Digital Commons Network^™

Billing And Compliance Issues With Devices, Yi Zhang, Carlos Brown

2011 Device Advice from the FDA

No abstract provided.

Conference Faculty, Human Research Protection Office, Washington University School Of Medicine In St. Louis

2011 St. Louis OHRP National Research Forum and Community-Engaged Research Conference

No abstract provided.

09. Essential Elements Of Design: Partnerships, Funding And Evaluation, Sarah Gehlert

2011 St. Louis OHRP National Research Forum and Community-Engaged Research Conference

No abstract provided.

Invasion Of A Littoral Cladoceran Sida Crystallina Into The Pelagic Zone Of Christine Lake, Nh And Its Potential Impact On The Phytoplankton Community, Kayla N. Huey

Center for Freshwater Biology

This study evaluated the phytoplankton community and grazing influences of the zooplankton in oligotrophic Christine Lake, NH, by assessing the body size and clearance rates of the three dominant crustaceans: Sida crystallina (0.08 individuals L-1 ), Daphnia dubia (0.11 individuals L-1 ), and Leptodiaptomus sicilis (2.11 individuals L-1 ). Sida crystallina, typically a littoral cladoceran, was abundant throughout the water column in the open water, and contributed approximately 44% of the grazing in the pelagic zone. Phytoplankton abundance was examined to assess the potential impact S. crystallina might have on the phytoplankton in Christine lake. Aphanocapsa, the dominant phytoplankton in …

Effect Of Substrate Composition And Alignment On Corneal Cell Phenotype, Donna Phu '09, Lindsay S. Wray '08, Robert V. Warren '10, Richard C. Haskell, Elizabeth J. Orwin

All HMC Faculty Publications and Research

Corneal blindness is a significant problem treated primarily by corneal transplants. Donor tissue supply is low, creating a growing need for an alternative. A tissue-engineered cornea made from patient-derived cells and biopolymer scaffold materials would be widely accessible to all patients and would alleviate the need for donor sources. Previous work in this lab led to a method for electrospinning type I collagen scaffolds for culturing corneal fibroblasts ex vivo that mimics the microenvironment in the native cornea. This electrospun scaffold is composed of small-diameter, aligned collagen fibers. In this study, we investigate the effect of scaffold nanostructure and composition …

A New Genus Of Soft Coral Of The Family Alcyoniidae (Cnidaria, Octocorallia) With Re-Description Of A New Combination And Description Of A New Species, Catherine S. Mcfadden, Yehuda Benayahu

All HMC Faculty Publications and Research

A new genus, Aldersladum (family Alcyoniidae), is established to accommodate a previously described species, Effl atounaria sodwanae Benayahu, 1993 (family Xeniidae) from Sodwana Bay, South Africa that was wrongly assigned to the latter genus. Th is species is redescribed and a second new species, A. jengi from Penghu Is., Taiwan, is described. Th e diagnostic features of the new genus include the presence of only figure-eight shaped platelets in all parts of the colony, thus differentiating it from all known genera of the Alcyoniidae. Based on examination of additional material from other localities, the zoogeographical distribution of the genus is …

Inter-Colony Comparison Of Diving Behavior Of An Arctic Top Predator: Implications For Warming In The Greenland Sea, Nina J. Karnovsky, Zachary W. Brown '07, Jorg Welcker, Ann M.A. Harding, Wojciech Walkusz, André Cavalcanti, Johanna S. Hardin, Alexander Kitaysky, Geir Gabrielsen, David Grémillet

Pomona Faculty Publications and Research

The goal of this study was to assess how diverse oceanographic conditions and prey communities affect the foraging behavior of little auks Alle alle. The Greenland Sea is characterized by 3 distinct water masses: (1) the East Greenland Current (EGC), which carries Arctic waters southward; (2) the Sørkapp Current (SC), which originates in the Arctic Ocean but flows north along the west coast of Spitsbergen; and (3) the West Spitsbergen Current (WSC), which carries warm Atlantic-derived water north. Each of these 3 water masses is characterized by a distinct mesozooplankton community. Little auks breeding adjacent to the EGC have …

Do Longer Delays Matter? The Effect Of Prolonging Delay In Ctl Activation, Angela Gallegos, Ami E. Radunskaya

Pomona Faculty Publications and Research

The activation of a specific immune response takes place in the lymphoid organs such as the spleen. We present here a simplified model of the proliferation of specific immune cells in the form of a single delay equation. We show that the system can undergo switches in stability as the delay is increased, and we interpret these results in the context of sustaining an effective immune response to a dendritic cell vaccine.

