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Keeping Them Fed Or Keeping Them Frozen: Disaster Preparedness And Response For Laboratories And Research Animals, Suzanne M. Blake

DRU Workshop 2011 Presentations - Disaster Resistant University Workshop: Building Partnerships in Mitigation

This presentation will explore the additional items to add to emergency preparedness and response plans to protect research and animals on campus.  Using examples from recent disasters and events, the speaker will describe consequences of lack of preparedness, considerations for research continuity, and laws and requirements associated with protecting laboratories and animals in a disaster or emergency.

Flyer News, Vol. 58, No. 23 (Jan. 28, 2011), University Of Dayton

Flyer News

Student-run newspaper of the University of Dayton.

Daily Eastern News: January 20, 2011, Eastern Illinois University

January

No abstract provided.

Nsf Extends Invitation For Ethnobotanical Workshop Proposal, Miriam Kritzer Van Zant

Ethnobotanical Leaflets

No abstract provided.

Central Washington University 2011-2012 Undergraduate/Graduate Catalog, Central Washington University

Course Catalogs

No abstract provided.

Populations Of The Gorgonian Genus Leptogorgia At Two Jetties In The Northwestern Gulf Of Mexico, Emily A. Williamson, Kevin B. Strychar, Kim Withers

Gulf of Mexico Science

No abstract provided.

Types Of Prayer And Depressive Symptoms Among Cancer Patients: The Mediating Role Of Rumination And Social Support, John E. Perez, Amy Rex Smith, Rebecca L. Norris, Katia M. Canenguez, Elizabeth F. Tracey, Susan B. Decristofaro

Psychology

We examined the association between different types of prayer and depressive symptoms—with rumination and social support as potential mediators—in a sample of predominantly White, Christian, and female ambulatory cancer patients. In a cross-sectional design, 179 adult cancer outpatients completed measures of prayer, rumination, social support, depressive symptoms, and demographic variables. Type and stage of cancer were collected from electronic medical charts. Depressive symptoms were negatively correlated with adoration prayer (r = −.15), reception prayer (r = −.17), thanksgiving prayer (r = −.29), and prayer for the well-being of others (r = −.26). In the path analysis, …

Coupling Sensitive In Vitro And In Silico Techniques To Assess Cross-Reactive Cd4+ T Cells Against The Swine-Origin H1n1 Influenza Virus, Brian C. Schanen, Anne S. De Groot, Leonard Moise, Matt Ardito, Elizabeth Mcclaine, William Martin, Vaughan Wittman, William L. Warren, Donald R. Drake Iii

Institute for Immunology and Informatics Faculty Publications

The outbreak of the novel swine-origin H1N1 influenza in the spring of 2009 took epidemiologists, immunologists, and vaccinologists by surprise and galvanized a massive worldwide effort to produce millions of vaccine doses to protect against this single virus strain. Of particular concern was the apparent lack of pre-existing antibody capable of eliciting cross-protective immunity against this novel virus, which fueled fears this strain would trigger a particularly far-reaching and lethal pandemic. Given that disease caused by the swine-origin virus was far less severe than expected, we hypothesized cellular immunity to cross-conserved T cell epitopes might have played a significant role …

Combinatorial Effect Of Non-Steroidal Anti-Inflammatory Drugs And Nf-Κb Inhibitors In Ovarian Cancer Therapy, Luiz F. Zerbini, Rodrigo E. Tamura, Ricardo G. Correa, Akos Czibere, Jason Coideiro, Manoj Bhasin, Fernando M. Simabuco, Yihong Wang, Xuesong Gu, Linglin Li, Devanand Sarkar, Jin-Rong Zhou, Paul B. Fisher, Towia A. Libermann

Human and Molecular Genetics Publications

Several epidemiological studies have correlated the use of non-steroidal anti-inflammatory drugs (NSAID) with reduced risk of ovarian cancer, the most lethal gynecological cancer, diagnosed usually in late stages of the disease. We have previously established that the pro-apoptotic cytokine melanoma differentiation associated gene-7/Interleukin-24 (mda-7/IL-24) is a crucial mediator of NSAID-induced apoptosis in prostate, breast, renal and stomach cancer cells. In this report we evaluated various structurally different NSAIDs for their efficacies to induce apoptosis and mda-7/IL-24 expression in ovarian cancer cells. While several NSAIDs induced apoptosis, Sulindac Sulfide and Diclofenac most potently induced apoptosis and reduced tumor …

2011 Cancer Care Annual Report, Children's Mercy Hospital

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center.

