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Download Entire Pdf: The Medicine Forum, Vol 5, Winter 2003

The Medicine Forum

Download entire PDF: The Medine Forum, (The Journal of Thomas Jefferson University Hospital, Department of Internal Medicine), Vol 5, Winter 2003.

Training Residents In Acls/Code Response Using A Computerized Medical Simulator: Improving Resident Comfort And Preparedness, Elisabeth Dial, Md, Henry Schairer, Md, Steven Silver, Md, Jennifer Claves, Md, David Gardiner, Md, John Caruso Md, Salvatore Mangione, Md, Gregory C. Kane, Md

The Medicine Forum

Internal Medicine residents are responsible for leading the
code response team at most teaching hospitals, yet many
graduating interns (PGY1s) may feel unprepared to run
codes. Currently, the only formal training for house staff
is the two-day American Heart Association’s Advanced
Cardiac Life Support (ACLS) course, generally required at
the beginning of internship, with recertification necessary
every two years. This course does not address leadership
skills or a resident’s self-reported sense of comfort with
leading a code team within a teaching hospital. Prior
investigations have highlighted the deterioration in
knowledge of important ACLS protocols, with knowledge
levels at or near …

A Male With Chills And Arthralgias, Lo-Ku Chiang, Md, Ambrish Ojha, Md

The Medicine Forum

A 53-year old man presented to the ED with complaints
of fevers and chills for 5 days. Two days prior, he started
having generalized arthralgias and a painfully numb left
index finger. Similar symptoms had also begun on his
left great toe (See Figures D and E, Color Plates page
19). The patient denied recent trauma, although he was
unsure if he had sustained an insect bite on the dorsal
aspect of his left hand 8 hours prior to the onset of
symptoms. Three sets of blood cultures obtained prior
to admission were positive for methacillin-sensitive
Staphylococcus aureus. The patient …

A Man With A Soft Tissue Lesion Of The Hand, Susan Masonis Md

The Medicine Forum

A fifty year old male presents with a lesion on his right
hand. Approximately 2 months prior to presentation, the
patient, who is a dentist and avid boater, first noted the
lesion after hitting his hand when working in his boat’s
engine room. Initially he had a 1 cm erythematous
macular lesion on the dorsum of his right hand at the
5th metacarpal. He believed the lesion was present prior
to the time he struck his hand, and the injury brought it
to his attention.

Adaptive Threat Detector Testing Using Bayesian Gaussian Process Models, Bradley Thomas Ferguson

Theses and Dissertations

Detection of biological and chemical threats is an important consideration in the modern national defense policy. Much of the testing and evaluation of threat detection technologies is performed without appropriate uncertainty quantification. This paper proposes an approach to analyzing the effect of threat concentration on the probability of detecting chemical and biological threats. The approach uses a probit semi-parametric formulation between threat concentration level and the probability of instrument detection. It also utilizes a bayesian adaptive design to determine at which threat concentrations the tests should be performed. The approach offers unique advantages, namely, the flexibility to model non-monotone curves …

Potency Testing For Ntd Vaccines: Determining Relative Potency For The Na-Gst-1 Human Hookworm Vaccine, Amar R. Jariwala, Brian Keegan, Pavithra Raghavendra, Jordan L. Plieskatt, Maria Elena Bottazzi, Peter J. Hotez, Jeffrey M. Bethony

Microbiology, Immunology, and Tropical Medicine Posters and Presentations

Over the next decade, a new generation of vaccines will target the neglected tropical diseases (NTDs) . The goal of most NTD vaccines will be to reduce the morbidity and decrease the chronic debilitating nature of these often-forgotten infections - outcomes that are hard to measure in the traditional potency-testing paradigm . The absence of measurable correlates of protection, a lack of permissive animal models for lethal infection, and a lack of clinical indications that do not include the induction of sterilizing immunity required us to reconsider the traditional bioassay methods for determining vaccine potency . Owing to these limitations, …

Van Wagoner Selected For Fellowship, Alicia Rohan

Browse All News

No abstract provided.

