Digital Commons Network^™

Genetic Variants In Lpl, Oasl And Tomm40/Apoe-C1-C2-C4 Genes Are Associated With Multiple Cardiovascular-Related Traits, Rita Ps Middelberg, Manuel Ar Ferreira, Anjali K. Henders, Andrew C. Heath, Pamela Af Madden, Grant W. Montgomery, Nicholas G. Martin, John B. Whitfield

Open Access Publications

No abstract provided.

Investigation Of 95 Variants Identified In A Genome-Wide Study For Association With Mortality After Acute Coronary Syndrome, Thomas M. Morgan, John A. House, Sharon Cresci, Philip Jones, Hooman Allayee, Stanley L. Hazen, Yesha Patel, Riyaz S. Patel, Danny J. Eapen, Salina P. Waddy, Arshed A. Quyyumi, Marcus E. Kleber, Winfried Marz, Bernhard R. Winkelmann, Bernhard O. Boehm, Harlan M. Krumholz, John A. Spertus

Open Access Publications

No abstract provided.

Interferon Regulatory Factor-1 (Irf-1) Shapes Both Innate And Cd8⁺ T Cell Immune Responses Against West Nile Virus Infection, James D. Brien, Stephane Daffis, Helen M. Lazear, Hyelim Cho, Mehul S. Suthar, Michael Gale Jr, Michael S. Diamond

Open Access Publications

No abstract provided.

Evolving Diagnostic And Treatment Strategies For Pancreatic Neuroendocrine Tumors, Matthew H. Kulke, Johanna Bendell, Larry Kvols, Joel Picus, Rodney Pommier, James Yao

Open Access Publications

No abstract provided.

Tunepal: Searching A Digital Library Of Traditional Music Scores, Bryan Duggan, Brendan O'Shea

Reports

Purpose – This paper aims to describe the Tunepal project as an example of a music information retrieval (MIR) system that is having an impact on how musicians access, learn and play traditional Irish music around the world. Design/methodology/approach – This paper describes the functionality of the Tunepal system: consisting of the tune corpus, the web site tunepal.org and mobile apps supporting iOS and Android OS. Tunepal facilitates query-by-title and query-by-playing music (QBP) searches and allows a musician to retrieve and playback scores amongst other supported functions. Findings – Tunepal has been favorably received and musicians report that the system …

Differential Precipitation And Solubilization Of Proteins., Barry Ryan

Books/Book Chapters/ Proceedings

Differential protein precipitation is a rapid and economical step in protein purification and is based on exploiting the inherent physico-chemical properties of the polypeptide. Precipitation of recombinant proteins, lysed from the host cell, is commonly used to concentrate the protein of choice before further polishing steps with more selective purification columns (e.g. His-Tag, Size Exclusion etc.). Recombinant proteins can also precipitate naturally as inclusion bodies due to various influences during over-expression in the host cell. Although this phenomenon permits easier initial separation from native proteins, these inclusion bodies must carefully be differentially solubilised so as to reform functional, correctly folded …

Do Organic Cherry Vine Tomatoes Taste Better Than Conventional Cherry Vine Tomatoes? A Sensory And Instrumental Comparative Study From Ireland, Clare Gilsenan, Roisin Burke, Catherine Barry-Ryan

Articles

A consumer panel was able to distinguish a perceptible difference between organically farmed and conventionally produced tomatoes, and preferred the taste of the conventional tomatoes. The sensory evaluation results of the trained panel revealed that the conventional tomatoes were sweeter and less sour than the organic tomatoes. In addition to this, the conventional tomatoes showed significant differences for ^oBrix, reducing sugars and electrical conductivity. No significant differences were observed between the organic and conventional tomato samples for color, size, firmness, pH and dry matter values.

Cancer Genome Sequencing And Its Implications For Personalized Cancer Vaccines, Lijin Li, Peter Goedegebuure, Elaine R. Mardis, Matthew J.C. Ellis, Xiuli Zhang, John M. Herndon, Timothy P. Fleming, Beatriz M. Carreno, Ted H. Hansen, William E. Gillanders

Open Access Publications

No abstract provided.

Genetic Incorporation Of Human Metallothionein Into The Adenovirus Protein Ix For Non-Invasive Spect Imaging, J. Michael Mathis, Shilpa Bhatia, Alok Khandelwal, Imre Kovesdi, Stephen J. Lokitz, Yoshi Odaka, Amol M. Takalkar, Tracee Terry, David T. Curiel

Open Access Publications

No abstract provided.

Batf3-Dependent Cd11b Peripheral Dendritic Cells Are Gm-Csf-Independent And Are Not Required For Th Cell Priming After Subcutaneous Immunization, Brian T. Edelson, Tara R. Bradstreet, Wumesh Kc, Kai Hildner, Jeremy W. Herzog, Julia Sim, John H. Russell, Theresa L. Murphy, Emil R. Unanue, Kenneth M. Murphy

Open Access Publications

No abstract provided.

