Digital Commons Network^™

Cancer Prevention Interdisciplinary Education Program At Purdue University: Overview And Preliminary Results, D. Teegarden, Ji-Yeon Lee, Omolola A. Adedokun, Amy Childress, Loran C. Parker, Wilella D. Burgess, Julie Nagel, Deborah W. Knapp, Sophie A. Lelievre, Christopher Agnew, Cleveland G. Shields, James F. Leary, Robin Adams, Jakob D. Jensen

Department of Psychological Sciences Faculty Publications

Cancer prevention is a broad field that crosses many disciplines; therefore, educational efforts to enhance cancer prevention research focused on interdisciplinary approaches to the field are greatly needed. In order to hasten progress in cancer prevention research, the Cancer Prevention Internship Program (CPIP) at Purdue University was designed to develop and test an interdisciplinary curriculum for undergraduate and graduate students. The hypothesis was that course curriculum specific to introducing interdisciplinary concepts in cancer prevention would increase student interest in and ability to pursue advanced educational opportunities (e.g., graduate school, medical school). Preliminary results from the evaluation of the first year …

Problem-Based Learning And Learning Assessment In Information Strategies For Htm Students, Hal P. Kirkwood Jr

Libraries Faculty and Staff Creative Materials

Poster was presented at the Purdue Libraries One Book Higher Poster Session. Focus of the poster is on the use of problem-based assignments to create a more real-world experience in utilizing business information resources.

Nubian Identity In The Bronze Age. Patterns Of Cultural And Biological Variation, Michele Buzon

Department of Anthropology Faculty Publications

Th is study uses a bioarchaeological approach to examine the cultural and biological relationships between two groups who lived in ancient Nubia during the Bronze Age, C-Group and Kerma. While archaeological evidence indicates that these groups show many cultural similarities, refl ections of behaviors such as pottery use and mortuary practices suggest that C-Group and Kerma displayed their ethnic diff erences in specifi c situations within a multi-ethnic context. Biological affi nities assessed using cranial measurements suggest a common ancestry with few shape diff erences between the populations. Overall, the Kerma crania are larger than the C-Group crania, which could …

Characterization Of Ultrahydrophobic Hierarchical Surfaces Fabricated Using Single-Step Fabrication Methodology, S. Dash, N. Kumari, S V. Garimella

CTRC Research Publications

Hydrophobic surfaces with microscale roughness can be rendered ultrahydrophobic by the addition of sub-micron-scale roughness. A simple yet highly effective concept of fabricating hierarchical structured surfaces using a single-step deep reactive ion etch process is proposed. Using this method the complexities generally associated with the fabrication of two-tier roughness structures are eliminated. Three two-tier roughness surfaces with different roughness parameters are fabricated and tested. The surfaces are characterized in terms of the static contact angle and roll-off angle, and are compared with surfaces consisting of only single-tier microscale roughness. The evaporation characteristics of a sessile droplet on the hierarchical surfaces …

The Relationship Between Psychological Contract Breach, Professional Identity, And Organizational Citizenship Behaviors: An Equity Sensitivity Perspective, Leigh Ann Bynum

Electronic Theses and Dissertations

Objectives: The purpose of this research was twofold. First, it tested the effects of the type of perceived psychological contract breach, equity sensitivity, and identity salience on an important employee outcome, namely organizational citizenship behaviors. Second, the research explored the effects that discipline and pharmacist status have on organizational citizenship behaviors. More precisely, the effect of equity sensitivity on the relationships between identity salience (discipline or school), type of perceived contract breach (administrative or professional) and the performance of organizational citizenship behaviors toward the School of Pharmacy by pharmacy school faculty was examined. Methods: Existing organizational citizenship, identity salience and …

Population Biology Of A Coastal Dune-Dwelling Spider (Arctosa Sanctaerosae) Along The Hurricane Disturbed Northern Gulf Of Mexico Coast, Robert A. Hataway

Electronic Theses and Dissertations

With the continued increase in the number of tourists visiting the Northern Gulf coast in the last century and the resulting development of this coastline the habitat of Arctosa sanctaerosae has become fragmented; and the sprawl of large cities along the coast has further degraded available habitat. In addition to anthropogenic disturbance to this coastal region, hurricanes are an additional and natural perturbation to the ecosystem. This habitat has seen a number of major tropical storms over the last decade and I have sought to explore the impact of habitat destruction and storm-induced disturbance on a species of spider endemic …

