Digital Commons Network^™

January 10, 2011 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

News You Can Use From Uab - Flu, Jim Bakken

Browse All News

No abstract provided.

Sutton, Wyatt Join Uab's Media Relations, Staff

Browse All News

No abstract provided.

When Saving The Environment Hurts The Environment: Balancing Solar Energy Development With Land And Wildlife Conservation In A Warming Climate, Sarah Pizzo

Colorado Environmental Law Journal

No abstract provided.

Antibodies Elicited In Response To Ebna-1 May Cross- React With Dsdna, Pragya Yadav, Hoa Tran, Roland Ebegbe, Paul Gottlieb, Hui Wei, Rita H. Lewis, Alice Mumbey-Wafula, Atira Kaplan, Elina Kholdarova, Linda Spatz

Publications and Research

Background:Several genetic and environmental factors have been linked to Systemic Lupus Erythematosus (SLE). One environmental trigger that has a strong association with SLE is the Epstein Barr Virus (EBV). Our laboratory previously demonstrated that BALB/c mice expressing the complete EBNA-1 protein can develop antibodies to double stranded DNA (dsDNA). The present study was undertaken to understand why anti-dsDNA antibodies arise during the immune response to EBNA-1.

Methodology/Principal Findings: In this study, we demonstrated that mouse antibodies elicited in response to EBNA-1 cross-react with dsDNA. First, we showed that adsorption of sera reactive with EBNA-1 and dsDNA, on dsDNA cellulose …

Screening For Cytomegalovirus During Pregnancy, Stuart P. Adler

Pediatrics Publications

The epidemiology and pathogenesis of CMV infections among pregnant women have been intensely studied over the last three decades. This paper highlights recent developments that make either universal or limited serologic screening for CMV during pregnancy potentially attractive. The developments include an understanding of the pathogenesis of CMV infections, a knowledge of high-risk women, the availability of accurate methods for the serologic diagnosis of a primary CMV infection using either single or serial blood samples, accurate methods for the diagnosis of fetal infection via amniotic fluid, sensitive fetal and placental indicators for neonatal outcomes, and the availability of potentially effective …

Town Report Milford, New Hampshire 2010., Milford Town Representatives

Milford, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Engineering Research 2011, College Of Engineering, Michigan Technological University

Michigan Tech Engineering Magazine

Table of Contents

• Air & Water
• Energy
• Engineered Materials
• Health
• Sensing & Controls
• People
• Research Centers & Institutes

An Introduction To Clinical Decision Support Systems, Mary Moore Phd, Kimberly A. Loper

Faculty Research, Publications, and Presentations

Library support of clinical decision-making ranges from passive (traditional library collections of books and journals) to highly active (professional services, such as clinical medical librarians, LATCH, and informationists). Support of mobile computing resources and subscriptions to services, such as UpToDate and DynaMed, moves libraries toward interactive resources to aid healthcare providers in their decisions about specific patient questions. Librarians seeking to add robust clinical decision support systems should partner with clinicians and medical educators to weigh usability, ability to integrate with electronic health records and other systems, accuracy, reliability, depth of knowledge base, and improvements to process and patient outcomes, …

Getting Ink: A Rhetorical Analysis Of Miami Ink Via Social Stigma And Narrative Paradigm, Joseph Robert Nicola

All Electronic Theses and Dissertations

The following rhetorical analysis examines the various forms of tattoo stigma presented in the first American television program about tattooing, Miami Ink. This work includes the origins of tattoos and their development in North America. Within this framework, the varieties of tattoo stigma are discussed. The theory of Stigma and The Narrative Paradigm Theory are utilized to examine the narratives addressing tattoo stigma presented in Miami Ink.

