Digital Commons Network^™

Coordinate Linkage Of Hiv Evolution Reveals Regions Of Immunological Vulnerability, Vincent Dahirel, Karrthik Shekhar, Florencia Pereyra, Toshiyuki Miura, Mikira Artyomov, Shiv Talsania, Todd M. Allen, Marcus Altfeld, Mary Carrington, Darrell J. Irvine, Bruce D. Walker, Arup K. Chakraborty

United States Public Health Resources

Cellular immune control of HIV is mediated, in part, by induction of single amino acid mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we sought to determine if higher order constraints on viral evolution exist, because some coordinately linked combinations of mutations may hurt viability. Immune targeting of multiple sites in such a multidimensionally conserved region might render the virus particularly vulnerable, because viable escape pathways would be greatly restricted. We analyzed available HIV sequences using a method from physics to reveal distinct groups of amino acids whose mutations are collectively coordinated (“HIV sectors”). From the …

A Cancer And Leukemia Group B Multi-Center Study Of Da-Epoch-Rituximab In Untreated Diffuse Large B-Cell Lymphoma With Analysis Of Outcome By Molecular Subtype, Wyndham Wilson, Sin-Ho Jung, Pierluigi Porcu, David Hurd, Jeffrey Johnson, S. Eric Martin, Myron Czuczman, Raymond Lai, Jonathan Said, Amy Chadburn, Dan Jones, Kieron Dunleavy, George Canellos, Andrew D. Zelenetz, Bruce D. Cheson, Eric D. Hsi

United States Public Health Resources

Background

A phase II trial of dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (DA-EPOCH-R) from the National Cancer Institute showed promising activity in untreated diffuse large B-cell lymphoma. The Cancer and Leukemia Group B conducted a study to determine if these results could be reproduced in a multi-institutional setting.

Design and Methods

The study included 69 patients with untreated diffuse large B-cell lymphoma at least 18 years of age and at least stage II. Radiaton therapy was not permitted on study. Median age was 58 years (range 23-83) and 40% had high-intermediate or high International Prognostic Index risk. Immunohistochemical …

Hippocampal Volume Differences In Gulf War Veterans With Current Versus Lifetime Posttraumatic Stress Disorder Symptoms, Brigitte A. Apfel, Jessica Ross, Jennifer Hlavin, Dieter J. Meyerhoff, Thomas J. Metzler, Charles R. Marmar, Michael W. Weiner, Norbert Schuff, Thomas C. Neylan

United States Public Health Resources

Background: Decreased hippocampal volume is described in posttraumatic stress disorder (PTSD) and depression. However, it is not known whether it is a risk factor for the development of PTSD or a consequence of PTSD. We sought to determine the effects of PTSD and depressive symptoms on hippocampal volume.

Methods: Clinical and magnetic resonance imaging data were collected in a cross sectional study of 244 GulfWarveterans. Measures included lifetime and current Clinician Administered PTSD Scale, Hamilton Depression Scale, Life Stressor Checklist, and Lifetime Drinking History. Magnetic resonance imaging data were acquired with a 1.5-T scanner and analyzed with automated …

Long Term Depleted Uranium Exposure In Gulf War I Veterans Does Not Cause Elevated Numbers Of Micronuclei In Peripheral Blood Lymphocytes, M. V. Bakhmutskya, M. S. Oliver, M. A. Mcdiarmid, K. S. Squibb, J. D. Tucker

United States Public Health Resources

Depleted uranium (DU) is a high density heavy metal that has been used in military munitions since the 1991 Gulf War. DU is weakly radioactive and chemically toxic. Long term exposure can cause adverse health effects. This study assessed genotoxic effects in DU exposed Gulf War I veterans as a function of uranium (U) body burden. Levels of urine U were used to categorize the cohort into low and high exposure groups. Exposure to DU occurred during friendly fire incidents in 1991 involving DU munitions resulting in inhalation and ingestion exposure to small particles of DU and soft tissue DU …

Receptor Specificity Of Subtype H1 Influenza A Viruses Isolated From Swine And Humans In The United States, Li-Mei Chen, Pierre Rivailler, Jaber Hossain, Paul Carney, Amanda Balish, Ijeoma Perry, C. Todd Davis, Rebecca Garten, Bo Shu, Xiyan Xu, Alexander Klimov, James C. Paulson, Nancy J. Cox, Sabrina L. Swenson, James Stevens, Amy Vincent, Marie Gramer, Ruben O. Donis

United States Public Health Resources

The evolution of classical swine influenza viruses receptor specificity preceding the emergence of the 2009 H1N1 pandemic virus was analyzed in glycan microarrays. Classical swine influenza viruses from the α, β, and γ antigenic clusters isolated between 1945 and 2009 revealed a binding profile very similar to that of 2009 pandemic H1N1 viruses, with selectivity for α2-6-linked sialosides and very limited binding to α2-3 sialosides. Despite considerable genetic divergence, the ‘human-like’ H1N1 viruses circulating in swine retained strong binding preference for α2-6 sialylated glycans. Interspecies transmission of H1N1 influenza viruses from swine to humans or …

Factors Associated With Suicidal Ideation In Oef/Oif Veterans, Chad M. Lemaire, David P. Graham

United States Public Health Resources

Background: The purpose of this projectwas to examine factors associated with suicidal ideation in returning Iraq and Afghanistan war veterans.