Genetic Polymorphisms And The Treatment Outcome In Standard-Risk Pediatric Acute Lymphoblastic Leukemia, Qi Wei

Electronic Theses and Dissertations

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for 30 - 35% of all cancers in children. Significant improvement in the treatment of pediatric ALL has been achieved in recent years. Only 50 years ago, the disease was uniformly fatal with an Overall Survival (OS) rate < 5%. Modern-day, multi-drug chemotherapy is associated with an overall survival rate over 80%. Standard-risk ALL comprises the majority of ALL with an overall survival approaching 90%. Despite this success, children who relapse from this disease accounts for the majority of cancer-related deaths in children. The backbone of treatment protocols have incorporated somatic but not host genetic features in the treatment regimens. The current study examined 12 genetic polymorphisms affecting the pharmacodynamics of antileukemic drugs in an attempt to identify biologic markers related to the risk of disease relapse.

In the current research program, 125 standard-risk ALL patients who were treated at The Children's Hospital were enrolled in a retrospective study. Statistical analysis was performed to evaluate the association between genetic polymorphisms and risk of disease relapse in this study cohort. The GSTM1 null genotype was associated with a …

Microfluidic Paper-Based Analytical Devices: From Pocket To Paper-Based Elisa, Andres W. Martinez

Chemistry and Biochemistry

Microfluidic paper-based analytical devices (microPADs) began as a simple idea with an ambitious goal. The idea was to make microfluidic devices out of paper instead of plastic or glass. The goal was to develop low-cost and portable paper-based diagnostic devices to improve healthcare in developing countries. Over the past 6 years, many developments have been made in the emerging field of paper-based microfluidic devices. Reviewing the development of these devices in the Whitesides group at Harvard University (Cambridge, MA, USA) can provide some insight into the future of the field and encourage scientists from a variety of backgrounds to contribute …

Characterisation Of The Metacaspase Gene Family In Arabidopsis Thaliana, Paige N. Cox

Dissertations, Master's Theses and Master's Reports - Open

Caspases are known to be involved in animal programmed cell death (PCD). The objective of this thesis was to use gene expression analysis and reverse genetics to determine if Arabidopsis metacaspase (AtMC) genes play a role in plant PCD. The majority of AtMC genes were found to be expressed nearly constitutively in various tissues, developmental stages, and under various inductive treatments. Transgenic Arabidopsis plants generated with AtMCpromoter::AtMCgene::GUS fusions showed expression of the reporter gene in leaves, vasculature, trichomes, siliques, anthers, and during embryo development. Preliminary phenotypic characterization of single and double Arabidopsis AtMC loss-of-function mutants suggested that the …

Profiles In Science For Science Librarians: "What Lives Where, And Why": Alfred Russel Wallace, And The Field Of Biogeography, Charles H. Smith

DLPS Faculty Publications

Biogeography, the study of animal and plant distribution, has a history extending back to at least the eighteenth century. But it was not until the work of Charles Darwin and Alfred Russel Wallace in the mid-nineteenth century that it really came into its own as a science. Darwin’s importance notwithstanding, it was really Wallace who put the field on the map, and many of today’s research threads can be traced back to his influence. This article provides a summary review of Wallace’s life and work and biogeography as a field of study, including Wallace’s role in its development.

Development Of An Ecosystem Approach To The Monitoring And Management Of Western Australian Fisheries. Final Frdc Report : Project 2005/063, Norman G. Hall, Brent S. Wise

Fisheries Research Reports

Objectives 1. Test the robustness of statistical procedures to identify impacts of multi-sector fishing on community composition using existing fishery data. 2. Assess the level of change in community composition in each bioregion of WA during the previous 30 years. 3. Identify key data to which ecosystem structure and management strategies are most sensitive and which should be collected in the future. 4. Identify critical changes in exploitation and/or environment that would impact marine ecosystems markedly. 5. Identify areas where more detailed research and/or monitoring are needed.

P62, Ref(2)P And Ubiquitinated Proteins Are Conserved Markers Of Neuronal Aging, Aggregate Formation And Progressive Autophagic Defects, Bryan J. Bartlett, Pauline Isakson, Jan Lewerenz, Heriberto Sanchez, Roxanne W. Kotzebue, Robert Cumming, Greg L. Harris, Ioannis P. Nezis, David Schubert, Anne Simonsen, Kim D. Finley

Paediatrics Publications

Suppression of macroautophagy, due to mutations or through processes linked to aging, results in the accumulation of cytoplasmic substrates that are normally eliminated by the pathway. This is a significant problem in long-lived cells like neurons, where pathway defects can result in the accumulation of aggregates containing ubiquitinated proteins. The p62/Ref(2)P family of proteins is involved in the autophagic clearance of cytoplasmic protein bodies or sequestosomes. These unique structures are closely associated with protein inclusions containing ubiquitin as well as key components of the autophagy pathway. In this study we show that detergent fractionation followed by western blot analysis of …

Reducing Mass Incarceration: Lessons From The Deinstitutionalization Of Mental Hospitals In The 1960s, Bernard E. Harcourt

Articles

No abstract provided.

