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Autoimmune Consequences Of Histone Deimination During Neutrophil Activation, Nishant Dwivedi

Theses and Dissertations (ETD)

Tolerance blocks the expression of autoantibodies, whereas autoimmunity promotes it. How tolerance breaks and autoantibody production begins, thus, are crucial questions for the understanding and treatment of autoimmune diseases. Evidence implicates cell death and autoantigen modifications in the initiation of autoimmune reactions. One form of neutrophil cell death deserves attention because it occurs as a consequence of neutrophil activation, requires the post-translational modification of histones and results in the extracellular release of chromatin. The extracellular chromatin incorporates histones in which arginines have been converted to citrullines by peptidylarginine deiminase IV (PAD4) creating structures that capture or "trap" bacterial pathogens. Neutrophil …

Testing Whether Mrp4 (A Camp Efflux Pump) And The Beta 2 Andrenergic Receptor (An Upstream Regulator Of Camp Signaling Pathways, Praveen Kumar Potukuchi

Theses and Dissertations (ETD)

Background and Aim: MRP4/ABCC4 is an ABC transporter that can efflux the second-messenger, cAMP, from cells. MRP4 has a PDZ interacting motif at its carboxy terminal end through which it binds to scaffolding proteins NHERF1 and PDZK1. Previous studies have shown that PDZK1 serves as a scaffold physically coupling MRP4 with the cystic fibrosis transmembrane conductance regulator (CFTR). This protein complex functionally couples cAMP regulation of CFTR function with MRP4 cAMP transporter activity [Li, C., et al., Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell, 2007. 131(5): p. 940-51]. We hypothesized that the …

The Effects Of Pten Deletion On Cell Size And Plasticity In The Hippocampus, Margaret Sperow

Theses and Dissertations (ETD)

The tumor suppressor phosphatase and tensin homolog (PTEN) is the central negative regulator of the phosphatidylinositol 3-kinase (PI3K) -signaling pathway, which mediates diverse processes in various tissues. In the nervous system, the PI3K pathway modulates proliferation, migration, cellular size and synaptic transmission and plasticity. Neurologic abnormalities such as autism, seizures, and ataxia are associated with inherited PTEN mutations. Yet, how PTEN loss contributes to neurologic dysfunction remains unknown. PTEN loss during early development is associated with extensive deficits in neuronal migration and substantial hypotrophy of neurons and synaptic densities. However, whether its effect on synaptic transmission and plasticity is direct …

Characterization Of The Key Mouse Cochlear Developmental Genes For Auditory Hair Cell Regeneration, Zhiyong Liu

Theses and Dissertations (ETD)

Mammalian inner ear cochlear auditory hair cells (HCs) and adjacent supporting cells (SCs) are believed to derive from the same progenitors during development. However, unlike SCs of nonmammalian vertebrates, mammalian cochlear SCs cannot be converted into functional hair cells (HCs) after damage, thus leading to permanent deafness. To entitle mammals with the ability to restore hearing capacity after HC damage, we first achieved proliferation of SCs by acute ablation of p27 or Sox2. Secondly, we overactivated Notch1 signaling in the mouse inner ear at different developmental stages, and found that the ability of Notch signaling in generating new HCs declines …

Recycle, Christopher R. Smith

Senior Honors Theses

This thesis documents the creation of RECYCLE, a short narrative incorporating all of the techniques acquired at the University of New Orleans. He elaborates on the creative and practical aspects of the narrative ’s production, including appendices to elaborate on the process of pre-production.

A Masterable Past? Swiss Historical Memory Of World War Ii, Sara Ormes

Senior Honors Theses

After World War II, every country that had been touched by or involved in the war had to come to terms with its past. In the case of Switzerland, the Swiss government, the army and some of the country’s leadership established a strong official historical memory of the war, portraying Switzerland as a neutral, benevolent and well-fortified country that remained innocent and untouched by the war.

From the 1960s onwards, Swiss artists and intellectuals challenged these myths by presenting alternative views of the Swiss past in their work. Beginning in the 1970s, Swiss historians published an increasing amount of scholarly …

The Ripple Effect, Ashley J. Hunter

Senior Honors Theses

In 2006, Steven Oakley, an eighteen-year-old high school senior from Pennsylvania, is bribed by his father to go on a volunteer trip to hurricane-ravaged New Orleans, Louisiana. During his time, he meets a broken family whose experiences change Steven’s perspective on his own privileged life.

