Digital Commons Network^™

Dengue Fever (Df) In Pakistan., Fridous Jahan

Department of Family Medicine

Dengue is a widespread mosquito-borne infection in human beings, which in recent years has become a major international public health concern. Symptomatic dengue virus infections can present with a wide range of clinical manifestations, from a mild febrile illness to a life-threatening shock syndrome. Both viral and host factors are thought to contribute to the manifestations of disease in each infected. It is important to understand its burden on health care, morbidity and mortality. Early diagnosis and suspicion of DF in primary care might reduce the complications if handled properly. We must understand the depth of the problem in terms …

February 21, 2011 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The Cowl - V. 75 - N. 16 - Feb 17, 2011

The Cowl

The Cowl - student newspaper of Providence College. Volume 75 - Number 16 - February 17, 2011. 32 pages.

Septic Shock: Current Management And New Therapeutic Frontiers, R. Phillip Dellinger, Md

Division of Pulmonary, Allergy, and Critical Care Medicine Presentations and Grand Rounds

No audio is available for this presentation.

Dr. R. Phillip Dellinger is a Professor of Medicine who holds a faculty appointment in the Division of Pulmonary and Critical Care Medicine at the Robert Wood Johnson School of Medicine, University of Medicine and Dentistry of New Jersey. He is also the Vice-Chair, Department of Medicine and the Director, Medical/Surgical/Cardiovascular Surgical Intensive Care Unit at the Cooper Medical Center in Camden New Jersey. In 2006-2007, he was selected as South Jersey Top Docs by South Jersey Magazine. Dr. Dellinger's interests are in the treatment and outcomes of septic shock.

Aspirin Treatment Of Mice Infected With Trypanosoma Cruzi And Implications For The Pathogenesis Of Chagas Disease, Shankar Mukherjee, Fabiana S. Machado, Huang Huang, Helieh S. Oz, Linda A. Jelicks, Cibele M. Prado, Wade Koba, Eugene J. Fine, Dazhi Zhao, Stephen M. Factor, J. Elias Collado, Louis M. Weiss, Herbert B. Tanowitz, Anthony W. Ashton

Center for Oral Health Research Faculty Publications

Chagas disease, caused by infection with Trypanosoma cruzi, is an important cause of cardiovascular disease. It is increasingly clear that parasite-derived prostaglandins potently modulate host response and disease progression. Here, we report that treatment of experimental T. cruzi infection (Brazil strain) beginning 5 days post infection (dpi) with aspirin (ASA) increased mortality (2-fold) and parasitemia (12-fold). However, there were no differences regarding histopathology or cardiac structure or function. Delayed treatment with ASA (20 mg/kg) beginning 60 dpi did not increase parasitemia or mortality but improved ejection fraction. ASA treatment diminished the profile of parasite- and host-derived circulating prostaglandins in infected …

Real-Time Dynamic Imaging Of Virus Distribution In Vivo, Sean E. Hofherr, Kristen E. Adams, Christopher Y. Chen, Shannon May, Eric A. Weaver, Michael A. Barry

School of Biological Sciences: Faculty Publications

The distribution of viruses and gene therapy vectors is difficult to assess in a living organism. For instance, trafficking in murine models can usually only be assessed after sacrificing the animal for tissue sectioning or extraction. These assays are laborious requiring whole animal sectioning to ascertain tissue localization. They also obviate the ability to perform longitudinal or kinetic studies in one animal. To track viruses after systemic infection, we have labeled adenoviruses with a near-infrared (NIR) fluorophore and imaged these after intravenous injection in mice. Imaging was able to track and quantitate virus particles entering the jugular vein simultaneous with …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern University School of Nursing Awarded Nearly $800,000 to Address Nationwide Shortage of Nursing Faculty

Animal Welfare In Multipurpose Cattle Production Systems And Its Implications On Beef Quality, Saymore P. Ndou, Voster Muchenje, Michael Chimonyo

Farm Animal Welfare Collection

Animal welfare and its influence on beef production are major considerations in many developed countries. In the developing world, where food insecurity and poverty are prevalent, the welfare of animals receives low priority due to factors such as traditional customs and beliefs, lack of knowledge in animal handling and sub standard handling facilities. This is worsened by the fact that cattle are used for several purposes, such as meat production, milk production, draught power and traditional ceremonies. Research on animal welfare and how it relates to animal production have been done in the developed world. The objective of this study …

Medical School Watercooler Newsletter - February 13, 2011, Lindsey Lyle

Watercooler Newsletter

This is the February 13, 2011 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler

Contents Include:

• USA College of Medicine Mourns Loss of Sandy Worley

• 2011 Sickle Cell Conference Set For April 9 - Make Plans To Attend

• Med School Café - Expert Advice for the Community

• Mark Your Calendar - Women's Imaging Conference

Hepatitis B Vaccine Coverage And The Immune Response In Children Under Ten Years Old In Sana’A, Yemen, Hassan A. Al-Shamahy, Samira H. Hanash, Iqbal A. Al-Madhaji, Nameem M., Samarih M. Naser