Prospective Surveillance Of Multivariate Spatial Disease Data, A. Corberan-Vallet, A. B. Lawson

MUSC Department of Public Health Sciences Working Papers

Surveillance systems are often focused on more than one disease within a predefined area. On those occasions when outbreaks of disease are likely to be correlated, the use of multivariate surveillance techniques integrating information from multiple diseases allows us to improve the sensitivity and timeliness of outbreak detection. In this paper, we present an extension of the surveillance conditional predictive ordinate to monitor multivariate spatial disease data. The proposed surveillance technique, which is defined for each small area and time period as the conditional predictive distribution of those counts of disease higher than expected given the data observed up to …

Applying The Swot Analysis On Egyptian Nonprofit Organizations: A Case Study Of Future Protectors For Care And Development Association, Nashwa Ghoneim

Papers, Posters, and Presentations

The civil society has taken a very active role in the quest for democracy that continues to spread across the continents till it reached the Middle East region only recently. This is clear given the successive revolts that have taken place in many of the Arab countries calling for real democracy. Therefore, especially in Egypt, efforts should be directed toward defending civil society organizations and activists who are being threatened by the coercive authoritarian government actions over the past decades (Naidoo, 2007).

Nursing Annual Report 2010, Children's Mercy Hospital

Nursing Annual Reports

Annual report for nursing services at Children's Mercy Kansas City.

From The Big Apple To Big Ben: An Insight Into Menu Labeling, Liza M. Escapa Lima

ILSA Journal of International & Comparative Law

Imagine looking around and recognizing that you are much heavier than your fellow peers.

Spread Of Plague Among Black-Tailed Prairie Dogs Is Associated With Colony Spatial Characteristics, Christopher Frey, Tammi L. Johnson, Jack Cully Jr., Sharon K. Collinge, Chris Ray, Brett Sandercock

Faculty Publications

Sylvatic plague (Yersinia pestis) is an exotic pathogen that is highly virulent in black-tailed prairie dogs (Cynomys ludovicianus) and causes widespread colony losses and individual mortality rates >95%. We investigated colony spatial characteristics that may influence inter-colony transmission of plague at 3 prairie dog colony complexes in the Great Plains. The 4 spatial characteristics we considered include: colony size, Euclidean distance to nearest neighboring colony, colony proximity index, and distance to nearest drainage (dispersal) corridor. We used multi-state mark–recapture models to determine the relationship between these colony characteristics and probability of plague transmission among prairie dog colonies. Annual mapping of …

National Center For Pharmaceutical Crops, Wei Yuan, Shiyou Li, Zushang Su, Ping Wang

NCPC Presentations

The mission of the National Center for Pharmaceutical Crops is to develop crops for the production of pharmaceutical and other bioactive compounds. The NCPC, located in the Arthur Temple College of Forestry and Agriculture, is the only one of its kind in the U.S. and it seeks to improve human health, revitalize rural economies and enhance U.S. security in strategic pharmaceuticals. This poster provides a background to the department, its functions and activities and notable achievements.

Caring For Compromised Cattle: Assessing Animals At Risk

Nebraska Beef Quality Assurance Program

Cattlemen have long recognized the need to properly care for their livestock. Sound animal husbandry practices – based on research and decades of practical experience – are known to impact the well-being of cattle, individual animal health and herd productivity. There is no doubt that producers work hard to ensure that their cattle are properly cared for throughout all stages of production. Unfortunately, it’s a fact of raising cattle that some animals will become injured to the extent that they are unable to stand or walk without assistance.

The Prevalence Of Canine Leishmania Infantum Infection In Western China Detected By Pcr And Serological Tests, Jun-Yun Wang, Yu Ha, Chun-Hua Gao, Yong Wang, Yue-Tao Yang, Hai-Tang Chen

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Canine leishmaniasis (CanL) is endemic in western China, resulting in important public health problem. It is essential to evaluate the prevalence of canine Leishmania infantum infection for designing control policy. In the present study we report for the first time prevalence of Leishmania infection in dogs living in Jiuzhaigou County (Sichuan Provence, China), which is not only an important endemic area of CanL but also a tourism scenic spot, detected by PCR, ELISA and dipstick test. The results could provide key information for designing control programs against canine and human leishmaniasis. In addition, the complete sequence of the …