Ada News - 05/16/2011, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Inflammatory Gene Variants In The Tsimane, An Indigenous Bolivian Population With A High Infectious Load, Sarinnapha Vasunilashorn, Caleb E. Finch, Eileen M. Crimmins, Suvi A. Vikman, Jonathan Stieglitz, Michael Gurven, Hillard Kaplan, Hooman Allayee

ESI Publications

The Tsimane of lowland Bolivia are an indigenous forager-farmer population living under conditions resembling pre-industrial European populations, with high infectious morbidity, high infection and inflammation, and shortened life expectancy. Analysis of 917 persons ages 5 to 60+ showed that allele frequencies of 9 SNPs examined in the apolipoprotein E (apoE), C-reactive protein (CRP), and interleukin-6 (IL-6) genes differed from some European, African, and north Asian-derived populations. The apoE2 allele was absent, whereas four SNPs related to CRP and IL-6 were monomorphic: CRP (rs1800947, rs3093061, and rs3093062) and IL-6 (rs1800795). No significant differences in apoE, CRP, and IL-6 variants across age …

Dengue Haemorrhagic Fever Presenting As Acute Abdomen, Hanaa Al-Araimi, Amal Al-Jabri, Arshad Al-Abri, Seif

Sultan Qaboos University Medical Journal

We describe a case of a 38 year-old Sri Lankan female who was referred to the surgeon on call with a picture of acute abdomen. She presented with a three-day history of fever, headache, abdominal pain and diarrhoea; however, the physical examination was not consistent with acute abdomen. Her platelet count was 22 x109/L. A diagnosis of dengue haemorrhagic fever (DHF) was made and dengue serology was positive. Dengue epidemics have been associated with a variety of gastrointestinal symptoms and signs, including acute abdomen. Acute abdomen in patients with DHF makes the diagnosis and management challenging.

Oman International Conference On Laboratory Medicine – Part Ii Sultan Qaboos University 9 – 11th November 2010, Sultan Qaboos University

Sultan Qaboos University Medical Journal

No abstract provided.

Re: Un Millennium Development Goals And Oman : Kudos To Oman On Its 40th National Day, Moeness M. Alshishtawy

Sultan Qaboos University Medical Journal

No abstract provided.

Cultural Definitions Of Health Care: A Case Study Of Burmese Refugees, Marielena Rose White

Undergraduate Honors Thesis Collection

As a result of ongoing civil war and civil unrest in the Southeast Asian country of Myanmar, every year the United States accepts increasing numbers of refugees from Burma of which there is a population of significance within the greater Indianapolis area. When considering options for health care, Burmese refugees may opt for self care as opposed to care from a health care professional as a result of clashing cultural factors or fears of the unknown.

This study aims to uncover how members of the Chin ethnic group have been challenged or confronted by the social, cultural, and political institutions …

Toll-Like Receptor 9 Is Required For Opioid-Induced Microglia Apoptosis, Lei He, Hui Li, Lin Chen, Junying Miao, Yulin Jiang, Yi Zhang, Zuoxiang Xiao, Gregory Hanley, Yi Li, Xiumei Zhang, Gene Lesage, Ying Peng, Deling Yin

ETSU Faculty Works

Opioids have been widely applied in clinics as one of the most potent pain relievers for centuries, but their abuse has deleterious physiological effects beyond addiction. However, the underlying mechanism by which microglia in response to opioids remains largely unknown. Here we show that morphine induces the expression of Toll-like receptor 9 (TLR9), a key mediator of innate immunity and inflammation. Interestingly, TLR9 deficiency significantly inhibited morphine-induced apoptosis in microglia. Similar results were obtained when endogenous TLR9 expression was suppressed by the TLR9 inhibitor CpGODN. Inhibition of p38 MAPK by its specific inhibitor SB203580 attenuated morphine-induced microglia apoptosis in wild …

Interventions For Trichomoniasis In Pregnancy, A. Metin Guelmezoglu, Maimoona Azhar

Woman and Child Health

Background: Vaginitis due to Trichomonas vaginalis is one of the most common of sexually transmitted diseases. Trichomoniasis affects women during pregnancy as well but it is not clearly established whether it causes preterm birth and other pregnancy complications.
Objectives: The objective of this review was to assess the effects of various treatments for trichomoniasis during pregnancy.
Search strategy: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register ( 14 January 2011).
Selection criteria: Randomized trials comparing anti-trichomonas agents during pregnancy. Trials including symptomatic or asymptomatic women with trichomoniasis were eligible.
Data collection and analysis: Two review authors assessed …

Influenza And Bacterial Coinfections In The 20th Century, Xuan-Yi Wang, Paul E. Kilgore, Kyung Ah Lim, Song-Mei Wang, Jeongseok Lee, Wei Deng, Mei-Qi Mo, Batmunkh Nyambat, Jing-Chen Ma, Michael O. Favorov, John D. Clemens

Department of Pharmacy Practice

To help understand the potential impact of bacterial coinfection during pandemic influenza periods, we undertook a far-reaching review of the existing literature to gain insights into the interaction of influenza and bacterial pathogens. Reports published between 1950 and 2006 were identified from scientific citation databases using standardized search terms. Study outcomes related to coinfection were subjected to a pooled analysis. Coinfection with influenza and bacterial pathogens occurred more frequently in pandemic compared with seasonal influenza periods. The most common bacterial coinfections with influenza virus were due to S. pneumoniae, H. influenzae, Staphylococcus spp., and Streptococcus spp. …

