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A 61 Year-Old Man With Delayed Hypersensitivity Reaction To Joint Prosthesis, Regina C. Lee, Md

The Medicine Forum

Case Presentation

61 year-old male with a past medical history of coronary arterydisease complicated by myocardial infarction in 1984, type 2diabetes mellitus, hyperlipidemia, hypertension, and right totalknee replacement in 2006 presents to the outpatient allergist’s officefor evaluation. The patient reports that he never fully recoveredafter the knee surgery and never regained function. The right kneeremained swollen and painful with limited range of motion andweight bearing as a result. He denies any rash, redness, or itching inthe area. He also denies any history of reactions to metals in the past.The orthopedic surgeon referred the patient to an allergist to assessfor an …

4th Graders Write Their First Lab Report - Phun Week Poster Session Eb 2011, Patricia A. Halpin

Life Sciences Faculty Scholarship

This poster describes a Physiology Understanding (PhUn) Week activity performed in a 4th grade classroom testing the hypothesis that heart rate and respiration rate increase with exercise. This poster was presented at the PhUn Week Poster Session, Experimental Biology 2011, by Patricia A. Halpin, PhD, University of New Hampshire Manchester.

Adult Attachment: A Framework For Predicting Dating Patterns, Franklin Owen Poulsen

Theses and Dissertations

Although adult attachment has been the focus of a great deal of relationship research, few studies have attempted to examine how adult attachment style may be related to relationship initiation. This study investigates how adult attachment is associated with dating processes and patterns in a sample (N = 587) of college students at a private religious university. Results indicate that attachment anxiety and attachment avoidance are related to a pattern of being mostly dateless in a twenty-five week period. Furthermore, attachment avoidance but not anxiety is related to having fewer relationships in the period. Along with attachment avoidance and anxiety, …

Eddy Impaction As An Ash Deposition Mechanism: A Theoretical And Experimental Investigation, Minmin Li

Theses and Dissertations

The eddy impaction ash deposition model derived and validated in this document predicts eddy impaction rates as a function of turbulence intensity, boundary layer thickness, and gas velocity. The experimental apparatus introduces small particles (200 nm, 25 µm, and 500 µm diameter) into a gas stream flowing through a horizontal pipe (Re 2,300-8,000). The particles deposit on the pipe wall and the total mass of impacted particles provides a measure of collection efficiency. Experimental results indicate deposition velocity increases with Reynolds number, consistent with eddy impaction theory and based on increased turbulent energy. Eddy impaction also increases with particle size …

Modeling Techniques For The High-Resolution Interpretation Of Cryo-Electron Microscopy Reconstructions, Mirabela Rusu

Dissertations and Theses (Open Access)

Essential biological processes are governed by organized, dynamic interactions between multiple biomolecular systems. Complexes are thus formed to enable the biological function and get dissembled as the process is completed. Examples of such processes include the translation of the messenger RNA into protein by the ribosome, the folding of proteins by chaperonins or the entry of viruses in host cells. Understanding these fundamental processes by characterizing the molecular mechanisms that enable then, would allow the (better) design of therapies and drugs. Such molecular mechanisms may be revealed trough the structural elucidation of the biomolecular assemblies at the core of these …

Pathway Activation Discovery May Lead To New Cancer Drugs, Jim Bakken

Browse All News

No abstract provided.

Marker Discovery In Allotetraploid Cotton Using 454 Pyrosequencing, Robert L. Byers

Theses and Dissertations

A narrow germplasm base and a complex allotetraploid genome have historically made the discovery of single nucleotide polymorphism (SNP) markers difficult in cotton (Gossypium hirsutum). We conducted a genome reduction experiment to identify SNPs from two accessions of G. hirsutum and two accessions of G. barbadense. Approximately 2 million sequence reads were assembled into contigs with an N50 of 508 bp and analyzed for SNPs. A total of 11,834 and 1,679 SNPs between the accessions G. hirsutum and G. barbadense, respectively, were identified with highly conservative parameters (a minimum read depth of 8x at each SNP …

The George-Anne, Georgia Southern University

The George-Anne

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Evolving Hard Problems: Generating Human Genetics Datasets With A Complex Etiology, Daniel S Himmelstein, Casey S Greene, Jason H Moore

Dartmouth Scholarship

BackgroundA goal of human genetics is to discover genetic factors that influence individuals' susceptibility to common diseases. Most common diseases are thought to result from the joint failure of two or more interacting components instead of single component failures. This greatly complicates both the task of selecting informative genetic variants and the task of modeling interactions between them. We and others have previously developed algorithms to detect and model the relationships between these genetic factors and disease. Previously these methods have been evaluated with datasets simulated according to pre-defined genetic models.

