Digital Commons Network^™

Pattern Of Relapse After Curative Surgery For Metastatic Colorectal Cancer, Jau-Jie You, Hong-Chang Chen, Hung-Jen Chen, Ching-Shui Hsieh, Mei-Chuan Chang, Jui-Hung Yu, Yao-Li Chen, Cheng-Shyong Chang

Saudi Medical Journal

OBJECTIVE: To investigate patterns in the relapse frequency after curative surgical intervention, with the intention of determining the feasibility of a complete holiday from chemotherapy for metastatic colorectal cancer (mCRC) patients. METHODS: Patients with stage IV mCRC who received curative surgical intervention between January 1999 and December 2009 at Changhua Christian Hospital, Changhua, Taiwan were investigated retrospectively. Factors influencing the frequency and pattern of relapse were analyzed by logistic regression. Factors influencing overall survival (OS) were analyzed with Cox proportional hazard ratios. Significant factors were extracted and relationships to OS were evaluated by Kaplan-Meier with Log-Rank test. RESULTS: One hundred …

Effect Of Quality Of Life Improvement On Type 2 Diabetes Patients’ Self-Esteem, Mahboubeh Safavi, Nasrin Samadi, Mahmood Mahmoodi

Saudi Medical Journal

OBJECTIVE: To study the effects of the quality of life (QoL) improvement on their QoL and self-esteem. METHODS: This was a random controlled clinical trial study on 123 type 2 diabetes patients admitted to the Diabetes Clinic in Imam Khomeini Hospital at Ardebil, Iran from April 2009 to June 2010. The 30-70 years old participants are afflicted with type 2 diabetes, and randomly divided into 2 groups (experimental group n=61, and control group n=62). The questionnaires were composed of sociodemographic status, Farrel … Grant, and Rosenberg’s self-esteem questionnaires and the quality of life (QoL) improvement plan was codified to educate …

Teaching Students To Assess Information In Biomedical Sciences: Simple Strategies, P. K. Rangachari

Journal of Medical Education

Simple strategies are described to help students acquire skills for seeking and assessing information in student-centered courses, including problem-based learning. Emphasis is placed on assessing the peer-reviewed literature in basic biomedical sciences.

A Comparative Risk Assessment Framework For Wildland Fire Management: The 2010 Cohesive Strategy Science Report, David E. Calkin, Alan Ager, Matthew P. Thompson, Mark A. Finney, Danny C. Lee, Thomas M. Quigley, Charles W. Mchugh, Karin L. Riley, Julie M. Gilbertson-Day

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

The FLAME Act of 2009 requires the U.S. Department of Agriculture Forest Service and the U.S. Department of Interior to submit to Congress a Cohesive Wildfire Management Strategy. In this report, we explore the general science available for a risk-based approach to fire and fuels management and suggest analyses that may be applied at multiple scales to inform decisionmaking and tradeoff analysis. We discuss scientific strengths and limitations of wildfire risk assessment frameworks, including the benefit of broad scalability as demonstrated by four recent case studies. We further highlight the role of comparative risk assessment, which extends the analysis to …

Time Course Of Prepulse Inhibition Disruption Induced By Dopamine Agonists And Nmda Antagonists: Effects Of Drug Administration Regimen, Ming Li, Wei He, Jing Chen

Department of Psychology: Faculty Publications

Prepulse inhibition (PPI) of acoustic startle response is impaired in patients with schizophrenia and in animals acutely treated with dopamine agonists and NMDA antagonists. In this study, we investigated the time course of PPI disruption induced by repeated amphetamine, quinpirole, phencyclidine (PCP), and dizocilpine (MK-801) treatment. We focused on how PPI disruption development was influenced by drug administration regimens, comparing a constant versus an escalating dosing regimen. Male Sprague–Dawley rats were repeatedly treated with amphetamine (1.25–5.0 mg/kg, or constant 5.0 mg/kg, sc), PCP (0.50–2.0 mg/kg, or constant 0.5, 1.0 or 2.0 mg/kg, sc), quinpirole (0.03–0.12 mg/kg, or constant 0.12 mg/kg, …

Relationship Formation And Stability In Emerging Adulthood: Do Sex Ratios Matter?, Tara D. Warner, Wendy D. Manning, Peggy C. Giordano, Monica A. Longmore

Department of Sociology: Faculty Publications

Research links sex ratios with the likelihood of marriage and divorce. However, whether sex ratios similarly influence precursors to marriage (transitions in and out of dating or cohabiting relationships) is unknown. Utilizing data from the Toledo Adolescent Relationships Study and the 2000 U.S. Census, this study assesses whether sex ratios influence the formation and stability of emerging adults’ romantic relationships. Findings show that relationship formation is unaffected by partner availability, yet the presence of partners increases women’s odds of cohabiting, decreases men’s odds of cohabiting, and increases number of dating partners and cheating among men. It appears that sex ratios …

Propagation System Manual, Margaret Kane

Hydroponic Center

Contained in this manual you will find the required materials, assembly instructions, operation procedures and safety protocols to construct, run and maintain a hydroponic propagation system.