Methods: A cross-sectional review of 1740 veterans' initial mental health screening evaluations. One-hundred and thirteen (6.5%) OEF/OIF veterans reported active suicidal ideation at the time of the interview.

Results: Prior exposures of physical or sexual abuse and having a history of a prior suicide attempt(s) were associated with the presence of current suicidal ideation, as were having a diagnosis of a psychotic disorder, a depressive disorder, or posttraumatic stress disorder (PTSD). Deployment concerns related to training (protective), …

Annual Report 2010-2011, Houston Academy Of Medicine-Texas Medical Center Library

Annual Reports: 1943 - Present

This file contains the Annual Report for the library from 2010-2011.

Rscn 571.01: International Conservation And Development, Stephen F. Siebert

University of Montana Course Syllabi

No abstract provided.

Suffolk Alumni Magazine, Vol. 6, No. 2, 2011, Suffolk University

Suffolk University Magazine

No abstract provided.

Suffolk Alumni Magazine, Vol. 7, No.2, 2011, Suffolk University

Suffolk University Magazine

No abstract provided.

A Study On The Consequences Of Workplace Romance In Iranian Organizations, Davood Salmani, Ali Taatian, Masoud Hakiminia

Academic Leadership: The Online Journal (2003-2012)

The Central Educational Center is a product of multiple visions, desires, and hopes. The ideal vision is outlined in a book entitled “The Eden Conspiracy” (Harless, 1997). Other perspectives include a requirement from local business that basic skills of high school graduates need to be rapidly improved, the desire of a growing local school system to provide costly industry-standard career-technical education to all high school students, the vision of a regional technical college to “dual enroll” high school students and make technical college a viable post-secondary option, and the hopes of a Governor looking for a viable model to support …

Patronage Of Educational Broadcasts And Its Effects On Academic Growth Of Students Of Winneba And Apam Senior High Schools In The Central Region Of Ghana., Daniel Yelkpieri, Wilson Esia-Donkoh Kweku, Kwesi

Academic Leadership: The Online Journal (2003-2012)

The importance of Mathematics transcends all definitions and the prosperity of any country depends on the volume and quality of Mathematics offered in its school system. Obe (1996) conceptualises Mathematics as the master and servant of most disciplines and thus, a source of enlightenment and understanding of the universe. He further opines that without it, the understanding of national problems would be superficial. Graeber and Weisman (1995) agree that Mathematics helps the individual to understand his/her environment and to give accurate account of the physical phenomena around him/her. To this end, Setidisho (2001) submits that no other subject forms a …

Social Perceptions Of Government Regulated Ecological Managment In Sarasota County Past, Present, And Potential Future Of Tree Ordinances, Dayna Lazarus

Theses & ETDs

Rules that require us to consider the health of the environment have been increasingly finding their way into American politics. However, rigid regulations are sometimes more of a monkey wrench in the gears of sustainability than a catalyst for achieving a community�s sustainability goals, especially when regulations require expert knowledge and careful consideration of local conditions. An overall negative social perception of a regulation is one indication that the monkey-wrench phenomenon may be in play. Negative social perception, and any other indication that a regulation is either not working or causing more harm than good, calls for a code review. …

God's Liberated People? Men And Women In The Metropolitan Community Church, Kathleen O'Neal

Theses & ETDs

The Metropolitan Community Church, as a liberal mainline Christian denomination that caters to the LGBT community, provides an open and safe space for people with non-normative sexual and gender identities to practice religion. However, Christianity has a history of being a patriarchal and heteronormative institution. As a progressive denomination, the MCC strives for gender equality, but still works within a religion built on rigid hierarchies. Twenty qualitative interviews were conducted with attendants of a MCC church to determine how queer men and women understand gender in their gay-affirming church. The aim was to determine what role gender plays in the …

Determining Factors Of Transfer: Their Implications For Teaching To Foster Generalisation And Conceptual Restructuring, Stephen Ntim

Academic Leadership: The Online Journal (2003-2012)