Sultan Qaboos University Medical Journal

Objectives: The study was undertaken, first, to determine the coverage rate of hepatitis B (HB) vaccine and second to evaluate the immune response to HB vaccine among children under 10 years old by measuring the level of circulating anti-HB surface antigen (anti-HBs) antibodies after immunisation with three doses. Methods: First, 840 children were randomly selected from 4 randomly selected sites in Sana'a city to study the coverage rate of the vaccine; of these, 504 children vaccinated against HBV prior to the study, were tested (56% males and 44% females). Sera were tested for anti-HBs antibodies by ELISA quantitative technique. Each …

Unmasking Immune Reconstitution Inflammatory Syndrome (Iris) : A Report Of Five Cases And Review Of The Literature, Abdullah Balkhair, Sudheer Ahamed, Dilip

Sultan Qaboos University Medical Journal

Immune reconstitution inflammatory syndromes (IRIS) in patients with acquired immune deficiency syndrome (AIDS) are characterised by atypical manifestations of opportunistic pathogens. These occur in patients experiencing improvement in CD4 cell counts following receipt of highly active anti-retroviral therapy (HAART). Although well established as a syndrome, IRIS still presents challenges in diagnosis and management. We report five cases of IRIS with diverse clinical presentations and due to different infectious aetiologies. A review of the published literature on this syndrome is also included.

Studies Of A Cyanine-Based Biosensor And Light-Induced Antibacterial Activities Of Oligo(Phenylene Ethynylene)S, Zhijun Zhou

Chemistry and Chemical Biology ETDs

This dissertation has been focusing on two subjects: biosensor development and light-activated antimicrobials. A cyanine-based fluorescent biosensor is developed with high sensitivity to detect the presence and activity of caspase-3/7. We demonstrated that supramolecular self-assembly can be useful for designing biosensors. A series of p-Phenylene Ethynylenes (OPEs) have been synthesized. Further photophysical studies show that these molecules have good singlet oxygen yields. The antimicrobial capability increases dramatically when exposed to UV-365 radiation, though dark biocidal activity can be obtained as well. This phenomenon is probably due to the high yields of singlet oxygen of these OPEs, which oxidizes unsaturated membrane …

Evaluation Of Immune Responses Following Infection Of Ponies With An Ehv-1 Orf1/2 Deletion Mutant, Gisela Soboll Hussey, Stephen B. Hussey, Bettina Wagner, David W. Horohov, Gerlinde R. Van De Walle, Nikolaus Osterrieder, Lutz S. Goehring, Sangeeta Rao, David P. Lunn

Veterinary Science Faculty Publications

Equine herpesvirus-1 (EHV-1) infection remains a significant problem despite the widespread use of vaccines. The inability to generate a protective immune response to EHV-1 vaccination or infection is thought to be due to immunomodulatory properties of the virus, and the ORF1 and ORF2 gene products have been hypothesized as potential candidates with immunoregulatory properties. A pony infection study was performed to define immune responses to EHV-1, and to determine if an EHV-1 ORF1/2 deletion mutant (ΔORF1/2) would have different disease and immunoregulatory effects compared to wild type EHV-1 (WT). Infection with either virus led to cytokine responses that coincided with …

Isolation Of A Rickettsial Pathogen From A Non-Hematophagous Arthropod, Chutima Thepparit, Piyanate Sunyakumthorn, Mark L. Guillotte, Vsevolod L. Popov, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Rickettsial diversity is intriguing in that some species are transmissible to vertebrates, while others appear exclusive to invertebrate hosts. Of particular interest is Rickettsia felis, identifiable in both stored product insect pests and hematophagous disease vectors. To understand rickettsial survival tactics in, and probable movement between, both insect systems will explicate the determinants of rickettsial pathogenicity. Towards this objective, a population of Liposcelis bostrychophila, common booklice, was successfully used for rickettsial isolation in ISE6 (tick-derived cells). Rickettsiae were also observed in L. bostrychophila by electron microscopy and in paraffin sections of booklice by immunofluorescence assay using anti-R. felis polyclonal antibody. …

Impaired Memory Cd8 T-Cell Responses Against An Immunodominant Retroviral Cryptic Epitope, Melanie R. Rutkowski, Cynthia A. Stevens, William R. Green

Dartmouth Scholarship

The immunodominant cryptic epitope SYNTGRFPPL, encoded within open reading frame 2 of the LP-BM5 retroviral gag gene, is critical for protection against retroviral-induced pathogenesis. The goal of this study was to dissect the memory response against this unique immunodominant cryptic epitope. Unlike the protective acute effector population of SYNTGRFPPL-specific CD8 T cells, long-lived SYNTGRFPPL-specific CD8 T cells lacked the ability to protect susceptible mice infected with LP-BM5 retrovirus. Compared to memory CD8 T cells against a conventional epitope with similar MHC-I specificity, primed and restimulated using similar conditions, long-lived SYNTGRFPPL-specific CD8 T cells were impaired in their ability to recall …

The Inkwell, Armstrong Atlantic State University

The Inkwell

No abstract provided.