The Propagation System is designed to provide an environment for seeds to germinate with optimal conditions for seedling growth. The purpose of the Propagator is to create an environment that is suitable for seedlings to develop a strong root system and uprooted stem so they can be transplanted into a new system where they are able to fully develop and be harvested. This procedure introduces plants, vegetables, and fruits to a new system of …

Thirdhand Tobacco Smoke: Emerging Evidence And Arguments For A Multidisciplinary Research Agenda, Georg E. Matt, Penelope J. Quintana, Hugo Destaillats, Lara A. Gundel, Mohamad Sleiman, Brett C. Singer, Peyton Jacob, Jonathan P. Winickoff, Prue Talbot, Suzaynn Schick, Yinsheng Wang, Bo Hang, Manuela Martins-Green, James F. Pankow, Melbourne F. Hovell, Neal L. Benowitz, Virender K. Rehan, Jonathan M. Samet

Civil and Environmental Engineering Faculty Publications and Presentations

There is broad consensus regarding the health impact of tobacco use and secondhand smoke exposure, yet considerable ambiguity exists about the nature and consequences of thirdhand smoke (THS). We introduce definitions of THS and THS exposure and review recent findings about constituents, indoor sorption-desorption dynamics, and transformations of THS; distribution and persistence of THS in residential settings; implications for pathways of exposure; potential clinical significance and health effects; and behavioral and policy issues that affect and are affected by THS. Physical and chemical transformations of tobacco smoke pollutants take place over time scales ranging from seconds to months and include …

Dynamic Alteration Of Adiponectin/Adiponectin Receptor Expression And Its Impact On Myocardial Ischemia/Reperfusion In Type 1 Diabetic Mice., Yanzhuo Ma, Yi Liu, Shaowei Liu, Yan Qu, Rutao Wang, Chenhai Xia, Haifeng Pei, Kun Lian, Tao Yin, Xiaoyan Lu, Lu Sun, Lu Yang, Yanjie Cao, Wayne Bond Lau, Erhe Gao, Haichang Wang, Ling Tao

Department of Emergency Medicine Faculty Papers

The present study determined the dynamic change of adiponectin (APN, a cardioprotective adipokine), its receptor expression, and their impact upon myocardial ischemia/reperfusion (MI/R) injury during type 1 diabetes mellitus (T1DM) progression, and involved underlying mechanisms. Diabetic state was induced in mice via multiple intraperitoneal injections of low-dose streptozotocin. The dynamic change of plasma APN concentration and cardiac APN receptor-1 and -2 (AdipoR1/2) expression were assessed immediately after diabetes onset (0 wk) and 1, 3, 5, and 7 wk thereafter. Indicators of MI/R injury (infarct size, apoptosis, and LDH release) were determined at 0, 1, and 7 wk of DM duration. …

The Use Of Phonetic Motor Invariants Can Improve Automatic Phoneme Discrimination, C Castellini, L Badino, G Metta, G Sandini, Et Al

School of Engineering, Computing and Mathematics

We investigate the use of phonetic motor invariants (MIs), that is, recurring kinematic patterns of the human phonetic articulators, to improve automatic phoneme discrimination. Using a multi-subject database of synchronized speech and lips/tongue trajectories, we first identify MIs commonly associated with bilabial and dental consonants, and use them to simultaneously segment speech and motor signals. We then build a simple neural network-based regression schema (called Audio-Motor Map, AMM) mapping audio features of these segments to the corresponding MIs. Extensive experimental results show that (a) a small set of features extracted from the MIs, as originally gathered from articulatory sensors, are …

Influence Of Earli1‐Like Genes On Flowering Time And Lignin Synthesis Of Arabidopsis Thaliana, Y. Shi, X. Zhang, Z.-Y. Xu, C. Zhang, Michael Schläppi, Z.-Q. Xu

