan O. Zubo, Victor V. Kusnetsov, Thomas Börner, Karsten Liere

Dartmouth Scholarship

Transcriptional activity of entire genes in chloroplasts is usually assayed by run-on analyses. To determine not only the overall intensity of transcription of a gene, but also the rate of transcription from a particular promoter, we created the Reverse RNase Protection Assay (RePro): in-organello run-on transcription coupled to RNase protection to define distinct transcript ends during transcription. We demonstrate successful application of RePro in plastid promoter analysis and transcript 3' end processing.

Development Of Photographic Dynamic Measurements Applicable To Evaluation Of Flapping Wing Micro Air Vehicles, Jeremy C. Murray

Theses and Dissertations

Developments in the area of flapping wing micro air vehicles (FWMAVs) of a small size and with limited range. This has lead to a great deal of interest in biomimetric designs based on flapping wing flyers, including the North American Hawkmoth (Manduca Sexta). By utilizing high speed photography and photogrammetry the dynamic flapping of the wing can be characterized for comparison with mathematical models, namely computational fluid dynamics (CFD) and finite element analysis (FEA).To successfully utilize high speed image capture, a method of successfully digitizing many data points in a short period of time needs to be developed. The effort …

Curricular Affairs Committee Minutes December 19, 2011, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

The Murine Caecal Microrna Signature Depends On The Presence Of The Endogenous Microbiota, Natasha Singh, Elize A. Shirdel, Levi Waldron, Regan-Heng Zhang, Igor Jurisica, Elena M. Comelli

Publications and Research

The intestinal messenger RNA expression signature is affected by the presence and compo-sition of the endogenous microbiota, with effects on host physiology. The intestine is also characterized by a distinctive micronome. However, it is not known if microbes also impact intestinal gene expression epigenetically. We investigated if the murine caecal microRNA expression signature depends on the presence of the microbiota, and the potential implica-tions of this interaction on intestinal barrier function. Three hundred and thirty four mi-croRNAs were detectable in the caecum of germ-free and conventional male mice and 16 were differentially expressed, with samples from the two groups clustering …

Triterpenoid Modulation Of Il-17 And Nrf-2 Expression Ameliorates Neuroinflammation And Promotes Remyelination In Autoimmune Encephalomyelitis, Tej K. Pareek, Abdelmadjid Belkadi, Sashi Kesavapany, Anita Zaremba, Sook L. Loh, Lianhua Bai, Mark L. Cohen, Colin Meyer, Karen T. Liby, Robert H. Miller, Michael B. Sporn, John J. Letterio

Dartmouth Scholarship

Inflammatory cytokines and endogenous anti-oxidants are variables affecting disease progression in multiple sclerosis (MS). Here we demonstrate the dual capacity of triterpenoids to simultaneously repress production of IL-17 and other pro-inflammatory mediators while exerting neuroprotective effects directly through Nrf2-dependent induction of anti-oxidant genes. Derivatives of the natural triterpene oleanolic acid, namely CDDO-trifluoroethyl-amide (CDDO-TFEA), completely suppressed disease in a murine model of MS, experimental autoimmune encephalomyelitis (EAE), by inhibiting Th1 and Th17 mRNA and cytokine production. Encephalitogenic T cells recovered from treated mice were hypo-responsive to myelin antigen and failed to adoptively transfer the disease. Microarray analyses showed significant suppression of …

Design And Synthesis Of Cationic Steroid Antimicrobial Compounds, Synthesis Of Glycolipids Recognized By Natural Killer T Cells And Development Of Tlr-1, Tlr-6 Heterodimer Binders And Studies Of Their Immunology Activities, Yanshu Feng

Theses and Dissertations

Cationic steroid antimicrobial agents (CSAs) are a family of bile acid derivatives. These compounds are amphiphilic and mimic endogenous antimicrobial peptides. The antimicrobial activities of CSA-13 have been investigated and due to portent bactericidal activities and low toxicity, a large amount of CSA-13 is demanded for clinic trails and other antimicrobial applications. During our studies, we optimized the synthetic route of CSA-13, so that it can be prepared at the kilogram, even in tons scale. We investigated three routes and one of them is suitable for industry, because only recrystallization is needed in the synthesis. Natural killer T cells (NKT …

Deafdigest: Gold Edition, December 18, 2011, Barry Strassler

DeafDigest Gold 2011

No abstract provided.

Kate's Untested Baby (Huntington’S Disease And Abortion - Part Ii), Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Addressing Global Climate Change In An Age Of Political Climate Change, Brigham Daniels

BYU Law Review

For a number of years, many within the environmental legal community have advocated an all-out attack strategy of forcing the United States to address climate change by bringing novel lawsuits under existing environmental laws. In 2007, with the seminal case of Massachusetts v. EPA, it appeared that those advocating this strategy had a winning game plan. That sense grew and solidified when the Obama Administration came to power. However, over the past several years, we have seen a countervailing movement embodied in a growing resentment towards EPA and climate change policy in general. This movement has mobilized into a powerful …

Environmental Crisis And The Paradox Of Organizing, Gregg P. Macey

BYU Law Review

Public organizations, including those involved in contingency planning, have tremendous influence over the ultimate scale and scope of an environmental crisis. Yet our understanding of how organizational behavior can either rein in or exacerbate crises continues to lag behind advances in technology. This Article considers the role of public organizations in the blowout of the Macondo well in the Gulf of Mexico. Its theoretical lens is the “paradox of organizing,” a frame that I suggest should be applied to interorganizational responses to low-probability, high-consequence events. The struggle to differentiate tasks and subunits and then piece them together during moments of …

The Impact Of Breast Cancer Screening On Sleep, Affect, And Immune Functioning, Caitlin Burbridge

Master's Theses

Despite great strides that have been made over the past several decades in terms of diagnosis and treatment, breast cancer remains the most commonly diagnosed cancer in American women and the second leading cause of cancer-related mortality for women in the United States. Although the benefits of early detection of breast cancer have been clearly established, the advantages of screening must also be weighed against a potential corresponding negative psychological impact of screening procedures. The purpose of the present study was to further investigate the impact of breast cancer screening on previously unstudied or understudied aspects of psychological and physiological …

Computational Modeling For Transportation Network Security, Sherif A. Tolba

Master's Theses

No abstract provided.