Suffolk University Newsletter (Sun) Electronic Edition, October 2011, Suffolk University Office Of Public Affairs

Suffolk University Newsletter (SUN)

No abstract provided.

Proceedings Of The 123rd Annual Meeting Of The Iowa Academy Of Science [Program, 2011], Iowa Academy Of Science

Iowa Academy of Science Documents

Contents:

Program Summary --- 2-3
Acknowledgements --- 4
Contents --- 5
Welcome --- 5
Iowa Junior Academy of Science Competition --- 6
Geology Special Event Using Geographic Information Systems in Iowa's K-16 Classrooms --- 7
General Session I-Roaming Mars, a Personal Perspective --- 8
Iowa Junior Academy of Science Award Luncheon --- 9
Iowa Academy of Science Business Meeting --- 9
Iowa Academy of Science Volunteers for 2010-2011 --- 10
Symposium A-Unintended Health & Environmental Consequences of Confinement Agriculture --- 11
Symposium B-Investigating Forensic Science --- 12
Symposium C-150th Anniversary-Science and the Civil War --- 13
Symposia Speakers --- 14-15 …

Inflamation And Depression, Elena Jeliazkova

Theses & ETDs

Over a century ago, Professor Julius Wagner von Jauregg received the Nobel Prize for his work on the immunological implications of psychiatry. In the past twenty years, Psychoneuroimmunology has produced novel research on the immunological implications of psychiatric disorders, such as depression. Established by the American Psychiatric Association, the Diagnostic and Statistical Manual of Mental Disorders, defines the depression as a depressed mood and loss of interest, insomnia or hypersomnia, fatigue, inability to concentrate, suicidality, psychomotor retardation and weight change. While no clear etiological explanation has been discovered, the pathophysiology of depression involves neurotransmitter imbalance. This review investigates the bidirectional …

Social Perceptions Of Government Regulated Ecological Managment In Sarasota County Past, Present, And Potential Future Of Tree Ordinances, Dayna Lazarus

Theses & ETDs

Rules that require us to consider the health of the environment have been increasingly finding their way into American politics. However, rigid regulations are sometimes more of a monkey wrench in the gears of sustainability than a catalyst for achieving a community�s sustainability goals, especially when regulations require expert knowledge and careful consideration of local conditions. An overall negative social perception of a regulation is one indication that the monkey-wrench phenomenon may be in play. Negative social perception, and any other indication that a regulation is either not working or causing more harm than good, calls for a code review. …

Constituents Of Plantago Major Subsp. Intermedia With Antioxidant And Anticholinesterase Capacities, Ufuk Kolak, Mehmet Boğa, Emi̇ne Akalin Uruşak, Ayhan Ulubelen

Turkish Journal of Chemistry

The methanol extract of Plantago major subsp. intermedia (Gilib.) Lange afforded 4 known compounds, namely isomartynoside (1), 10-hydroxymajoroside (2), \beta -sitosterol (3), and ursolic acid (4). Their structures were established by spectroscopic methods. After determination of the total phenolic and flavonoid contents of the methanol extract, the antioxidant potentials of the crude extract and isolated compounds 1-4 were determined by \beta -carotene bleaching, DPPH free radical and ABTS cation radical scavenging, and cupric reducing antioxidant capacity methods. The methanol extract, rich in phenolic contents, indicated the same DPPH free radical scavenging activity (72\% inhibition) as a standard compound, butylated hydroxytoluene, …

In Vivo Liver Endocytosis Followed By Purification Of Liver Cells By Liver Perfusion, Sandhya Gopalakrishnan, Edward N. Harris

Department of Biochemistry: Faculty Publications

The liver is the metabolic center of the mammalian body and serves as a filter for the blood. The basic architecture of the liver is illustrated in figure ¹ in which more than 85% of the liver mass is composed of hepatocytes and the remaining 15% of the cellular mass is composed of Kupffer cells (KCs), stellate cells (HSCs), and sinusoidal endothelial cells (SECs). SECs form the blood vessel walls within the liver and contain specialized morphology called fenestrae within in the cytoplasm. Fenestration of the cytoplasm is the appearance of holes (˜100 μm) within the cells so that the …

Review Of Explanation And Teleology In Aristotle's Science Of Nature By Mariska Leunissen, Owen Goldin

Philosophy Faculty Research and Publications

No abstract provided.

