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The Constitution of Jamaica with amendments through 2011

Medicine@Yale May/June 2011 Volume 7, Issue 2, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

The Effect Of Untreated And Enzyme-Treated Commercial Dairy Powders On The Growth And Adhesion Of Streptococcus Mutans, Rachel Halpin, D.B. Brady, E.D. O’Riordan, M. O’Sullivan

Articles

Dental caries is a common bacterial infection, but the progression of this disease can be delayed by preventing initial attachment of cariogenic bacteria such as Streptococcus mutans to tooth surfaces. This study firstly compares the effect of untreated (UT) and enzyme-treated (ET) dairy powders on the adherence of S. mutans to hydroxylapatite (HA), an analogue of tooth enamel. A fluorescence-based method was used to quantify adherence of S. mutans to HA both in the presence (S-HA) and absence (PBS-HA) of saliva. Secondly, binding of proteins present in the test materials to HA was quantified using bicinchonic acid assays and SDS-PAGE. …

Efficacy Of Biocides Used In The Modern Food Industry To Control Salmonella Enterica, And Links Between Biocide Tolerance And Resistance To Clinically Relevant Antimicrobial Compounds, Orla Condell, Carol Iversen, Shane Cooney, Karen Power, Ciara Walsh, Catherine Burgess, Seamus Fanning

Articles

Biocides play an essential role in limiting the spread of infectious disease. The food industry is dependent on these agents, and their increasing use is a matter for concern. Specifically, the emergence of bacteria demonstrating increased tolerance to biocides, coupled with the potential for the development of a phenotype of cross-resistance to clinically important antimicrobial compounds, needs to be assessed. In this study, we investigated the tolerance of a collection of susceptible and multidrug-resistant (MDR) Salmonella enterica strains to a panel of seven commercially available food-grade biocide formulations. We explored their abilities to adapt to these formulations and their active …

University Of Montana Forensic Case #12: Comprehensive Case Analysis, Lauren Leanne Richardson

Graduate Student Theses, Dissertations, & Professional Papers

The remains labeled University of Montana Forensic Case #12 (UMFC 12) were unearthed on August 30, 1983 during the construction of Cruse Avenue in Helena, Montana near the old School Administration Building on Allen Street. Construction workers, using a bulldozer accidently exposed the decomposing grave (Roesgen, 1983). It has been speculated that these remains might belong to a Chinese laborer dating back to the gold rush (Joyce, 1983). An 1884 map of Last Chance Gulch, in which the remains were discovered, indicate that a Chinese cemetery is in the area but the exact coordinates have never been determined (Joyce, 1983). …

Stem Cell Tourism: The Challenge And Promise Of International Regulation Of Embryonic Stem Cell-Based Therapies, Lesley N. Derenzo

Case Western Reserve Journal of International Law

Note of the Year

"The Crisis In The Implementation Of International Law", Richard Goldstone Hon.

Case Western Reserve Journal of International Law

No abstract provided.

Evaluation Of The Tick Bites In A Crimean-Congo Haemorrhagic Fever (Cchf) Endemic Area In Turkey, Serpi̇l Erol, Ahmet Yeni̇solak, Göknur Yapar Toros, Ayşe Albayrak

Turkish Journal of Medical Sciences

After the first description of a CCHF outbreak in Turkey, tick bites became an increasing cause of visits to health-care facilities. In this study, we evaluated tick bites in a CCHF endemic region. Materials and methods: The study included cases of tick bites that were referred to 2 hospitals in Erzurum between June and October 2008. All cases were followed-up for 10 days for the results of CCHF. Results: During the study period, 161 patients were admitted for a tick bite. The majority (56.3%) were farmers and housewives. Children ≤ 13 years of age were bitten mostly on the head …

A Pattern Of Lymphadenopathies Seen In A Tertiary Care Hospital In Lahore, Pakistan, Sobia Naseem, Saira Bilal, Maham Akhlaq, Nausheen Henna, Waqas Sami, Abdul Nagi, Muhammad Ashraf

Turkish Journal of Medical Sciences

This cross sectional study was conducted to assess various clinicopathological parameters in 1785 patients from various regions of Punjab. Materials and methods: These cases were collected from Gulab Devi Chest Hospital, Lahore, Pakistan. The data were collected from all patients during a period of 2 years, from June 2006 to June 2008. All the cases were diagnosed after routine hematoxylin and eosin staining. Results: Our observations revealed that the most prevalent lymphadenopathy in these patients was tuberculous lymphadenitis 53% (n = 946), and the most common group of lymph nodes involved is cervical lymph nodes. A significant association was observed …

Exploring The Experiences Of Living With A Controversial Illness In Patients With Fibromyalgia, Samantha L. Wheeler

Dissertations

Fibromyalgia is an illness of great controversy estimated to affect approximately 4% of the US population. There are no widely accepted etiological causes or clear physiological explanations of fibromyalgia. Only a few research studies have addressed the concept of illness uncertainty in patients with fibromyalgia. There are no current studies that examine how fibromyalgia patients experience, perceive, and understand their illness in terms of having a syndrome with an unknown etiology.