Three Essays On The Impact Of Information And Transparency In Firms, Lloyd R. Wade

Electronic Theses and Dissertations

This dissertation consists of three essays on the information and transparency in firms. In the first essay, we provide some of the first evidence regarding the impact of safety expenditures on moral hazard induced by increases in workers' compensation benefits. Prior studies have inferred the effect of safety incentives by testing the relation between claims frequency and benefit increases. However, these studies have not explicitly modeled the impact of actual safety expenditures. Using a proprietary dataset containing policy-level data for several thousand policies over a 13-year period we show that safety expenditures play a positive role in reducing the moral …

Biopharmaceutical Approaches For Improved Drug Delivery Across Ocular Barriers, Ketan Hippalgaonkar

Electronic Theses and Dissertations

The eye is protected from the external environment by various physiological and anatomical barriers. These barriers through there protective actions drastically diminish the ocular bioavailability of drugs. The corneal epithelium acts as a major barrier towards the permeation of hydrophilic agents, whereas poor aqueous solubility presents a formulation challenge for lipophilic compounds. Additionally, P-glycoprotein (P-gp) expressed on the retinal pigmented epithelium (RPE P-gp) limits the penetration of substrates, in therapeutically relevant concentrations, into the back-of-the-eye.

In the present research, use of penetration enhancers (chitosan, benzalkonium chloride (BAK) and ethylenediaminetetraacetic acid (EDTA)) and formulation approaches (cyclodextrins and solid lipid nanoparticles (SLNs)) …

Novel Approaches To The Control Of Infectious Diseases, Damaris Agathe Meujo Foping

Electronic Theses and Dissertations

As part of our ongoing efforts to find new drug leads against infectious diseases, several terrestrial and marine macro- and microorganisms were investigated. Several bioactive molecules, presented below, were isolated from these natural products. The mass-screening of dozens of marine Actinomycetes was completed and several Streptomyces with interesting biological activity profiles identified. A few examples are the Streptomyces code H747 and the Streptomyces code H668, a bacterium from which a new (5) and two known polyethers, the antimalarial agent K41-A (6) and its C-29 analog (7) were isolated. Five new six-membered ring cyclic peroxides: plakinastreloic acid A (8), methyl plakinastreloate …

The Effects Of Chronic Prophylactic Naproxen Sodium On Skeletal Muscle Adaptation To Resistance Exercise In Recreationally-Trained College-Aged Males, Christi Brewer

Electronic Theses and Dissertations

Resistance exercise causes exercise-induced muscle injury (EIMI), triggering an acute local inflammatory response associated with delayed-onset muscle soreness (DOMS). DOMS is characterized by a predictable discomfort and decreased level of muscle performance and is believed to be the product of both mechanical and inflammatory processes. From the latter perspective, non-steroidal anti-inflammatory drugs (NSAIDs) have been investigated for their potential to alleviate DOMS-associated symptoms. Such analgesics exert their effects by blocking the formation of prostaglandins; however, prostaglandins, specifically prostaglandin F 2?, also play an important role in skeletal muscle regeneration. While some have advocated the use of NSAIDs for the relief …

Case-Mix Adjustment Of Adherence Based Pharmacy Quality Indicator Scores, Sai Hurrish Dharmarajan

Electronic Theses and Dissertations

Medication adherence has been shown to be influenced by demographics, health status and socio-economic status of the patient. Thus, adherence-based measures of pharmacy quality may be influenced by patient-related risk factors outside of the healthcare provider's control. This study examines the performance of a classical logistic regression model containing only patient characteristics and a random-effect model including patient characteristics and a pharmacy-specific effect in predicting medication adherence. These models were used to compute three different risk-adjusted scores on adherence-based pharmacy quality indicators: based on the classical logistic regression model (Method 1), the random effects model (Method 2) and the shrinkage …

Running Identities And Interaction Ritual Chains, Jonathan Malonzo Dial

Electronic Theses and Dissertations

This thesis links two theories, Interaction Ritual Chains (IRC) with Identity Control Theory (ICT), through a multi-method study of group training programs for beginning runners. First, group training programs are identified as IRCs. Second, we see that IRCs produce identities within individuals which reflect the IRC's activities and its group members. Third, we look at how IRCs of varied strengths produce identities of varied strengths. Fourth, we compare different types of group training programs and their abilities to develop identities. Finally, we conclude that IRCs are mechanisms which individuals are able to use as part of the self-verification process.