Subaerial Freshwater Stromatolites In Deer Cave, Sarawak – A Unique Geobiological Cave Formation, Joyce Lundberg, Donald A. Mcfarlane

WM Keck Science Faculty Papers

A suite of distinctive freshwater subaerial phosphatic stromatolites is developed close to the northeastern entrance of Deer Cave, Gunung Mulu National Park, Sarawak, Borneo, in conditions of very low light but ample supply of nutrients from guano. These stromatolites are not particulate; they are composed of alternating layers of more porous and more dense amorphous hydroxylapatite. This biomineralization occurs as moulds of coccoid (the majority) and filamentous (less abundant) cyanobacteria. Mineralization occurs at a pH of ~ 7.0 in the extracellular sheaths and in micro-domains of varying carbonate content in the surrounding mucus of the biofilm. The most recent surfaces …

Eeg Complexity As A Biomarker For Autism Spectrum Disorder Risk, William Bosl, Adrienne Tierney, Helen Tager-Flusberg, Charles Nelson

Nursing and Health Professions Faculty Research and Publications

Background: Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later cognitive impairments. The nonlinear complexity of electroencephalography (EEG) signals is believed to contain information about the architecture of the neural networks in the brain on many scales. Early detection of abnormalities in EEG signals may be an early biomarker for developmental cognitive disorders. The goal of this paper is to demonstrate that the modified multiscale entropy (mMSE) computed on the basis of resting state EEG data can be used as a biomarker …

Transmen: The Hiv Risk Of Gay Identity, Stefan Rowniak, C Chesla, C D. Rose, W L. Holzemer

Nursing and Health Professions Faculty Research and Publications

Many female-to-male transgender individuals, or transmen, are situated within the gay community, one of the highest risk communities for HIV, yet there has been little research regarding the experience of risk for these transmen. Seventeen transmen were interviewed regarding their sexuality and HIV risk behavior. Fourteen of the 17 reported having non-trans gay men as sexual partners. Risk behaviors included not using condoms with multiple partners who were HIV-positive, or of unknown HIV status. Aspects of risk included the unfamiliarity of the gay community and the lack of safe sex negotiating skills. The dynamics of acceptance and rejection between transmen …

The Mythos Of Sin: C. S. Lewis, The Genesis Fall, And The Modern Mood, Jeremy G. Grinnell

CTS PhD Doctoral Dissertations

This dissertation wrestles with the question how to profitably and theologically handle the Fall narrative of Genesis 3 once it has been classified as “myth,” as was the conclusion of the Formgeschichte school. The dissertation begins by establishing the theological conversation of the mid-twentieth century, which marks a zenith in the discussion. Beginning with a survey of the traditional interpretation of the narrative as historical account, which dominated pre-Enlightenment churchly thought, the survey then summarizes the change of tenor that Enlightenment and higher critical voices brought to the question. The survey concludes with consideration of Reinhold Niebuhr, Karl Barth, and …

Mvip: Math Villages For Inclusive Practices: A Model To Engage All Students And Teachers In Stem Experiences, Ida Malian Ph.D.

Electronic Journal for Inclusive Education

The Math Villages for Inclusive Practices (MVIP) model supports inclusive practices through a) the inclusion of students with disabilities, specifically mathematics disabilities into STEM related activities, b) co-teaching of STEM related topics as professional development, c) “hands-on” real life problems to be addressed collaboratively with students and co-teachers.

