Digital Commons Network^™

Microrna Regulation Of Prostate Cancer Desensitization To Androgen Receptor Antagonist Drugs During Androgen Deprivation Therapy, Robert A. Lorch

HIM 1990-2015

The current standard treatment of prostate cancer by androgen deprivation therapy involves using drugs such as bicalutamide (Casodex) to antagonistically block androgen receptors that are normally present within prostate cells. Usually, the therapy is successful in the short run at limiting the growth of prostate cancer. However, in virtually all cases tumors begin to grow aggressively again after several months of treatment and new therapies must be started. The mechanism by which these prostate cells transform from androgen sensitive to androgen independent and anti-androgen resistant is unclear. In this study, we investigated the role of microRNAs, small 15 to 18 …

Perceived Gender And Its Effect On Attributions Toward Avatars In The Video Game Spore, Victoria Marie Sweeney

HIM 1990-2015

In this study, 174 undergraduates from the University of Central Florida were asked to rate individual human and animal avatar features from the video game Spore on their level of femininity, masculinity, likability, and how well the feature represented them on a 7 point Likert scale of agreeability. Avatar features were presented on a neutral gray, quadruped body in two different views. It was expected that participants would show higher likability for avatar features that they perceived as corresponding to their Personal Attribute Questionnaire (PAQ) gender. Males liked feminine features approximately the same as females, however, in many categories females …

Activity Of Epithelial Defensin Hbd-3 Against A Periodontal Pathogen, Norman B. Fine

Theses and Dissertations (ETD)

Defensins are cationic (positive-charged) peptides with broad-spectrum antibiotic activity. In humans, there are two types of defensins, alpha (α) and beta (β). Human neutrophils contain four α-defensins known as Human Neutrophil Peptide (HNP) 1-4. Epithelial cells produce four β-defensins known as Human Beta Defensin (HBD) 1-4. Gram-negative anaerobic bacteria that are associated with periodontal disease are resistant to human α-defensins, but are killed by β-defensins.

HBD-3 is the most active β-defensin. HBD-3 is a longer peptide than HNP 1-4. HBD-3 has additional amino acid residues with hydrophobic side chains near the N-terminus and residues with cationic side chains at the …

Role Of Protein Kinase C Zeta (Pkcζ) In Regulation Of Epithelial Tight Junctions, Suneet Kumar Jain

Theses and Dissertations (ETD)

Occludin is hyperphosphorylated on Ser and Thr residues in intact epithelial tight junctions. The dynamics of epithelial tight junctions appear to involve reversible phosphorylation of occludin on Ser and Thr residues. In the present study we determined the role of PKCζ in occludin phosphorylation and the dynamics of tight junctions. Inhibition of PKCζ by specific PKCζ pseudo substrate rapidly reduced TER, increased inulin permeability and induced redistribution of occludin and ZO‑1 in Caco‑2 and MDCK cell monolayers without inducing cytotoxicity. Reduced expression of PKCζ also resulted in compromised tight junction integrity. Both PKCζ pseudo substrate and reduced expression of PKCζ …

Cross-Talk Of Retinoic Acid And Adrenergic Hormone Signaling May Influence Development Of Cardiac Conduction And Rhythmicity In Utero, Sabikha Alam

HIM 1990-2015

Stress hormones, adrenaline and noradrenaline, have been shown to be critical for heart development. Mice lacking dopamine greek lower case letter beta]-hydroxylase (Dbh), an enzyme responsible for synthesis of these adrenergic hormones, die during mid-gestation due to cardiac failure. Prior research showed that adrenergic cells are found within the electrical conduction system of the heart, and adrenergic deficiency leads to slowed cardiac conduction during embryogenesis. Microarray analysis of wild-type (Dbh+/+) and knockout (Dbh-/-) mouse hearts revealed significant differences in expression of retinoic acid (RA) signaling genes. RA signaling has also been shown to be critical for heart development. These data …

