Digital Commons Network^™

Isg15 Is Critical In The Control Of Chikungunya Virus Infection Independent Of Ube1l Mediated Conjugation, Scott W. Werneke, Clementine Schilte, Anjali Rohatgi, Kristen J. Monte, Alain Michault, Fernando Arenzana-Seisdedos, Dana L. Vanlandingham, Stephen Higgs, Arnaud Fontanet, Matthew L. Albert, Deborah J. Lenschow

Open Access Publications

No abstract provided.

Targeting Protein-Protein Interactions For Parasite Control, Christina M. Taylor, Kerstin Fischer, Sahar Abubucker, Zhengyuan Wang, John Martin, Daojun Jiang, Marc Magliano, Marie-Noelle Rosso, Ben-Wen Li, Peter U. Fischer, Makedonka Mitreva

Open Access Publications

No abstract provided.

Mixed Infection With Caga Positive And Caga Negative Strains Of Helicobacter Pylori Lowers Disease Burden In The Gambia, Ousman Secka, Martin Antonio, Douglas E. Berg, Mary Tapgun, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Julian E. Thomas, Richard A. Adegbola

Open Access Publications

No abstract provided.

Complement-Mediated Neutralization Of Dengue Virus Requires Mannose-Binding Lectin, Panisadee Avirutnan, Richard E. Hauhart, Mary A. Marovich, Peter Garred, John P. Atkinson, Michael S. Diamond

Open Access Publications

No abstract provided.

Molecular Characterization Of The North American Lung Fluke Paragonimus Kellicotti In Missouri And Its Development In Mongolian Gerbils, Peter U. Fischer, Kurt C. Curtis, Luis A. Marcos, Gary J. Weil

Open Access Publications

No abstract provided.

Expression During Host Infection And Localization Of Yersinia Pestis Autotransporter Proteins, Jonathan D. Lenz, Matthew B. Lawrenz, David G. Cotter, M. Chelsea Lane, Rodrigo J. Gonzalez, Michelle Palacios, Virginia L. Miller

Open Access Publications

No abstract provided.

Statistical Methods For Assays With Limits Of Detection: Serum Bile Acid As A Differentiator Between Patients With Normal Colons, Adenomas, And Colorectal Cancer, Bonnie Lafleur, Wooin Lee, Dean Billhiemer, Craig Lockhart, Junmei Liu, Nipun Merchant

Open Access Publications

No abstract provided.

Effectiveness Of Measures To Eradicate Staphylococcus Aureus Carriage In Patients With Community-Associated Skin And Soft-Tissue Infections: A Randomized Trial, Stephanie A. Fritz, Bernard C. Camins, Kimberly A. Eisenstein, Joseph M. Fritz, Emma K. Epplin, Carey-Ann Burnham, Jonathan Dukes, Gregory A. Storch

Open Access Publications

No abstract provided.

Electronic Surveillance For Healthcare-Associated Central Line-Associated Bloodstream Infections Outside The Intensive Care Unit, Keith F. Woeltje, Kathleen M. Mcmullen, Anne M. Butler, Ashleigh J. Goris, Joshua A. Doherty

Open Access Publications

No abstract provided.

Epidemiological Model For Clostridium Difficile Transmission In Healthcare Settings, Cristina Lanzas, Erik R. Dubberke, Z Lu, Kimberly Ann Reske, Y T. Grohn

Open Access Publications

No abstract provided.

Prevalence Of Nasal Carriage Of Mupirocin-Resistant Staphylococcus Aureus Among Hospitalized Patients In Thailand, Anucha Apisarnthanarak, David K. Warren, Victoria J. Fraser

Open Access Publications

No abstract provided.

Development And Validation Of A Clostridium Difficile Infection Risk Prediction Model, Erik R. Dubberke, Yan Yan, Kimberly A. Reske, Anne M. Butler, Joshua Doherty, Victor Pham, Victoria J. Fraser

Open Access Publications

No abstract provided.

Genome-Wide Identification Of Allele-Specific Expression (Ase) In Response To Marek’S Disease Virus Infection Using Next Generation Sequencing, Sean Maceachern, William M. Muir, Seth Crosby, Hans H. Cheng

Open Access Publications

No abstract provided.

Genetic Basis For In Vivo Daptomycin Resistance In Enterococci, Elizabeth Lobos, Erica Sodergren, George M. Weinstock, Et Al

Open Access Publications

No abstract provided.