MVIP model levels the playing field for students with math disabilities to be engaged in integrated STEM activities. Co-teachers support these activities through professional development that creates content-rich and differentiated instruction for all students. The village concept is derived from the membership of the village learners which includes students, special educators and …

State Preparedness: A Study Of State Plans, Zachary Fehrman

Master of Public Health Program Student Publications

Non-pharmaceutical interventions (NPIs) have been used since the early years of public health. The Centers for Disease Control and Prevention (CDC) provides a standard definition for NPI and what NPI strategies are contained within the definition. This paper seeks to discover if state pandemic influenza plans use the term NPI and its strategies, and if states’ use of NPI strategies in their state pandemic plans is consistent with the CDC definition. To determine how states were defining and using the term NPI and NPI strategies a survey of forty-eight (48) state plans was conducted using each respective states’ pandemic plan. …

Symposium: A Futuristic Look Through Ancient Lenses - Egypt, Booth Library

Booth Library Programs

Further information about this program can be found on the SYMPOSIUM: A FUTURISTIC LOOK THROUGH ANCIENT LENSES - EGYPT exhibit page.

Exhibit Dates This exhibit was displayed at Booth Library October 6 - November 2, 2011

Disability In The Context Of Higher Education: Issues And Concerns In India, Syed Salma Jameel

Electronic Journal for Inclusive Education

Disability in higher education has different implications from that of school Education. Higher education increases the chance of employability, thus, affirming dignified life for the persons with disabilities. While going through the policies and programmes in India it is found that not much has been done in the field of disability and higher education. There are number of groups working on the school education of children with disabilities. This has not translated in the entry of students to higher education because of various reasons. Infrastructural facilities within institutions, attitudes towards persons with disabilities, transportation facilities, and lack of support services …

Developing Mechanisms For The Transfer And/Or Adjustment Of Rock Lobster Shares Between Sectors In Western Australia And South Australia Frdc Project No. 2007/050, Chris Reid, Western Australian Department Of Fisheries

Fisheries Management Papers

The purpose of this report has been to investigate potential reallocation mechanisms for the transfer and/or adjustment of catch shares between sectors and the requirements to allow for their implementation, with particular reference to their application in the Western and South Australian rock lobster fisheries. While the report focuses on the commercial and recreational sectors of these fisheries, potentially all non-commercial fishing sectors could be included under a given mechanism in the same manner as that outlined for the recreational sector, subject to the appropriateness of allowing the sector’s allocation to be transferable.

Anti-Amyloid-Β Single-Chain Antibody Brain Delivery Via Aav Reduces Amyloid Load But May Increase Cerebral Hemorrhages In An Alzheimer's Disease Mouse Model, Jinghong Kou, Hong-Duck Kim, Hiroaki Taguchi, Sudhir Paul, Selvarangan Ponnazhagan, Ken-Ichiro Fukuchi

NYMC Faculty Publications

Accumulation of amyloid-β protein (Aβ) in the brain is thought to be a causal event in Alzheimer's disease (AD). Immunotherapy targeting Aβ holds great promise for reducing Aβ in the brain. Here, we evaluated the efficacy and safety of anti-Aβ single-chain antibody (scFv59) delivery via recombinant adeno-associated virus (rAAV) on reducing Aβ deposits in an AD mouse model (TgAβPPswe/PS1dE9). First, delivery of scFv59 to the brain was optimized by injecting rAAV serotypes 1, 2, and 5 into the right lateral ventricle. Symmetrical high expression of scFv59 was found throughout the hippocampus and partly in the neocortex in both hemispheres via …

Fact Book, 2011-12, John Carroll University

Fact Book

2011-12 Fact Book

Faculty Bibliography 2011 (Updated 11/2013), John Carroll University

Faculty Bibliography (2002-2016)

No abstract provided.

Sleep Estimates In Children: Parental Versus Actigraphic Assessments, Ehab A. Dayyat, Karen Spruyt, Dennis L. Molfese, David Gozal

Center for Brain, Biology, and Behavior: Faculty Publications

Background: In the context of increasing awareness about the need for assessment of sleep duration in community and clinical settings, the use of questionnaire-based tools may be fraught with reporter bias. Conversely, actigraphy provides objective assessments of sleep patterns. In this study, we aimed to determine the potential discrepancies between parentally-based sleep logs and concurrent actigraphic recordings in children over a one-week period.