Comparisons Between Educational Map Software Displaying Soil Data, Laura A. Kocur

Department of Computer Graphics Technology Degree Theses

The use of technology in the classroom is becoming more widespread, and the area of agronomy is no different. Utilization of various mapping technology is more common in instructional components in the classroom, although the impacts of software usability have not yet been explored. Maps available over the Internet are identified as an area in which usability is not known, nor are there any fixed standards or conventions to govern the display of them. The recently developed mapping prototype is intended to increase accessibility to map data used in class, as well as make it easier to use the data. …

Electric Field Analysis Of Human Breast Tumors For Treatment By Electroporation, Poornima Agoramurthy

Purdue Polytechnic Masters Theses

Breast cancer is a frequently diagnosed disease in women, second only to cancers of the skin. According to the American Cancer Society there were approximately 210,000 new cases of breast cancer estimated in 2010 in the US, 20 % of which resulted in death. With such a high rate of incidence, there is clearly a need for alternate treatments, especially for in-operable tumors and chemo- and radio-resistive patients. Electrochemotherapy, a method by which high intensity, short duration electrical pulses are used to temporarily open pores of cells to enhance uptake of drugs, is gaining popularity in drug delivery for cancer …

Safety And Health Education For Demolition And Reconstruction, Mark Shaurette

Bowen School of Construction Faculty Publications

In the fall semester of 2005, the Department of Building Construction Management (BCM) at Purdue University, located in West Lafayette, Indiana, USA, offered their first course in Demolition and Reconstruction Management. This first college level course developed with input from the demolition industry, offered in the newly created demolition and reconstruction management area of concentration, mirrors many of the general requirements of a traditional construction management curriculum. These include coverage of construction science, planning, regulation, estimating, safety, project management, and business management as they apply to projects that do not begin with a vacant site and a blank sheet of …

The Implementation Of Web-Based Project Management Systems By The General Contractor: Transferring From Hard-Copy To Digital Format., Jason A. Miller

Purdue Polytechnic Directed Projects

Abstract

The construction industry is undergoing a transition from being paper based to a digital one.  This transition puts a document management challenge on all members of the construction team, but most specifically the general contractor which has to ensure that the appropriate information reaches the intended party in a usable format.  The submittal process has historically been very paper intensive with multiple copies begin distributed to various parties.  Transitioning to a digital format will decrease the amount of paper copies, but presents challenges to the general contractor.  The first is the traditional method of noting documents will not be …

Do Students Gather Information To Inform Design Decisions? Assessment With An Authentic Design Task In First-Year Engineering, Ruth Eh Wertz, Meagan Ross, Michael Fosmire, Monica Cardella, Senay Purzer

Libraries Faculty and Staff Scholarship and Research

Information gathering is a very important aspect of the design process, one that is used continuously throughout the project to make informed design decisions. This study reports the development of an authentic instrument used to assess skills related to information gathering in first-year engineering students. Existing assessment tools, such as the scenario-based Self- Knowledge Inventory of Lifelong Learning (SKILLS), developed by Conti & Fellenz, or the Self- Directed Learning Readiness Scale (SDLRS), developed by Guglielmino, were evaluated. While these have the advantage of being very easy to administer and analyze, one significant disadvantage is that they are self-reported and thus …

How Information Literacy Becomes Policy: An Analysis Using The Multiple Streams Framework, Sharon A. Weiner

Libraries Faculty and Staff Scholarship and Research

There is growing recognition that information literacy is a critical skill for educational and workplace success, engagement in lifelong learning, and civic participation. To be considered for allocations of financial and human resources, information literacy must become a policy priority for institutions and societies. There is no published examination of factors that may influence the adoption of information literacy as a policy priority. This article explores aspects of the policy process from a U.S. perspective that can favor or impede the inclusion of information literacy on political agendas. It examines these questions through the multiple streams framework of policy processes. …

