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Early Prediction And Diagnosis Of Peripheral Neuropathy In Type 2 Diabetes Using Biochemical Parameters, Eman Naim Taher, Narjis Hadi Al – Saadi

Al-Ameed Journal for Medical Research and Health Sciences

Background: Type II diabetes mellitus is commonly related to diabetic peripheral neuropathy (DPNP), which manifests as a gradual progression of damage to the peripheral nerves after excluding other causes. As initial alterations may lie hidden, focus has moved to easy crude markers. Neuron-specific Enolase (NSE) was chosen since it increases early after axonal injury, Whereas, Nerve Growth Factor (NGF) reflects neurotrophic activity. Material and Methods: A case control study was done on 45 cases of DPNP after diagnosing through a nerve conduction study (NCS), 48 diabetics without neuropathy DWNP and 45 healthy individuals. Ages ranged from 35 to 60. …

Technical Disclosure: Zero-Idle Asynchronous Hardware Architecture For Linear-Complexity State Space Models And Metabolic Gating, Samuel John Church

Defensive Publications Series

This disclosure describes a semiconductor architecture designed to eliminate dynamic idle

power consumption in Edge AI applications by utilizing clockless, event-driven logic to execute

linear-complexity State Space Models (SSMs). The system replaces the global synchronous

clock with local handshake protocols (Muller C-elements) implementing Pulsed Static CMOS

logic. This hardware substrate is coupled with a "Metabolic Gating" software router that

dynamically switches between low-precision "reflex" networks and high-precision "reasoning"

networks based on real-time energy availability and input "surprise" (prediction error). The

disclosed invention enables "Zero-Idle" operation, where power consumption scales strictly

linearly with input token arrival, achieving near-zero leakage during inter-token …

The Stories Of African American Mothers Working Part-Time Without Mandated Job Protections, Chantelle Sharese Yancy

Walden Dissertations and Doctoral Studies

The Family and Medical Leave Act (FMLA) provides unpaid, job‑protected leave only for eligible workers, and rules tied to hours, tenure, and employer size often exclude mothers working part-time. Research on U.S. family and medical leave has documented inequities in access to job protections. The lived experiences of African American/Black mothers navigating this gap remain underrepresented. The purpose of this narrative qualitative study was to explore the lived experiences of African American/Black mothers who worked part-time without mandated job protections, with specific attention to FMLA. General systems theory provided the theoretical framework, and an Afrocentric paradigm centered African/African American/Black voice …

Itbs Stimulation Of The Bilateral Ifg/Ipl Alters The Oscillatory Pattern In Asd, Mitra Assadi, Reza Koiler, Ryan Ally, Richard Fischer, Rod C. Scott

Farber Institute for Neuroscience Faculty Papers

BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by impairments in social communication, reciprocity, and adaptive behavior. Converging neurobiological evidence suggests that these clinical features arise from aberrant connectivity and dysregulated neuronal oscillations across distributed brain networks. In particular, dysfunction within the mirror neuron regions, concentrated in the inferior frontal gyrus (IFG) and inferior parietal lobule (IPL), has been implicated in deficits of imitation, empathy, and social cognition in ASD. Non-invasive neuromodulation using repetitive transcranial magnetic stimulation (rTMS) has shown modest behavioral benefits in ASD. However, most studies apply the conventional protocols targeting the dorsolateral prefrontal cortex. The …

Early Detection Of Infectious Diseases: A Review Of Recent Advances In Pathogen Identification, Molecular Tools, And Metabolomics-Driven Biomarker Discovery, Patrica Ivy Agorsor, Michael O. Eze

Chemistry Faculty Research & Creative Works

The recent COVID-19 pandemic has heightened public interest in noninvasive methods for early diagnosis of infectious diseases. In addition, various government agencies have implemented "infectious disease preparedness" to mitigate future outbreaks. This review highlights conventional and advanced methods for infectious disease diagnosis with an emphasis on emerging mass spectrometry methods. Conventional methods for pathogen identification, such as culture-based techniques and molecular methods, have limitations with respect to sensitivity, specificity, and turnaround time. Recent advances in high-resolution mass spectrometry have revolutionized the field of infectious disease biomarker discovery. These techniques enable the comprehensive profiling of metabolites in various biological samples, identification …

Annotated Checklist Of Amphibian And Reptile Species Observed At The Gordon Natural Area (West Chester University, Pa) 2004-2022. Checklist Ii, Nur Ritter, Harry Tiebout