Prevention Of Intraoperative Awareness In A High-Risk Surgical Population, Michael S. Avidan, Beth A. Burnside, Lini Zhang, Saima Kamal, Brian Torres, Alex S. Evers, Stephen Gradwohl, Ben J. Palanca, Nan Lin, David Glick, Leah Karl, Michael O'Connor, George A. Mashour

Open Access Publications

No abstract provided.

Prevention Of Nosocomial Pneumonia In The Intensive Care Unit: Beyond The Use Of Bundles, Marin H. Kollef

Open Access Publications

No abstract provided.

Role Of Nadph Oxidase Versus Neutrophil Proteases In Antimicrobial Host Defense, R. Robert Vethanayagam, Nikolaos G. Almyroudis, Melissa J. Grimm, David C. Lewandowski, Christine T. N Pham, Timothy S. Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J. Walsh, Constantin F. Urban, Brahm H. Segal

Open Access Publications

No abstract provided.

In-Depth Analysis Of The Antibody Response Of Individuals Exposed To Primary Dengue Virus Infection, Ruklanthi De Alwis, Martina Beltramello, William B. Messer, Soila Sukupolvi-Petty, Wahala M. P. B. Wahala, Annette Kraus, Nicholas P. Olivarez, Quang Pham, James Brian, Wen-Yang Tsai, Wei-Kung Wang, Scott Halstead, Srisakul Kliks, Michael S. Diamond, Ralph Baric, Antonio Lanzavecchia, Federica Sallusto, Aravinda M. De Silva

Open Access Publications

No abstract provided.

Astrovirus Mlb1 Is Not Associated With Diarrhea In A Cohort Of Indian Children, Lori R. Holtz, Irma K. Bauer, Priya Rajendran, Gagandeep Kang, David Wang

Open Access Publications

No abstract provided.

Complete Genome Sequence Of Treponema Paraluiscuniculi, Strain Cuniculi A: The Loss Of Infectivity To Humans Is Associated With Genome Decay, David Smajs, Marie Zobanikova, Michal Strouhal, Darina Cejkova, Shannon Dugan-Rocha, Petra Pospisilova, Steven J. Norris, Tom Albert, Xiang Qin, Kym Hallsworth-Pepin, Christian Buhay, Donna M. Muzny, Lei Chen, Richard A. Gibbs, George M. Weinstock

Open Access Publications

No abstract provided.

The Impact Of Vancomycin Susceptibility On Treatment Outcomes Among Patients With Methicillin Resistant Staphylococcus Aureus Bacteremia, Hitoshi Honda, Christopher D. Doern, Wm Michael Dunne Jr, David K. Warren

Open Access Publications

No abstract provided.

Effects Of Human Immunodeficiency Virus And Metabolic Complications On Myocardial Nutrient Metabolism, Blood Flow, And Oxygen Consumption: A Cross-Sectional Analysis, W Todd Cade, Dominic N. Reeds, E Turner Overton, Pilar Herrero, Alan D. Waggoner, Victor G. Davila-Roman, Sherry Lassa-Claxton, Robert J. Gropler, Pablo F. Soto, Melissa J. Krauss, Kevin E. Yarasheski, Linda R. Peterson

Open Access Publications

No abstract provided.

Gender-Associated Genes In Filarial Nematodes Are Important For Reproduction And Potential Intervention Targets, Ben-Wen Li, Amy C. Rush, Dao-Jun Jiang, Makedonka Mitreva, Sahar Abubucker, Gary J. Weil

Open Access Publications

No abstract provided.

Use Of Simulation To Reinforce Evidence-Based Collection Processes, Deborah Christeleit

UNF Graduate Theses and Dissertations

Proper collection of blood cultures is needed to identify pathogens causing serious infections and direct appropriate antibiotic therapy. Blood culture contamination can lead to longer hospital stays, incorrect antibiotic treatment, additional testing, and overall increased costs for the patient and hospital. Blood culture collection technique is the most important factor affecting contamination rates.

The purpose of this project was to determine the effect of simulation reinforcement of blood culture collection processes on the rate of contamination of blood cultures drawn by nurses in a community medical center emergency department.