Governance And Biosecurity: Strengthening Security And Oversight Of The Nation's Biological Agent Laboratories, Michael Greenberger, Talley Kovacs, Marita Mike

Faculty Scholarship

Since the advent of the Anthrax attacks in the fall of 2001, the United States has been confronted with a serious policy conundrum. On the one hand, we have strengthened programs that encourage the use of our best scientific resources to develop countermeasures to the weaponization of highly dangerous biopathogens. On the other hand, research on those countermeasures requires the use of the very biopathogens we seek to defeat. There have been many mishaps in the handling of those pathogens, which raises the frightening prospect that the research may be as (or more) dangerous than bioterrorist acts themselves. Indeed, the …

Checkup, Lehigh Valley Health Network

Checkup

No abstract provided.

Annual Report (2011): Together We Are A Symphony Of Care, Lehigh Valley Health Network

LVHN Annual & Statistical Reports

No abstract provided.

Annual Report (2011): Greater Hazleton Health Alliance; Community Service Report, Lehigh Valley Health Network

LVHN Annual & Statistical Reports

No abstract provided.

Coupling Sensitive In Vitro And In Silico Techniques To Assess Cross-Reactive Cd4+ T Cells Against The Swine-Origin H1n1 Influenza Virus, Brian C. Schanen, Anne S. De Groot, Leonard Moise, Matt Ardito, Elizabeth Mcclaine, William Martin, Vaughan Wittman, William L. Warren, Donald R. Drake Iii

Institute for Immunology and Informatics Faculty Publications

The outbreak of the novel swine-origin H1N1 influenza in the spring of 2009 took epidemiologists, immunologists, and vaccinologists by surprise and galvanized a massive worldwide effort to produce millions of vaccine doses to protect against this single virus strain. Of particular concern was the apparent lack of pre-existing antibody capable of eliciting cross-protective immunity against this novel virus, which fueled fears this strain would trigger a particularly far-reaching and lethal pandemic. Given that disease caused by the swine-origin virus was far less severe than expected, we hypothesized cellular immunity to cross-conserved T cell epitopes might have played a significant role …

Helicovax: Epitope-Based Therapeutic Helicobacter Pylori Vaccination In A Mouse Model, Steven F. Moss, Leonard Moise, Dong Soo Lee, Woojin Kim, Songhua Zhang, Jinhee Lee, Arlin B. Rogers, William Martin, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Helicobacter pylori is the leading cause of gastritis, peptic ulcer disease and gastric adenocarcinoma and lymphoma in humans. Due to the decreasing efficacy of anti-H. pylori antibiotic therapy in clinical practice, there is renewed interest in the development of anti-H. pylori vaccines. In this study an in silico-based approach was utilized to develop a multi-epitope DNA-prime/peptide-boost immunization strategy using informatics tools. The efficacy of this construct was then assessed as a therapeutic vaccine in a mouse model of gastric cancer induced by chronic H. pylori infection. The multi-epitope vaccine administered intranasally induced a broad immune response as determined …

Harnessing The Power Of Genomics And Immunoinformatics To Produce Improved Vaccines, Leonard Moise, Leslie Cousens, Joanna Fueyo, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

The role of cellular immunity as a mediator of protection against disease is gaining recognition, particularly with regard to the many pathogens for which we presently lack effective vaccines. As a result, there is an ever-increasing need to understand the T-cell populations induced by vaccination and, therefore, T-cell epitopes responsible for triggering their activation. Although the characterization and harnessing of cellular immunity for vaccine development is an active area of research interest, the field still needs to rigorously define T-cell epitope specificities, above all, on a genomic level. New immunoinformatic epitope mapping tools now make it possible to identify pathogen …