This qualitative study, using phenomenological methods, explored the concept of unknown etiology as one factor in illness uncertainty. Ten participants, diagnosed with fibromyalgia from 2-15 years were interviewed. The …

Surgical Site Infections In Gynecologic Oncology Patients: A Retrospective Study Of Patient Characteristics And Intraoperative Parameters, Christine C. Chen Md, Joanne N. Quiñones Md, Msce, Richard Boulay Md, M Bijoy Thomas Md, Martin Martino Md

Department of Obstetrics & Gynecology

No abstract provided.

The Effects Of Myd88 Inhibition On Bovine Lung Endothelial And Epithelial Cell Cytokine Expression, Cassandra Kay Hayne

Honors Program Theses

Bovine respiratory disease complex (BRDC) has major economical implications on the beef industry due to the severe health problems it produces in calves. Although several organisms are associated with it, Mannheimia haemolytica induces the severest amount of damage to the lungs. It has previously been demonstrated that lipopolysaccharide (LPS) produced by this bacterium causes significant permeability increases and cell apoptosis in bovine lung endothelial cells (BPMEC) but not bovine lung epithelial cells (TBPE). The purpose was to determine whether the main signaling pathway for cells that respond to LPS signaling, the Myeloid Differentiation 88 Pathway (MYD88), is present and functional …

Cumulative Clinical Experience From Over A Decade Of Use Of Levofloxacin In Community Acquired Pneumonia; Critical Appraisal And Role In Therapy, Ayman M. Noreddin, Walid F. Elkhatib, Kenji M. Cunnion, George G. Zhanel

Pharmacy Faculty Articles and Research

Levofloxacin is the synthetic L-isomer of the racemic fluoroquinolone, ofloxacin. It interferes with critical processes in the bacterial cell such as DNA replication, transcription, repair, and recombination by inhibiting bacterial topoisomerases. Levofloxacin has broad spectrum activity against several causative bacterial pathogens of community-acquired pneumonia (CAP). Oral levofloxacin is rapidly absorbed and is bioequivalent to the intravenous formulation such that patients can be conveniently transitioned between these formulations when moving from the inpatient to the outpatient setting. Furthermore, levofloxacin demonstrates excellent safety, and has good tissue penetration maintaining adequate concentrations at the site of infection. The efficacy and tolerability of …

A Comparison Of Pharmacist Travel-Health Specialists' Versus Primary Care Providers' Recommendations For Travel-Related Medications, Vaccinations, And Patient Compliance In A College Health Setting, Melissa J. Durham, Jeffery A. Goad, Lawrence S. Neinstein, Mimi Lou

Pharmacy Faculty Articles and Research

Background. Pretravel medication and vaccination recommendations and receipt were compared between primary care providers (PCPs) without special training and clinical pharmacists specializing in pretravel health.

Methods. A retrospective chart review of patients seen for pretravel health services in a pharmacist-run travel clinic (PTC) compared to PCPs at a University Student Health Center. Vaccine/medication recommendations were assessed for consistency with national/international guidelines. Medical/pharmacy records were queried to determine the receipt of medications/vaccinations.

Results. The PTC recommended antibiotics for travelers' diarrhea were given more often when indicated (96% vs 50%, p < 0.0001), and patients seen in the PTC received their medications more often (75% vs 63%, p = 0.04). PCPs prescribed more antibiotics for travelers' diarrhea that were inconsistent with guidelines (not ordered when indicated 49% vs 6%, p < 0.0001 and ordered when not indicated 21% vs 3%, p < 0.0001). The PTC prescribed antimalarials more often when indicated (98% vs 81%, p < 0.0001), while PCPs prescribed more antimalarials that were inconsistent with guidelines (not ordered when indicated 15% vs 1%, p < 0.0001 and ordered when not indicated 19% vs 2%, p < 0.0001). The PTC ordered more vaccines per patient when indicated (mean = 2.77 vs 2.31, p = 0.0012). PTC patients were more likely to receive vaccines when ordered (mean = 2.38 vs 1.95, p = 0.0039). PCPs recommended more vaccines per patient that were inconsistent with guidelines (not ordered when indicated: mean = 0.78 vs 0.12, p < 0.0001, ordered when not indicated: mean 0.18 vs 0.025, p < 0.0001).

