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2011

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The Victims' Burden Disrupted Identity And Social Tensions In The Reintegration Of Ex-Lra In Northern Uganda, Alexandra Pierce Jan 2011

The Victims' Burden Disrupted Identity And Social Tensions In The Reintegration Of Ex-Lra In Northern Uganda, Alexandra Pierce

Theses & ETDs

This study addresses the dilemmas with implementing Disarmament, Demobilization, and Reintegration (DDR) programs in conflict-ridden communities with limited resources such as in the case of Northern Uganda. The social identity theory considered in the first chapter supplies the foundation to explore whether or not the relationship between the LRA and the Acholi community is creating a separate and permanent identity around those identified as ex-LRA. The second chapter discusses the formulation and implementation of DDR programs since they were first employed as instruments for securing peace and ensuring post-conflict reconstruction. The final chapter applies the principles of the first two …


Scwds Briefs: Volume 26, Number 4 (January 2011), Gary L. Doster , Editor, Scwds Briefs, Michael J. Yabsley Jan 2011

Scwds Briefs: Volume 26, Number 4 (January 2011), Gary L. Doster , Editor, Scwds Briefs, Michael J. Yabsley

Southeastern Cooperative Wildlife Disease Study: Publications

Birds Falling From the Sky

CWD in Two New States

Update on Bat Fungus

World Equestrian Games

Cooperating to Regulate Live Animal Imports

Deer Parapoxvirus Infects Hunters

Woodchuck Victim of Raccoon Roundworm

Change in AFWA Health Committee Leadership

Advisory Committee on Animal Health


International Conference On Advances In Radiation Oncology (Icaro): Outcomes Of An Iaea Meeting, Eeva K. Salminen, Krystyna Kiel, Geoffrey S. Ibbott, Michael C. Joiner, Eduardo Rosenblatt, Eduardo Zubizarreta, Jan Wondergem, Ahmed Meghzifene Jan 2011

International Conference On Advances In Radiation Oncology (Icaro): Outcomes Of An Iaea Meeting, Eeva K. Salminen, Krystyna Kiel, Geoffrey S. Ibbott, Michael C. Joiner, Eduardo Rosenblatt, Eduardo Zubizarreta, Jan Wondergem, Ahmed Meghzifene

Wayne State University Associated BioMed Central Scholarship

Abstract

The IAEA held the International Conference on Advances in Radiation Oncology (ICARO) in Vienna on 27-29 April 2009. The Conference dealt with the issues and requirements posed by the transition from conventional radiotherapy to advanced modern technologies, including staffing, training, treatment planning and delivery, quality assurance (QA) and the optimal use of available resources. The current role of advanced technologies (defined as 3-dimensional and/or image guided treatment with photons or particles) in current clinical practice and future scenarios were discussed.

ICARO was organized by the IAEA at the request of the Member States and co-sponsored and supported by other …


Vascular Countercurrent Network For 3d Triple-Layered Skin Structure With Radiation Heating, Xiaoqi Zeng Jan 2011

Vascular Countercurrent Network For 3d Triple-Layered Skin Structure With Radiation Heating, Xiaoqi Zeng

Doctoral Dissertations

Heat transfer in living tissue has become more and more attention for researchers, because high thermal radiation produced by intense fire, such as wild fires, chemical fires, accidents, warfare, terrorism, etc, is often encountered in human's daily life. Living tissue is a heterogeneous organ consisting of cellular tissue and blood vessels, and heat transfer in cellular tissue and blood vessel is quite different, because the blood vessels provide channels for fast heat transfer. The metabolic heat generation, heat conduction and blood perfusion in soft tissue, convection and perfusion of the arterial-venous blood through the capillary, and interaction with the environment …


Essential Readings In E-Science, Kathy Szigeti, Kathy Wheeler, Jack M. Maness, Association Of College & Research Libraries - Science & Technology Section, Subject & Bibliographic Access To Science Materials Committee Jan 2011