Biological Sciences Faculty Research and Publications

EARLI1 encodes a 14.7 kDa protein in the cell wall, is a member of the PRP (proline‐rich protein) family and has multiple functions, including resistance to low temperature and fungal infection. RNA gel blot analyses in the present work indicated that expression of EARLI1‐like genes, EARLI1, At4G12470 and At4G12490, was down‐regulated in Col‐FRI‐Sf2 RNAi plants derived from transformation with Agrobacteriumstrain ABI, which contains a construct encoding a double‐strand RNA targeting 8CM of EARLI1. Phenotype analyses revealed that Col‐FRI‐Sf2 RNAi plants of EARLI1 flowered earlier than Col‐FRI‐Sf2 wild‐type plants. The average …

The Housewife, The Single Girl, And The Prostitute: Constructions Of Femininity In Postwar American Historiography, Marie Rowley

Psi Sigma Siren

America in the two decades after World War II experienced conditions that seemed to indicate an unprecedented focus on domesticity and traditional gender roles. Couples married at younger ages, fertility rates soared, and population shifted to suburban areas all over the country. Just beneath this surface, however, a more complex discourse about gender norms was also emerging. Gay and lesbian communities began to organize, teenagers emerged as a cultural force, and young single women began to view economic independence as a legitimate goal. These contradictory forces coexisted in a culture struggling to define gender and sexuality in the anxiety-ridden era …

Death, Etxtraversion, Commitment, And Sex: A Study On Terror Management, Jalaal Madyun, Wind Goodfriend

Modern Psychological Studies

Several studies have found that when confronted with mortality (i.e., mortality salience), the desire for intimate relationships and the desire for sex increase (Ben-Ari, 2004; Hirschberger, Florian, & Mikulincer, 2002). The current study examined desire for commitment to a romantic partner and the desire to engage in risky sexual behaviors when mortality is salient and added an examination of how these constructs overlap with the personality trait of extraversion. Results showed that, as expected, extraversion was correlated with the desire to engage in risky sexual behavior. Surprisingly, however, individuals under mortality salience were less likely to desire risky sexual encounters, …

Modeling The Collagen Fibril Network Of Biological Tissues As A Nonlinearly Elastic Material Using A Continuous Volume Fraction Distribution Function, Reza Shirazi, Pasquale Vena, Robert L. Sah, Stephen M. Klisch

Mechanical Engineering

Despite distinct mechanical functions, biological soft tissues have a common microstructure in which a ground matrix is reinforced by a collagen fibril network. The microstructural properties of the collagen network contribute to continuum mechanical tissue properties that are strongly anisotropic with tensile-compressive asymmetry. In this study, a novel approach based on a continuous distribution of collagen fibril volume fractions is developed to model fibril reinforced soft tissues as nonlinearly elastic and anisotropic material. Compared with other approaches that use a normalized number of fibrils for the definition of the distribution function, this representation is based on a distribution parameter (i.e. …

Bioactive Properties And Clinical Safety Of A Novel Milk Protein Peptide, Richard B. Kreider, Mike Iosia, Matt Cooke, Geoffrey M. Hudson, Chris Rasmussen, Helen Chen, Olof Mollstedt, Men-Hwei Tsai

Faculty Publications

Background: Milk protein fractions and peptides have been shown to have bioactive properties. This preliminary study examined the potential mechanisms of action and clinical safety of novel milk protein peptide ( MP).

Findings: A novel MP mixture inhibits the tyrosine kinase activity of epidermal growth factor receptor ( EGFR), vascular endothelial growth factor receptor 2 (VEGFR2), and insulin receptor (IR) with IC(50) of 9.85 mu M, 7.7 mu M, and 6.18 mu M respectively. In vitro, this multi-kinase inhibitor causes apoptosis in HT-29 colon cancer cells, and in a C. elegans worm study, showed a weak but significant …

Analysis Of Migration Models Of Biogeography-Based Optimization Using Markov Theory, Haiping Ma, Daniel J. Simon

Electrical and Computer Engineering Faculty Publications

Biogeography-based optimization (BBO) is a new evolutionary algorithm inspired by biogeography, which involves the study of the migration of biological species between habitats. Previous work has shown that various migration models of BBO result in significant changes in performance. Sinusoidal migration models have been shown to provide the best performance so far. Motivated by biogeography theory and previous results, in this paper a generalized sinusoidal migration model curve is proposed. A previously derived BBO Markov model is used to analyze the effect of migration models on optimization performance, and new theoretical results which are confirmed with simulation results are obtained. …

Autoimmune Responses To Atherosclerotic Lipids: A Study In Murine Models Of Atherosclerosis And Obesity, Hanjing Wu

Dissertations and Theses (Open Access)