Methods: We studied 327 children aged 3–10 years, and included otherwise healthy, nonsnoring children from the community who were reported by their parents to be nonsnorers and had normal polysomnography, habitually-snoring children from the community …

Minimal Information For Neural Electromagnetic Ontologies (Minemo): A Standards-Compliant Method For Analysis And Integration Of Event-Related Potentials (Erp) Data, Gwen Frishkoff, Jason Sydes, Kurt Mueller, Tim Curran, John F. Connolly, Kerry Kilborn, Dennis L. Molfese, Charles Perfetti, Allen D. Malony

Center for Brain, Biology, and Behavior: Faculty Publications

We present MINEMO (Minimal Information for Neural ElectroMagnetic Ontologies), a checklist for the description of event-related potentials (ERP) studies. MINEMO extends MINI (Minimal Information for Neuroscience Investigations)to the ERP domain. Checklist terms are explicated in NEMO, a formal ontology that is designed to support ERP data sharing and integration. MINEMO is also linked to an ERP database and web application (the NEMO portal). Users upload their data and enter MINEMO information through the portal. The database then stores these entries in RDF (Resource Description Framework), along with summary metrics, i.e., spatial and temporal metadata. Together these spatial, temporal, and functional …

Structural And Functional Analysis Of The Type Iii Secretion System From Pseudomonas Fluorescens Q8r1-96, Dmitri V. Mavrodi, Anna Joe, Olga V. Mavrodi, Karl A. Hassan, David M. Weller, Ian T. Paulsen, Joyce E. Loper, James R. Alfano, Linda S. Thomashow

Center for Plant Science Innovation: Faculty Publications

Pseudomonas fluorescens Q8r1-96 represents a group of rhizosphere strains responsible for the suppressiveness of agricultural soils to take-all disease of wheat. It produces the antibiotic 2,4-diacetylphloroglucinol and aggressively colonizes the roots of cereal crops. In this study, we analyzed the genome of Q8r1-96 and identified a type III protein secretion system (T3SS) gene cluster that has overall organization similar to that of the T3SS gene cluster of the plant pathogen Pseudomonas syringae. We also screened a collection of 30 closely related P. fluorescens strains and detected the T3SS genes in all but one of them. The Q8r1-96 genome contained …

Mpk6, Sphinganine And The Lcb2a Gene From Serine Palmitoyltransferase Are Required In The Signaling Pathway That Mediates Cell Death Induced By Long Chain Bases In Arabidopsis, Mariana Saucedo-García, Arturo Guevara-Garcia, Ariadna González-Solís, Felipe Cruz-García, Sonia Vázquez-Santana, Jennifer E. Markham, M. Guadalupe Lozano-Rosas, Charles R. Dietrich, Maricela Ramos-Vega, Edgar B. Cahoon, Marina Gavilanes-Ruíz

Center for Plant Science Innovation: Faculty Publications

• Long chain bases (LCBs) are sphingolipid intermediates acting as second messengers in programmed cell death (PCD) in plants. Most of the molecular and cellular features of this signaling function remain unknown.

• We induced PCD conditions in Arabidopsis thaliana seedlings and analyzed LCB accumulation kinetics, cell ultrastructure and phenotypes in serine palmitoyltransferase (spt), mitogen-activated protein kinase (mpk), mitogenactivated protein phosphatase (mkp1) and lcb-hydroxylase (sbh) mutants.

• The lcb2a-1 mutant was unable to mount an effective PCD in response to fumonisin B1 (FB1), revealing that the LCB2a gene is essential for the …

Managing Soil Nitrogen To Restore Annual Grass Infested Communities: An Effective Strategy Or Incomplete Framework?, Rebecca Drenovsky

Biology

Theoretical and empirical work has established a positive relationship between resource availability and habitat invasibility. For nonnative invasive annual grasses, similar to other invasive species, invader success has been tied most often to increased nitrogen (N) availability. These observations have led to the logical assumption that managing soils for low N availability will facilitate restoration of invasive plant-dominated systems. Although invasive annual grasses pose a serious threat to a number of perennial-dominated ecosystems worldwide, there has been no quantitative synthesis evaluating the degree to which soil N management may facilitate restoration efforts. We used meta-analysis to evaluate the degree to …