Essential Readings In E-Science, Kathy Szigeti, Kathy Wheeler, Jack M. Maness, Association Of College & Research Libraries - Science & Technology Section, Subject & Bibliographic Access To Science Materials Committee

University Libraries: Faculty Scholarship

The amount of data that scientists produce continues to increase every year. People are needed to handle, preserve, describe, and organize that data, and, because many of these tasks are similar to what librarians have done with publications for centuries, it makes sense that librarians would have a role in the emerging task of managing scientific data. It is the purpose of this paper to give librarians a core set of readings to turn to in order to begin learning about this new task in our field; to help us, as individuals and as a profession, understand what our roles …


Nematode Parasites Of Costa Rican Snakes (Serpentes) With Description Of A New Species Of Abbreviata (Physalopteridae), Charles R. Bursey, Daniel R. Brooks Jan 2011

Nematode Parasites Of Costa Rican Snakes (Serpentes) With Description Of A New Species Of Abbreviata (Physalopteridae), Charles R. Bursey, Daniel R. Brooks

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Seventy-eight snakes collected in the Area de Conservación Guanacaste, Costa Rica were necropsied: Boidae (1 species), boa constrictor, Boa constrictor; Colubridae (21 species), Ecuador sipo, Chironius grandisquamis; road guarder, Conophis lineatus; South American forest racer, Dendrophidion percarinatus; speckled racer, Drymobius margaritiferus; mimic false coral snake, Erythrolamprus mimus; blunthead tree snake, Imantodes cenchoa; western tree snake, Imantodes inornatus; banded cat-eyed snake, Leptodeira annulata; striped lowland snake, Leptodrymus pulcherrimus; Cope’s parrot snake, Leptophis depressirostris; yellow-bellied racer, Liophis epinephelus; neotropical whip snake, Masticophis mentovarius; brown vinesnake, Oxybelis aeneus; …


Intelligent Processing In Wireless Communications Using Particle Swarm Based Methods, Weihua Gao Jan 2011

Intelligent Processing In Wireless Communications Using Particle Swarm Based Methods, Weihua Gao

Electrical Engineering and Computer Science - Dissertations

There are a lot of optimization needs in the research and design of wireless communica- tion systems. Many of these optimization problems are Nondeterministic Polynomial (NP) hard problems and could not be solved well. Many of other non-NP-hard optimization problems are combinatorial and do not have satisfying solutions either. This dissertation presents a series of Particle Swarm Optimization (PSO) based search and optimization algorithms that solve open research and design problems in wireless communications. These problems are either avoided or solved approximately before.

PSO is a bottom-up approach for optimization problems. It imposes no conditions on the underlying problem. Its …


Evolution Of Complex Sperm Morphology, Dawn M. Higginson Jan 2011

Evolution Of Complex Sperm Morphology, Dawn M. Higginson

Biology - Dissertations

Sperm form evolves rapidly and dramatically, particularly in taxa with internal fertilization. Post-copulatory sexual selection at the level of individual sperm has been suggested to explain the evolution of two enigmatic sperm phenotypes: sperm heteromorphism, where more than one type of sperm is produced by a male, and sperm conjugation, where multiple sperm join together for motility and transport through the female reproductive tract before dissociation prior to fertilization. I explore the taxonomic distribution of sperm heteromorphism and conjugation, speculate on the potential developmental origins and discuss functional hypotheses for evolutionary maintenance of these remarkable traits. I subsequently focus on …


Effects Of Nitrogen Deposition And Empirical Nitrogen Critical Loads For Ecoregions Of The United States, Linda H. Pardo, Mike E. Fenn, Christine L. Goodale, Linda. H. Geiser, Charles T. Driscoll, Edith B. Allen, Jill S. Baron, Roland Bobbink, Williams D. Bowman, Christopher M. Clark, Bridget Emmett, Frank S. Gilliam, Tara L. Greaver, Sharon J. Hall, Erik A. Lilleskov, Lingli Liu, Jason A. Lynch, Knute J. Nadelhoffer, Steven S. Perakis, Molly J. Robin-Abbott, John L. Stoddard, Kathleen C. Weathers, Robin L. Dennis Jan 2011