Atherosclerosis is a chronic, complex arterial disease characterized by intimal lipid accumulation and inflammation. A unique lipid-binding molecule, namely cluster of differentiation 1d (CD1d), may impact atherosclerosis. Structurally, CD1d acts as a nonpolymorphic cell-surface receptor, resembling the major histocompatibility complex-I (MHC-I). While MHC-I restricts peptide antigen presentation to T cells, CD1d presents lipid antigens to T cells named CD1d-restrictedd T cells. Although increased expression of CD1d has been found in human plaques, the exact nature of CD1d-recognized lipids in atherosclerosis remains to be determined. Three groups of lipids may undergo oxidation in atherosclerosis producing atherogenic lipids: phospholipids, fatty acids, and …

Atypical Inventions, Sean B. Seymore

Vanderbilt Law School Faculty Publications

Patent law is constantly evolving to accommodate advances in science and technology. But, for a variety of reasons, some aspects of patent doctrine have not evolved over time leading to a growing disconnect between the patent system and certain technical communities. Particularly vulnerable to the ill effects of this disconnect are "atypical" inventions, which this Article definesas those in which either (1) a technical aspect of the invention or the inventive process does not conform to an established legal standard in patent law or (2) the technical underpinnings of the invention depart from well-established scientific paradigms. An example of the …

Type Ii Toxoplasma Gondii Ku80 Knockout Strains Enable Functional Analysis Of Genes Required For Cyst Development And Latent Infection, Barbara A. Fox, Alejandra Falla, Leah M. Rommereim, Tadakimi Tomita

Dartmouth Scholarship

Type II Toxoplasma gondii KU80 knockouts (Δku80) deficient in nonhomologous end joining were developed to delete the dominant pathway mediating random integration of targeting episomes. Gene targeting frequency in the type II Δku80 Δhxgprt strain measured at the orotate (OPRT) and the uracil (UPRT) phosphoribosyltransferase loci was highly efficient. To assess the potential of the type II Δku80 Δhxgprt strain to examine gene function affecting cyst biology and latent stages of infection, we targeted the deletion of four parasite antigen genes (GRA4, GRA6, ROP7, and tgd057 …

Examining Juvenile Transfer Practices In Arkansas For The Years 2000-2005., Joseph Mcsherry

Theses and Dissertations

There has been a trend over recent decades to hold juvenile offenders more accountable for their actions and punish them more severely, which has resulted in more diverse avenues to transfer these offenders to adult court. This research examines emerging literature related to transfer and sentencing of juvenile offenders in criminal court. Further, this research will explore the characteristics of juvenile offenders transferred in Arkansas between 2000 and 2005. Results of the analysis will be discussed along with implications and limitations of the study.

An Examination Of Laboratory Activities For Elements Of Inquiry In Arkansas Secondary Biology Courses, Michele E. Snyder

Theses and Dissertations

In the last 20 years, several panels recommended improving science teaching by incorporating inquiry approaches into K-12 classrooms. These panels assert that inquiry improves student learning in large part by giving students ownership. However, many teachers still present labs that simply call for students to follow written directions. This cookbook approach is the antithesis of inquiry. To take a "snap shot" of biology teaching, I surveyed Arkansas biology teachers to 1) determine teachers' qualifications, 2) assess the labs that they considered their "best" via a rubric that assesses inquiry activities, and 3) discover the reasons teachers valued certain labs. The …

Fruitful Research: A Biblical Perspective On The Affective Dimension Of Research, Ken Badley, Jane Scott

The Christian Librarian

Librarians and professors in Christian colleges and universities can work collaboratively to help reduce the stress and anxiety that student researchers experience as they carry out their undergraduate or graduate research. This collaboration focuses on understanding the affective dimension of the research process and relating the research process to St. Paul’s list of nine fruit of the Spirit (Galatians 5:22). The student researcher who can view the research process within the frame of these nine dispositions will have additional resources with which to integrate God’s presence in the research process, thereby reducing research anxiety.

