Digital Commons Network^™

Lymphotoxin-Beta Receptor Blockade Reduces Cxcl13 In Lacrimal Glands And Improves Corneal Integrity In The Nod Model Of Sjögren's Syndrome, Roy A. Fava, Susan M. Kennedy, Sheryl G. Wood, Anne I. Bolstad, Jadwiga Bienkowska, Adrian Papandile, John A. Kelly

Dartmouth Scholarship

In Sjögren's syndrome, keratoconjunctivitis sicca (dry eye) is associated with infiltration of lacrimal glands by leukocytes and consequent losses of tear-fluid production and the integrity of the ocular surface. We investigated the effect of blockade of the lymphotoxin-beta receptor (LTBR) pathway on lacrimal-gland pathology in the NOD mouse model of Sjögren's syndrome.

Erect Wing Facilitates Context-Dependent Wnt/Wingless Signaling By Recruiting The Cell-Specific Armadillo-Tcf Adaptor Earthbound To Chromatin, Nan Xin, Hassina Benchabane, Ai Tian, Kerrie Nguyen, Lindsay Klofas, Yashi Ahmed

Dartmouth Scholarship

During metazoan development, the Wnt/Wingless signal transduction pathway is activated repetitively to direct cell proliferation, fate specification, differentiation and apoptosis. Distinct outcomes are elicited by Wnt stimulation in different cellular contexts; however, mechanisms that confer context specificity to Wnt signaling responses remain largely unknown. Starting with an unbiased forward genetic screen in Drosophila, we recently uncovered a novel mechanism by which the cell-specific co-factor Earthbound 1 (Ebd1), and its human homolog jerky, promote interaction between the Wnt pathway transcriptional co-activators B-catenin/Armadillo and TCF to facilitate context-dependent Wnt signaling responses. Here, through the same genetic screen, we find an unanticipated requirement …

Combined Fluorescence And Reflectance Spectroscopy For In Vivo Quantification Of Cancer Biomarkers In Low- And High-Grade Glioma Surgery, Pablo A. ValdéS, Anthony Kim, Keith D. Paulsen, Frederic Leblond, Olga M. Conde, Brent T. Harris, David W. Roberts

Dartmouth Scholarship

Biomarkers are indicators of biological processes and hold promise for the diagnosis and treatment of disease. Gliomas represent a heterogeneous group of brain tumors with marked intra- and inter-tumor variability. The extent of surgical resection is a significant factor influencing post-surgical recurrence and prognosis. Here, we used fluorescence and reflectance spectral signatures for in vivo quantification of multiple biomarkers during glioma surgery, with fluorescence contrast provided by exogenously-induced protoporphyrin IX (PpIX) following administration of 5-aminolevulinic acid. We performed light-transport modeling to quantify multiple biomarkers indicative of tumor biological processes, including the local concentration of PpIX and associated photoproducts, total hemoglobin …

Sorting Through The Junk Box: Dickens's Objects And The Great Exhibition Of 1851, Audrey Raymi Grounds

USF Tampa Graduate Theses and Dissertations

In Bleak House , Dickens satirizes contemporary conditions in London in order to diagnose what he sees as social and industrial ills to prescribe a solution to the "Condition-of-England" question. Beginning with a review of the topicality in the novel, I use Dickens's personal letters, the text of Bleak House , and articles from Household Words to explain his contempt with the Great Exhibition, misguided philanthropy, and sanitary conditions, among others. Ultimately, it is his anathema to the Great Exhibition which drives both Dickens's plot and the issues he explores. Dickens's mockery of England is refracted and emphasized through his …

Portland Public Schools Enrollment Forecasts, 2011-12 To 2025-26, Based On October 2010 Enrollments, Portland State University. Population Research Center, Charles Rynerson, Vivian Siu, David West

School District Enrollment Forecast Reports

In Fall 2011, Portland Public Schools (PPS) enrolled 46,206 students in grades K-12, an increase of 465 students from Fall 2010. This is the third consecutive year of enrollment growth, following 12 consecutive years of enrollment losses that occurred between 1996- 97 and 2008-09. For the three year period since 2008-09, PPS K-12 enrollment has grown by 1,182 students, or 2.6 percent. In seven of the past eight years, actual K-12 enrollment in the first year of the forecast has been within 300 students of the medium scenario characterized as the “most likely” Enrollment Forecast in reports similar to this …

Litigating Bp's Contribution Claims In Publicly Subsidized Courts: Should Contracting Parties Pay Their Own Way?, Bruce L. Hay, Christopher Rendall-Jackson, David Rosenberg

Vanderbilt Law Review

In this Article, we focus on an important problem involving mass-accident cases that was highlighted by the Deepwater Horizon litigation: overuse of courts to enforce contribution claims. These claims seek to shift incurred or expected liability and damages between the business and governmental entities that participated in the activity that gave rise to the mass-accident risk. Participants in such ventures generally have the option to determine by contract beforehand whether to subject themselves to contribution claims and, if so, whether such claims will be resolved by a publicly funded court or by a privately funded process, such as arbitration. Because …