Effects Of Nitrogen Deposition And Empirical Nitrogen Critical Loads For Ecoregions Of The United States, Linda H. Pardo, Mike E. Fenn, Christine L. Goodale, Linda. H. Geiser, Charles T. Driscoll, Edith B. Allen, Jill S. Baron, Roland Bobbink, Williams D. Bowman, Christopher M. Clark, Bridget Emmett, Frank S. Gilliam, Tara L. Greaver, Sharon J. Hall, Erik A. Lilleskov, Lingli Liu, Jason A. Lynch, Knute J. Nadelhoffer, Steven S. Perakis, Molly J. Robin-Abbott, John L. Stoddard, Kathleen C. Weathers, Robin L. Dennis

Civil and Environmental Engineering - All Scholarship

Human activity in the last century has led to a significant increase in nitrogen (N) emissions and atmospheric deposition. This N deposition has reached a level that has caused or is likely to cause alterations to the structure and function of many ecosystems across the United States. One approach for quantifying the deposition of pollution that would be harmful to ecosystems is the determination of critical loads. A critical load is defined as the input of a pollutant below which no detrimental ecological effects occur over the long-term according to present knowledge.

The objectives of this project were to synthesize …


Unm's Science And Technology Corporation: The Impact Of Start-Up Companies, Unm Bureau Of Business And Economic Research Jan 2011

Unm's Science And Technology Corporation: The Impact Of Start-Up Companies, Unm Bureau Of Business And Economic Research

Office of the Vice President for Research

The University of New Mexicos Science & Technology Corporation (STC) is a nonprofit corporation formed for the purposes of protecting, commercializing and transferring faculty inventions and university patents and is a vital tool in the economic development of a high-tech industry in New Mexico.'


Development Of Biomarkers For Endocrine Disrupting Compounds In The Fathead Minnow, Pimephales Promelas, Tara Frare Jan 2011

Development Of Biomarkers For Endocrine Disrupting Compounds In The Fathead Minnow, Pimephales Promelas, Tara Frare

Undergraduate Review

Organic waste compounds (OWC’s) are an environmental concern that can have adverse effects on humans, animals, and the environment. Ethinyl estradiol (EE2) is one common OWC and is an active ingredient in oral birth control pills. The presence of EE2 in aquatic environments and drinking water can be linked to decreased fertility and altered physiology in fish. I am developing Q-PCR biomarkers to detect changes in fish at low concentrations before adverse effects occur at higher concentrations. RNA was extracted from twenty fathead minnows that had not been exposed to OWC’s and will be used to synthesize cDNA. Thus far …


A Slip Of Paper In A Black Walnut Box: An Examination Of The Suffrage Debate In Beverly, Massachusetts 1913-1915, Sarah R. Fuller Jan 2011

A Slip Of Paper In A Black Walnut Box: An Examination Of The Suffrage Debate In Beverly, Massachusetts 1913-1915, Sarah R. Fuller

Undergraduate Review

It was not until 1920, 72 years after the birth of the suffrage movement, that Massachusetts women gained the right to vote. While other state suffrage associations succeeded in persuading their governments to pass laws securing the vote for women, Massachusetts reformers were met with an overwhelming amount of resistance. The forces behind much of this resistance were the white, middle-class women active in small cities and towns throughout the Commonwealth. Women in support, as well as in opposition, to suffrage in Massachusetts at the turn-of-the twentieth century were the same women swept up in the changing gender roles of …


Community-Based Service-Learning @ St. John Fisher College, Lynn Donahue Jan 2011

Community-Based Service-Learning @ St. John Fisher College, Lynn Donahue

Upstate New York Science Librarians Conference

No abstract provided.


