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Beyond Rehabilitation: A New Theory Of Indeterminate Sentencing, Michael M. O'Hear

Faculty Publications

Indeterminate sentencing - that is, sentencing offenders to a range of potential imprisonment with the actual release date determined later, typically by a parole board - fell into disrepute among theorists and policymakers in the last three decades of the twentieth century. This sentencing practice had been closely associated with the rehabilitative paradigm in criminal law, which also fell from favor in the 1970’s. In the years that followed, most states eliminated or pared back the various devices that had been used to implement indeterminate sentencing, especially parole release. Yet, sentencing remained indeterminate most places to varying degrees, and now …

Licensee Patent Validity Challenges Following Medimmune: Implications For Patent Licensing, Alfred C. Server, Peter Singleton

UC Law Science and Technology Journal

The recent Supreme Court decision in MedImmune v. Genentech, resolved a jurisdictional question while refusing to address questions regarding application of the common law doctrine of licensee estoppel. This doctrine prevents a licensee enjoying the benefits of a license agreement from challenging the validity of the underlying patent. Although the Supreme Court in Lear v. Adkins rejected application of the doctrine where the licensee had ceased making payments under the agreement, it left open the same question which the MedImmune Court mentioned, but refused to address. Namely: Whether the doctrine still applies to a non-repudiating licensee in good standing. In …

Medicine@Yale November/December 2011 Volume 7, Issue 5, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Access To Justice: The Use Of International Law Clinics To Advance The Case For Vulnerable Members Of Society, Yvonne Dausab

Maryland Journal of International Law

No abstract provided.

Searching The Protein Structure Database For Ligand-Binding Site Similarities Using Cpass V.2, Robert Powers, Jennifer C. Copeland, Jaime L. Stark, Adam Caprez, Ashu Guru, David R. Swanson

Robert Powers Publications

Background: A recent analysis of protein sequences deposited in the NCBI RefSeq database indicates that ~8.5 million protein sequences are encoded in prokaryotic and eukaryotic genomes, where ~30% are explicitly annotated as “hypothetical” or “uncharacterized” protein. Our Comparison of Protein Active-Site Structures (CPASS v.2) database and software compares the sequence and structural characteristics of experimentally determined ligand binding sites to infer a functional relationship in the absence of global sequence or structure similarity. CPASS is an important component of our Functional Annotation Screening Technology by NMR (FAST-NMR) protocol and has been successfully applied to aid the annotation of a number …

Immunization With Hiv Gag Targeted To Dendritic Cells Followed By Recombinant New York Vaccinia Virus Induces Robust T-Cell Immunity In Nonhuman Primates, Barbara J. Flynn, Kathrin Kastenmüller, Ulrike Wille-Reece

Publications

Protein vaccines, if rendered immunogenic, would facilitate vaccine development against HIV and other pathogens. We compared in nonhuman primates (NHPs) immune responses to HIV Gag p24 within 3G9 antibody to DEC205 ("DEC-HIV Gag p24"), an uptake receptor on dendritic cells, to nontargeted protein, with or without poly ICLC, a synthetic double stranded RNA, as adjuvant. Priming s.c. with 60 ?g of both HIV Gag p24 vaccines elicited potent CD4⁺ T cells secreting IL-2, IFN-γ, and TNF-α, which also proliferated. The responses increased with each of three immunizations and recognized multiple Gag peptides. DEC-HIV Gag p24 showed better cross-priming for …

Expanding The Horizons Of Enzybiotic Identification, Jonathan Edward Schmitz

Student Theses and Dissertations

Recently, phage lytic enzymes (also known as endolysins or, simply, lysins) have received considerable attention as potential antibacterial agents. During the infective cycle of double-stranded DNA phage, these peptidoglycan hydrolases are responsible for digesting the cell wall of the host bacterium and freeing newly-assembled viral particles. At the same time, an increasing body of evidence has demonstrated that recombinantly-purified phage lysins—when added exogenously—can potently kill Gram-positive bacteria, whose peptidoglycan is accessible from the extracellular space. Consequently, lysins have been proposed as novel enzybiotic (i.e. enzyme-antibiotic) molecules that could serve as novel weapons in the fight against drug-resistant bacteria. Most lysins …

Achilles' Heel: How The Ats And Nafta Have Combined To Create Substantial Tort Liability For Us Corporations Operating In Mexico, Travis Robert-Ritter

University of Miami Inter-American Law Review

No abstract provided.

Altered Standards Of Care: Needed Reform For When The Next Disaster Strikes, Rebecca Mansbach

Journal of Health Care Law and Policy

No abstract provided.