Correlation Of Cag Repeat Length Between The Maternal And Paternal Allele Of The Huntingtin Gene: Evidence For Assortative Mating, Peg Nopoulos, Eric A. Epping, Tom Wassink, Bradley L. Schlaggar, Joel Perlmutter

Open Access Publications

No abstract provided.

Detecting Disease Rare Alleles Using Single Snps In Families And Haplotyping In Unrelated Subjects From The Genetic Analysis Workshop 17 Data, Aldi T. Kraja, Jacek Czajkowski, Mary F. Feitosa, Ingrid B. Borecki, Michael A. Province

Open Access Publications

No abstract provided.

Rnai Effector Diversity In Nematodes, Jonathan J. Dalzell, Paul Mcveigh, Neil D. Warnock, Makedonka Mitreva, David Mck Bird, Pierre Abad, Colin C. Fleming, Tim A. Day, Angela Mousley, Nikki J. Marks, Aaron G. Maule

Open Access Publications

No abstract provided.

Deficiency Of The Mitochondrial Electron Transport Chain In Muscle Does Not Cause Insulin Resistance, Dong-Ho Han, Chad R. Hancock, Su Ryun Jung, Kazuhiko Higashida, Sang Hyun Kim, John O. Holloszy

Open Access Publications

No abstract provided.

Sap Transporter Mediated Import And Subsequent Degradation Of Antimicrobial Peptides In Haemophilus, Catherine L. Shelton, Forrest K. Raffel, Wandy L. Beatty, Sara M. Johnson, Kevin M. Mason

Open Access Publications

No abstract provided.

New Technologies In Clinical Microbiology, Donna M. Wolk, W. Michael Dunne Jr.

Open Access Publications

No abstract provided.

Role Of Fatty Acid Transporters In Epidermis: Implications For Health And Disease, Denis Khnykin, Jeffrey H. Miner, Frode Jahnsen

Open Access Publications

No abstract provided.

Differential Microbicidal Effects Of Human Histone Proteins H2a And H2b On Leishmania Promastigotes And Amastigotes, Yingwei Wang, Yang Chen, Lijun Xin, Stephen M. Beverley, Eric D. Carlsen, Vsevolod Popov, Kwang-Poo Chang, Ming Wang, Lynn Soong

Open Access Publications

No abstract provided.

Implications Of The Prion-Related Q/N Domains In Tdp-43 And Fus, Maria Udan, Robert H. Baloh

Open Access Publications

No abstract provided.

Characterization Of A Novel, Dominant Negative Kcnj2 Mutation Associated With Andersen-Tawil Syndrome, Scott B. Marrus, Phillip S. Cucilich, Wei Wang, Jeanne M. Nerbonne

Open Access Publications

No abstract provided.

Specific Objects: Lee Bontecou’S Steel And Canvas Reliefs, 1959-1964, Lesley E. Shipley

Bryn Mawr College Dissertations and Theses

This dissertation focuses on the reception and interpretation of the welded steel and canvas reliefs that the American artist Lee Bontecou created between 1959 and 1964.In Chapter 1,I present an overview of the initial critical reception of Bontecou’s steel and canvas reliefs, highlighting those exhibitions and texts from the first half of the 1960s that stand out as important records of this work’s reception. In Chapter 2, I examine the feminist claiming of Bontecou’s reliefs that occurred between 1965 and 1976.Here, I contextualize the feminist response to Bontecou’s art within its historical moment, in order to consider how feminism has …

Family Relationships And Latina Teen Suicide Attempts: Reciprocity, Asymmetry, And Detachment, Lauren E. Gulbas, Luis H. Zayas, Allyson P. Nolle, Carolina Hausmann-Stabile, Jill A. Kuhlberg, Ana A. Baumann, Juan B. Peña

Graduate School of Social Work and Social Research Faculty Research and Scholarship

Using qualitative data collected from adolescent Latinas and their parents, this article describes ways in which family relationships are organized within low-income Latino families (n = 24) with and without a daughter who attempted suicide. Based on a family-level analysis approach, we present a framework that categorizes relationships as reciprocal, asymmetrical, or detached. Clear differences are identified: Families of nonattempters primarily cluster in reciprocal families, whereas families with an adolescent suicide attempter exhibit characteristics of asymmetrical or detached families. Our results highlight the need for detailed clinical attention to family communication patterns, especially in Latino families. Clinicians may reduce the …

Evaluation Of Mass Spectrometric Methods For Detection Of The Anti-Protozoal Drug Imidocarb, A. F. Lehner, J. A. Hitron, J. May, C. Hughes, R. Eisenberg, N. Schwint, D. P. Knowles, P. Timoney, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Imidocarb [N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea, C₁₉H₂₀N₆O₁, m.w. 348.41] is a symmetrical carbanilide derivative used to treat disease caused by protozoans of the Babesia genus. Imidocarb, however, is also considered capable of suppressing Babesia-specific immune responses, allowing Babesia-positive horses to pass a complement fixation test (CFT) without eliminating the infection. This scenario could enable Babesia-infected horses to pass CFT-based importation tests. It is imperative to unequivocally identify and quantify equine tissue residues of imidocarb by mass spectrometry to address this issue. As a pretext to development of sensitive tissue assays, we have investigated possibilities of mass …