Genetic Intervention As A Lifestyle Approach An Analysis Of Disease And Treatment, Jennifer L. Dempton

HIM 1990-2015

Purpose: The scientific knowledge of how genes affect disease expression and evolution can facilitate more effective environmental and drug therapy interventions delivered by health care professionals. The purpose of this paper is to a) describe the role of genetic science in healthcare; b) explore genotype determinants for environmental and pharmacological interventions; c) and analyze ethical dilemmas, barriers to access, and allocation of resources based on genotype. Methods: A review of literature was conducted from the disciplines of nursing, medicine, psychology, and sociology using the CINAHL, Ebsco Host, Medline, and PsychINFO databases. The search was limited to peer reviewed, full text …

Analysis Of The Repair Of Topoisomerase Ii Dna Damage, Eric D. Goldstein

HIM 1990-2015

A large number of anti-cancer chemotherapeutics target DNA topoisomerases. Etoposide is a specific topoisomerase II poison which causes reversible double strand DNA breaks. The focus of this project is to analyze the repair of DNA damage induced by etoposide.. Double strand DNA break repair is mediated by through either non-homologous end joining (NHEJ) or homologous recombination. NHEJ repairs through direct ligation of a double stranded break while homologous recombination utilizes a homologous template to recover the wild type sequence. A reporter cassette, RYDR-GFP, has been stably integrated into HeLa cells. This reporter contains an ultra-high affinity topoisomerase II cleavage site …

Saved, Sanctified And Filled With Gay Liberation Theology With Aamsm And The Black Church, Adam Green

HIM 1990-2015

AAMSM (African American men who have sex with men) endure homophobia and racism in their political realities because of their identity. How do multiple oppressions impact the experiences of AAMSM participating within Black churches? Despite the Black church's legacy for liberating African Americans, AAMSM feel demonized and alienated while enduring religion-based homophobia espoused within many Black churches. In the church, AAMSM are pushed further down the hierarchy of oppression and privilege. In response to these observations, this thesis employs a sexual discourse of resistance. I engage this discourse with a literature review in order to discover links between homophobia and …

The Relationship Between Genre Choice Of Music And Altruistic Behavior, Christine Hippler

HIM 1990-2015

Extensive research has documented the relationship between listening to certain genres of music and negative effects on social behavior such as aggressive and antisocial behavior. The present study explored whether there are genres of music associated with altruism. Altruistic behavior is defined as behavior that is consistently more caring, helpful, considerate of other's feelings, and self- sacrificing. These behaviors promote our ability to thrive as a community. Yet, few studies have addressed the relationship between music and altruism. Data was collected from 608 college students who completed a self-report altruism scale, music preference measure, the Marlowe Crowne social desirability scale, …

Pre-Screen Of Traits That Lead To Post-Traumatic Stress Disorder, Krystal A. Lee

HIM 1990-2015

Post-Traumatic Stress Disorder (PTSD) is a disorder that is affecting many lives and families. Since it is believed that over 50% of Americans will experience a traumatic event and 25% will experience multiple traumatic events, PTSD is an issue that cannot be overlooked. Although PTSD is most commonly associated with war victims, the official definition of PTSD was stated in the DSM-IV as "an extreme traumatic stressor involving direct personal experience or that involves actual or threatened death or serious injury or other threat to one's physical integrity; or witness to an event that involves death, injury, or a threat …

High Yield Assembly And Electron Transport Investigation Of Semiconducting-Rich Local-Gated Carbon Nanotube Field Effect Transistors, Kristy Kormondy

HIM 1990-2015

Single-walled carbon nanotubes (SWNTs) are ideal for use in nanoelectronic devices because of their high current density, mobility and subthreshold swing. However, assembly methods must be developed to reproducibly align all-semiconducting SWNTs at specific locations with individually addressable gates for future integrated circuits. We show high yield assembly of local-gated semiconducting SWNTs assembled via AC-dielectrophoresis (DEP). Using individual local gates and scaling the gate oxide shows faster switching behavior and lower power consumption. The devices were assembled by DEP between prefabricated Pd source and drain electrodes with a thin Al/Al2O3 gate in the middle, and the electrical characteristics were measured …