Transfer can be defined as ‘the degree to which behaviour will be repeated in a new situation’ (Detterman and Sternberg, 1993, p. 4). Thus transfer of learning occurs when learning in one context or with one set of materials impacts on performance in another context or with related material. Pennington and Rehder (1995) borrowing from Larkin (1989) also define transfer as the use of knowledge or skill acquired in one situation in the performance of a new, novel task, a task sufficiently novel that it involves additional learning as well as the use of old knowledge. Research evidence as to …

Parents’ Education, Occupation And Real Mother’S Age As Predictors Of Students’ Achievement In Mathematics In Some Selected Secondary Schools In Ogun State, Nigeria., K.O. Muraina, Kassim Ajayi

Academic Leadership: The Online Journal (2003-2012)

Educational leaders are responsible for the academic success of all students. As greater numbers of students exhibit disruptive behaviors, educational leaders are challenged with the task of maintaining high academic standards while simultaneously managing problem behaviors that interrupt the learning environment. Many schools have implemented character development programs aimed to decrease student disruptive behavior by increasing student prosocial skills. Character can be defined as “the emotional, intellectual and moral qualities of a person or group as well as the demonstration of these qualities in prosocial behavior” (United States Department of Education, 2008, p.1). Character education is “an inclusive term encompassing …

Case Study Scenario And Simulation: Supplementing A Student Nurse's Missed Foundational Clinical Nursing Experience, Lori Versaguis

Theses and Graduate Projects

Optimizing clinical education for student nurses in a local associate degree nursing (ADN) program is essential to prepare them to become competent professional nurses. The focus of this project is to develop a case study scenario and related simulation for associate degree nursing students who are absent from clinical experiences in a foundational nursing class. An innovative approach to replace a missed clinical experience is an educational module utilizing a patient care scenario followed by realistic nursing evaluation and interuentions in a simulation lab. Margaret Newman's theory of health as expanding consciousness supports this case scenario and simulation project. Bloom's …

Development, Implementation And Analysis Of A Project-Based Model In A Special Education Setting, Joel Dimock

Theses and Graduate Projects

Project-based learning is becoming a more cofirmon practice in schools around America, particularly small independently operated charter schools such as Learning for Leadership. Learning for Leadership Charter School (LLCS) is a project-based charter school in urban Minneapolis with a mission of delivering a project-based approach to learning compared to a more traditional direct instruction approach. LLCS does not uniformly deliver a consistent model of project-based learning through its various grade levels. Through extensive research of literature, a preliminary project-based model was developed and tested in a small group special education setting. From this experience, along with input from professionals and …

According To Secondary Female Science Students, What Creates An Engaging And Interesting Science Class, Colleen Victoria Quinn Schroeder

Theses and Graduate Projects

In gender comparisons, females are still under-represented in the professional scientific world. Understanding how to engage females in the field of science during their secondary school careers could help reverse this phenomenon. The participants in this study were all 11th grade female students enrolled in some science class at the time. Through direct conversations in focus groups the results show that to actively engage females in science, they need to have fun, be taught by knowledgeable teachers, participate in hands-on activities and have challenging classes.

Student Perceptions Of Responsive Classroom In An Urban Setting, Jeremy Lee Jones

Theses and Graduate Projects

Responsive Classroom is an approach to elementary teaching that focuses on the social, emotional, and academic needs of children by creating a warrn classroom environment. Responsive Classroom incorporates ten classroom practices into its educational framework. These classroom practices consist of: morning meeting, rule creation, interactive modeling, positive teacher language, logical consequences, guided discovery, academic choice, classroom organization, working with families, and collaborative problem solving. Through the use of in- depth interviews, this study seeks to explore student perceptions of Responsive Classroom based on a specific population of urban students. Themes that emerged from the interviews were: (l) Responsive Classroom establishes …

Patterns Of Maternal Yolk Hormones In Eastern Screech Owl Eggs (Megascops Asio), D. Caldwell Hahn

United States Geological Survey: Staff Publications

Owl clutches typically hatch asynchronously, and brood size hierarchies develop. In this study, we describe intra-clutch variation of testosterone, androstenedione, estradiol, and corticosterone in Eastern screech owl egg yolks. In order to assess whether these hormones may have originated in the follicle, we also characterize variation of testosterone, androstenedione, and corticosterone within the exterior, intermediate, and interior regions of the yolk. Concentrations of testosterone and androstenedione were distributed relatively evenly across egg lay order with the exception of first-laid eggs that had significantly lower concentrations of both androgens than eggs later in the laying sequence. Corticosterone and estradiol did not …

Supercomputers And Supercomputing, Jeffrey S. Cook

Faculty Publications

What is a Supercomputer? A Supercomputer is defined as the fastest type of computer used for specialized applications that require a massive number of mathematical calculations. The term “supercomputer” was coined in 1929 by the New York World, referring to tabulators manufactured by IBM. To modern computer users, these tabulators would probably appear awkward, slow, and cumbersome to use, but at the time, they represented the cutting edge of technology. This continues to be true of supercomputers today, which harness immense processing power so that they are incredibly fast, sophisticated, and powerful.