Sr-A Ligand And M-Csf Dynamically Regulate Sr-A Expression And Function In Primary Macrophages Via P38 Mapk Activation, Dejan Nikolic, Lindsay Calderon, Liqin Du, Steven R. Post

Pharmacology and Nutritional Sciences Faculty Publications

BACKGROUND: Inflammation is characterized by dynamic changes in the expression of cytokines, such as M-CSF, and modifications of lipids and proteins that result in the formation of ligands for Class A Scavenger Receptors (SR-A). These changes are associated with altered SR-A expression in macrophages; however, the intracellular signal pathways involved and the extent to which SR-A ligands regulate SR-A expression are not well defined. To address these questions, SR-A expression and function were examined in resident mouse peritoneal macrophages incubated with M-CSF or the selective SR-A ligand acetylated-LDL (AcLDL).

RESULTS: M-CSF increased SR-A expression and function, and required the specific …

Thin-Ideal Internalization, Body Misperception, And Their Association With Weight Control Behaviors Among Adolescent Girls, Erin Lindsey Moore

Theses and Dissertations

Negative body image and preoccupation with weight are the norm for most women and girls in Western society, despite their potentially harmful consequences for psychological and physical wellness. While we know that many in this population experience negative feelings towards their bodies, we do not know if their beliefs about their body size are accurate and what effect a correct or incorrect assessment of one's body size has in terms of actual behavior. I examine this question among adolescent girls using data from the 2002 Health Behaviors in School-Age Children Survey. With a sample of 2,784 girls between the ages …

Higher Education In Native American Communities: Who Graduates And Why?, Ramon Francisco Castillo Ii

Theses and Dissertations

In this case study, I examine the graduation patterns of students attending Chief Dull Knife College located on the Northern Cheyenne Reservation in Lame Deer, Montana. While comparing the characteristics of students attending this college with that of two-year colleges nationally and tribal schools throughout the nation, we begin to understand the unique situation that this community faces. With the use of logistic and linear regressions, I explored the characteristics of those who graduate and ask the question, who graduates and what makes them unique? This study found that the credits attempted per semester, the number of credits they earned …

Mechanical Characterization Of The Interspinous Ligament Using Anisotropic Small Punch Testing, Rachel Jane Bradshaw

Theses and Dissertations

Objective: The objective of this work was to characterize the nonlinear anisotropic material constitutive response of the interspinous ligament (ISL).

Methods: Cadaveric test samples of the interspinous ligament were tested using the anisotropic small punch test. The measured force-displacement response served as experimental input into a system identification optimization routine to determine the constitutive material parameters that replicated the measured material response.

Results: The constitutive behavior of the ISL is notably different from that reported for knee, shoulder, and hip ligaments. Specifically, the high collagen fiber content and unique collagen architecture provided a stiffer material response. The results from the …

Merging Resource Availability With Isotope Mixing Models: The Role Of Neutral Interaction Assumptions, Justin D. Yeakel, Mark Novak, Paulo R. Guimarães, Nathaniel J. Dominy, Paul L. Koch, Eric J. Ward, Jonathan W. Moore, Brice X. Semmens

Dartmouth Scholarship

Bayesian mixing models have allowed for the inclusion of uncertainty and prior information in the analysis of trophic interactions using stable isotopes. Formulating prior distributions is relatively straightforward when incorporating dietary data. However, the use of data that are related, but not directly proportional, to diet (such as prey availability data) is often problematic because such information is not necessarily predictive of diet, and the information required to build a reliable prior distribution for all prey species is often unavailable. Omitting prey availability data impacts the estimation of a predator's diet and introduces the strong assumption of consumer ultrageneralism (where …

Using A Behavioral Skills Approach To Train A Mother To Teach Basic Learning And Self-Help Skills To Her Daughter Diagnosed With Rett Syndrome, Christina Racz

Research Papers

No abstract provided.

Community Satisfaction, Community Attachment, Community Experience, Internet Use And Internet Access In Rural Utah Communities, Tisah M. Quarnberg

Theses and Dissertations

This study examines the impact of the Internet on rural community satisfaction, attachment and overall experience. With the geographic dispersion of social networks, the majority of the population has a greater need for long-distance social networking. The Internet has the potential to mitigate distance and connect social networks much faster than letter writing or face-to-face visits. While the Internet is available, to at least some extent, in rural communities in Utah, does it positively affect overall perceptions of community life? This study finds that this is not the case. There is a negative relationship between Internet use and community satisfaction …

Oncogene-Induced Nrf2 Transcription Promotes Ros Detoxification And Tumorigenesis., Gina M. Denicola, Florian A. Karreth, Timothy J. Humpton, Aarthi Gopinathan, Cong Wei, Kristopher Frese, Dipti Mangal, Kenneth H. Yu, Charles J. Yeo, Eric S. Calhoun, Francesca Scrimieri, Jordan M. Winter, Ralph H. Hruban, Christine Iacobuzio-Donahue, Scott E. Kern, Ian A Blair, David A. Tuveson