Relationships Of Combined Parenting Styles Of Step And Biological Parents In Stepfamily Relationship Formation And Emerging Adult Stepchildren's Adjustment, Saarah Kison

HIM 1990-2015

Previous stepfamily research suggested that the parenting styles of biological parents and stepparents are related to children's behavioral adjustment. Scant research also provided evidence of the significance of combined parenting styles on emerging adults' behavioral adjustment. In conjunction with this literature, the scope of the current study served four purposes. First, the current study examined the degree to which parenting styles predict emerging adults' behavioral adjustment. Second, the degree to which biological parent and stepparent parenting styles predict the emerging adult-biological parent and stepparent relationships was examined. Third, the degree to which the emerging adult-biological parent and stepparent relationships predict …

An Exploration Of Materials For Music Integration In Elementary Science Education, Nicole Jennet Mills

HIM 1990-2015

Strong educators always look for different ways to excite and enthrall their students in the curriculum. The field of science education often loses student interest due to the complexities and vocabulary found in the scientific realm. Incorporating music into the classroom has shown positive results as a way to integrate student learning and a different way of facilitating students in the learning process (Brewer, 1992; Davies, 200). Resources for implementing the integration of music and science exist throughout the Internet in a variety of mediums. This study looks at the availability of said resources and the concepts they cover, for …

On Rights A Defense And Analysis Of Rights Through Natural Law, Ramon E. Lopez

HIM 1990-2015

One of the central questions in political theory deals with the nature of rights. What sorts of rights do people possess? How are these rights justified? How ought these rights be reflected and related when seen in political, economic, and social institutions? Following the publication of John Rawls' A Theory of Justice (1971) and Robert Nozick's Anarchy, State, and Utopia (1974), rights have once again returned to dominate much of contemporary political theory. However, natural law, which was the historical basis of the early Enlightenment theories of rights, is no longer the primary system appealed to when discussing rights. In …

Intolerance Of Ambiguity And Gender Differences Between Humanists And Normativists, Jorge I. Mendoza

HIM 1990-2015

A study was conducted to test Tomkins' Polarity theory (1963) on the psychological basis for being ideologically liberal or conservative and its relationship with intolerance of ambiguity and gender differences. Normativism, the conservative orientation, was found to have a positive relationship with intolerance for ambiguity. Males were found to be generally less humanist than females. Theoretical background and relevant research is discussed. Suggested applications of this study are to political persuasion, voting behavior, and the psychology of partisanship. This study intends to contribute to the literature on the psychology of ideology, political behavior and ideological differences between men and women.

Examining The Relationship Between Female Parents With Low Perceived Control And Adolescent Child Stress, Brendan P. Monaghan

HIM 1990-2015

Adolescence is a stressful time for many children. Changes in their environment or changes in social situations are some typical stressors that an adolescent child might encounter. Interactions with parents can also be a stressor for a child. Previous research has shown that a risk factor for a parent using harsh parenting techniques is perceived control. Parents who have low perceived control are at a higher risk to engage in physical parenting techniques or child abuse. This study included 198 middle school students and their female parent or guardian pairs (296 total participants), with the adolescent participants ranging in age …

A Tripartile Biosensor For Real-Time Snss Detection In Dna Hairpin Motif, Camha Nguyen

HIM 1990-2015

The hybridization between two complementary strands of nucleic acid is the basis for a number of applications in DNA and RNA analysis, including in vivo RNA monitoring, microarrays, SNPs detection, and so on. The short oligonucleotide probes form Watson/Crick base pairs (A-T and G-C) with the analyzed nucleic acid. Molecular beacon (MB) probe is one of the most advantageous tools for nucleic acid analysis in real-time. A traditional MB probe consists of a DNA strand folded in hairpin motif with a fluorophore attached to the 5'end and a quencher attached to the 3' end. The loop segment is complementary to …