Promotion, Prevention Or Both: Regulatory Focus And Culture Revisited, Jenny Kurman, Chin Ming Hui

Online Readings in Psychology and Culture

Regulatory focus theory (e.g., Higgins, 1997) presented a differentiation between promotion orientation, focused on growth and advancement, and prevention orientation, focused on safety and security. Cross-culture differences in these systems generally show that that collectivist, Eastern cultures (mostly East-Asian cultures) are considered as prevention oriented whereas Western cultures are considered as promotion oriented. Two main claims that contribute to the refinement of the relations between culture and regulatory foci will be presented. The first refinement pertains to the relations between individualism-collectivism and regulatory foci on base of the vertical-horizontal distinction, showing that vertical collectivism is especially relevant to regulatory foci. …

Communication And Cultural Competence: The Acquisition Of Cultural Knowledge And Behavior, Jianglong Wang

Online Readings in Psychology and Culture

This essay expounds on individuals’ acquisition and development of cultural competence via the process of communication. It highlights both the importance of culture and communication in our lives and the close associations between culture, communication, cultural literacy, and cultural competence. The author explicates the commonly experienced difficulty in “knowing the true face” of one’s culture, and illuminates the communication process by which individuals acquire their cultural knowledge and behavior.

Development And Initial Validation Of The Managerial Success Factors Inventory: Transportation Version (Msfi: Tv), Michael Robert Durr Ii

Electronic Theses and Dissertations

The purpose of this study was to develop and initially validate the Managerial Success Factors Inventory: Transportation Version (MSFI: TV), a scale generated to more accurately assess managerial competence in transportation than general managerial competence and leadership scales. The literature on managerial competencies, leadership, and the state of transportation management is summarized. Reigning models of general managerial competency were used with focus group and cognitive interview data to develop the scale. The conventional three-phase scale development research design was followed (exploratory factor analysis, confirmatory factor analysis, and validation phases) by administering the instrument to a sample of 287 managers from …

Vesicular Stomatitis Virus In The Treatment Of Hepatocellular Carcinoma, Celene Joza

Animal Science

No abstract provided.

Post Hurricane Katrina-Rita Planning, Recovery And Resiliency, New Orleans, Louisiana 2005-2011: Faith + Fortitude + Plans = Resurrection, James R. Amdal

UNOTI Publications

No abstract provided.

Review Essay: The Vatican—Two Accounts, David Reese

The US Army War College Quarterly: Parameters

No abstract provided.

Which Measures Of Physical Function And Motor Impairment Best Predict Quality Of Life In Parkinson's Disease?, Terry D. Ellis, James T. Cavanaugh, Gammon M. Earhart, Matthew P. Ford, Kenneth B. Foreman, Leland E. Dibble

Physical Therapy Faculty Publications

No abstract provided.

Unlv - Ccsd Collaborative English Language Learners, Sylvia R. Lazos, Leann Putney, Ralph E. Reynolds

Policy Briefs and Reports

This proposal will provide statistical context of the overall performance of English Language Learner (ELL) students in Clark County School District (CCSD) and proposes a study that will assist the CCSD in identifying programs and strategies that increase ELL student performance on the third grade State mandated Criterion Reference Test (SMCRT) in reading and mathematics. To accomplish this goal, the proposed research project will first identify teaching methodologies, curricular strategies and support services that CCSD teachers are employing to assist ELL students in achieving satisfactory performance. These factors will be analyzed in comparison to SMCRT scores to determine the relative …

Atg Interviews David Burleigh, Tom Gilson, Katina Strauch

Against the Grain

No abstract provided.

Imhbco (In My Humble But Correct Opinion): Top 10 Things You Can Do To Make Your Scholarly Resources More Accessible To (And More Accessed By) Undergraduates, Adriana Parker, Rick Anderson

Against the Grain

No abstract provided.

Biz Of Acq -- Where's The Backlog?, Kim Wallis, Mary Dolan, Michelle Flinchbaugh

Against the Grain

No abstract provided.

Under The Hood -- Adopting & Adapting, Xan Arch

Against the Grain

No abstract provided.

Library Perspective, Vendor Response, Robin Champeiux, Steven Carrico

Against the Grain

No abstract provided.

Table Of Contents

Against the Grain

No abstract provided.