The Role Of The Pediatrican In The Effort To Prevent Congenital Malformations, Robert L. Brent Dr.

The Selected Works of Robert Brent

No

Estimating The Impact Of Human Papillomavirus (Hpv) Vaccination On Hpv Prevalence And Cervical Cancer Incidence In Mali, Leree Tracy, Holly Gaff, Colleen Burgess, Samba Sow, Patti E. Gravitt, J. Kathleen Tracy

Biological Sciences Faculty Publications

Human papillomavirus vaccines have potential to reduce cervical cancer incidence and mortality; however, cultural and economic barriers may hinder success in developing countries. We assessed impact of a single vaccine campaign in Mali with use of mathematical modeling. Our model shows that decreases in the prevalence of Human papillomavirus infection are proportional to achieved vaccination coverage.

Social And Biological Constructions Of Youth: Implications For Juvenile Justice And Racial Equity, Patricia Soung

Northwestern Journal of Law & Social Policy

No abstract provided.

Mechanistic Studies Of The Anti-Ulcerogenic Activity And Acute Toxicity Evaluation Of Dichlorido-Copper(Ii)-4-(2-5-Bromobenzylideneamino)Ethyl) Piperazin-1-Ium Phenolate Complex Against Ethanol-Induced Gastric Injury In Rats, M.S. Salga, A.H.A. Hadi, P.D. Hussain, S.I. Abdelwahab, M.A. Abdullah, Hapipah Mohd Ali

Research Publications (2011 to 2015)

The compound dichlorido-copper(II)-4-(2-5-bromobenzylideneamino)ethyl) piperazin-1-ium phenolate (CuLBS) was synthesized, characterized and screened for acute toxicity and protective activity against ethanol-induced gastric mucosal injury in rats. Gross microscopic lesions, biochemical and immunological parameters and histochemcial staining of glycogen storage were taken into consideration. Oral administration of CuLBS (30 and 60 mg/Kg) for two weeks dose-dependently flattened gastric mucosa, significantly increased gastric mucus and total acidity, compared with control group (P < 0.01). Serum levels of liver enzymes aspartate (AST) and alanine transaminases (ALT), pro-inflammatory (IL-6 and TNF-alpha) and anti-inflammatory (IL-10) cytokines in the rats exposed to ethanol induced ulceration have been altered. Administration of CuLBS showed considerable (P < 0.05) protection against ulceration by modulating the acute alterations of cytokines AST, ALT and stomach glycogen. Interestingly, CuLBS did not interfere with the natural release of nitric oxide. CuLBS alone (60 mg/Kg) did not exhibit any ulcerogenic effect as assessed using Adami's scoring scale. An acute toxicity study showed that rats treated with CuLBS (1,000 and 2,000 mg/Kg) manifested no abnormal signs. These findings therefore, suggested that the gastroprotective activity of CuLBS might contribute in modulating the inflammatory cytokine-mediated oxidative damage to gastric mucosa.

Leiodermatolide, A Potent Antimitotic Macrolide From The Marine Sponge Leiodermatium Sp., Ian Paterson, S. M. Dalby, J. C. Roberts, G. J. Naylor, Esther A. Guzman, Richard A. Isbrucker, Tara P. Pitts, P. A. Linley, D. B. Divlianska, John K. Reed, Amy E. Wright

Faculty Scholarship

Marine macrolides that selectively disrupt cell cycle events continue to occupy a central position as lead compounds in the ongoing search for novel anticancer agents, [1, 2] highlighted by the recent FDA approval of Halaven (eribulin mesylate, a fully synthetic analogue of the halichondrins) for the treatment of advanced breast cancer.[3] Lithistid sponges have proven to be a particularly fertile source[4] of such biologically relevant polyketide metabolites, including dictyostatin [5] and discodermolide. [5d, 6] As part of a continued program aimed at the discovery of novel bioactive natural products from deepwater marine invertebrates, we have examined the relatively Unexplored [7] …

Improving Hypothesis Testing Skills: Evaluating A General Purpose Classroom Exercise With Biology Students In Grade 9., Michael Gregg Wilder

Dissertations and Theses

There is an increased emphasis on inquiry in national and Oregon state high school science standards. As hypothesis testing is a key component of these new standards, instructors need effective strategies to improve students' hypothesis testing skills. Recent research suggests that classroom exercises may prove useful. A general purpose classroom activity called the thought experiment is proposed. The effectiveness of 7 hours of instruction using this exercise was measured in an introductory biology course, using a quasi-experimental contrast group design. An instrument for measuring hypothesis testing skill is also proposed. Treatment (n=18) and control (n=10) sections drawn from preexisting high …