Gordon Natural Area Biodiversity Studies Documents

ata were compiled from surveys by Dr. Harry Tiebout, augmented by observations from GNA staff (which, as used here, includes student interns), graduate student Steven Clay, the Stroud Water Research Center, additional WCU Faculty, Ty Showers of the WCU Grounds Department, and observations that have been posted to iNaturalist. Local residents who are regular visitors to the Gordon have also occasionally contributed observations. Because herptile data haven't been systematically archived by the GNA staff until recent years, there are many gaps in the observation timeline that are clearly artificial. For example, although the observation history for the Eastern American Toad, …

Annotated Checklist Of The Avian Species Observed At The Gordon Natural Area (West Chester University, Pa) 2003-2026. Version Xi, Nur Ritter, Josh R. Auld

Gordon Natural Area Biodiversity Studies Documents

Summary Data

Number of Surveys: 'Site Visits' by 153 Birders. Note: this does not count the birders who participated in the 2004 West Chester Bird Club Survey as participants were not identified by name on the data sheets.

Number of Taxa: 140 Species, in 94 Genera and 40 Families.

Years Noted: Although the title suggests that observations began in 2003, data for three species that were seen in the Gordon during 1970 are included here. This inclusion is because one of these species—the Blue Grosbeak—was observed in the GNA in 1970 and has not been noted since. Nevertheless, 2003 remains …

Annotated Checklist Of The Fish Species Observed At The Gordon Natural Area (West Chester University, Pa) 1997-2025. Version Ii, Nur Ritter

Gordon Natural Area Biodiversity Studies Documents

Summary Data

Number of Taxa: 16 Species, in 14 Genera, 7 Families, and 6 Orders.

Description: Investigation of the ichthyofauna (i.e., fish) of the GNA has a fairly long-history, but has been sporadic and the findings have been poorly archived. The earliest known research was undertaken by former WCU Biology Professor Win Fairchild. Regrettably, we only have his data from a single study (Butler & Fairchild 2005). WCU graduate student Danielle DiFederico (one of Win Fairchild's students) conducted her Master's research in Plum Run in the early 2000. Following this, there was a long fallow period (with just a single …

Bull Shark (Carcharhinus Leucas) Jaw, Roman Devlin, Jade A. Mells, Rileigh Gonzalez, Nicholas D. Burchett, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Assessing Climate Adaptation Among Canada Lynx (Lynx Canadensis) Populations At The Trailing Edge, Tanya Lama, Blair P. Bentley, Warren E. Johnson, Lisa M. Komoroske, Stephen Destefano, Jennifer Vashon, Kaela Beaulerc, Jason M. Kamilar, Giulio Formenti, Andrea Batista, Andrew G. Spencer, Olivier Fedrigo, Erich D. Jarvis, Jeff S. Bowman, Paul Wilson, John F. Organ

Biological Sciences: Faculty Publications

Species must acclimate, shift their distributions, or adapt in place in response to anthropogenic climate change. Populations at low-latitude trailing edges of species distributions typically experience thermal conditions closest to the upper limit of their thermoregulatory capacity. Landscape and functional genomic approaches provide quantitative measures of risk and adaptive capacity which can inform and prioritize conservation actions. Using low-coverage whole genomes from Canada lynx (Lynx canadensis), we characterized population genomic structure and identified putatively adaptive loci using genotype-environment association analyses across the eastern extent of their distribution. We detected genetic breaks across two previously identified biogeographical barriers, the St. Lawrence …

Dupilumab Beyond The Airway: Decreased Morbidity In A Real-World Analysis, Emma J. Anisman, Spencer Short, Emma Tam, Benjamin F. Bitner, Abdulghafoor Alani, Marc Rosen, Mindy Rabinowitz, Damaris Pena Evertz, Elina Toskala, Gurston G. Nyquist

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Background: Post hoc analyses of clinical trials have characterized dupilumab's adverse effects, yet the real-world impact in chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma is not well described. This study aims to characterize the risks of lymphoma, cardiovascular events, eosinophilia, joint pain, inflammatory arthritis, and sleep apnea in dupilumab-treated CRSwNP and/or asthma patients compared to those not taking dupilumab, and to other biologics.

Methods: This retrospective cohort study used TriNetX, a de-identified database containing over 100 million patient records. Demographics and adverse effects associated with immunotherapy use were collected.