Racial/Ethnic Differences In Possible Selves Of Diverse Adolescents: Implications For Higher Education And Mental Health, Viana Y. Turcios-Cotto

Master's Theses

There are striking disparities in the academic achievement of American youth, with Latino and Black adolescents attaining higher education at vastly lower rates than White adolescents. Though numerous reasons exist for these educational disparities this study examines possible selves as they may relate to educational achievement among Latinos. Specifically, this study investigates: a) racial/ethnic differences in the content and themes of expected possible selves held by young adolescents; b) within group differences among Latino students and their expected possible selves; c) racial/ethnic differences in the relation between higher education possible selves and current mental health adjustment. Written responses reflecting types …

Psychometric Evaluation Of The Timeline Followback For Exercise Among Young Adults, Gregory A. Panza

Master's Theses

Objectives: Two separate studies assessed psychometric properties of a retrospective behavioral measure adapted for exercise called the Timeline Followback for Exercise (TLFB-E). Study one examined criterion, convergent, and predictive validity. Study two examined test-retest reliability. Methods: Study one participants (N = 66) were college students 20.0 ± 1.4yr. Validity of frequency, intensity, time, and type of exercise as assessed on the TLFB-E was examined using Pearson r correlations with accelerometers, weekly exercise contracts between participants and researchers, College Alumni Questionnaire, and a health-related physical fitness battery. Study two participants were a separate sample (N = 40) of college …

An Assessment Of Moose (Alces Alces Americana) And Moose Management In Connecticut, Andrew M. Labonte

Master's Theses

Eastern moose (Alces alces americana) populations have been increasing in New England over the past decade. Moose populations have the potential to generate human conflict due to their size, speed, nocturnal behavior, and seasonal mobility. As problems associated with increasing moose populations become more common, the need to develop management strategies that are both effective and acceptable to stakeholders becomes increasingly important. The potential for moose to continue to expand in southern New England and the long-term impacts they may have on Connecticut residents, is unclear. The overall purpose of this study was to assess how suitable Connecticut …

Effects Of 4-Hydroxy-2-Nonenal On Mutant Sperm Whale Myoglobins, Nantawat Tatiyaborworntham

Master's Theses

No abstract provided.

Testing The Limits Of Hyperspectral Airborne Remote Sensing By Mapping Eelgrass In Elkhorn Slough, Kelley J. Bostrom

Master's Theses

Seagrass ecosystems are a valuable resource, but vulnerable to changing conditions in the coastal ocean. Quantification of seagrass density and distribution from aerial imagery can be applied as a tool in resource management and ecosystem health and stability monitoring. This study investigates analytical methods for mapping eelgrass beds in an optically complex shallow, turbid estuary. Hyperspectral imagery (HSI) of Elkhorn Slough, CA was collected by the Spectroscopic Aerial Mapper with Onboard Navigation (SAMSON) instrument. In-situ data of water column and benthic optical properties and Hydrolight Radiative Transfer model were used to create a spectral library describing the reflectance of Elkhorn …

Bias Correction And Downscaling Of Climate Model Outputs Required For Impact Assessments Of Climate Change In The U.S. Northeast, Kazi F. Ahmed

Master's Theses

Global Climate Models (GCMs) are the typical sources of future climate data required for impact assessments of climate change. However, GCM outputs are related to model-related uncertainties and involve a great deal of biases. Bias correction of model outputs is, therefore, necessary before their use in impact studies. The coarse resolution of GCM simulations is another hindrance to their direct use in fine-scale impact analysis of climate change. Although downscaling of GCM outputs can be performed by dynamical downscaling using Regional Climate Models (RCMs), it requires large computational capacity. When daily climate data from multiple GCMs are required to be …

Reconstituting Land-Use Federalism To Address Transitory And Perpetual Disasters: The Bimodal Federalism Framework, Blake Hudson

BYU Law Review

Scholars analyzing the intersection of federalism and disaster law and policy have primarily focused on the difficulties federalism poses for interjurisdictional coordination of disaster response. Though scholars have highlighted that rising disaster risks and costs are associated with “land-use planning that exacerbates, rather than mitigates, disaster risk,” a more holistic analysis of land-use-related disaster law and policy is needed. This Article provides a more comprehensive framework within which to analyze prospective mitigation or prevention of disaster risk and costs through a rebalancing—or reconstituting—of the respective roles of the federal and state governments in land-use planning. The federal government does not …

A Learning Collaboratory: Improving Federal Climate Change Adaptation Planning, Alejandro E. Camacho

BYU Law Review

No abstract provided.

Legal Remedies For Deep Marine Oil Spills And Long-Term Ecological Resilience: A Match Made In Hell, Robin Kundis Craig

BYU Law Review

The Deepwater Horizon oil spill that lasted from April to September 2010 was not only the worst oil spill disaster in United States history, but also the first to occur at great depth. Drilling at great depth multiplies the risks and complications of offshore oil extraction. It also, as this Article explores, makes natural resource damages a decisively inadequate remedy for the injuries done to the Gulf of Mexico’s (the “Gulf”) ecosystems, especially the poorly understood but highly productive ecosystems that exist almost a mile below the surface. This Article argues that our current natural resource damages regimes for oil …