Department of Surgery Faculty Papers

Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer. Normally, ROS levels are tightly controlled by an inducible antioxidant program that responds to cellular stressors and is predominantly regulated by the transcription factor Nrf2 (also known as Nfe2l2) and its repressor protein Keap1 (refs 2-5). In contrast to the acute physiological regulation of Nrf2, in neoplasia there is evidence for increased basal activation of Nrf2. Indeed, somatic mutations that disrupt the Nrf2-Keap1 interaction to stabilize Nrf2 and increase the constitutive transcription of Nrf2 target genes were recently identified, indicating that enhanced ROS detoxification and additional Nrf2 functions may …

The Professional Identity Development Of Gerontologists: An Experiential Learning Approach, Tracey Gendron

Theses and Dissertations

Professional identity is a complex construct that describes how an individual develops a sense of self-concept within a chosen profession. Professional identity refers to a self definition within a professional role based on attributes, beliefs, values, motives, and experiences (Ibarra, 1999). This study explored the relationships between the professional identity of gerontology graduates and age, career stage, student typology, occupation, and value of experiential learning both quantitatively and qualitatively. Survey results indicate that experiential learning opportunities provide a framework for all gerontology students to gain and apply the skills and knowledge necessary for professional identity development in the field of …

Solid-State Synthesis Of Imide Ligands For The Self-Assembly Of Metal-Organic Materials, Jason Alexander Perman

USF Tampa Graduate Theses and Dissertations

In this research project, reduction or complete elimination of organic solvents is explored in the synthesis of cyclic imides using a technique that brings reagents into favorable position to react. Cocrystal Controlled Solid-State Synthesis (C³S^y3), takes advantage of supramolecular interactions such as hydrogen bonding and π-π stacking to form a cocrystal which can sequential be heated to complete the condensation reaction and produce a desirable product. Twenty-five successful condensation reactions result in high and clean yield.

C³S^y3 of cyclic imides with auxiliary hydrogen bonding moieties like carboxylic acid, carboxylate or pyridyl groups are …

A Man With Abdominal Pain And Acute Renal Failure, Faisal Shaikh Md, Marina Serper, Md

The Medicine Forum

Case Presentation

A 33 year-old African American male with a past medical history significant for HIV on HAART therapy presented to the emergency department (ED) with acute onset of right upper quadrant abdominal pain and mild shortness of breath. The abdominal pain was not associated with any fevers, chills, nausea, vomiting or diarrhea. The patient denied any chest pain, palpitations, lightheadedness or syncopal episodes. He did report some dysphagia with solids more than liquids over the last 2 months as well as decreased oral intake. His review of systems was otherwise significant for weight loss which he was unable to …

Woman With Facial And Neck Swelling, Meredith Chiaccio, Msiii, Donna Mscisz Williams, Md

The Medicine Forum

A 28 year-old Caucasian female, 3.5 months postpartum, presented to the TJUH ED with facial and neck swelling. She was in her usual state of health until approximately 1 month prior to admission when she noted the gradual onset of neck swelling. The neck swelling progressed to her face 4 days prior to admission; swelling in both areas was progressive and increasingly uncomfortable. Two months prior, the patient was treated for sinusitis with a course of antibiotics by an allergist; this treatment was unsuccessful, and she was referred her to an otolaryngologist, who performed a neck ultrasound and lab work. …

Band-Aid Solutions: New York’S Piecemeal Attempt To Address Legal Issues Created By Doma In Conjunction With Advances In Surrogacy, James Healy

Pace Law Review

No abstract provided.

Phoenix, 2011-07-06, Student Life

Phoenix

The Phoenix is a student newspaper published at Governors State University since August 2002. The newspaper features student reporting, opinions, news, and photos.

Lgbt 101 And Safe Spaces Program 2011, Joseph A. Santiago

Lesbian Gay Bisexual Transgender Queer Center

LGBT 101 and Safe Spaces Program was what Joseph Santiago put together to train the RAs in 2011. The LGBT 101 and Safe Spaces Program was designed to be become a train the trainer program here at URI. Purpose LGBT 101 information is part of a program to create a safer and more receptive campus and work place environment for gay, lesbian, bisexual, transgender and/or questioning people through education and ally development. It is modeled after similar programs at colleges and universities throughout the United States. This short introduction to LGBT 101 and introduction to SafeSpace training will begin to …

The Effects Of Β-Amyloid On Α7 Nicotinic Acetylcholine Receptors Expressed In Xenopus Oocytes, Malia L. Anderson

