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Medicine@Yale March/April 2011 Volume 7, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Medicine@Yale July/August 2011 Volume 7, Issue 3, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Medicine@Yale September/October 2011 Volume 7, Issue 4, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Carbon Monoxide And Nitric Oxide Induced-Heme-Based Modification Of Alpha-2-Antiplasmin And Plasmin Activity, Matthew R. Arkebauer

PCOM Biomedical Studies Student Scholarship

Objectives: Carbon monoxide (CO) derived from cigarette smoke or released from carbon monoxide releasing-molecule 2 (CORM-2), diminishes fibrinolysis. The primary purpose of this study was to determine if CO diminished fibrinolysis by means of enhancing α2-antiplasmin via an alleged heme group. Methods: Plasma, isolated α2-antiplasmin and isolated plasmin were exposed to CO released from CORM-2 (tricarbonyldichlororuthenium (II) dimer) and nitric oxide (NO) via a NO donor to induce carboxyheme and metheme states. Exposed, isolated enzymes were placed in either α2-antiplasmin deficient or normal plasma. Effects of CO and NO on tissue-type plasminogen activator initiated fibrinolysis were determined by thrombelastography. Liquid …

Small Intestine Submucosa Effects On Long Term Viability Of Transplanted Pancreatic Cells, Joshua P. Pregnar

PCOM Biomedical Studies Student Scholarship

The biologic functions carried out by the pancreas are, without a doubt, essential to life. This can be demonstrated by the fact that some diabetics require insulin supplementation and those suffering from other diseases of the pancreas, such as pancreatitis, or who have undergone pancreatectomy require supplementation with exocrine enzymes. As would be expected, we are constantly searching for more longterm, patient oriented solutions to chronic health conditions. As such, there has been a gradual transition from daily insulin injections to insulin pumps which allow for easier and more closely controlled glucose levels. Work has also been done regarding various …

Androgen Receptor-Dependent Effects Of Resveratrol On Tnsin Mrna Levels In Prostate Cancer Cells, Courtney Pisano

PCOM Biomedical Studies Student Scholarship

The chemopreventive effects of resveratrol (RSV) on cancers, including prostate cancer, have been well documented; but the mechanisms are not well known. It has been reported recently that tensin, a matrix-adhesion protein, which is greatly down-regulated in prostate cancer, has been induced by RSV in several cancer cell lines. In order to know if RSV up-regulates tensin in prostate cells, we first treated LNCaP cells with RSV and demonstrated that tensin mRNA levels were upregulated by RSV in a time and dose dependent manner. Since LNCaP cells are androgen receptor (AR) positive and previous findings have shown that RSV down-regulates …

The Role Of Endothelial Nitric Oxide Synthase (Enos) Uncoupling On Leukocyte-Endothelial Interactions In Rat Mesenteric Postcapillary Venules, Maria Kern

PCOM Biomedical Studies Student Scholarship

Endothelial derived nitric oxide (NO) is essential in the regulation of blood pressure and attenuates leukocyte-endothelial interactions associated with vascular injury. However, when endothelial-derived NO is decreased, endothelial dysfunction results and promotes inflammation characterized by increased leukocyte-endothelial interactions. Under normal conditions, eNOS produces NO in the presence of an essential cofactor, tetrahydrobiopetrin (BH4) by facilitating the reduction of molecular oxygen to L-arginine oxidation and generation of L-citrulline. Whereas uncoupled eNOS refers to the electron transfer that becomes uncoupled to L-arginine oxidation and therefore superoxide (SO) is generated when the dihydrobiopetrin (BH2) to BH4 ratio is increased. SO is subsequently converted …

The Effects Of Protein Kinase C Inhibitors On Blood Nitric Oxide And Hydrogen Peroxide Release In Ischemia And Reperfusion Injury, Kyle D. Bartol

PCOM Biomedical Studies Student Scholarship

Vascular endothelial dysfunction is a key component initiating oxidative stress in ischemia/reperfusion (I/R). Endothelial dysfunction is characterized by an increase in hydrogen peroxide (H2O2) and a decrease in the bioavailability of nitric oxide (NO). Previous studies using protein kinase C (PKC) inhibitor Gö 6983 or PKC Beta (β) II inhibitor improved cardiac function in myocardial I/R, decreased leukocyte-endothelial interactions and leukocyte superoxide (SO) release and increased endothelial-derived NO release in vitro. This study examined the effects of Gö 6983 or PKC β II inhibitor on realtime H2O2 and NO release in femoral vein I/R in vivo. NO or H2O2 microsensors …