Wynn Resorts, Ltd., Myung Ji Doh

MBA Student Scholarship

Wynn Resorts, Ltd. ("Wynn Resorts"), established in 2002, is an international corporat ion, providing the luxurious casino resorts destinations in two areas: Las Vegas and Macau. A total of four properties offers casino and non-casino services including rooms, F&B, entertainment, meetings, retail outlets and otbers. The company generates approximately 70% of revenues from casino and Macau properties. The company sets up several subsidiaries to operate business more effectively and retains the most influential person, Steve Wynn, in the casino resorts business. The maturity of the casino resorts varies based on the region: the US market is in the mature stage …

Cord Blood Collection In Pregnant Women For Stem Cell Research, Irene Carr Phd

Dissertations

Umbilical cord blood (UCB) stem cells form commonly banked types of human tissue. Confusion remains about sources of stem cells and their use. Birth is a once in a lifetime opportunity with 74 million births per year in the world and four million occur in the United States. Cord blood contains hematopoietic stem cells and pluripotent mesenchymal cells (Moise, 2005). There is a surge of interest in the clinical use and research investigation of umbilical cord blood for transplantation and regenerative medicine. Clinicians need increased awareness and education of options for private versus public donation and banking of cord blood …

Expression Of Porcine Reproductive And Respiratory Syndrome Virus (Prrsv) Non-Structural Protein 12 In Escherichia Coli, Ariann Boylan

Honors Scholar Theses

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is single-stranded, positive-sense RNA virus in the family Arteviridae, order Nidovirales. PRRSV began circulating in the U.S swine population in the 1980's and since then becoming the most economically significant disease of swine herds. PRRSV is now disseminated worldwide causing great economic losses to pork industries. PRRSV single-stranded RNA genome is15 kb in length. The genome encodes 9 open reading frames (ORF1a, ORF1b,

ORF2a, ORF2b and ORFs 3 through 7). ORFs 1a and 1b encode for 13 non-structural proteins (nsp) that are suggested to be involved in transcription and viral genome replication. The …

Expression Of The Porcine Reproductive And Respiratory Syndrome Virus Non-Structural Protein 3 (Nsp 3) In Escherichia Coli, Lidia Beka

Honors Scholar Theses

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is single-stranded, positive-sense RNA virus in the family Arteriviridae, order Nidovirales. PRRSV is the most economically significant viral infection of swine herds in the United States. The single-stranded RNA genome is 15 kb in length and encodes 9 open reading frames (ORF1a, ORF1b, ORF2a, ORF2b and ORFs 3 through 7). ORFs 1a and 1b encode for 13 non-structural proteins (nsp) that are suggested to be involved in transcription and viral genome replication. The exact role of non-structural proteins in PRRSV cycle is still unknown. Moreover, there is a limited availability of reagents such …

Modeling Human Immune Response To The Lyme Disease-Causing Bacteria, Yevhen Rutovytskyy

Honors Scholar Theses

The purpose of this project is to develop and analyze a mathematical model for the pathogen-host interaction that occurs during early Lyme disease.

Based on the known biophysics of motility of Borrelia burgdorferi and a simple model for the immune response, a PDE model was created which tracks the time evolution of the concentrations of bacteria and activated immune cells in the dermis. We assume that a tick bite inoculates a highly localized population of bacteria into the dermis. These bacteria can multiply and migrate. The diffusive nature of the migration is assumed and modeled using the heat equation. Bacteria …

A Source Of Human Ovarian Cortical Tissue From Sex Assignment Surgery, Quynh T. Nguyen

Rollins Undergraduate Research Journal

A Source of Human Ovarian Cortical Tissue from Sex Assignment Surgery Cryopreservation of ovarian cortical tissue is a novel technique for the preservation of primordial follicles with the aim to restore fertility in young female cancer patients after chemotherapy. Grafting of cryopreserved ovarian cortical tissue has attracted much interest as a means for the restoration of fertility. There is a scarce availability of donated cortical ovarian tissue that limits the research on follicular growth after grafting. A new resource of donors can be found in young female-to-male transsexual donors who have been on androgen therapy for prolonged periods of time. …

Team Physicians’ Practice Beliefs Regarding The Recognition And Treatment Of Exertional Heat Stroke, Lindsey Mcdowell

Master's Theses

Recognition and Treatment of Exertional Heat Stroke: A Perspective from the Team Physician

McDowell LH, Mazerolle SM, Casa DJ, Pagnotta KD, Armstrong LE: University of Connecticut, Storrs, CT

