Digital Commons Network^™

Genomic Instability May Be A Signal Of Human Embryonic Stem Cell Differentiation, Clara Ines Esteban-Perez

Theses and Dissertations

Embryonic stem (ES) cells have the ability to maintain pluripotency and self-renewal during in vitro maintenance, which is a key to their clinical applications. ES cells are a model in developmental biology studies due to their potential to differentiate in vitro. Understanding critical pathways of pluripotency, self-renewal, and differentiation during early embryonic development is important for the evaluation of the therapeutic potential of ES cells because of their ability for tumor transformation due to genetic and epigenetic instability acquired during in vitro culture maintenance. Single tandem repeats are sequences of DNA that have been implicated in the deregulation of gene …

A Proteomic Approach To Profiling The Pipping Muscle Of The Broiler Embryo, Adebayo Oluwaseun Sokale

Theses and Dissertations

The Musculus complexus (pipping muscle) plays a primary role in the hatching of the chick from the eggshell at the end of its embryonic life. Various metabolic and cellular changes have been associated with the pipping muscle during development. These studies profiled the pipping muscle at the molecular level by identifying proteins which are associated with the developmental changes. In the first phase of the study, protein expression profile of the Day 13 chicken embryo pipping muscle was obtained using DDF with nano HPLC mass spectrometric analyzer. Identified proteins were categorized based on Gene Ontology. In the second phase, pipping …

Spatial Parameters In Therapeutic Spaces: Design Of A Residential Treatment Facility For Eating Disorder Patients, Sarah Beth Basinger

Theses and Dissertations

Can the built environment positively influence the treatment of an eating disorder? Does the built environment play a role in the quality of care, the rehabilitation process and the lasting affects of treatment in eating disorders and if so, what role does it play? What are the important parameters to consider in designing such a space? Currently there are few facilities designed specifically for the treatment of this disorder. Of those facilities, there is a lack of research regarding the effects of the built environment. Therefore, the process of answering these questions must begin by assessing parameters in architectural precedents …

April 2011 Academic Affairs Minutes, University Of Nebraska At Kearney Academic Affairs Committee

Academic Affairs Committee Minutes

No abstract provided.

A Study On The Use Of Double Helix Point Spread Functions In 3d Fluorescence Microscopy, Sreya Ghosh

Electronic Theses and Dissertations Archive

Noninvasive three-dimensional (3D) imaging of thick samples in fluorescence microscopy is traditionally achieved via the method of optical sectioning where multiple two-dimensional images of an object acquired while focusing at different depths within the object. Defocus, spherical aberrations (SA) and photo bleaching are known to affect the accuracy achieved in 3D images. Double-Helix point spread functions (DH-PSF), the result of PSF engineering, have been used for super localization of point sources in 3D samples. The unique DH-PSF design features 2 dominant lobes in the image plane which appear to rotate as the axial (z) position of a point light source …

The Winonan, Winona State University

The Winonan - 2010s

No abstract provided.

Silica Nanomatrix Effect On The Properties Of Encapsulated Molecules And Silica-Metal Nanoparticles For Bioapplications, Song Liang

Theses and Dissertations

Dye-doped silica nanoparticles (DDSNs) are one of the most popular fluorescent nanomaterials in bioapplications. The first chapter of this dissertation provides an overview of the DDSNs including general fabrication methods, unique properties, and current challenges. In the following three chapters, this dissertation is focused on two challenging areas of DDSN studies. One is the fundamental properties of dye molecules in the DDSNs, and the other is the design of new multifunctional DDSNs for bioapplications. In the first area, the effect of silica nanomatrix on the properties of doped molecules was investigated. Two important molecular properties were covered including the reaction …

The Setonian, April 7, 2011, Seton Hall University

2011

No abstract provided.