Results: We identified 21,249 dupilumab-treated CRSwNP and/or asthma patients. After …

Staff Education Project Staff Education To Increase Knowledge Of The Patient Health Questionnaire-9 Screening Tool, Linda Ejem

Walden Dissertations and Doctoral Studies

This staff education doctoral project focused on educating nursing staff about the Patient Health Questionnaire-9 (PHQ-9) for depression screening in inpatient psychiatric care. Addressing this issue is crucial, as poor adherence leads to missed diagnoses and treatment, increased hospital visits, and poor patient outcomes. Low adherence to the PHQ-9 depression screening protocol has emerged as a significant practice gap. The purpose of this doctoral project was to increase nursing staff knowledge of the PHQ-9 depression screening tool in psychiatric care through staff education. The practice-focused question was: Does education on PHQ-9 depression symptoms improve nursing staff knowledge as compared pre- …

Overcoming Host Restrictions To Enable Continuous Passaging Of Gii.3 Human Norovirus In Human Intestinal Enteroids, Gurpreet Kaur, Sue E Crawford, Sara Javornik Cregeen, Anil Surathu, B Vijayalakshmi Ayyar, Carmen V Apostol, Hoa Nguyen Phuc, Khalil Ettayebi, Aaya Boussattach, Xi-Lei Zeng, Sarah E Blutt, Harsha Doddapaneni, Donna M Muzny, Cristian Coarfa, Ramakrishnan Anish, B V Venkataram Prasad, Robert L Atmar, Sasirekha Ramani, Mary K Estes

Faculty, Staff and Students Publications

The establishment of human intestinal enteroids (HIEs) as a model for human norovirus (HuNoV) replication has been transformative for studying this leading cause of gastroenteritis. However, indefinite passaging of HuNoVs in HIEs remained a challenge, necessitating the use of patient stool samples as viral inocula. Using RNA-seq, we identified CXCL10, CXCL11, and CCL5 as up-regulated chemokines, suggesting their potential as host restriction factors. TAK-779, a CXCR3/CCR5/CCR2 antagonist, enhanced GII.3 HuNoV replication and viral spread in a dose- and time-dependent manner, enabling successful passaging of GII.3 HuNoV in two different HIE lines and generation of viral stocks. Sequencing passaged virus revealed …

Health Care Systems: Responsibilities And Resilience., Carol Iddins, Ziad Kazzi, Arthur Chang, Nicholas Maikai Studer, James Jeng, Ann Jakubowski, Ibrahim Ahmed, Cullen Case, Mark Ervin, Shannon G. Loelius, Joel Ross, Jonathan Gill, Nelson Chao

Manuscripts, Articles, Book Chapters and Other Papers

This paper addresses the challenges and preparedness strategies for health care systems in responding to nuclear and radiological emergencies. It emphasizes the critical role of medical centers in pre-incident preparedness, immediate response, and long-term care, focusing on the need for coordinated efforts between local, state, and federal agencies. Key components include specialized training, resource allocation, triage protocols, and the integration of networks like the Radiation Injury Treatment Network and the American Burn Association. This paper highlights the importance of resilience through collaboration, infrastructure planning, and community support to manage mass casualties and mitigate long-term health consequences. It underscores the lessons …

High Nkap Expression Predicts Poor Prognosis Of Breast Cancer Patients, Yonghao Li, Zheng Shu, Chenyu Sun, Scott Lowe, Rachel Bentley, Yaru Li, Bethany King, Shuya Chen, Qin Zhou, Mei Zhang

Student Publications

NF-κB activating protein (NKAP) plays important roles in various cancers, including breast cancer. However, its expression and prognosis value in breast cancer remains uncertain. Gene expression profiling interactive analysis, Human protein atlas database, and University of Alabama at Birmingham Cancer data analysis portal database were used to predict the expression and prognostic value of NKAP in breast cancer. Immunohistochemistry, quantitative real time polymerase chain reaction (qRT-PCR) and western blot were performed to detect NKAP expression. The effects of NKAP on cell proliferation, migration and drug sensitivity were investigated in MDA-MB-231 and SK-BR-3 cells. NKAP protein expression differed in breast cancer …