Biobanking Newborn Bloodspots For Genetic Research Without Consent, Sandra J. Carnahan

Journal of Health Care Law and Policy

No abstract provided.

Patients' Perspectives On Discussing Complementary And Alternative Medicine Therapies With Conventional Doctors, Deborah A. Mcninch

Walden Dissertations and Doctoral Studies

Currently, little is known about patients' perceptions and beliefs in discussing complementary and alternative medicine (CAM) with their conventional medical (CM) doctor. The purpose of this descriptive research was to show whether CAM-using patients have an interest in discussing CAM treatments with their CM doctor for comprehensive care as described by the health belief model (HBM) constructs of perceived susceptibility, perceived seriousness, and perceived benefits of taking action. A sample of 165 participants age 18 or older from 2 chiropractic clinics in the midwestern United States completed a Likert-scaled survey. The data were analyzed using descriptive statistics and multiple regression …

Effect Of Clinical Laboratory Practitioner Licensing On Wages, Mary Hotaling

Walden Dissertations and Doctoral Studies

Professional licensing directly affects about 29% of U.S. workers and is considered a primary means to establish and maintain health care practitioner competence. Clinical laboratory practitioner licensing was largely ignored in the literature with only 2 studies 30 years apart that provided conflicting conclusions regarding wage effects. This research provided the first study of clinical laboratory practitioner licensing effects on wages after controlling for human capital and individual characteristics wage determinants. This nonexperimental correlational study extended the literature on licensing effects on wages, including women's wages and professions not uniformly licensed across 50 states. The theoretical foundation relied on the …

Leadership And Attitudes On Adopting Evidence-Based Practice For Influenza Vaccination, Pamela A. Paparone

Walden Dissertations and Doctoral Studies

The United States has set a 90% benchmark for influenza vaccinations for healthcare personnel. Unfortunately, healthcare personnel fall far short of that mark with current rates as low as 62%. Low vaccination rates are responsible for influenza, nosocomial influenza, influenza-like illness, and mortality during influenza season. The purpose of this quantitative correlational study was to understand the relationship between leadership styles, attitudes towards evidence-based practice, and vaccination intention among New Jersey registered nurses (RNs). Diffusion of innovations theory was the theoretical foundation. The 3 instruments used were the Multifactor Leadership Questionnaire, Evidence Based Practice Attitude Scale, and Behavioral Intention Scales, …

The Water Project: A Short-Term Study Abroad Program Design For Alfred University, Caitlin Paul

Capstone Collection

The Water Project is a short term, faculty-led program, which will address the global water crisis by using the strengths of Alfred University (AU). The Water Project will include students from five different disciplines -Engineering, Art, Business, Language, and Anthropology- and have them work in collaboration with each other and the faculty of AU to create low-cost, ceramic water filters for a community in need of a clean water source in a rural area of Burkina Faso. The Water Project is not intended to be an imposing force on the community, but a welcomed collaborator that works to create a …

Calculus, Biology And Medicine: A Case Study In Quantitative Literacy For Science Students, Kim Rheinlander, Dorothy Wallace

Numeracy

This paper describes a course designed to enhance the numeracy of biology and pre-medical students. The course introduces students with the background of one semester of calculus to systems of nonlinear ordinary differential equations as they appear in the mathematical biology literature. Evaluation of the course showed increased enjoyment and confidence in doing mathematics, and an increased appreciation of the utility of mathematics to science. Students who complete this course are better able to read the research literature in mathematical biology and carry out research problems of their own.

Maize And Stone A Functional Analysis Of The Manos And Metates Of Santa Rita Corozal, Belize, Lisa Glynns Duffy

Electronic Theses and Dissertations

The manos and metates of Santa Rita Corozal, Belize are analyzed to compare traditional maize-grinding types to the overall assemblage. A reciprocal, back-and-forth grinding motion is the most efficient way to process large amounts of maize. However, rotary movements are also associated with some ground stone implements. The number of flat and trough metates and two handed manos are compared to the rotary-motion basin and concave type metates and one-handed manos to determine predominance and distribution. Flat is the predominant type and, together with the trough type, these grinding stones make up the majority of metates at the site. Manos …

Modeling Medical Diagnosis Using A Comprehensive Cognitive Architecture, S. Strain, S. Franklin

CCRG Papers

No abstract provided.

The Role Of The Pediatrican In The Effort To Prevent Congenital Malformations, Robert L. Brent Dr.