Conclusions. A pharmacist-run pretravel health clinic can …

Attention-Deficit/Hyperactivity Disorder In Childhood Is Associated With Cognitive Test Profiles In The Geriatric Population But Not With Mild Cognitive Impairment Or Alzheimer's Disease, N. Ivanchak, Erin L. Abner, S. A. Carr, S. J. Freeman, A. Seybert, John Ranseen, Gregory A. Jicha

Sanders-Brown Center on Aging Faculty Publications

The frequency of ADHD in the aging population and its relationship to late-life cognitive decline has not been studied previously. To address this gap in our understanding, the Wender-Utah ADHD Rating scale (WURS) was administered to 310 geriatric subjects with cognitive status ranging from normal cognition to mild cognitive impairment to overt dementia. The frequency of WURS-positive ADHD in this sample was 4.4%. WURS scores were not related to cognitive diagnoses, but did show nonlinear associations with tasks requiring sustained attention. The frequency of ADHD appears stable across generations and does not appear to be associated with MCI or dementia …

A Nutty Approach To Disease Prevention, Amin Esfahani

Quill & Scope

Tree nuts are healthy foods with a favourable macro- and micronutrient profile. They are low in sat-urated fats and high in mono- and polyunsaturated fatty acids. They are also good sources of vegeta-ble protein, fiber, phytosterols, polyphenols, vitamins and minerals. Because of this healthy nutrient profile, it has been postulated that tree nuts may play a significant role in health maintenance and disease prevention. The purpose of this paper is 1) to provide a brief overview of the current scien-tific evidence on the role of tree nuts in prevention and management of diabetes and heart disease and 2) to outline …

Retarder Le Mariage Précoce Chez Les Filles Défavorisées En Milieu Rural Dans La Région Amhara, En Éthiopie, Grâce Au Soutien Social, À L'Éducation Et À La Sensibilisation Des Communautés, Eunice N. Muthengi, Annabel Erulkar

Poverty, Gender, and Youth

L'Éthiopie affiche des taux extrêmement élevés de mariage d'enfants et une épidémie de VIH qui touche les femmes de façon disproportionnée. Dans la région rurale d'Amhara, 50% des filles sont mariées avant l’âge de 15 ans et plus de 80% sont mariées avant l’âge de 18 ans. Les chercheurs ont réalisé une enquête auprès de plus de 1800 adolescentes dans la région d'Amhara. Sur la base des conclusions, en 2004, le Bureau Régional de la Jeunesse et des Sports d'Amhara et le Population Council ont créé le projet Berhane Hewan («Light for Eve»). L'objectif de Berhane Hewan est la mise …

Neighborhood Context As A Predictor Of Nursing Home Placement Among Older Adults, David Russell Buys

All ETDs from UAB

Persons who are aging face an increased risk of adverse health events and decreased levels of personal competencies, potentially inhibiting their ability to age in place. Sometimes, nursing home placement (NHP) may be imperative, especially if persons experience environmental docility-- an incongruence of their physical capacity with their environment. This study links the neighborhood disadvantage literature with Lawton's environmental press and environmental docility theories to examine how the environment interacts with individual level variables to impact likelihood of NHP. Findings suggest that there is not a direct link between living in a disadvantaged context and likelihood of NHP, but that …

Individual, Socio-Cultural And Structural Factors Associated With Cervical Cancer Screening And Treatment In Tanzania, Renicha Tomeka Mccree-Hale

All ETDs from UAB

Most African countries including Tanzania have limited cervical cancer screening and treatment programs. Only about 5% of women have ever been screened for cervical cancer. A constellation of individual and structural factors contributes to the challenge of cervical cancer screening and treatment in countries that bear significant burdens of disease. Yet, little is known about country specific factors that may constrain or facilitate scale up of health services. This dissertation is an attempt to identify and understand the country specific individual and structural barriers along with facilitators to cervical cancer screening and treatment in Tanzania. Individual, institutional and structural level …

Limited Transplantation Of Antigen-Expressing Hematopoietic Stem Cells Induces Long-Lasting Cytotoxic T Cell Responses And Effect Of Altered Suppressive Myeloid Population On Hiv-Disease Progression, Warren L. Denning