Chronic Pulmonary Cavitary Tuberculosis In Rabbits: A Failed Host Immune Response, Selvakumar Subbian, Liana Tsenova, Guibin Yang, Paul O'Brien, Sven Parsons, Blas Peixoto, Leslie Taylor, Dorothy Fallows, Gilla Kaplan

Publications and Research

The molecular determinants of the immune response to Mycobacterium tuberculosis HN878 infection in a rabbit model of pulmonary cavitary tuberculosis were studied. Aerosol infection of rabbits resulted in a highly differentially expressed global transcriptome in the lungs at 2 weeks, which dropped at 4 weeks and then gradually increased. While IFNγ was progressively upregulated throughout the infection, several other genes in the IFNγ network were not. T-cell activation network genes were gradually upregulated and maximally induced at 12 weeks. Similarly, the IL4 and B-cell activation networks were progressively upregulated, many reaching high levels between 12 and 16 weeks. Delayed peak …

The Rights And Liberties Of The Palau Constitution, Kevin Bennardo

Faculty Publications

No abstract provided.

Why Copperweld Was Actually Kind Of Dumb: Sound, Fury, And The Once And Still Missing Antitrust Theory Of The Firm?, Chris Sagers

Law Faculty Articles and Essays

Since even before Copperweld Corp. v. Independence Tube Corp., 467 U.S. 752 (1984), it has been thought that antitrust needs some "theory of the firm" to inform its application of a "single-entity" defense in Sherman Act section 1 litigation. Not only is that sense mistaken, it is emblematic of the deep misdirection of contemporary antitrust. It shows just how far antitrust has forgotten that it is a law, a practical tool to implement policy choices made through our system of government. Much too much of the time, it seems to fancy itself rather an abstract policy seminar to be …

Weaning Ohio Employers Off Of Lactation Discrimination: The Need For A Clear Interpretation Of Ohio's Pregnancy Discrimination Act Following Allen V. Totes/Isotoner Corp. Note, Shannon Byrne

Cleveland State Law Review

Part II of this Note will explain the relevant statutory and case law background behind pregnancy and lactation discrimination at both the federal and state levels. Part III.A will explain why the Supreme Court of Ohio's decision [in Allen v. Totes/Isotoner Corp, 123 Ohio St. 3d 21, 2009 Ohio 4231, 915 N.E.2d 622 (2009)] to affirm the appellate court's grant of summary judgment was improper. Part III.B will explain why the Supreme Court of Ohio's analysis of the accommodation issue is incorrect. Part IV.A will describe how this improper decision could open the door to facially discriminatory workplace policies that …

Taking Stare Decisis Seriously: A Cautionary Tale For A Progressive Supreme Court, James G. Wilson

Law Faculty Articles and Essays

To better understand stare decisis and to normatively explore our constitutional future, this article assumes that President Obama's election signifies a constitutional shift similar to the one occurring after President Nixon won in 1968. From that contentious, self-righteous era to the present day, all American Presidents selected Supreme Court nominees who were more conservative than the members of the Warren Court majority, much less that aggressively liberal duo, Justices Brennan and Marshall. Justice Stevens, appointed by the moderate Republican President Gerald Ford, is arguably the most liberal member on the Court. It is impossible to predict how far the country …

Privacy Analysis Of User Association Logs In A Large-Scale Wireless Lan, Keren Tan, Guanhua Yan, Jihwang Yeo, David Kotz

Computer Science Technical Reports

User association logs collected from a large-scale wireless LAN record where and when a user has used the network. Such information plays an important role in wireless network research. One concern of sharing these data with other researchers, however, is that the logs pose potential privacy risks for the network users. Today, the common practice in sanitizing these data before releasing them to the public is to anonymize users' sensitive information, such as their devices' MAC addresses and their exact association locations. In this work, we demonstrate that such sanitization measures are insufficient to protect user privacy because the differences …

Significant Inhibition Of Corneal Scarring In Vivo With Tissue-Selective, Targeted Aav5 Decorin Gene Therapy, Rajiv R. Mohan, Ashish Tandon, Ajay Sharma, John W. Cowden, Jonathan C. K. Tovey

Pharmacy Faculty Articles and Research

PURPOSE. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the stroma with adeno-associated virus serotype 5 (AAV5) inhibits corneal fibrosis in vivo without significant side effects.

METHODS. An in vivo rabbit model of corneal fibrosis was used. Targeted decorin gene therapy was delivered to the rabbit cornea by a single topical application of AAV5 (100 L; 6.5 1012 g/mL) onto the bare stroma for 2 minutes. The levels of corneal fibrosis were determined with stereomicroscopy, slit lamp biomicroscopy, -smooth muscle actin ( SMA), fibronectin, and F-actin immunocytochemistry, and/or immunoblotting. CD11b, F4/80 immunocytochemistry, and TUNEL assay …