Critical Evaluation Of The Use Of Dogs In Biomedical Research And Testing In Europe, Nina Hasiwa, Jarrod Bailey, Peter Clausing, Mardas Daneshian, Sándor Farkas, István Gyertyán, Robert Hubrecht, Werner Kobel, Goran Krummenacher, Marcel Leist, Hannes Lohi, Adám Miklósi, Frauke Ohl, Klaus Olejniczak, Georg Schmitt, Patrick Sinnett-Smith, David Smith, Kristina Wagner, James D. Yager, Joanne Zurlo, Thomas Hartung

Companion Animals as Laboratory Research Subjects Collection

Dogs are sometimes referred to as “man’s best friend” and with the increase in urbanization and lifestyle changes, dogs are seen by their owners as family members. Society expresses specific concerns about the experimental use of dogs, as they are sometimes perceived to have a special status for humans. This may appear somewhat conflicting with the idea that the intrinsic value of all animals is the same, and that also several other animal species are used in biomedical research and toxicology. This aspect and many others are discussed in an introductory chapter dealing with ethical considerations on the use of …

The Effects Of Mycorrhizae On The Growth Of The Radish, Raphanus Sativus L., Sally Jo Detloff

ESSAI

No abstract provided.

Manipulating Cellular Growth Responses To Patterning, Apoptotic, And Environmental Cues, James N. Mcnamara

Doctoral Dissertations

In this work, various methods of controlling cell growth are examined. Cell-cell interaction, apoptotic cues, three dimensional scaffolds, and non-adherent environments are evaluated for their ability to affect the differentiation, morphology, and growth rate of different cell types. Previous work has shown that cell growth and cell morphology can be influenced by patterns of polymers coated on surfaces in two dimensions, designated here as the x and y dimensions of a standard Cartesian coordinate system. Tissue engineering and regenerative medicine studies have shown limited success in modifying growth in the third, z dimension. This work considers not only the x, …

Philosophy & World Religions Department Newsletter, V2, Spring 2011, University Of Northern Iowa. Department Of Philosophy And World Religions.

Philosophy & World Religions Department Newsletter

Inside this issue:

-- Notes from the Head
-- Francis Degnin, Service Work
-- Betty DeBerg, American Academy of Religion Task Force
-- Professors Named to Advisory Board of Turkish American Society of Iowa
-- Faculty Spotlight: Bill Clohesy, Professor of Philosophy
-- Faculty Spotlight: Martie Reineke, Professor of Religion
-- Darwin & Intelligent Design: A Lecture by Elliot Sober
-- Holiday Party
-- Discussion & Lectures by Stephen Nathanson
-- Look for UNI Department of Philosophy & World Religions on facebook
-- Student Interview: Joel Anderson
-- Student Interview: John Anderson
-- Student Interview: Selena Losee
-- Philosophy Club …

2011 Friends Of The University Of Montana Herbarium Newsletter, Peter Lesica, David Dyer

Newsletters of the Friends of the University of Montana Herbarium

Consortium for Pacific Northwest Herbaria Online Portal / Matt Lavin -- Notes from the Board: Herbaria: Crypts for the Dead or Gardens of Eden? / Dean E. Pearson -- MONTU People: Wilfred W. White / Peter Lesica -- MONTU News Briefs -- Activities -- 2011 Friends of the UM Herbarium Annual Meeting -- Farewell to the Aceraceae: Changes in the Angiosperm Family Tree / Walter Fertig -- The Mission and Geographic Scope of the MONTU Herbarium / Scott Mincemoyer -- The Herbarium Staff From A to Z! / Dave Dyer

Direct Current Electrokinetic Particle Transport In Micro/Nano-Fluidics, Ye Ai

Mechanical & Aerospace Engineering Theses & Dissertations

Electrokinetics has been widely used to propel and manipulate particles in micro/nano-fluidics. The first part of this dissertation focuses on numerical and experimental studies of direct current (DC) electrokinetic particle transport in microfluidics, with emphasis on dielectrophoretic (DEP) effect. Especially, the electrokinetic transports of spherical particles in a converging-diverging microchannel and an L-shaped microchannel, and cylindrical algal cells in a straight microchannel have been numerically and experimentally studied. The numerical predictions are in quantitative agreement with our own and other researchers' experimental results. It has been demonstrated that the DC DEP effect, neglected in existing numerical models, plays an important …