The Significance Of Human Remains In Museum Collections: Implications For Collections Management, Kacey M. Page

History Theses

The significance of a museum collection has changed over the years, in how it is managed and cared for, and how it is viewed by the public. Best practice mandates that professional policies and guidelines be developed to standardize the acquisition, care, and use of all objects or artifacts that are kept within a museum environment. Although human remains are not an exception to these policies, they hold a unique position within museums; standardized guidelines for their care and management are still developing. The following thesis will look into the policies and issues of housing human remains within museums, both …

A Comparison Of Caregiver Report And Performance-Based Measures Of Functional Ability In Dementia: An Examination Of Moderating Variables, Christine M. Snyder

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study examined the association between data collection techniques used to measure functional abilities in individuals with dementia. Cognitive, functional, and behavioral data were collected through the Cache County Dementia Progression Study for individuals with dementia and their caregivers. The caregivers’ reports of care recipients’ functional status were compared with the care recipients’ scores on a performance-based measure of functional abilities. Analyses showed moderate correlation between caregivers’ reports and objective measures, with no significant effect of caregiver demographic or mental health factors. However, care recipients’ sensory motor impairments reduced the association between the two assessment methods.

Visits occurred at the …

Managing Water Shortages In The Weber Basin Using The Water Evaluation And Planning (Weap) System, Bereket K. Tesfatsion

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Water is a scarce natural resource while the demand for water grows constantly. In Utah, most of the water resources have already been developed. In addition, Utah is prone to drought events and the effects of climate change may exacerbate the already dire situation. Hence, managing this scarce resource efficiently is very important in meeting the growing demand.

Reservoirs are used to store water which is subsequently released to meet demands. For management purposes, reservoirs have different zones such as flood control zone, conservation zone, buffer zone and inactive zone. Water is normally released from the conservation zone. The water …

Relative Importance Of Environmental Variables For Spawning Cues And Tributary Use By An Adfluvial Lake Sucker, Brian A. Hines

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The endangered June sucker (Chasmistes liorus mictus), which is only found in Utah Lake, UT, historically spawned in all streams flowing into the lake, but due to human-caused changes their spawning is restricted to the Provo River. The purpose of this study was to gain a better understanding of the spawning and early life-history of the
June sucker for recovery purposes. My specific objectives were to determine:

1. what environmental factors attract or deter June suckers to certain Utah Lake tributaries for spawning,
2. what cues June suckers to migrate upstream to spawn,
3. if June suckers use more than one …

Mexican American Youths’ Academic Outcomes: The Role Of Ethnic And Academic Socialization In Buffering Discrimination, Spencer M. Richards

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

An increasingly diversifying educational landscape in the United States has accompanied distressing academic disparities among ethnic minority youths. As Latinos represent the largest and fastest growing ethnic minority group within the U.S., particular attention to their academic outcomes is warranted. Alarming educational statistics have been reported for Latinos, with some estimating that nearly half fail to complete high school, and only a fraction go on to complete a degree in higher education. As Latinos grow to represent an increasing segment of the American educational system, more attention is required to understand what leads Latinos to engage (or disengage) in the …

The Relationship Of Acculturation And Acculturative Stress In Latina/O Youths’ Psychosocial Functioning, Marsha Tafoya

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study was conducted to better understand how acculturation and acculturative stress are related to self-esteem, depression, substance use, and substance use problems in 206 Latina/o youth. Acculturation is the social and psychological process of change that occurs when an individual or group comes in contact with a different culture. The acculturation process can be positive, improving one’s life chances in the new culture, or it could be negative due to the challenging nature of change and adaptation to new cultural and social expectations. This difficulty creates a type of stress, called acculturative stress that has been found to be …

Anti-Catholicism V. Al Smith: An Analysis Of Anti-Catholicism In The 1928 Presidential Election, Michael Rooney

Verbum

In lieu of an abstract, below is the essay's first paragraph.

"With few exceptions, the details of past presidential elections are largely forgotten over the course of history. As specific campaigns and elections become more distant from contemporary society, people tend to focus on the larger picture of what that election produced, mainly, who actually became the president. And for the majority of the American public, the presidential election of 1928 is no exception to this. But as Allan Lichtman suggests in his book Prejudice and the Old Politics: The Presidential Election of 1928, ―Presidential elections are central events of …

Full Issue, No Author

Verbum

This is the full issue of Volume 9, Issue 1 of Verbum, published in Fall 2011 by the REST Club at St. John Fisher College. Articles from this issue are available as separate PDFs at http://fisherpub.sjfc.edu/verbum/vol9/iss1/