All ETDs from UAB

While each type of cancer and chronic viral infection has its own specific pathology, they share two common mechanisms of immune evasion. The first mechanism is the exhaustion or deletion of antigen-specific T cells. The second mechanism is the formation of an immunosuppressive environment responsible for the block of T cell function. Elicitation of antigen-specific T cells be accomplished by immunotherapy in place of conventional treatments such as HAART and chemotherapy. In addition, immunotherapy can alleviate the side-effects associated with long-term use of conventional therapies while reducing the total cost. The results presented here provide an alternative to conventional methods …

Restoring Health To Health Reform: Integrating Medicine And Public Health To Advance The Population's Wellbeing, Lawrence O. Gostin, Peter D. Jacobson, Katherine L. Record, Lorian E. Hardcastle

Georgetown Law Faculty Publications and Other Works

The Patient Protection and Affordable Care Act is a major achievement in improving access to health care services.  However, evidence indicates that the nation could achieve greater improvements in health outcomes, at a lower cost, by shifting its focus to public health.  By focusing nearly exclusively on health care, policy makers have chronically starved public health of adequate and stable funding and political support.  The lack of support for public health is exacerbated by the fact that health care and public health are generally conceptualized, organized, and funded as two separate systems.  In order to maximize gains in health status …

Biodefense And Constitutional Constraints, Laura K. Donohue

Georgetown Law Faculty Publications and Other Works

The United States and United Kingdom have different approaches to quarantine law that reflect each country’s unique historical context and constitutional structure. Under the Tudors, England vested quarantine authority in the monarch, with its subsequent exercise conducted by the military. As the constitutional structure changed, the manner in which quarantine was given effect subtly shifted, leading to constitutional reforms. Authorities transferred first to the Privy Council and, subsequently, to Parliament, where commercial interests successfully lobbied them out of existence. By the end of the 19th Century, quarantine authorities had been pushed down to the local port authorities. In the United …

Integrating Tuberculosis Case Finding And Treatment Into Postnatal Care, Charity Ndwiga, Harriet Birungi, Chi-Chi Undie, Shiphrah Kuria, Joseph Sitienei, Sam Ochola

Reproductive Health

Under the USAID funded FRONTIERS program, the Population Council conducted a study in six health facilities in Western Kenya that demonstrated that screening for TB within an antenatal care (ANC) setting is feasible and acceptable among the service providers. However, a major challenge remains: although TB detection is encouraged among ANC clients within the maternal and child health clinics in the country, providers in these settings fail to appreciate the need for a continuum of care from pregnancy through to the postnatal period. In order to address this gap, the APHIA II Operations Research Project developed and tested an intervention …

Climate Services To Support Sustainable Tourism And Adaptation To Climate Change, D.J. Scott, Christopher J. Lemieux, Leslie Malone

Geography and Environmental Studies Faculty Publications

Tourism is one of the largest global economic sectors, is a vital contributor to the economy of many nations, and is highly promoted as an important means of future development and poverty reduction in developing countries. The interface between climate and tourism is multifaceted and complex, with broad significance for tourist decision-making and expenditures, as well as industry marketing and operations worldwide. With the close relationship of tourism to the environment and climate, the integrated effects of climate change are anticipated to markedly affect tourism businesses and destinations, as well as the destination choices and mobility of individual tourists in …

How Mri Can Contribute To The Diagnosis Of Acute Demyelinating Encephalomyelitis In Children, Emna Daoud, Imen Chabchoub, Henda Neji, Nozha Toumi, Rim B. Abdallah, Hajer Aloulou, Fatma Kammoun, Abdelmajid Mahfoudh, Mongia Hachicha, Jamel Mnif, Kheireddine B. Mahfoudh, Zeineb Mnif

Neurosciences

OBJECTIVE: To illustrate through 10 pediatric cases, the clinical features, course, and importance of neuroimaging (especially MRI) in guiding the diagnosis of acute disseminated encephalomyelitis (ADEM) and controlling patients after treatment. METHODS: A retrospective review of 10 pediatric cases of ADEM, with special regard to the MRI features, presenting to the Pediatric Departments, Hedi Chaker Hospital, Sfax, Tunisia between January 2002 and December 2008. RESULTS: Children with ADEM presented with variable and multiple neurological signs most often occurring after an infectious episode, especially after upper respiratory tract infection. The MRI permitted confirmation of the diagnosis by showing demyelinating lesions either …

Evaluation Of Viral Antibodies In Iranian Multiple Sclerosis Patients, Mohsen Khaki, Ali Ghazavi, Keyvan Ghasami, Mohammad Rafiei, Mohammah-Ali Payani, Ehsanollah Ghaznavi-Rad, Ghasem Mosayebi