This one-group before-and-after cohort study utilized a convenience sample of 50 …

Human Cytomegalovirus Ul97 Kinase Activity Modifies Cell Cycle Checkpoint Regulators, Rachel Brooke Gill

All ETDs from UAB

Human cytomegalovirus (CMV) infection results in destructive infections in neonates and immunocompromised individuals. Being the primary congenital infection in the United States, it can often result in permanent neurological deficits in infants. The current therapies for CMV infections all target the viral DNA polymerase and also have dose-limiting toxicities. Isolates resistant to ganciclovir (GCV), the therapy of choice, can sometimes overwhelm immunocompromised hosts. Better therapies for this infection are required. The CMV UL97 kinase is a key enzyme in the treatment of CMV infection because it phosphorylates GCV. Additionally, maribavir (MBV) specifically inhibits UL97 kinase activity and inhibits viral replication. …

Identification And Characterization Of Novel Adenosine Cleavage Enzymes In Mycobacteria, Kajal Buckoreelall

All ETDs from UAB

Tuberculosis (TB) is one of the leading infectious diseases in the world. An estimated one third of the world's population is infected with Mycobacterium tuberculosis, the causative pathogen of TB. With the emergence of drug resistant strains of the mycobacterium, and the HIV-TB coinfection epidemic, TB remains a global health emergency. Purine metabolism is an essential cellular component to all living cells. Previous studies have shown that differences exist between mycobacterial and human purine metabolism. One of the differences was in the metabolism of adenosine (Ado), whose cleavage was observed in mycobacterial cells whereas Ado cleavage is inefficient in human …

Elucidation Of The Elongated Fibrillar Structure Of Streptococcus Mutans Antigen I/Ii, Matthew Rodney Larson

All ETDs from UAB

Streptococcus mutans (S. mutans) is the causative agent behind dental caries, an infectious disease also known as tooth decay or dental cavities. S. mutans has a cell wall-attached protein known as Antigen I/II (AgI/II) utilized for bacterial adhesion to the tooth surface. Here we have solved the structures of both amino- and carboxy-terminal regions of the AgI/II molecule using X-ray crystallography. Using this structural information we have now built a tertiary model for AgI/II as a fibrillar protein. Further, we have functionally characterized AgI/II and determined minimal regions of AgI/II that are implicated in its adherence to the salivary agglutinin …

Decision Aid Models For Resource Sharing Strategies During Global Influenza Pandemics, Alfredo Santana Reynoso

USF Tampa Graduate Theses and Dissertations

Pandemic influenza outbreaks have historically entailed significant societal and economic disruptions. Today, our quality of life is threatened by our inadequate preparedness for the imminent pandemic. The key challenges we are facing stem from a significant uncertainty in virus epidemiology, limited response resources, inadequate international collaboration, and the lack of appropriate science-based decision support tools. The existing literature falls short of comprehensive models for global pandemic spread and mitigation which incorporate the heterogeneity of the world regions and realistic travel networks. In addition, there exist virtually no studies which quantify the impact of resource sharing strategies among multiple countries. This …

Tarnished Golden Years: Older Offenders With Mental Health Problems And Late Life First Time Offenders, Brianne Stanback

USF Tampa Graduate Theses and Dissertations

Older offenders (offenders 50 years and older) are a distinct groups within the U.S. correctional system. Studies 1 and 2 were intended to investigate mental health and stressors among jailed older offenders.

Study 1 examined the prevalence rates of mental health disorders and explored the relationship between mental health disorders and stressors. Participants 50 years and older (N=330) from the 2002 wave of the Survey of Inmates in Local Jails (SILJ) were studied via descriptive analysis, factor analysis, and a logistic regression to determine which variables were related to the probability of having a mental health problem. 65.8% of participants …

Personal Narratives Of Women's Leadership And Community Activism In Cherkasy Oblast, Martha Kichorowska Kebalo

Dissertations, Theses, and Capstone Projects

Ukraine's women's movement is part of a complex social field characteristic of formerly Soviet countries, but it also emerges from its own specific political history. Post-Soviet period, (neo-) nationalism, feminism and (neo-) socialism are significant forces shaping women's collective behavior. Their activism resonates with the pre-Soviet liberation struggle while it is shaped also by practices from the recent Soviet past. It also is sensitive to external pressures, including the agendas of Western aid and the Ukrainian diaspora.

This study accepts the emergence of non-state women's organizations as indicative of an incipient movement and examines this field of social activism in …