Context: Rectal temperature assessment (T_re) and cold-water immersion (CWI) are the gold standards for the recognition and treatment of exertional heat stroke (EHS), but athletic trainers (ATs) are reluctant to implement them regularly into clinical practice. ATs work under the guidance of a physician, but little information is available regarding the perceptions of the aforementioned methods from the team physician’s perspective. Objective: To investigate team physicians’ practice beliefs regarding the …

The Effect Of Total Work Performed During Acute Heavy Resistance Exercise On Circulating Lymphocytes In Untrained Men, Neil A. Kelly Jr

Master's Theses

Lymphocytes are one of many leukocytes which exert a biphasic response to acute intense resistance exercise. Exercise volume (i.e. total work) has been shown to have an immunomodulatory effect. This study evaluates the effect of total work performed during an intense resistance exercise protocol on lymphocyte concentrations in the circulation. Untrained, college-aged (18-35) males who performed high amounts of work (HW) were compared to those who performed low amounts of work (LW). Resistance exercise testing consisted of 6 sets of 10 repetitions of the squat exercise with 2 minutes rest between sets. Both HW and LW performed the same relative …

The Healthcare Needs Of Patients In Rural Kaduna, Nigeria, Jaime Stevens

Master's Theses

No abstract provided.

Modeling Human Immune Response To The Lyme Disease-Causing Bacteria, Yevhen Rutovytskyy

Honors Scholar Theses

The purpose of this project is to develop and analyze a mathematical model

for the pathogen-host interaction that occurs during early Lyme disease.

Based on the known biophysics of motility of Borrelia burgdorferi and a

simple model for the immune response, a PDE model was created which tracks

the time evolution of the concentrations of bacteria and activated immune

cells in the dermis. We assume that a tick bite inoculates a highly

localized population of bacteria into the dermis. These bacteria can

multiply and migrate. The diffusive nature of the migration is assumed and

modeled using the heat equation. Bacteria …

Impacts Of Goat Browsing And Disease On Lilium Grayi, Gray's Lily, On Roan Mountain., Joseph Powell

Undergraduate Honors Theses

The flora of southern Appalachian high elevation balds has strong representation of northern disjuncts and regional endemics. Among the endemics, the showy Lilium grayi (Gray’s Lily), is most noteworthy for its historical significance and for a high public profile. As bald vegetation changes in response to human and natural environmental shifts, active bald management has been implemented on public lands. Among managed balds, the Roan Mountain massif supports a large population of L. grayi. The purpose of this study was to describe the demography of adult plants, compare browsed and non-browsed plots, and determine the extent to which disease …

Role Of Stress In The Onset Of Diabetes Mellitus In Mice., Lindsey Brianne Mcamis

Undergraduate Honors Theses

This study investigated the effects of stress on the onset of chemically-induced diabetes mellitus in mice. Sixty male ICR mice were randomly divided into 6 groups of 10 mice. A factorial arrangement of 2 factors (streptozotocin (STZ) and stress) was used to produce 6 treatments. Three levels of STZ (0, 25 and 50 mg/kg bodyweight) and 2 levels of stress (stress and no-stress) were used. Stressed groups were exposed to restraint stress 6 hours daily for 18 days. Mice bodyweight, feed consumption and blood glucose levels were recorded regularly during the study period. At the end of the study period, …

The Fate Of Alpine Species In The Face Of Climate Change: A Biogeographic Perspective, Madaline Cochrane

Macalester Reviews in Biogeography

Will global climate change affect the spatial distribution and abundance of biodiversity along mountains equally? The elevational gradients inherent as one moves up a mountain slope help define the many biological patterns that emerge as key indicators for species richness in an era of rising global temperatures. When global temperatures arise, the microclimates found along different elevational ranges on mountains also fluctuate. As abiotic characteristics such as daily air temperature, daily precipitation, and annual snowmelt change overtime, so will the biotic communities on a mountain. Some species may be able to adapt to their new environments, while other may have …

The Effect Of Interactivity In An Online Course On Behavior Change And Self-Efficacy Among Health Care Professionals, Monica Blackwell

Masters Theses, 2010-2019

Continuing Medical Education (CME) interventions continue to be an important factor in the lifelong learning of health care professionals. Online interventions have become increasingly popular since the inception of the Internet. Many CME courses (traditional and online) are evaluated solely on the knowledge gained and participant reactions. However, this study focused on the instructional design of an online CME course and how the design affected the self-efficacy of the learner and the amount of knowledge transferred to the professionals’ practice. Specifically, this study answered the following research questions: 1) How can one design online instruction that will foster a change …