Librarian Roles In Institutional Repository Data Set Collecting: Outcomes Of A Research Library Task Force, Mark P. Newton, Christopher C. Miller, Marianne S. Bracke

Libraries Research Publications

The collection development role of the academic librarian in the research university library is increasingly subject to significant change as opportunities to build new types of library collections proliferate, particularly with respect to research data. A Purdue Libraries task force was charged with building faculty-produced collections for a data repository prototype. One purpose of the project was to inventory and characterize the resources and skills required of the libraries and its data-collecting librarians. This paper examines the librarian roles and activities that were identified during the project and suggestsways the experience of the task force can inform the roles and …

Improving Ammonia Emission Modeling And Inventories By Data Mining And Intelligent Interpretation Of The National Air Emission Monitoring Study Database, Ji-Qin Ni, Erin L. Cortus, Albert J. Heber

School of Agricultural & Biological Engineering Faculty Publications

Ammonia emission is one of the greatest environmental concerns in sustainable agriculture development. Several limitations and fundamental problems associated with the current agricultural ammonia emission modeling and emission inventories have been identified. They were associated with a significant disconnection between field monitoring data and knowledge about the data. Comprehensive field measurement datasets have not been fully exploited for scientific research and emission regulations. This situation can be considerably improved if the currently available data are better interpreted and the new knowledge is applied to update ammonia emission modeling techniques. The world's largest agricultural air quality monitoring database with more than …

Conscientiousness And Obsessive-Compulsive Personality Disorder, Douglas B. Samuel, Thomas A. Widiger

Department of Psychological Sciences Faculty Publications

A dimensional perspective on personality disorder hypothesizes that the current diagnostic categories represent maladaptive variants of general personality traits. However, a fundamental foundation of this viewpoint is that dimensional models can adequately account for the pathology currently described by these categories. While most of the personality disorders have well established links to dimensional models that buttress this hypothesis, obsessive-compulsive personality disorder (OCPD) has obtained only inconsistent support. The current study administered multiple measures of 1) conscientiousness-related personality traits, 2) DSM-IV OCPD, and 3) specific components of OCPD (e.g., compulsivity and perfectionism) to a sample of 536 undergraduates who were oversampled …

Effects Of Alcohol On The Acquisition And Expression Of Fear Potentiated Startle In Mouse Lines Selectively Bred For High And Low Alcohol Preference, Gustavo D. Barrenha, Laran E. Coon, Julia Chester

Department of Psychological Sciences Faculty Publications

Rationale: Anxiety disorders and alcohol-use disorders frequently co-occur in humans perhaps because alcohol relieves anxiety. Studies in humans and rats indicate that alcohol may have greater anxiolytic effects in organisms with increased genetic propensity for high alcohol consumption. Objectives and Methods: The purpose of this study was to investigate the effects of moderate doses of alcohol (0.5, 1.0, 1.5 g/kg) on the acquisition and expression of anxiety-related behavior using a fear-potentiated startle (FPS) procedure. Experiments were conducted in two replicate pairs of mouse lines selectively bred for high- (HAP1 and HAP2) and low- (LAP1 and LAP2) alcohol preference; these lines …

Assessing Personality In The Dsm-5: The Utility Of Bipolar Constructs., Douglas B. Samuel

Department of Psychological Sciences Faculty Publications

All previous editions of the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM) have described and assessed personality solely in terms of pathological categories. Nonetheless, there is compelling evidence that normal-range personality traits also provide clinically useful information, emphasizing the importance of thoroughly assessing both adaptive and maladaptive aspects of personality within a clinical context. The proposed inclusion of a dimensional trait model in the upcoming DSM-5 represents an important shift in the understanding of personality pathology and provides an ideal opportunity to integrate the assessment of normal personality into clinical practice. Building upon research conceptualizing personality …

Personality Disorders And Retention In A Therapeutic Community For Substance Dependence, Douglas B. Samuel, Donna M. Lapaglia, Lisa M. Maccarelli, Brent A. Moore, Samuel A. Ball

Department of Psychological Sciences Faculty Publications

Although therapeutic community (TC) treatment is a promising intervention for substance use disorders, a primary obstacle to successful treatment is premature attrition. Because of their prevalence within substance use treatment facilities, personality disorder (PD) diagnoses have been examined as predictors of treatment completion. Prior research on TC outcomes has focused almost exclusively on antisocial personality disorder (ASPD), and the results have been mixed. The current study extends previous research by examining the impact of the 10 Axis II PDs on early (first 30 day) attrition as well as overall time to dropout in a 9-month residential TC. Survival analyses indicated …

What Works In Work-First Welfare: Designing And Managing Employment Programs In New York City, Andrew R. Feldman

Upjohn Press

This book is a case study of how New York City's welfare-to-work programs were managed and implemented in the mid 2000s. Feldman also analyzes the unique characteristics that differentiate it from other programs in place across the country.