Resource Allocation, Level Of International Diversification And Firm Performance, Aziz Bakay, Ahmed Elkassabgi, Murad Moqbel

Information Systems Faculty Publications

This paper investigates the threads between international diversification and firm performance, resource allocation to R&D and capital expenditure. The context of this study is a resource-based view and transaction costs theory. Firms that are going international, benefit from the resources available to them outside their home country as well as from the utilization of their core competencies in other countries. Regression models without interactive terms indicate that resource allocation significantly impacts firm performance. Capital expenditure is positively associated with return on assets, while research and development expenditure undermines the firm’s performance. Analyses suggest that there is no thorough relation between …

Race, Gender, And Tokenism In Policing: An Empirical Elaboration, Meghan S. Stroshine, Steven G. Brandl

Social and Cultural Sciences Faculty Research and Publications

According to tokenism theory, “tokens” (those who comprise less than 15% of a group’s total) are expected to experience a variety of hardships in the workplace, such as feelings of heightened visibility, isolation, and limited opportunities for advancement. In the policing literature, most previous studies have defined tokenism narrowly in terms of gender. The current research extends prior research by examining tokenism as a function of gender and race, with an examination of racial/ethnic subgroups. Particular attention is paid to Latino officers as this study represents the first known study of tokenism and Latino police officers. Quantitative analyses reveal that, …

Concept Tests For A New Wire Flying Vehicle Designed To Achieve High Horizontal Resolution Profiling In Deep Water, Chris Roman, Dave Hebert

Graduate School of Oceanography Faculty Publications

Efficiently profiling the water column to achieve both high vertical and horizontal resolution from a moving vessel in deep water is difficult. Current solutions, such as CTD tow-yos, moving vessel profilers, and undulating tow bodies, are limited by ship speed or water depth. As a consequence, it is difficult to obtain oceanographic sections with sufficient resolution to identify many relevant scales over the deeper sections of the water column. This paper presents a new concept for a profiling vehicle that slides up and down a towed wire in a controlled manner using the lift created by wing foils. The wings …

Contingency Planning Task Force

NASIG Newsletter

No abstract provided.

Report – Alpsp International Conference

NASIG Newsletter

No abstract provided.

Alignment Within The Software Development Unit: Assessing Structural And Relational Dimensions Between Testing And Development, Jasbir Dhaliwal, Colin Onita, Robin Poston, Xihui Zhang

Faculty Publications

Just as business-IT alignment has received significant focus as a strategic concern in the IS literature, it is also important to consider internal alignment between the diverse subunits within the IT organization. This study investigates alignment between developers and testers in software development to understand alignment within the IT unit. Prior evidence of tension between these sub-groups (and others as well) suggests that all is not necessarily well within the IT organization. Misalignment within the IT unit can certainly make it difficult for the IT unit to add strategic value to the organization. This study is an important initial step …

Access, December 2011, San Jose State University, School Of Journalism And Mass Communications

Access Magazine

No abstract provided.

Bibliography: Aviation And Space Law: Relevant Publications, P. J. Blount

Journal of Space Law

No abstract provided.

The Application Of The Death On The High Seas Act (Dohsa) To Commercial Space Flight Accidents, Jeffrey Robert Kuhns

Journal of Space Law

No abstract provided.

National Regulation Of Space Activities, Edited By Ram Jakhu (Springer, 2010), 457 Pages, Michael Dodge

Journal of Space Law

No abstract provided.

Preparing The Australian Early Childhood Workforce For Rural And Remote Settings: A Review Of The Literature, Nicole C. Green, Andrea Nolan

Australian Journal of Teacher Education

This article presents the findings of a literature review of research on teacher preparation for rural settings. In the past there has been little or no preparation of teachers for rural teaching, with the emphasis placed on supporting beginning teachers once they commenced (Baills, Bell, Greensill & Wilcox, 2002; Howe, 2006); now there is a strong movement to prepare preservice teachers adequately before their first teaching appointment. However, what has become clear is that the focus of research has been predominantly on primary and secondary education. In our search we have not been able to identify a substantial body of …

Front Matter

The Synapse: Intercollegiate science magazine

No abstract provided.

Alohamora! Unlocking Magic With The Wonders Of Science, Anna Dardick

The Synapse: Intercollegiate science magazine

No abstract provided.

What's Up, Weelic?: Tracking Neural Pathways With A Sugar-Coated Virus, Weelic Chong

The Synapse: Intercollegiate science magazine

No abstract provided.

This Is Your Brain On Acetylcholine, Ksenia Vlasov

The Synapse: Intercollegiate science magazine

No abstract provided.