Genome And Transcriptome-Wide Analyses Identify Multiple Candidate Genes And A Significant Polygenic Contribution In Bicuspid Aortic Valve, Sébastien Thériault, Jacob A Holdcraft, Dinara Sharipova, Adèle Faucherre, Radoslaw M Debiec, Gina M Peloso, Baravan Al-Kassou, Sary Aranki, Elena Ashikhmina Swan, Andrea Ballotta, Michele Bellino, Hanna M Björck, Anne Sophie Boureau, Peter S Braund, François Corriveau, François Dagenais, Lasse Folkersen, Amalia Forte, Michael D Francke, Alessandro Frigiola, Svetlana Gorbatov, Dongchuan Guo, Karam M Habchi, Mahyar Heydarpour, Eric M Isselbacher, Chris Jopling, Fabien Laporte, Solena Le Scouarnec, Zhonglin Li, Peter Lichtner, Carlo Maj, Hasanga D Manikpurage, Christopher P Nelson, Thy B Nguyen, Russell A Norris, Chin Siang Ong, Philippe Pibarot, Tanmoy Roychowdhury, Berardo Sarubbi, Floriane Simonet, Thoralf Sundt, Ida Surakka, Idit Tessler, Cristen J Willer, Susanne Wittmann, Bo Yang, Igor Berezovets, Stefanie A Doppler, Martina Dreßen, Katharina Knoll, Thomas Puehler, Heribert Schunkert, Jean-François Avierinos, Malenka M Bissell, Aidan P Bolger, Yohan Bossé, Eduardo Bossone, María Brion, Rodolfo Citro, Carlo De Vincentiis, G Michael Deeb, Alessandro Della Corte, Christian Dina, Ronen Durst, Stephan Ensminger, Per Eriksson, Arturo Evangelista, Anders Franco-Cereceda, Dan Gilon, Betti Giusti, Simon L Hetherington, Gordon S Huggins, Markus Krane, Thierry Le Tourneau, Giuseppe Limongelli, Patrick Mathieu, David Messika-Zeitoun, Hector I Michelena, Dianna Milewicz, Jochen D Muehlschlegel, David R Murdock, Georg Nickenig, Stefano Nistri, Markus M Nöthen, Francesca Pluchinotta, Siddharth K Prakash, Nilesh J Samani, Jean-Jacques Schott, Tom R Webb, Stéphane Zaffran, Salim Abdelilah-Seyfried, Kim Eagle, Johannes Schumacher, Teresa Trenkwalder, Simon Body

Faculty, Staff and Student Publications

Background: Bicuspid aortic valve (BAV) is a frequent congenital heart defect with a high heritability. Despite this, only a limited number of genes have been associated with the disease, and the molecular mechanisms remain unexplained in most cases. This study aimed to further understand the genetic architecture of BAV.

Methods: A genome-wide association study meta-analysis including 9631 cases among 65 677 participants was performed. Genes were prioritized using transcriptomic analyses based on RNA sequencing in relevant tissues, including human fetal and adult aortic valves. The impact of the knockdown or knockout of 4 candidate genes on cardiac development was verified …

Tracking Focal Adhesion Turnover: A Novel Reporter For Fa-Phagy Flux, Kuizhi Qu, Mengjun Dai, Ying Jiang, Sophie Liu, John P Hagan, Louise D Mccullough, Zhen Xu, Yan-Ning Rui

Faculty, Staff and Student Publications

Focal adhesions (FAs) are critical multi-protein complexes regulating cell adhesion, migration, and survival, and their dysregulation contributes to cancer metastasis and vascular diseases. Despite extensive research on FA formation, little is known about FA turnover, particularly its regulation by autophagy. This study introduces a novel tandem fluorescence reporter capable of tracking the entire FA-phagy flux, from autophagosome formation to lysosomal degradation. The reporter, based on a red–green fluorescence system with a lysosome-specific cleavage site, integrates seamlessly into endogenous focal adhesion complexes, demonstrating sensitivity and specificity to autophagy stimuli. Validated in multiple cell lines, the tool revealed dynamic FA-phagy responses to …

Iguana Don, Patricia Frisella

Creative Nonfiction Magazine

No abstract provided.

Snapshots In Black And White, Shara Mccallum

Creative Nonfiction Magazine

No abstract provided.

The Green Room, Eliot Sloan

Creative Nonfiction Magazine

No abstract provided.

Aristotle’S Ghost, Kurt Schwenk

Creative Nonfiction Magazine

No abstract provided.

Second Chances, Melissa Bloch

Creative Nonfiction Magazine

No abstract provided.

Notes On My Dying, Ruthann Robson

Creative Nonfiction Magazine

No abstract provided.

Second Chances, Melissa Bloch

Creative Nonfiction Magazine

No abstract provided.

Notes On My Dying, Ruthann Robson

Creative Nonfiction Magazine

No abstract provided.

Privacy Lessons, Molly Peacock

Creative Nonfiction Magazine

No abstract provided.

As Engineering Technology, 2025-26, Arkansas State University - Jonesboro

Associates Degrees

No abstract provided.

As Engineering Technology, 2021-22, Arkansas State University - Jonesboro

Associates Degrees

No abstract provided.

As Engineering Technology, 2023-24, Arkansas State University - Jonesboro

Associates Degrees

No abstract provided.

As Engineering Technology, 2024-25, Arkansas State University - Jonesboro

Associates Degrees

No abstract provided.