Theses and Dissertations

The exact mechanism and progression of Alzheimer's disease (AD) at present is not fully understood. In patients suffering from AD, damage to the hippocampal region and impairment of learning and memory is present. It is also known that a buildup of β-amyloid plaques occur in AD patients and that β-amyloid interacts with some subtypes of neuronal nicotinic acetylcholine receptors (neuronal nAChRs). These receptors are composed of five subunits. The most prevalent nAChR subunit composition through the brain as a whole is α7. Previous data produced from our lab suggests that α7 nAChRs are also one of the most prevalent subunits …

Microglial P38Α Mapk Is A Key Regulator Of Proinflammatory Cytokine Up-Regulation Induced By Toll-Like Receptor (Tlr) Ligands Or Beta-Amyloid (Aβ), Adam D. Bachstetter, Bin Xing, Lucia De Almeida, Edgardo R. Dimayuga, D. Martin Watterson, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Overproduction of proinflammatory cytokines from activated microglia has been implicated as an important contributor to pathophysiology progression in both acute and chronic neurodegenerative diseases. Therefore, it is critical to elucidate intracellular signaling pathways that are significant contributors to cytokine overproduction in microglia exposed to specific stressors, especially pathways amenable to drug interventions. The serine/threonine protein kinase p38α MAPK is a key enzyme in the parallel and convergent intracellular signaling pathways involved in stressor-induced production of IL-1β and TNFα in peripheral tissues, and is a drug development target for peripheral inflammatory diseases. However, much less is known about the quantitative …

Characterization Of The Mechanical Response Of The Lumbar Spine, Shannon Alisa Zirbel

Theses and Dissertations

The primary objective of this research is to associate lumbar segmental mechanical response with intervertebral disc degeneration under physiologic testing conditions. Because no mathematical model exists for lumbar spine segmental rotations, a portion of this thesis evaluates potential methods for curve fitting the torque-rotation curves. The Dual Inflection Point (DIP) Boltzmann equation was developed during the course of this research and is presented here as a method for fitting spinal motion data wherein a physical meaning can be assigned to each of the model coefficients. This model can tell us more about the effects of degeneration, testing conditions, and other …

Comparing The Effects Of Two Forms Of Dynamic Corrective Feedback On Four Characteristics Of English Language Learner Writing, Judson Mc Kay Hart

Theses and Dissertations

Particular English language learners have a need to demonstrate high levels of accuracy in their written and spoken language production. Dynamic corrective feedback (dynamic CF) has been shown to facilitate L2 learner written accuracy attainment through providing manageable, meaningful, timely and constant feedback on authentic and frequent written language production. The research of this thesis examined the benefits of altering the dynamic CF model to be responsive to students' spoken production rather than solely their written production and measured the impact this adaptation would have on the established benefits of the instructional strategy on students' gains in written accuracy. The …

Transcriptome Sequencing, And Rapid Development And Application Of Snp Markers For The Legume Pod Borer Maruca Vitrata (Lepidoptera: Crambidae), Venu M. Margam, Brad S. Coates, Darrell O. Bayles, Richard L. Hellmich, Tolulope Agunbiade, Mandredo J. Seufferheld, Weilin Sun, Jeremy A. Kroemer, Malick N. Ba, Clementine L. Binso-Dabire, Ibrahim Baoua, Mohammad F. Ishiyaku, Fernando G. Covas, Ramasamy Srinivasan, Joel Armstrong, Larry L. Murdock, Barry R. Pittendrigh

Department of Entomology Faculty Publications

The legume pod borer, Maruca vitrata (Lepidoptera: Crambidae), is an insect pest species of crops grown by subsistence farmers in tropical regions of Africa. We present the de novoassembly of 3729 contigs from 454- and Sanger-derived sequencing reads for midgut, salivary, and whole adult tissues of this non-model species. Functional annotation predicted that 1320M. vitrata protein coding genes are present, of which 631 have orthologs within the Bombyx mori gene model. A homology-based analysis assigned M. vitrata genes into a group of paralogs, but these were subsequently partitioned into putative orthologs following phylogenetic analyses. Following sequence quality filtering, …

The Molecular Mechanism Of Migraine, Kristin Dawn Watson

Theses and Dissertations

Migraine is a common, episodic neurological disorder that includes headache, nausea and hypersensitivity to sensory stimuli. During the headache phase of migraine, migraine patients can be especially hypersensitive to thermal stimuli. The unpredictable and episodic nature of migraine makes it difficult to treat and much of the mechanism of migraine has yet to be elucidated. A T44A substitution in casein kinase 1δ is inherited with migraine with aura. A transgenic mouse model suggests that animals with this mutation exhibit increased sensitivity to thermal stimuli after injection with nitroglycerin (NTG). We performed behavior assays that measure animal responses to thermal stimuli, …