The Selected Works of Robert Brent

No

A Survey Of The Chemical Content And Medicinal Activity Of Shrub-Steppe Plants Of The Pacific Northwest, Aaron M. John

Undergraduate Honors Theses

A need for new modes of antibiotic therapy has resulted from the increasing incidence of bacterial resistance to drugs. One approach to this problem involves the search for plant compounds that may help to overcome multi-drug resistance. Many plant genera have been utilized in Native American traditional medicine for their beneficial properties. Such plants include the shrub-steppe genera, Eriogonun and Collomia, which have been used as cold remedies, pain relievers, and for antibiotic-related uses. Limited chemical studies of these genera have revealed medicinally useful compounds such as flavonoids and terpenoids, and further research may result in the identification of …

Animal Models For Periodontal Disease, Helieh S. Oz, David A. Puleo

Center for Oral Health Research Faculty Publications

Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced in vitro. Among the animal kingdom, rodents, rabbits, pigs, dogs, and nonhuman primates have been used to model human periodontitis, each with advantages and disadvantages. Periodontitis commonly has been induced by placing a bacterial plaque retentive ligature in the gingival sulcus around the molar teeth. In addition, alveolar bone loss has been induced by inoculation or …

Determinants Of Multimethod Contraceptive Use In A Sample Of Adolescent Women Diagnosed With Psychological Disorders, Delia L. Lang, Jessica M. Sales, Laura F. Salazar, Ralph J. Diclemente, Richard A. Crosby, Larry K. Brown, Geri R. Donenberg

Health, Behavior & Society Faculty Publications

OBJECTIVE: Despite recommendations for concurrent use of contraceptives and condoms to prevent unintended pregnancy and STIs, multimethod contraceptive use among women is poor. This study examined individual-, interpersonal-, and environmental-level factors that predict multimethod use among sexually active adolescent women diagnosed with psychological disorders.

METHODS: This multisite study analyzed data from 288 sexually active adolescent women who provided sociodemographic, psychosocial, and behavioral data related to birth control and condom use.

RESULTS: 34.7% of the participants reported multimethod use in the past three months. Controlling for empirically and theoretically relevant covariates, a multivariable logistic regression identified self-efficacy, multiple partners, pregnancy history, …

Nurses' Knowledge Of Evidence-Based Guidelines For Prevention Of Ventilator-Associated Pneumonia In Critical Care Areas: A Pre And Post Test Design, Sm Meherali, Y Parpio, Tazeen S. Ali, F Javed

School of Nursing & Midwifery

Background: Ventilator associated pneumonia (VAP) is a common hospital acquired pneumonia inventilated patients. VAP is associated with increasedmorbidity, mortality duration of hospitalization and cost of treatment. Critical care nurses are usually unaware of evidence based preventiveguidelines for VAP, resulting in negative impact on all aspects of patient care. This studyinvestigated the impact of a 5-hour teaching moduleon nurses’ knowledge to practice evidence based guidelines for the prevention of VAP.
Methods: This study was conducted at a private tertiary care teaching hospital in Karachi, Pakistan. Single group pre-test post-test design was used. Fortynurses were included in the study. The knowledge of …

Hiv/Aids And Human Rights In Botswana And Swaziland: A Matter Of Dignity And Health, Vincent Iacopino, Sheri D. Weiser, Madhavi Dandu, David Tuller

UC Law SF International Law Review

A health and human rights framework provides a comprehensive perspective for understanding complex interactions between HIV/AIDS, human rights, and the health of individuals and communities. By helping to identify a broad range of social factors that affect health, such a framework also facilitates the development of interventions and policies that maximize both health and human rights benefits. In this Article, we discuss the various linkages between health and human rights and review the literature on HIV/AIDS and human rights, with a focus on under-resourced settings. In particular, we examine how the framework is relevant to the specific epidemics in Botswana …

Rock Pigeon Use Of Livestock Facilities In Northern Colorado: Implications For Improving Farm Bio-Security., James C. Carlson, Larry Clark, Michael F. Antolin, M. D. Salman

United States Department of Agriculture Wildlife Services: Staff Publications

Rock pigeons (Columba livia) have been implicated in the spread of pathogens within commercial livestock facilities. Currently, there is no data characterizing pigeon habitat use and movement patterns within and among commercial livestock facilities. To better understand the capacity for pigeons to spread pathogens, we used radio-telemetry techniques to estimate the home-range, travel distance, activity, and habitat use of pigeons roosting on and off dairies and feedlots in western Weld County, Colorado. Our observations suggest that pigeons roosting on (resident) and off (nonresident) livestock facilities use habitat differently. Nonresident pigeons used larger home-range areas than did resident pigeons. Nonresident pigeons …