Properties, Solution State Behavior, And Crystal Structures Of Chelates Of Dotma, Silvio Aime, Mauro Botta, Zoltán Garda, Benjamin E. Kucera, Gyula Tircso, Victor G. Young, Mark Woods

Chemistry Faculty Publications and Presentations

The chemistry of polyamino carboxylates and their use as ligands for Ln(3+) ions is of considerable interest from the point of view of the development of new imaging agents. Of particular interest is the chemistry of the macrocyclic ligand 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and its derivatives. Herein we report that the tetramethylated DOTA derivative, DOTMA, possess several properties that, from an imaging agent development point of view, are more advantageous than those of the parent DOTA. In particular, the Ln(3+) chelates of DOTMA exhibit a marked preference for the monocapped twisted square antiprismatic coordination isomer which imparts more rapid water exchange …

The Role Of Human Ubc9 During The Human Immunodeficiency Virus Replication Cycle, Christopher R. Bohl

School of Biological Sciences: Dissertations, Theses, and Student Research

Human immunodeficiency virus type 1 (HIV-1) is a retrovirus and the causative agent of the acquired immune deficiency syndrome (AIDS) pandemic. The retrovirus replication cycle is divided into early infectious events, which involve the infection and integration of the viral DNA into target cell chromosomes; and late events, which involve the expression of viral genes and assembly of infectious virions. To complete the replication cycle, HIV-1 utilizes various cellular pathways.

We identified the Ubc9 E2 SUMO conjugating enzyme as a HIV-1 Gag interaction partner. When this interaction was disrupted in HIV-1 producer cells by Ubc9 siRNA, the virus that was …

Addressing Work-Related Traumatic Stress Nebraska - Resilience Alliance Participant Handbook, Asc-Nyu Children's Trauma Institute

Other QIC-WD Products

Child welfare staff are first responders; just like police officer and fire fighters, they are asked to respond to emergency situations with very little information, and by doing so often put themselves at risk. In addition to the very real physical risks involved with responding to a report of suspected child abuse or neglect, there are equally real psychological risks involved with taking care of children and families that have experienced abuse, neglect, family and community violence, and other traumas. Unlike police officers and fire fighters, however, child welfare staff get very little public recognition for the hard work they …

Some Thoughts About Medical Humanities Education, Yen-Yuan Chen, Wei-Dean Wang, Kai-Kuen Leung

Journal of Medical Education

Since the late 20(superscript th) century, medical professionals are faced with challenges that have never been so important before. The traditional way of teaching medical students in a lecture hall with a particular emphasis on scientific knowledge is getting more and more insufficient. Like the Seven Liberal Arts in the Western World, the Six Arts (Rites, Music, Archery, Charioting, Calligraphy, and Mathematics) in ancient China, firmly rooted in Confucian philosophy, is essential for the education towards cultivating a perfect gentleman. Based on the concepts of the Six Arts and the aims of medical humanities education in Taiwan, we proposed several …

2011 September, Office Of Communications & Marketing, Morehead State University.

Morehead State Press Release Archive, 1961 to the Present

Press releases for September of 2011.

Antiviral Trims: Friend Or Foe In Autoimmune And Autoinflammatory Disease?, Caroline A. Jefferies, Claire Wynne, Rowan Higgs

Articles

The concept that viral sensing systems, via their ability to drive pro-inflammatory cytokine and interferon production, contribute to the development of autoimmune and autoinflammatory disease is supported by a wide range of clinical and experimental observations. Recently, the tripartite motif-containing proteins (TRIMs) have emerged as having key roles in antiviral immunity — either as viral restriction factors or as regulators of pathways downstream of viral RNA and DNA sensors, and the inflammasome. Given their involvement in these pathways, we propose that TRIM proteins contribute to the development and pathology of autoimmune and autoinflammatory conditions, thus making them potential novel targets …

The Role Of The Neighborhood In Making Welfare Reform Possible, David I. Siegel

The Journal of Sociology & Social Welfare

This article will analyze the role of the neighborhood in making welfare reform possible. It will consider the neighborhood and its environment as a context for welfare reform, the influence of neighborhood conditions and effects, recent neighborhood theory building, the neighborhood as a source of relevant values, and finally neighborhood programs that contribute to welfare reform.

A Single Phenylalanine Residue In The Main Intracellular Loop Of Α1 Γ-Aminobutyric Acid Type A And Glycine Receptors Influences Their Sensitivity To Propofol, Gustavo Moraga-Cid, Gonzalo E. Yevenes, Günther Schmalzing, Robert W. Peoples, Luis G. Aguayo

Biomedical Sciences Faculty Research and Publications

Background: The intravenous anesthetic propofol acts as a positive allosteric modulator of glycine (GlyRs) and γ-aminobutyric acid type A (GABA_ARs) receptors. Although the role of transmembrane residues is recognized, little is known about the involvement of other regions in the modulatory effects of propofol. Therefore, the influence of the large intracellular loop in propofol sensitivity of both receptors was explored. Methods: The large intracellular loop of α₁ GlyRs and α₁β₂ GABA_ARs was screened using alanine replacement. Sensitivity to propofol was studied using patch-clamp recording in HEK293 cells transiently transfected with …