Action Anthropology And Pedagogy: University-Community Collaborations In Setting Policy, Lutchmie Narine, Sandra D. Lane, Robert A. Rubinstein, Inga Back, Caitlin Cornell, Alexander Hodgens, Monique Brantley, Rachel Kramas, Kathleen Keough, Brandon O'Connor, William Suk, Eric Morrissette, Mary Benson Jan 2011

Action Anthropology And Pedagogy: University-Community Collaborations In Setting Policy, Lutchmie Narine, Sandra D. Lane, Robert A. Rubinstein, Inga Back, Caitlin Cornell, Alexander Hodgens, Monique Brantley, Rachel Kramas, Kathleen Keough, Brandon O'Connor, William Suk, Eric Morrissette, Mary Benson

Public Health, Food Studies, and Nutrition

This article describes a student-led, community-participatory project focused on reducing the burden of childhood lead poisoning in rental housing. A multidisciplinary group of students and faculty worked with community members. We compiled the social, public health, economic, and policy information on the human and fiscal costs of childhood lead poisoning. This analysis was done for community advocates to use to persuade policymakers to enact a local law strengthening the prevention of childhood lead poisoning in rental property. In conducting this work, the students gained experience in qualitative research methods, quantitative data analysis, the health consequences of lead exposure, health policy, …


Summer 2011, Nova Southeastern University Jan 2011

Summer 2011, Nova Southeastern University

Currents

No abstract provided.


Suffolk Alumni Magazine, Vol. 7, No.1, 2011, Suffolk University Jan 2011

Suffolk Alumni Magazine, Vol. 7, No.1, 2011, Suffolk University

Suffolk University Magazine

No abstract provided.


Ecological Design Of Marine Construction For Socio-Economic Benefits: Ecosystem Integration Of A Pipeline In Coral Reef Area, Sylvain Pioch, Philippe Saussola, Kirk Kilfoyle, Richard E. Spieler Jan 2011

Ecological Design Of Marine Construction For Socio-Economic Benefits: Ecosystem Integration Of A Pipeline In Coral Reef Area, Sylvain Pioch, Philippe Saussola, Kirk Kilfoyle, Richard E. Spieler

Marine & Environmental Sciences Faculty Articles

It is critical to understand that an ecosystem integration of construction requires a close Engineering/Biology partnership to meet socio-economic benefits in management goals. Biologists are not typically trained or licensed for the requisite engineering involved in construction. Likewise, non-biologists designing habitat often can lead to egregious results. For example, unintentionally constructing the wrong habitat, i.e., refuge for predators in a nursery area, or habitat that facilitates the spread of non-desirable species can increase, rather than ameliorate, the impact of construction. In recent years, Pioch and co-workers (unpublished) developed an alternative to the “classic” engineering approach to marine construction. This new …


Environmental Science And Policy, Master's Of Science, 2011-2012, University Of South Florida St. Petersburg Jan 2011

Environmental Science And Policy, Master's Of Science, 2011-2012, University Of South Florida St. Petersburg

Academic Learning Compacts

The Academic Learning Compact for 2011-2012 for the Master's of Science in Environmental Science and Policy.


2011 Breeding Raptor Survey Of The Upper Rio Grande Gorge, Hawks Aloft, Inc. Jan 2011

2011 Breeding Raptor Survey Of The Upper Rio Grande Gorge, Hawks Aloft, Inc.

Multi-Species Reports (Hawks Aloft)

No abstract provided.