A Plant Dj-1 Homolog Is Essential For Arabidopsis Thaliana Chloroplast Development, Jiusheng Lin, Tara J. Nazarenus, Jeanine L. Frey, Xinwen Liang, Mark A. Wilson, Julie M. Stone

Center for Plant Science Innovation: Faculty Publications

Protein superfamilies can exhibit considerable diversification of function among their members in various organisms. The DJ-1 superfamily is composed of proteins that are principally involved in stress response and are widely distributed in all kingdoms of life. The model flowering plant Arabidopsis thaliana contains three close homologs of animal DJ-1, all of which are tandem duplications of the DJ-1 domain. Consequently, the plant DJ-1 homologs are likely pseudo-dimeric proteins composed of a single polypeptide chain. We report that one A. thaliana DJ-1 homolog (AtDJ1C) is the first DJ-1 homolog in any organism that is required for viability. Homozygous disruption of …

Two Distinct Roles Of Arabidopsis Homolog Of Trithorax1 (Atx1) At Promoters And Within Transcribed Regions Of Atx1-Regulated Genes, Yong Ding, Zoya Avramova, Michael E. Fromm

Center for Plant Science Innovation: Faculty Publications

The Arabidopsis thaliana trithorax-like protein, ATX1, shares common structural domains, has similar histone methyltransferase (HMT) activity, and belongs in the same phylogenetic subgroup as its animal counterparts. Most of our knowledge of the role of HMTs in trimethylating lysine 4 of histone H3 (H3K4me3) in transcriptional regulation comes from studies of yeast and mammalian homologs. Little is known about the mechanism by which ATX1, or any other HMT of plant origin, affects transcription. Here, we provide insights into how ATX1 influences transcription at regulated genes, playing two distinct roles. At promoters, ATX1 is required for TATA binding protein (TBP) and …

Structure Function Analysis Of An Adp-Ribosyltransferase Type Iii Effector And Its Rna-Binding Target In Plant Immunity, Byeong-Ryool Jeong, Yan Lin, Anna Joe, Ming Guo, Christin Korneli, Huirong Yang, Ping Wang, Min Yu, Ronald Cerny, Dorothee Staiger, James R. Alfano, Yanhui Xu

Center for Plant Science Innovation: Faculty Publications

Background: HopU1 ADP-ribosylates GRP7, suppressing plant immunity.

Results: The HopU1 structure has two novel loops required for GRP7 recognition, and HopU1 ribosylates GRP7 at an arginine in position 49 disrupting its function.

Conclusion: HopU1 targets a conserved arginine in GRP7, disabling its ability to bind immunity-related RNA.

Significance: The mechanistic details of how HopU1 recognizes its substrate reveal how HopU1 contributes to pathogenesis.

Secondary Science Teachers’ Translation Of Professional Development Through Affinity- And Institution-Identity, Elizabeth B. Lewis

Department of Teaching, Learning, and Teacher Education: Presentations

This study provides greater detail concerning how science teachers did, or did not, use a professional development model of a scientific classroom discourse community with their students. Two biology teachers, Cathy and David, from the same urban high school were the subjects of two case studies. Identity was used as an analytic lens to consider teachers in the dual contexts of their classroom environment and professional development. Over time, as Cathy adopted the inquiry-based instructional practices she learned at the professional development seminars, her professional identity became more aligned with the norms and affinity group teaching philosophy and instructional practices …

The Deep Ecology Movement: Origins, Development, And Future Prospects (Toward A Transpersonal Ecosophy), Alan Drengson, Bill Devall, Mark A. Schroll

International Journal of Transpersonal Studies

The deep ecology movement, which began with Arne Naess’ introduction of the term in

1972, is compared with other movements for social responsibility that developed in the

20th century. The paper discusses Naess’ cross-cultural approach to characterizing grassroots

movements via platform principles that can be supported from a diversity of cultures,

worldviews, and personal philosophies, and explains his use of “ecosophy.” The deep ecology

movement’s relationship with ecopsychology, ecocriticism, and humanistic and transpersonal

psychology is described as part of an emerging synthesis referred to as transpersonal ecosophy.

The inquiry concludes with a technical discussion of Naess’ Apron Diagram and reflections …