Uganda And The Current Hiv Treatment Crisis - A Perspective, Ellen J. Plumb Md

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Hpn Winter 2011 Download Full Pdf

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

February 2, 2011 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Montana Kaimin, February 2, 2011, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Imaging—And Imagining—Immune Responses To Infections, Kamal M. Khanna, Leo Lefrancois

UCHC Articles - Research

The use of sophisticated microscopy continues apace in analysis of infection and the induction of immune responses. Continued technological improvements in microscopy, fluorescent dyes, and transgenic reporter systems will allow constant improvements of our view of the microbial and immunological landscape. Understanding how anatomy, cellular movement and microbial pathogenesis are linked to the outcome of the immune response will allow us to make informed decisions regarding vaccine formulations and treatments for infectious diseases and their sequelae.

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Prism #52, February 2011, Office Of The Provost

Prism: Western Michigan University's Newsletter for Academic Affairs

No abstract provided.

Himmelfarb Headlines - February/March 2011, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News and information about Himmelfarb Health Sciences Library of interest to users. Includes articles on large LCD monitors, GWUMC Research Commons, and profiles of Karen McDonnell, PhD, and Catherine Harris.

T-705 (Favipiravir) Inhibition Of Arenavirus Replication In Cell Culture, Michelle Mendenhall, Andrew Russell, Terry Juelich, Emily L. Messina, Donald F. Smee, Alexander N. Freiberg, Michael R. Holbrook, Yousuke Furuta, Juan-Carlos De La Torre, Jack H. Nunberg, Brian B. Gowen

Biological Sciences Faculty Publications

A number of New World arenaviruses (Junin [JUNV], Machupo [MACV], and Guanarito [GTOV] viruses) can cause human disease ranging from mild febrile illness to a severe and often fatal hemorrhagic fever syndrome. These highly pathogenic viruses and the Old World Lassa fever virus pose a significant threat to public health and national security. The only licensed antiviral agent with activity against these viruses, ribavirin, has had mixed success in treating severe arenaviral disease and is associated with significant toxicities. A novel pyrazine derivative currently in clinical trials for the treatment of influenza virus infections, T-705 (favipiravir), has demonstrated broad-spectrum activity …

Fascin1 Promotes Cell Migration Of Mature Dendritic Cells, Michael Lipscomb

Department of Biology Faculty Publications

Dendritic cells (DCs) play central roles in innate and adaptive immunity. Upon maturation, DCs assemble numerous veil-like membrane protrusions, disassemble podosomes, and travel from the peripheral tissues to lymph nodes to present Ags to T cells. These alterations in morphology and motility are closely linked to the primary function of DCs, Ag presentation. However, it is unclear how and what cytoskeletal proteins control maturation-associated alterations, in particular, the change in cell migration. Fascin1, an actin-bundling protein, is specifically and greatly induced upon maturation, suggesting a unique role for fascin1 in mature DCs. To determine the physiological roles of fascin1, we …

Is Wildlife Going To The Dogs? Impacts Of Feral And Free-Roaming Dogs On Wildlife Populations, Julie K. Young, Kirk A. Olson, Richard P. Reading, Sukh Amgalanbaatar, Joel Berger

United States Department of Agriculture Wildlife Services: Staff Publications

In human-populated landscapes, dogs (Canis familiaris) are often the most abundant terrestrial carnivore. However, dogs can significantly disrupt or modify intact ecosystems well beyond the areas occupied by people. Few studies have directly quantified the environmental or economic effects of free-roaming and feral dogs. Here, we review wildlife-dog interactions and provide a case study that focuses on interactions documented from our research in Mongolia to underscore the need for studies designed to best determine how dogs affect native wildlife and especially imperiled populations. We suggest additional research, public awareness campaigns, and the exclusion of dogs from critical wildlife …

What's Happening: February, 2011, Maine Medical Center

What's Happening

No abstract provided.

An Analysis Of The Clinical Practice Of Emergency Medicine In Public Emergency Centres In Kenya, Benjamin W. Wachira

Master of Medicine in Internal Medicine

Objectives: To describe the case mix, interventions, procedures and management of patients in public accident and emergency departments (A&Es) in Kenya. Methods: This was an observational study of patients who presented to 15 A&Es from 1 October to 31 December 2010. The study was conducted across Kenya in two national referral hospitals, five secondary level hospitals, and eight primary level hospitals. All patients presenting alive to the A&E during the 24 hour study period that were seen by a doctor or clinical officer were included in the study. A data collection form was completed by the primary investigator at the …

Judgment And Decision Making In Adolescence, Dustin Albert, Laurence Steinberg

Psychology Faculty Research and Scholarship

In this article, we review the most important findings to have emerged during the past 10 years in the study of judgment and decision making (JDM) in adolescence and look ahead to possible new directions in this burgeoning area of research. Three inter-related shifts in research emphasis are of particular importance and serve to organize this review. First, research grounded in normative models of JDM has moved beyond the study of age differences in risk perception and toward a dynamic account of the factors predicting adolescent decisions. Second, the field has seen widespread adoption of dual-process models of cognitive development …