Baylisascariasis Fact Sheet, Emily L. Blizzard

United States Department of Agriculture Wildlife Services: Staff Publications

Fact Sheet compiled by: Emily L. Blizzard

Sheet completed on: May 27, 2011

Fact Sheet Reviewed by: Sarah Bevins, Kerri Pedersen, and Michael J. Yabsley

Susceptible animal groups Avian, Mammal, Human

Causative organism

Recognized species of Baylisascaris

Parasite Primary Definitive Host(s)

Distribution

Incubation period

Clinical signs

Post mortem, gross, or histologic findings

Diagnosis

Material required for laboratory analysis

Relevant diagnostic laboratories

Treatment

Prevention and control

Suggested disinfectant for housing facilities

Notification

Measures required under the Animal Disease Surveillance Plan

Measures required for introducing animals to infected animal

Conditions for restoring disease-free status after an outbreak None

Experts who may be …

Pituophis Catenifer Deserticola (Great Basin Gophersnake) Predation, Steven J. Wamback, Richard M. Engeman

United States Department of Agriculture Wildlife Services: Staff Publications

A variety of taxa have been observed to· prey upon Pituophis catenifer, including mammals, birds-of prey, and other snakes. Here, we describe an unusual two-day observation of predation on a mature Great Basin gophersnake by a brown trout (Salmo trutta).

The observation took place in Jones Canyon, Utah, USA, on the grounds of the Jones Hole National Fish Hatchery (JHNFH). Jones Creek' emanates from springs at the head of Jones Canyon on hatchery grounds, and flows north to south 6.4 km to the Green River, approximately paralleling the Utah-Colorado border. The stream runs for about 0.3 km …

Impacts Of Generalist Mesopredators On The Demography Of Small-Mammal Populations In Fragmented Landscapes, Timothy S. Eagan Ii, James C. Beasley, Zachary H. Olson, Olin E. Rhodes Jr.

United States Department of Agriculture Wildlife Services: Staff Publications

Abstract: A consequence of the reduction and subsequent fragmentation of native habitats has been the loss or severe reduction of specialist predator populations from these altered ecosystems, resulting in a “release” of generalist predators. Demographic aspects of small-rodent populations, especially predator-driven density cycles, have been extensively studied. However, the majority of studies examining predator–prey dynamics have been conducted in relatively undisturbed ecosystems, while more limited data are available for regions that have been greatly modified by human settlement. Using raccoons (Procyon lotor (L., 1758)) and white-footed mice (Peromyscus leucopus (Rafinesque, 1818)) as focal species, we used an …

Ic107: Cancer Facts: Children/Adolescents And Cancer, Intercultural Cancer Council

Informational and Promotional Materials

The fact sheet summarizes cancer facts related to children and adolescents. The document is organized into seven sections: Who We Are, Causes/Etiology, Patient/Provider Communication, Screening, Disparities, Outcomes, and References. See more at Intercultural Cancer Council Records.

Mechanism For Pre-B Cell Loss In Mutant Ali/Ali Rabbits, Gregory Robert Robbins

Dissertations

Pre-B cell receptor (pre-BCR) signaling is a critical checkpoint in B cell development in which B-lineage cells expressing functional μ-chains undergo selective expansion. My dissertation work used a rabbit model system to study how VH structure affects the early stages of B cell development in the bone marrow (BM). Developing B cells in mutant ali/ali rabbits predominantly utilize VH4 during VDJ gene rearrangement. However, most of the VH4-utilizing B cells encounter a severe block early in B cell development. In contrast, wildtype rabbit B cells predominantly rearrange VH1, a gene >90% identical to VH4, and develop normally. We hypothesized that …

Modeling And Surveillance Of Pandemic Influenza Outbreaks, Diana Prieto

USF Tampa Graduate Theses and Dissertations

Pandemic outbreaks are unpredictable as to their virus strain, transmissibility, and impact on our quality of life. Hence, the decision support models for mitigation of pandemic outbreaks must be user-friendly and operational, and also incorporate valid estimates of disease transmissibility and severity. This dissertation research is aimed at 1) reviewing the existing pandemic simulation models to identify their implementation gaps with regard to usability and operability, and suggesting research remedies, 2) increasing operability of simulation models by calibrating them via an epidemiological model that estimates infection probabilities using viral shedding profiles of concurrent pandemic and seasonal influenza, and 3) developing …