Plant-Made Oral Vaccines Evaluation Of Capsules, James Stewart New

HIM 1990-2015

Antigen expression through the Chloroplast Transformation Technology (CTT) produces bioencapsulated subunit-vaccines, capable of eliciting immune responses when delivered orally. Considerable challenges to effective plant-based vaccines are the normalization of dosage and preservation of accumulated antigen, which is complicated by variable high water content and protease activity. This study critically examines the efficacy of lyophilization in dehydrating plant-tissues and preserving plant-derived antigens with vaccine potential. Lyophilization was optimized through gravimetric analysis using lettuce expressing Protective Antigen (PA) of Bacillus anthracis (LS-HPAG) and the human autoantigen Proinsulin (Pins) fused to Cholera toxin subunit B (LS-CTB-Pins). Lyophilization for 48-hours was sufficient treatment to …

Ucf Upward Bound Program Promoting First Generation In College, Low Income And Multicultural Students Stem College Success, Christina Restrepo

HIM 1990-2015

The objective of this research is to explore the perceptions of UCF Upward Bound Program participants using focus groups and pre-posttest surveys in order to assess students' level of understanding of Science, Technology, Engineering, and Mathematics (STEM) related coursework, secondary education preparation in science and mathematics, and their perceptions of barriers to a STEM college education. Also, this study centers on the summer 2010 science and mathematics residential portion of the Upward Bound Program. Program outcomes and effectiveness were evaluated based on the change in student insight of the Upward Bound Program's stake in their secondary education. In addition, pre-posttest …

Ibully: The Impact Of Gender Of Bully And Victim On Perception Of Cyberbullying And Its Consequences, Christopher Sharpe

HIM 1990-2015

In today's technologically sophisticated world, people have many electronic methods of exchanging information and communicating. Unfortunately, these methods are not always used in positive ways; they can also be used to convey aggression and bullying. Recently, such acts of aggression have been labeled many things from cyberbullying to online social cruelty, and have received much media attention due to their tragic consequences including victim suicide. This study explores the impact of victim and bully gender in relation to perception of bully likability, punishment, impact on victim, and victim responses. Participants reviewed a Cyberbullying scenario in which the gender of the …

The Struggle For Regional Hegemony How The Iranian Revolutionary Guard Corps Continues To Influence Iraq, Juliana Velasco

HIM 1990-2015

Due to the recent war in Iraq, the Middle East has once against jumped to the forefront of everyone's mind. The world has been focused on Iraq and Iran for a decade now because Iran has established a strong foothold in Iraqi life since the toppling of Saddam Hussein. However, in order to understand this issue and attempt to solve it, an extensive study must be made of all the reasons that Iran is succeeding where the United States has not. The purpose of this thesis is to explore the historical influence that Iran, particularly the Iranian Revolutionary Guard Corps …

Crack Mothers, Crack Babies, And Black Male Dope Dealers Productions Of Deviance During America's Crack Cocaine Panic In The 1980s, Chantelle Yandow

HIM 1990-2015

A moral panic erupted during the 1980s among the American public when stories about crack cocaine saturated the media. In this thesis I analyze how discursive productions of deviancy operated in the CBS news documentary: 48 Hours on Crack Street (1986) and other print news sources at that time. Three salient characters that appear in news media discourse during the panic are "crack mothers," "crack babies," and "Black male dope dealers." The news media frightened the public with such representations (among others) and the public urged politicians to get tough on drug crime to control the so-called crack cocaine plague. …

Life, Death, And Neuroimaging: The Advantages And Disadvantages Of The Defense's Use Of Neuroimages In Capital Cases -Lessons From The Front, John H. Blume, Emily C. Paavola