Neurosciences

OBJECTIVE: To evaluate the viral antibodies in new Iranian multiple sclerosis (MS) patients. METHODS: In a cross-sectional study, sera from 61 MS patients and 60 healthy individuals were collected from January 2009 to March 2010 in the Immunology Department of Arak University of Medical Sciences, Arak, Iran, and examined for the presence of the anti-Epstein-Barr virus (EBV), human herpes virus 6 (HHV-6), measles, mumps, and para-influenza viruses IgG and IgM using an enzyme-linked immunosorbent assay or immunofluorescence. RESULTS: There were significant differences between the MS patients and the healthy individuals (controls) in the seroprevalence of anti-HHV-6 IgM (odds ratio [OR]=4.3, …

The Characterization Of Pg0228 In Porphyromonas Gingivalis W83, Courtney Schlenker

Theses and Dissertations

Periodontitis affects 10 to 15 percent of most adult populations and can contribute to numerous systemic diseases. Porphyromonas gingivalis, a gram-negative anaerobic bacterium, is a recognized prime causative agent in periodontitis. Studies have shown a number of small non-coding RNAs (sRNAs) have been related to bacterial virulence. Many of these sRNAs require the facilitation of the bacterial Sm-like protein, Hfq, for optimum function. Hfq is a RNA chaperone involved in RNA stability, sRNA function, and polyadenylation. Mutants lacking in Hfq often show pleiotropic phenotypes, although the extent and severity of hfq null phenotypes is often species-specific. Hfq has been encoded …

Acquired Cytogenetic Changes In Adult Twins Discordant For A History Of Childhood Sexual Abuse, Jenni Brumelle

Theses and Dissertations

The primary study aim was to evaluate the latent biological effect of childhood sexual abuse (CSA) on adults by quantifying acquired cytogenetic changes and cortisol levels in identical twins who were discordant (N=22) or concordant (N=2) for a history of CSA. Although the difference scores for cortisol values between discordant identical co-twins were not significantly different from zero, a trend was observed for the twins exposed to intercourse, the most severe form of CSA, to have a blunted cortisol awakening response. Acquired cytogenetic changes were assessed by scoring telomere lengths and somatic cell abnormality frequencies via a cytokinesis-block micronucleus (MN) …

Synthesis, Screening And Cocrystallization Of Adenosine Based Inhibitors With Methyltransferases, Ermc' And Ksga, Matthew Baker

Theses and Dissertations

Antibiotic resistance threatens to throw mankind back into an era when infectious disease was the predominant cause of death. In an effort to mitigate this danger, we targeted ErmC’ and KsgA. Both methylate N6-adenosine of ribosomal RNA, though each serve different roles in their bacterial host. ErmC’ dimethylates A2058 on 23S rRNA, conferring resistance to MLSB antibiotics (macrolides, lincosamides, streptogramin B). KsgA aids in ribosome assembly, binding inactive 30S until dimethylating A1518/A1519 of 16S rRNA. Like most methyltransferases, ErmC’ and KsgA use cofactor S-adenosylmethionine (SAM) as their methyl source, which binds adjacent to their specific adenosine substrate. ErmC’ inhibitors could …

Analogous Mechanisms Of Resistance To Benzothiazinones And Dinitrobenzamides In Mycobacterium Smegmatis, Ana Luisa Ribeiro, Giulia Degiacomi, Fanny Ewann, Silvia Buroni, Maria Loreto Incandela, Laurent R. Chiarelli, Giorgia Mori, Jaeseung Kim, Monica Contreras-Dominguez, Young-Sam Park, Sung-Jun Han, Priscille Brodin, Giovanna Valentini, Menico Rizzi, Giovanna Riccardi, Maria Rosalia Pasca

Faculty and Staff Publications

Tuberculosis is still a leading cause of death worldwide. The selection and spread of Mycobacterium tuberculosis multidrug-resistant (MDR-TB) and extensively drug-resistant strains (XDR-TB) is a severe public health problem. Recently, two different classes of chemical series, the benzothiazinones (BTZ) and the dinitrobenzamide (DNB) derivatives have been found to be highly active against M. tuberculosis, including XDR-TB strains. The target of BTZs is DprE1 protein which works in concert with DprE2 to form the heteromeric decaprenylphosphoryl-β-D-ribose 2'-epimerase, involved in Decaprenyl-Phospho-Arabinose (DPA) biosynthesis. Interestingly, it has been shown that the DNBs block the same pathway thus suggesting that both drugs could share …