Yongzhi Village: An Example For Sustainable Tourism And Development In Deqin County, Kiersten Brown

Independent Study Project (ISP) Collection

Nestled beneath misty mountain peaks, among the Salween, Mekong, and Yangtze rivers, a beautiful Tibetan village lies. Alongside low-lying mountain creeks and waterfalls this village is in Deqin County of Yunnan’s Deqin Tibetan Autonomous Prefecture (Deqin TAP). The Deqin TAP is the most Northwest prefecture of Yunnan. Deqin boasts that 33% of its population is comprised of the dominant minority group, Tibetans. Deqin prefecture is comprised of three counties, Shangrila County, Deqin County, and Weixi County. Deqin County is mostly comprised of small Tibetan towns and villages like Yongzhi. About 100 families inhabit Yongzhi. The village is placed right along …

41st Annual Wku Student Research Conference, Student Research Council, Western Kentucky University

Student Research Conference Select Presentations

No abstract provided.

Lipophilic Polyamines Providing Enhanced Intracellular Delivery Of Agents By A Polyamine Transport System, Otto Phanstiel, Kenneth Teter

UCF Patents

All cells require polyamines in order to grow. Many cell types (including cancer cells) have active polyamine transporters which import extracellular polyamines into the cell. Our invention is the development of new lipophilic polyamines which can access cells via their polyamine transport system. The long lipid tails facilitate the formation of assembled complexes which are recognized and imported into cells. The invention describes several examples of using this technology for drug delivery and includes: a) the efficient delivery of foreign DNA into Chinese hamster ovary cells and expression of the protein encoded by the foreign DNA; and b) the delivery …

Risk Factors For And Outcomes Of Bullying And Victimization, Susan M. Swearer Napolitano

Department of Educational Psychology: Faculty Publications

Individuals exist within multiple environments: home, school, neighborhood, church, community, and society. Within the interaction between individuals and these environments are risk factors for bullying and victimization. In this paper research on risk factors for bullying and victimization across multiple contexts-- individual, peer, school, family, community, and society will be synthesized.

Functional Analysis Of Novel Analogues Of E3330 That Block The Redox Signaling Activity Of The Multifunctional Ap Endonuclease/Redox Signaling Enzyme Ape1/Ref-1, Mark R. Kelley, Meihua Luo, April Reed, Dian Su, Sarah Delaplane, Richard F. Borch, Rodney L. Nyland Ii, Michael L. Gross, Millie M. Georgiadis

Open Access Publications

No abstract provided.

Announcements

Ethics and Animals

No abstract provided.

Developing Methods To Assess The Potential Effects Of Global Climate Change On Deer Creek Reservoir Using Water Quality Modeling, Reed Earl Chilton

Theses and Dissertations

To evaluate the potential impacts of future climate change on a temperate reservoir, I used a calibrated water quality and hydrodynamic model validated using three years of data (2007-2009) from Deer Creek Reservoir (Utah). I evaluated the changes due to altered air temperatures, inflow rates, and nutrient loads that might occur under Global Climate Change (GCC). I developed methods to study GCC on reservoirs. I produced Average Water Temperature Plots, Stratification Plots, and Total Concentration Plots. Average Water Temperature Plots show the sensitivity of the water temperature to various parameters. Stratification Plots quantify stratification length and strength as well as …

Biological Investigation Of The Stimulated Flapping Motions Of The Moth, Manduca Sexta, Travis B. Tubbs

Theses and Dissertations

No abstract provided.

Grapevine, Steve Holden

Teacher journal archive (2004-2011)

‘The amount of time that has been spent trying to sort this matter in a logical fashion with the (New South Wales) Department of Education and Training (DET) over the past two years is just ludicrous. There have been more twists and turns than an Agatha Christie novel, and now the school community has decided to add a gripping chapter of its own by bringing in a crane and chains. If there’s to be a truly climactic chapter, it will happen if or when the DET tries to remove the building. We’re watching the site 24/7, and if the community …

Pengembangan Model Induktif Dalam Pembelajaran Apresiasi Puisi, Warsiman Warsiman

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

This research was conducted to improve students’ ability to appreciate poetry through the use of the Inductive Model. This study applied a modified Research and Development method, and the results were analyzed descriptively. The results reveal that the use of the Inductive Model is able to improve students’ ability in appreciating poetry by implementing eight instructional steps. The numerical improvement can be seen in the students’ average scores in each treatment. In the first treatment, the students’ average score was 60.9; in the second treatment, it increased to 62.4; and in the third treatment, it reached 65.3. Based on the …

Vista: February 24, 2011, University Of San Diego

USD Vista (1965-)

No abstract provided.