The Raf/Mek/Extracellular Signal-Regulated Kinase 1/2 Pathway Can Mediate Growth Inhibitory And Differentiation Signaling Via Androgen Receptor Downregulation In Prostate Cancer Cells., Seung-Keun Hong, Jin-Hwan Kim, Ming-Fong Lin, Jong-In Park

Journal Articles: Biochemistry & Molecular Biology

Upregulated ERK1/2 activity is correlated with androgen receptor (AR) downregulation in certain prostate cancer (PCa) that exhibits androgen deprivation-induced neuroendocrine differentiation, but its functional relevance requires elucidation. We found that sustained ERK1/2 activation using active Raf or MEK1/2 mutants is sufficient to induce AR downregulation at mRNA and protein levels in LNCaP. Downregulation of AR protein, but not mRNA, was blocked by proteasome inhibitors, MG132 and bortezomib, indicating that the pathway regulation is mediated at multiple points. Ectopic expression of a constitutively active AR inhibited Raf/MEK/ERK-mediated regulation of the differentiation markers, neuron-specific enolase and neutral endopeptidase, and the cyclin-dependent kinase …

Recollection Is Impaired By The Modification Of Interpretation Bias, Paula T. Hertel, Elaina Vasquez, Amanda Benbow, Megan Hughes

Psychology Faculty Research

The interpretation paradigm of cognitive-bias modification (CBM-I) was modified with instructions used in process-dissociation procedures for the purpose of investigating processes contributing to performance on the transfer task. In Experiment 1 nonanxious students were trained to interpret ambiguous situations in either a negative or benign way (or they read nonambiguous scenarios). They were then asked to respond to new ambiguous situations in the same way as contextually similar analogues during training, or to respond differently. Benign training proactively impaired memory for negative outcomes. This effect was replicated by anxious students in Experiment 2 and discussed with respect to the assumptions …

Neutron Imaging And Applications: A Reference For The Imaging Community, Edmund Perfect, Chu-Lin Cheng, Peter Lehmann

Civil Engineering Faculty Publications

No abstract provided.

Simultaneity Between Trade And Conflict: Endogenous Instruments Of Mass Destruction, Cullen F. Goenner

Economics & Finance Faculty Publications

The classical liberal belief is trade, which economically benefits countries, creates ties binding the interests of countries and reduces conflict. While the vast majority of the empirical literature supports this view, recent research questions these findings by also considering the reciprocal relationship between trade and conflict. If conflict also influences trade, then trade is an endogenous right hand side regressor and previous estimates which ignore this are inconsistent. This article determines when one uses appropriate instruments for the endogenous regressors that trade reduces conflict and conflict reduces trade. Failure to use such instruments results in inconsistent estimates and can lead …

The Mechanics Of Federal Appeals: Uniformity And Case Management In The Circuit Courts, Marin K. Levy

Duke Law Journal

Case-management practices of appellate courts define the judicial review of appeals. The circuit courts constantly make decisions about which cases will receive oral argument, which will have dispositions written by staff attorneys in lieu of judges, and which will result in unpublished opinions—decisions that exert a powerful influence on the quality of justice that can be obtained from the federal appellate courts. Despite their importance, there has been no in-depth review of the case-management practices of the different circuit courts in the academic literature.

This Article begins to fill that void. It first documents and analyzes the practices of five …

Truth, Lies, And Stolen Valor: A Case For Protecting False Statements Of Fact Under The First Amendment, Julia K. Wood

Duke Law Journal

The Stolen Valor Act of 2005 (the Act) makes it a crime to lie about having received a medal authorized by Congress for the military. In 2010, in United States v. Alvarez, the Ninth Circuit found the Act unconstitutional under the First Amendment, holding that false statements of fact, like other content-based restrictions on speech, are subject to strict scrutiny. The Act failed this test because, according to the court, it was not narrowly tailored to serve a compelling government interest. The decision highlights the uncertainty of First Amendment protections for false speech. Though the Supreme Court has held that …

Pat 3: An Extensible Architecture For Building Multi-Domain Model Checkers, Yang Liu, Jun Sun, Jin Song Dong

Research Collection School Of Computing and Information Systems

Model checking is emerging as an effective software verification method. Although it is desirable to have a dedicated model checker for each application domain, implementing one is rather challenging. In this work, we develop an extensible and integrated architecture in PAT3 (PAT version 3.*) to support the development of model checkers for wide range application domains. PAT3 adopts a layered design with an intermediate representation layer (IRL), which separates modeling languages from model checking algorithms so that the algorithms can be shared by different languages. IRL contains several common semantic models to support wide application domains, and builds both explicit …

Tragic Rights: The Rights Critique In The Age Of Obama, Robin L. West

William & Mary Law Review

No abstract provided.

Treasures In Tension: Immigrant Churches And Opportunities For Mission, Daniëlle Koning

Journal of Adventist Mission Studies

No abstract provided.

Errors Spell Checkers Do Not Correct And Style Sheet, Charles J. Higgins

Finance Faculty Works

The article focuses on errors that are not corrected by spell checkers in writing programs and communication devices. It is said that spell checkers may change a written word to an unintended one, as well as may provide autocompletion. A list of words that spell checkers and auto completion programs may confuse is provided. Several words in which writing programs can do little to correct notational styles are also listed.