Does Use Of A Cell Phone Affect Cognition?, Kharma J. Lundy

PCOM Biomedical Studies Student Scholarship

This research examined the effects that a cell phone distraction had on subjects completing a maze task. Twenty-four subjects participated in the study (12 Younger subjects and 12 Older subjects; 14 females and 10 males). Subjects completed an identical maze task during each of three sessions. During the first session, subjects completed the maze task without the distraction of cell phone use. The second session involved completion of the maze task while listening to a transcript read over a cell phone. The third session involved completion of the maze task while participating in a cell phone conversation. Subjects’ performances were …

Alzheimer's Disease Association With Chlamydia Pneumoniae, Andrew Short

PCOM Biomedical Studies Student Scholarship

Exogenous bacteria, such as Chlamydia pneumoniae, may be a cause of inflammation that contributes to the progression of Alzheimer's disease (AD). Inflammation has been previously established as a contributor to AD progression. Balin et al. first reported C. pneumoniae in the brains of post-mortem late onset AD patients. PCR analysis showed that 17/19 AD patients were positive for the organism in areas of the brain with typical AD-related neuropathology while 18/19 control patients were PCR-negative. Gerard et al. determined, using real-time PCR, that C. pneumoniae-infected cells colocalize with both neuritic senile plaques and neurofibrillary tangles, the defining pathologies of AD. …

W(H)Ither The Jury? The Diminishing Role Of The Jury Trial In Our Legal System, Jennifer Walker Elrod

Washington and Lee Law Review

No abstract provided.

Fragmented Lives: Disability Discrimination And The Role Of "Environment-Framing", Ani B. Satz

Washington and Lee Law Review

This Article presents a novel theory that courts undermine the purpose of the Americans with Disabilities Act (ADA) by implicitly embracing environment-frames that disfavor disability protections. Courts employ environment-frames at two stages of judicial analysis under the Act: the disability eligibility and remedy stages. In determining whether a plaintiff is in the statutorily protected class, courts typically use a broad environment-frame to assess limitation of a "major life activity." The larger the environment-frame, the more likely a court will view an individual as able to perform a major life activity in some portion of her environment and deny her protected …

Employee Or Entrepreneur?, Jeffrey M. Hirsch

Washington and Lee Law Review

No abstract provided.

Yale School Of Medicine Facts & Figures 2011, Yale School Of Medicine Office Of Communications

Facts & Figures – annual Yale School of Medicine numbers

Provided by the Office of Communications, the Facts and Figures brochure is produced annually as a way to provide a snapshot of key facts and data related to the School of Medicine as well as the Medical Campus. This includes enrollment data, research activity, financial summaries, and more.

Regulating For Sustainability: The Legality Of Carrying Capacity-Based Environmental And Land Use Permitting Decisions, Richard Grosso

Nova Law Review

No abstract provided.

Stop The Beach Renourishment: A Case Of Macguffins And Legal Fictions, Sidney F. Ansbacher

Nova Law Review

No abstract provided.

Dispersants And Seafood Safety Assessment Of The Potential Impact Of Corexit® Oil Dispersants On Seafood Safety, Robert W. Dickey, Walton W. Dickhoff

Coastal Response Research Center

The April 20, 2010 explosion and subsequent sinking of the Deepwater Horizon oil production platform (DWH) resulted in the largest oil spill in U.S. history. On April 29th, a Spill of National Significance was declared as roughly 53 thousand barrels of oil per day flowed into the Gulf of Mexico (GOM). The U.S. Coast Guard estimated 4.9 million barrels of crude oil escaped before the damaged DWH wellhead was sealed on July 15, 2010 (National Commission on the BP Deepwater Horizon Oil Spill and Offshore Drilling 2010). Oil spill clean-up methods included skimming operations, burning of surface oil, siphoning oil …

Yul Annual Report; 2010-2011, Yale University Library

Yale University Library Annual Reports

No abstract provided.