Daily Eastern News: February 21, 2011, Eastern Illinois University

February

No abstract provided.

Ua12/2/1 College Heights Herald, Vol. 86, No. 35, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Stunson, Mike. Student Government Association Pushes for Fair-trade Designation
• WKU to Host National Fair-trade Conference
• Alleyne, Zirconia. Inked with Pride – Tattoos
• Harrison, Taylor. Pop Culture Major Has Wide Appeal
• Allen, Kevin. Activist Inspires a New Generation – Bernice Reago
• Edwards, Dorothy. After Class – Ben Polk, Musician
• Wade, Katherine. Information Technology Developing Virtual Labs, Improved Internet
• Carter, Caitlin. WKU Health Services Seeks New Director, Accreditation
• Oliver, Angela. Follow the Golden Rule with Roommates
• Vogt, Darren. Editorial Cartoon re: Valentine’s Day
• Beasley, Paul. Post-forum Regression
• West, Natalie. Q is …

Analysis Of Common And Specific Mechanisms Of Liver Function Affected By Nitrotoluene Compounds, Youping Deng, Sharon A. Meyer, Xin Guan, Barbara Lynn Escalon, Junmei Ai, Mitchell S. Wilbanks, Ruth Welti, Natàlia Garcia-Reyero, Edward J. Perkins

Faculty Publications

Background: Nitrotoluenes are widely used chemical manufacturing and munitions applications. This group of chemicals has been shown to cause a range of effects from anemia and hypercholesterolemia to testicular atrophy. We have examined the molecular and functional effects of five different, but structurally related, nitrotoluenes on using an integrative systems biology approach to gain insight into common and disparate mechanisms underlying effects caused by these chemicals.

Methodology/Principal Findings: Sprague-Dawley female rats were exposed via gavage to one of five concentrations of one of five nitrotoluenes [2,4,6-trinitrotoluene (TNT), 2-amino-4,6-dinitrotoluene (2ADNT) 4-amino-2,6-dinitrotoulene (4ADNT), 2,4-dinitrotoluene (2,4DNT) and 2,6-dinitrotoluene (2,6DNT)] with necropsy …

Studies In Organic Synthesis: Part I: Total Synthesis Of Plakortethers F And G Part Ii: Carbon-Hydrogen Insertion On Diazosulfones And Diazosulfonates, Jinu Philip John

Theses and Dissertations

This work consists of two independent studies. The first part of the dissertation focuses on the total synthesis of two marine based natural products, Plakortether F and G which represent a class of non-peroxide derivatives of Plakortin related metabolites that are isolated from the Caribbean sponge Plakortis simplex. The selective cytotoxic activity of Plakortethers against the RAW 264-7 cell line (murine macrophage) makes them promising candidates for biological studies. A strategy utilizing desymmetrization of a C2 symmetric intermediate was proposed and demonstrated to be effective for the synthesis of the core of Plakortethers. Initially, the symmetric intermediate could only be …

From Narrative To Data And Back: Archival Sources And The Dru, Mikeal Blackford

DRU Workshop 2011 Presentations - Disaster Resistant University Workshop: Building Partnerships in Mitigation

State and County Hazard Mitigation Plans rely on nationally available data sources. A Disaster Resistant University Plan operates at a much finer scale with limited data availability, particularly in digital format. Data collection for a DRU plan spans from universities, state archives, spatial data clearinghouses, to field work and beyond. While spatial data and GIS are essential for a sound plan, archival research provides necessary insight and data that is often neglected.