Textile Society Of America Newsletter 23:1 — Winter 2011, Textile Society Of America Jan 2011

Textile Society Of America Newsletter 23:1 — Winter 2011, Textile Society Of America

Textile Society of America: Newsletters

Lillian Elliott Award Recipient: Sharon Kallis
Symposium 2010: TSA Award and Scholarship Winners
From the President
TSA Study Tours
Symposium 2010 Photos
TSA Member News
Symposium 2010: Reports by TSA Award Recipients
Book Reviews
Conference Reviews
Textile Community News
Publication News
Calendar-Conferences & Symposia, Exhibitions, Lectures, Workshops, Tours


New Material World: Rethreading Technology, Sharon L. Kennedy Jan 2011

New Material World: Rethreading Technology, Sharon L. Kennedy

Sheldon Museum of Art: Catalogs and Publications

New Material World: Rethreading Technology highlights ten contemporary textile artists from Canada, Denmark, Japan, South Korea, and the United States, who engage modern technology either by employing or studiously resisting it in their work. The exhibition explores ways in which some artists utilize technology as a tool to expand their design capabilities and others use it to further their cultural, political, scientific, or social interests. Technology aids in planning and implementing artwork, allowing artists more time to explore new creative ventures. Modern exchanges of information facilitate collaborations between artists and industry. Although technology has benefited many textile artists, others find …


Malaria Distribution, Prevalence, Drug Resistance And Control In Indonesia, Iqbal R.F. Elyazar, Simon I. Hay, J. Kevin Baird Jan 2011

Malaria Distribution, Prevalence, Drug Resistance And Control In Indonesia, Iqbal R.F. Elyazar, Simon I. Hay, J. Kevin Baird

United States Public Health Resources

Approximately 230 million people live in Indonesia. The country is also home to over 20 anopheline vectors of malaria which transmit all four of the species of Plasmodium that routinely infect humans. A complex mosaic of risk of infection across this 5000-km-long archipelago of thousands of islands and distinctive habitats seriously challenges efforts to control malaria. Social, economic and political dimensions contribute to these complexities. This chapter examines malaria and its control in Indonesia, from the earliest efforts by malariologists of the colonial Netherlands East Indies, through the Global Malaria Eradication Campaign of the 1950s, the tumult following the coup …


Plasmodium Falciparum Malaria Endemicity In Indonesia In 2010, Iqbal R.F. Elyazar, Peter W. Gething, Anand P. Patil, Hanifah Rogayah, Rita Kusriastuti, Desak M. Wismarini, Siti N. Tarmizi, J. Kevin Baird, Simon I. Hay Jan 2011

Plasmodium Falciparum Malaria Endemicity In Indonesia In 2010, Iqbal R.F. Elyazar, Peter W. Gething, Anand P. Patil, Hanifah Rogayah, Rita Kusriastuti, Desak M. Wismarini, Siti N. Tarmizi, J. Kevin Baird, Simon I. Hay

United States Public Health Resources

Background: Malaria control programs require a detailed understanding of the contemporary spatial distribution of infection risk to efficiently allocate resources. We used model based geostatistics (MBG) techniques to generate a contemporary map of Plasmodium falciparum malaria risk in Indonesia in 2010.

Methods: Plasmodium falciparum Annual Parasite Incidence (PfAPI) data (2006–2008) were used to map limits of P. falciparum transmission. A total of 2,581 community blood surveys of P. falciparum parasite rate (PfPR) were identified (1985–2009). After quality control, 2,516 were included into a national database of age-standardized 2–10 year old PfPR data (PfPR …


Resistance To Chloroquine Unhinges Vivax Malaria Therapeutics, J. Kevin Baird Jan 2011

Resistance To Chloroquine Unhinges Vivax Malaria Therapeutics, J. Kevin Baird

United States Public Health Resources

After 6 decades during which it was almost completely neglected, malaria workers have begun to acknowledge that vivax malaria poses a serious threat to human health. Nearly 3 billion people live at risk of the infection, and 100 to 400 million suffer clinical attacks each year (21, 23). Recent studies challenge the notion of Plasmodium vivax as a benign infection. A spectrum of severe disease syndromes historically considered the reserve of Plasmodium falciparum have been demonstrated in vivax malaria (4, 20, 25, 28, 31). Realization of the threat posed by this parasite, along with acknowledgment of the need to eliminate …