Method Development And Applications To Screening And Characterization Of Rrna-Targeting Small Molecules, Papa Nii Asare-Okai

Wayne State University Dissertations

A series of single ring aminoglycoside analogues was tested for binding to a model RNA representing the A site using electrospray ionization mass spectrometry (ESI-MS). Several of the synthetic analogues with low molecular weights were found to bind to the RNA with affinities comparable to the parental aminoglycoside neamine, with apparent dissociation constants in the low micromolar range. Salt dependence of the affinity constants for the single ring analogues revealed a predominantly electrostatic binding mode. Footprinting experiments revealed that one of the compounds (DHR23) has a similar binding site as the antibiotic paromomycin. DMS chemical probing results also suggest that …

Feed Efficiency - How Should It Be Used For The Cow Herd?, Andrew J. Roberts, Rick Funston, Travis Mulliniks, Mark Petersen, Mike Macneil

Range Beef Cow Symposium

Improving cow herd efficiency is critical because approximately 70% of the feed inputs required to produce a slaughter animal are used for maintenance, the majority of which is utilized by the dam (Williams and Jenkins, 2006). To date, much of the efforts to improve efficiency in cattle have focused on different measures of feed efficiency (variations in amount of feed consumed and rate of weight gain) determined during the growing phase. While this approach provides pertinent information concerning efficiency during the growing phase, the relationship to cow efficiency remains to be determined. When considering the usefulness of feed efficiency as …

The Importance Of Maintaining Structure To Ring-Necked Pheasant And Waterfowl Production In The Upper Great Plains, Benjamin Geaumont, Kevin Sedivec, Christopher Schauer

Range Beef Cow Symposium

Introduction

Privately owned lands serve a crucial role in maintaining wildlife populations. Perhaps that is because approximately 60 percent of the land in the United States is privately owned (Lubowski et al. 2006). While many private landowners are aware that how they use their lands will impact wildlife, some private landowners are looking for ways to maintain wildlife populations at increased levels for both aesthetic and economical purposes. In recent years, expenditures associated with hunting have boosted many local economies as well as benefiting private landowners (Benson, 1989; Das and Rainey, 2009). As such, landowners who are concerned with both …

Cow Side Of Producing A 1,000 Lb. Feeder, Cow Size And Expenses, Ken Olson, Justin Waggoner, John Jaeger

Range Beef Cow Symposium

Introduction

Do relationships exist between cow size, nutrient requirements, and production capability? We can assume that a bigger cow will require more nutrients. What are the characteristics of that relationship? Is it a direct response wherein a cow that is 10% bigger than another will require 10% more nutrients, or is there economy of scale, so to speak? Can we assume that a bigger cow will be more productive? Is it automatic that bigger size means faster growth so we can expect the calves of bigger cows to grow faster? We will explore these relationships.

Cow Size

It is commonly …

Genomics For The Rancher: How Does It Work And What Does It Mean?, Jack C. Whittier

Range Beef Cow Symposium

Introduction

I am continually amazed at the tools we have in today’s world to assist in making better and better decisions. This is true in most aspects of our lives – from communications to computers; from entertainment to eating; from politics to travel; and many, many more components of what we do and how we live. The digital age has created an information explosion, and livestock production has not been left out of this progress.

Another amazing aspect of today’s world is the vast knowledge being uncovered and refined in the world of biology and science. Gregor Mendel, an Austrian …

Biological Diversity And Resilience: Lessons From The Recovery Of Cichlid Species In Lake Victoria, Alex Awiti

East Africa Institute

A fundamental feature of the Anthropocene is the inexorable erosion of the self-repairing capacity or adaptive renewal of natural systems because of natural perturbation, exploitation, or management failure. The concept of resilience offers a systematic framework for understanding the dynamics and variables that govern response dynamics of ecosystems. Resilience of haplochromine cichlids is assessed using limnological and biodiversity changes in Lake Victoria, the world’s second largest freshwater lake, over the last five decades. The review explores the resurgence of the haplochromine cichlids using Holling’s adaptive renewal cycle and attempts to illustrate how resilience-based management approaches might learn from an inadvertent …

Breakdown Of The Social Democratic State: Taking A Fresh Look At Waldron's Dignity, Rights, And Responsibilities, Richard A. Epstein

Articles

No abstract provided.

University Of Malaya-Kyoto University Secretariat Newsletter, Issue 1, Volume 1, 2011, Malaysia University Of Malaya

Archival Material (2010s)

No abstract provided.