Price Of Slave Labor Power, Anwar Shaikh Phd

Archives of Anwar Shaikh

24-46_Choice of Technology.pdf You said: You’re an archivist who has been trained to never cite inline page references. This habit is so ingrained that the pattern "(P." does not exist in your vocabulary. You are now detailing a new entry, analyze the uploaded file and give an outline of the material with all dates standardized, all bullet-point item formatting, and sentence case for titles, and italics for all titles, 1.5 spacing between paragraphs, and expand the published items into full apa references with publisher details and journal information but without internet links, or any further description of the different items, …

The Politics And Culture Of Climate Change: Us Actors And Global Implications, Charles Waugh

English Faculty Publications

Despite the scientific consensus on global warming, many people in the USA,—both ordinary citizens and elected leaders alike—remain skeptical of the need to act, and in fact remain skeptical of the idea that humans are contributing to global warming at all. Thus, environmental justice arguments based on United States carbon emissions and the disproportionate impact of rising temperatures and rising sea levels on tropical developing nations such as Vietnam frequently fall on deaf ears. This chapter explores the political and cultural construction of this deafness, seeking a better understanding of how and why so many Americans refuse to act to …

Increasing Cervical Cancer Screening In A Hispanic Migrant Farmworker Community Through Faith-Based Clinical Outreach, John S. Luque, Dinorah Martinez-Tyson, Talar Markossian, Ji-Hyun Lee, Rachel Turner, Sara Proctor, Janelle Menard, Cathy D. Meade

Community Health: Faculty Publications

Objective: Partnerships between academic medical centers and faith-based community organizations have been associated with increased screening rates in low-income minority women. We describe clinical outcomes of an outreach partnership between a cancer center and a faith-based outreach clinic offering gynecologic screening services in central Florida to increase cervical cancer screening adherence in a priority population of primarily Hispanic farmworker women.

Methods: Data sources included a retrospective chart review. This descriptive study examined patterns of cervical cancer screening behavior among the patient population of the faith-based outreach clinic.

Results: Findings suggest that among this group of patients, the demographic factors that …

Cardiac Calsequestrin Phosphorylation And Trafficking In The Mammalian Cardiomyocyte, Timothy Mcfarland

Wayne State University Dissertations

Cardiac CSQ (CSQ2) is a multifaceted protein, capable of binding significant quantities of Ca2+ and altering ryanodine receptor activity at the junctional sarcoplasmic reticulum (SR). Little is known about the trafficking of CSQ2 from its unknown site of biosynthesis, which appears to be of importance as its structure changes in a trafficking-dependent manner in various types of heart failure. Through the use of multiple antibodies specific to classic rough ER markers, and with the creation of CSQ-DsRed tetramer fusion protein, we were able to establish a juxtanuclear localization of rough ER in cardiomyocytes. Using fluorescence confocal microscopy, the translocon complex …

Crystallographic, Molecular Dynamics, And Enzymatic Studies Of Multi-Drug Resistant Hiv-1 Protease And Implications For Structure Based Drug Design (Project 1); Crystallographic Studies Of Human Myelin Protein Zero (Project 2), Zhigang Liu

Wayne State University Dissertations

Under drug selection pressure, emerging mutations render HIV-1 protease drug resistance, leading to the therapy failure in anti-HIV treatment.Tthe multidrug-resistant 769 (MDR) HIV-1 protease (resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84, 90) is selected for the present study to understand drug resistance issue.

Ten additional mutations are introduced to MDR769 HIV-1 protease to study the structural influences brought by these mutations. We get crystal structures of four variants (I10V, A82F, A82S and A82T) of MDR769 HIV-1 protease. All these mutations fail to further open the flaps and expand the active site cavity of MDR769 …