Radical Cure: The Case For Anti-Relapse Therapy Against All Malarias, J. Kevin Baird Jan 2011

Radical Cure: The Case For Anti-Relapse Therapy Against All Malarias, J. Kevin Baird

United States Public Health Resources

Douglas et al [1] describe patency with Plasmodium vivax in the 63 days after treatment of malaria caused by Plasmodium falciparum in >10,000 subjects in Thailand over a 14-year period who received 25 different therapies. Therapy for acute malaria aims at the asexual stages of the organism infecting blood. Among the many blood schizontocidal drugs that achieve this therapeutic effect, none eliminate dormant stages in the liver, which are known as hypnozoites. Regardless of the species being treated, if hypnozoites are present, relapse may occur in the absence of treatment with primaquine, which is the only registered hypnozoitocide. The patients …


Cryogenic Zone Compression For The Measurement Of Dioxins In Human Serum By Isotope Dilution At The Attogram Level Using Modulated Gas Chromatography Coupled To High Resolution Magnetic Sector Mass Spectrometry, Donald G. Patterson, Jr., Susan M. Welch, Wayman E. Turner, Andreas Sjödin, Jean-Francois Focant Jan 2011

Cryogenic Zone Compression For The Measurement Of Dioxins In Human Serum By Isotope Dilution At The Attogram Level Using Modulated Gas Chromatography Coupled To High Resolution Magnetic Sector Mass Spectrometry, Donald G. Patterson, Jr., Susan M. Welch, Wayman E. Turner, Andreas Sjödin, Jean-Francois Focant

United States Public Health Resources

A liquid nitrogen jet-cooled thermal modulator dedicated to comprehensive two-dimensional gas chromatography has been mounted in a GC oven coupled to a high resolution magnetic sector mass spectrometry instrument. The data acquisition parameters of the slow double-focusing magnetic sector MS instrument have been optimized to accommodate the description of the narrow modulated GC peaks. Acquisition rates were increased to 20 Hz, while maintaining high mass resolution. Selected ion monitoring (SIM) descriptors, typically including several ions for both native and labeled analytes, were thus reduced to one or two to ensure enough MS cycle time. For maximization of the sensitivity enhancement …


Landscape And Residential Variables Associated With Plague-Endemic Villages In The West Nile Region Of Uganda, Katherine Macmillan, Russell E. Enscore, Asaph Ogen- Odoi, Jeff N. Borchert, Nackson Babi, Gerald Amatre, Linda A. Atiku, Paul S. Mead, Kenneth L. Gage, Rebecca J. Eisen Jan 2011

Landscape And Residential Variables Associated With Plague-Endemic Villages In The West Nile Region Of Uganda, Katherine Macmillan, Russell E. Enscore, Asaph Ogen- Odoi, Jeff N. Borchert, Nackson Babi, Gerald Amatre, Linda A. Atiku, Paul S. Mead, Kenneth L. Gage, Rebecca J. Eisen

United States Public Health Resources

Plague, caused by the bacteria Yersinia pestis , is a severe, often fatal disease. This study focuses on the plagueendemic West Nile region of Uganda, where limited information is available regarding environmental and behavioral risk factors associated with plague infection. We conducted observational surveys of 10 randomly selected huts within historically classified case and control villages (four each) two times during the dry season of 2006 ( N = 78 case huts and N = 80 control huts), which immediately preceded a large plague outbreak. By coupling a previously published landscape-level statistical model of plague risk with this observational survey, …