Mercer Law Review

Over the past several decades, commentators and scholars from the medical, legal, and social science fields have produced a massive body of literature on the intersection of law and neuroimaging. Earlier writings focused on explaining various new techniques for developing brain images, exploring how such images might be relevant in legal proceedings, and addressing evidentiary issues posed by the use of such images in court. More recent publications correspond with a vast expansion of research and funding in the area of neuroscience and address a wide variety of topics, such as the use of neuroimaging to detect deception, predict recidivism …

Adsorbents With Chemically Bonded Saccharide Surfaces: Synthesis And Application For Stereoisomer Separation And The Synthesis Of Chiral Porous Silicas Using Templates Chiral Surfactant, Edwin Vega

Seton Hall University Dissertations and Theses (ETDs)

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Evidence-Base Practice: Screening For Depression And Suicidality In High Functioning Autistic Spectrum Disorder Adolescents, Jennifer A. Durward

Theses and Dissertations

Research regarding assessing for suicide and depression in high-functioning autistic spectrum disorders (HFASDs) is very limited. An extensive literature review focusing on HFASDs was conducted, which resulted in adolescents with HFASDs are likely to experience depression and suicidality compared to those who are neurotypical or those not diagnosed with an autistic spectrum disorder (ASD) because of limited social and communication skills. These deficits put these individuals at risk for depression, therefore, suicidality. PubMed, SCOPUS, PsychiatryOnline. and Cumulative Index to Nursing and Allied Health Literature (C1NAHL) were used to research information for this independent study. Implications for psychiatric nurse practitioners and …

Vitamin D And Malignant Melanoma Outcomes, Jenna L. Green

Theses and Dissertations

Ultraviolet exposure from sunlight and other sources is the major risk factor for the development of malignant melanoma of the skin. Exposure to sunlight is also the main pathway the human body obtains vitamin D. Cell proliferation, differentiation and inhibition is mediated in part by vitamin D, leading researchers to suspect vitamin D has a protective role in various cancers, including melanoma. The purpose of the project was to review the current available literature focusing on the relationship between vitamin D levels and melanoma outcomes. The review of the literature was designed to address the clinical question: What is the …

The Rhetorics Of Constructing Hiv/Aids In The United States And China: A Comparative Analysis Of Two Online Discussion Forums, Jingwen Zhang

All Theses

This thesis focuses on the cross-cultural comparison of the public rhetorics that construct HIV/AIDS in two online discussion forums from the United States and China. Social constructions of HIV/AIDS have previously been explored in specific countries and cultures; however, comparative studies have rarely been conducted, especially by applying rhetorical cultural analysis focusing on online discourses. Responding to these gaps in research, this study combines two underexplored dimensions -- comparative rhetorical analysis and online discourse -- to show how online communications, metaphors, and topoi identified in discussion forum posts reveal and construct the idea of HIV/AIDS in the public sphere for …

2011 Baccalaureate & Graduate Commencement, Lindenwood University

Commencement Programs

Lindenwood University Commencement program.

Probing Ground-State Single-Electron Self-Exchange Across A Molecule−Metal Interface, Yuanmin Wang, Papatya C. Sevinc, Yufan He, H. Peter Lu

Chemistry Faculty Publications

We have probed single-molecule redox reaction dynamics of hemin (chloride) adsorbed on Ag nanoparticle surfaces by single-molecule surface-enhanced Raman spectroscopy (SMSERS) combined with spectroelectrochemistry. Redox reaction at the molecule/Ag interface is identified and probed by the prominent fluctuations of the Raman frequency of a specific vibrational mode, nu(4), which is a typical marker of the redox state of the iron center in a hemin molecule. On the basis of the autocorrelation and cross-correlation analysis of the single-molecule Raman spectral trajectories and the control measurements of single-molecule spectroelectochemistry and electrochemical STM, we suggest that the single-molecule redox reaction dynamics at the …

Soundings 2011-05, N/A N/A

Soundings

No abstract provided.