One Session Of Ttm-Tailored Condom Use Feedback: A Pilot Study Among At-Risk Women In The Bronx, Colleen A. Redding, Pamela Brown-Peterside, Seth M. Noar, Joseph S. Rossi, Beryl A. Koblin

Cancer Prevention Research Center Faculty Publications

There is an urgent need to implement interventions to curb the spread of sexually transmitted infections (STIs), especially HIV. Consistent condom use is an effective preventive strategy, yet especially among those at highest risk, condom use remains too low. This paper describes changes in condom use and stages of condom use over two–three months time following a single session with an interactive multimedia computer-delivered Transtheoretical Model (TTM)-tailored expert system originally designed for at-risk adolescents. The intervention provided immediate TTM-tailored feedback to diverse urban women based on their stage of condom use and other TTM variables. Previous work found this system …

Individual Physician Versus Team-Based Medical Encounters: Maximizing The Efficiency Of A Medical Relief Service In Rural Honduras, Rachel Whitney, Michael P. Stevens, Gonzalo M. L. Bearman

Internal Medicine Publications

Background. For several years, the Virginia Commonwealth University (VCU) Department of Internal Medicine has traveled to the towns of La Hicaca and Coyoles in rural Honduras. In 2010, a new encounter method was employed during the brigade in Coyoles. Objectives. To examine the differences in clinical encounters and adherence with chronic diseases and public health screening between the traditional and team-based encounter methods. Methods. Chi-square analysis was used to determine statistical significance between encounter methods over several variables used in the standard interview form. Results. 314 patients were interviewed using the team-based approach, and 153 patients were interviewed with the …

Using Law To Fight A Silent Epidemic: The Role Of Healthy Literacy In Health Care Access, Quality & Cost, Brietta Clark

Annals of Health Law and Life Sciences

The dominant rhetoric in the health care policy debate about cost has assumed an inherent tension between access and quality on the one hand, and cost effectiveness on the other; but an emerging discourse has challenged this narrative by presenting a more nuanced relationship between access, quality, and cost. This is reflected in the discourse surrounding health literacy, which is viewed as an important tool for achieving all three goals. Health literacy refers to one's ability to obtain, understand and use health information to make appropriate health decisions. Research shows that improving patients' health literacy can help overcome access barriers …

Dendritic Cells Induce Antigen-Specific Regulatory T Cells That Prevent Graft Versus Host Disease And Persist In Mice, Uri Sela, Peter Olds, Andrew Park

Publications

Foxp3 ⁺ regulatory T cells (T reg cells) effectively suppress immunity, but it is not determined if antigen-induced T reg cells (iT reg cells) are able to persist under conditions of inflammation and to stably express the transcription factor Foxp3. We used spleen cells to stimulate the mixed leukocyte reaction (MLR) in the presence of transforming growth factor β (TGF-β) and retinoic acid. We found that the CD11c ^high dendritic cell fraction was the most potent at inducing high numbers of alloreactive Foxp3 ⁺ cells. The induced CD4 ⁺CD25 ⁺Foxp3 ⁺ cells appeared after extensive proliferation. When purified …

Synthetic Double-Stranded Rna Induces Innate Immune Responses Similar To A Live Viral Vaccine In Humans, Marina Caskey, François Lefebvre, Ali Filali-Mouhim

Publications

Adjuvants are critical for the success of vaccines. Agonists of microbial pattern recognition receptors (PRRs) are promising new adjuvant candidates. A mechanism through which adjuvants enhance immune responses is to stimulate innate immunity. We studied the innate immune response in humans to synthetic double-stranded RNA (polyinosinic:polycytidylic acid [poly IC] stabilized with poly-l-lysine [poly ICLC]), an agonist for toll-like receptor (TLR) 3, and the cytosolic RNA helicase MDA-5. Transcriptional analysis of blood samples from eight volunteers, after subcutaneous administration of poly ICLC, showed upregulation of genes involved in multiple innate immune pathways in all subjects, including interferon (IFN) and inflammasome signaling. …