The Shaping Of Modern Human Immune Systems By Multiregional Admixture With Archaic Humans, Laurent Abi-Rached, Matthew J. Jobin, Subhash Kulkarni, Alasdair Mcwhinnie, Klara Dalva, Loren Gragert, Farbod Babrzadeh, Baback Gharizadeh, Ma Luo, Francis A. Plummer, Joshua Kimani, Mary Carrington, Derek Middleton, Raja Rajalingam, Meral Beksac, Steven G. E. Marsh, Martin Maiers, Lisbeth A. Guethlein, Sofia Tavoularis, Ann-Margaret Little, Richard E. Green, Paul J. Norman, Peter Parham Jan 2011

The Shaping Of Modern Human Immune Systems By Multiregional Admixture With Archaic Humans, Laurent Abi-Rached, Matthew J. Jobin, Subhash Kulkarni, Alasdair Mcwhinnie, Klara Dalva, Loren Gragert, Farbod Babrzadeh, Baback Gharizadeh, Ma Luo, Francis A. Plummer, Joshua Kimani, Mary Carrington, Derek Middleton, Raja Rajalingam, Meral Beksac, Steven G. E. Marsh, Martin Maiers, Lisbeth A. Guethlein, Sofia Tavoularis, Ann-Margaret Little, Richard E. Green, Paul J. Norman, Peter Parham

United States Public Health Resources

Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic HLA class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia through admixture with archaic humans called Denisovans, a likely sister group to the Neandertals. Virtual genotyping of Denisovan and Neandertal genomes identified archaic HLA haplotypes carrying functionally distinctive alleles that have introgressed into modern Eurasian and Oceanian populations. These alleles, of which several encode unique or strong ligands for natural killer cell receptors, now represent more than half the HLA alleles of …


Hla/Kir Restraint Of Hiv: Surviving The Fittest, Arman A. Bashirova, Rasmi Thomas, Mary Carrington Jan 2011

Hla/Kir Restraint Of Hiv: Surviving The Fittest, Arman A. Bashirova, Rasmi Thomas, Mary Carrington

United States Public Health Resources

Multiple epidemiological studies have demonstrated associations between the human leukocyte antigen (HLA) loci and human immunodeficiency virus (HIV) disease, and more recently the killer cell immunoglobulin-like (KIR) locus has been implicated in differential responses to the virus. Genome-wide association studies have convincingly shown that the HLA class I locus is the most significant host genetic contributor to the variation in HIV control, underscoring a central role for CD8 T cells in resistance to the virus. However, both genetic and functional data indicate that part of the HLA effect on HIV is due to interactions between KIR …


Differential Microrna Regulation Of Hla-C Expression And Its Association With Hiv Control, Smita Kulkarni, Ram Savan, Ying Qi, Xiaojiang Gao, Yuko Yuki, Sara E. Bass, Maureen P. Martin, Peter Hunt, Steven G. Deeks, Amalio Telenti, Florencia Pereyra, David Goldstein, Steven Wolinsky, Bruce Walker, Howard A. Young, Mary Carrington Jan 2011

Differential Microrna Regulation Of Hla-C Expression And Its Association With Hiv Control, Smita Kulkarni, Ram Savan, Ying Qi, Xiaojiang Gao, Yuko Yuki, Sara E. Bass, Maureen P. Martin, Peter Hunt, Steven G. Deeks, Amalio Telenti, Florencia Pereyra, David Goldstein, Steven Wolinsky, Bruce Walker, Howard A. Young, Mary Carrington

United States Public Health Resources

The HLA-C locus is distinct relative to the other classicalHLA class I loci in that it has relatively limited polymorphism1, lower expression on the cell surface, and more extensive ligand–receptor interactions with killer-cell immunoglobulin-like receptors. A single nucleotide polymorphism (SNP) 35 kb upstream of HLA-C (rs9264942; termed -35) associates with control of HIV, and with levels of HLA-C messenger RNA transcripts and cell-surface expression, but the mechanism underlying its varied expression is unknown. We proposed that the -35 SNP is not the causal variant for differential HLA-C expression, but rather is marking another polymorphism that directly affects levels of HLA-C. …