The Non-Aristotelian Character Of Aquinas's Ethics: Aquinas On The Passions, Eleonore Stump

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Colonial Cartographies, Postcolonial Borders, And Enduring Failures Of International Law: The Unending Wars Along The Afghanistan-Pakistan Frontier, Tayyab Mahmud

Faculty Articles

Many of today's pervasive and intractable security and nation-building dilemmas issue from the dissonance between the prescribed model of territorially bounded nation-states and the imprisonment of postcolonial polities in territorial straitjackets bequeathed by colonial cartographies. With a focus on the Durand Line, the border between Afghanistan and Pakistan and the epicenter of the prolonged war in the region, this article explores the enduring ramifications of the mutually constitutive role of colonialism and modern law. The global reach of colonial rule reordered subjects and reconfigured space. Fixed territorial demarcations of colonial possessions played a pivotal role in this process. Nineteenth century …

A.W.A.R.E. The Assessment Of Autism Spectrum Disorders: A Resource Manual For Parents With Young Children (Ages 0-3 Years), Tiffany Lin

Theses and Dissertations

Autism spectrum disorder is the most common pervasive developmental disorder affecting young children. It results in significant impairments in the acquisition of language, social, and adaptive behaviors. In recent years, participation in intensive early intervention has resulted in significant improvements in communication skills and a more positive prognosis. While the symptoms of autism spectrum disorder, such as impaired social reciprocal interactions, can be identified in the first months of a child's life, parents often encounter difficulty in obtaining appropriate diagnostic assessments. Delays in the assessment process result in a later involvement in critical early intervention and a poorer outcome. To …

Women's Social Networking: Steps That Organize Low-Technology Users With Emergency Needs, Jon O. Gary

Theses and Dissertations

The purpose of the study was for the researcher to develop and have evaluated the content, organization and ease of use of a computer-training program Emergency Response Quick Start book based on Information and Communication Technology environmental designs. This book was most notably based on underutilized women social networking traditions (food recipe/ meal preparation, and service). One research objective guided the development and evaluation of this training program: 1. This study provided an opportunity for a group of urban adults to evaluate, clarify, and test the ease of use of this computer-training program Emergency Response Quick Start book. The 14 …

I Am Here - Are You There? Sense Of Presence And Implications For Virtual World Design, Vicki Suter

Theses and Dissertations

We use the language of presence and place when we interact online: in our instant text messaging windows we often post: "Are you there?" Research indicates the importance of the sense of presence for computer-supported collaborative virtual learning. To realize the potential of virtual worlds such as Second Life, which may have advantages over conventional text-based environments, we need an understanding of design and the emergence of the sense of presence. A construct was created for the sense of presence, as a collaborative, action-based process (Spagnolli, Varotto, & Mantovani, 2003) with four dimensions (sense of place, social presence, individual agency, …

Lived Experience Of Social Cliques, Shalen Bishop

Theses and Dissertations

The purpose of this study was to determine the extent to which, if at all, students' perceptions of their teachers' care of specific types of cliques was related to those students' high school lived experience for the following four main cliques: popularity, Goths, loners, and others. The goal of this study was to shed light on the history of the preceding variables and the current research related to cliques. Furthermore, it was intended to help guide the researcher in illuminating what has been studied previously regarding social cliques, factors within them, and their effects on student social and academic achievement. …

A Systemic Perspective Of Stress In Emergency Medical Personnel: Emergency Medical Technicians And Firefighters, Rob W. Wennerberg

Theses and Dissertations

Emergency medical personnel (firefighters and ambulance personnel) have higher levels of lifetime PTSD symptoms than the general population. Historically this has been attributed to the number of exposures to traumatic incidents, called the dose effect, but recent literature has suggested that there is a complex web of variables that affect an individual's experience of trauma. Through an interpretive review of the literature this dissertation takes the concepts supported by empirical research and organizes them into an integrated theoretical structure. With ecological psychology at the core, the integration uses Living Systems theory as a structure with which to organize and explore …

Positive Emotions: An Informational Workshop, Rebecca M. Kessler

Theses and Dissertations

The purpose of this thesis was to design and evaluate an educational intervention focusing on the role of positive emotions in the workplace. An informational workshop was delivered to the full staff of 18 teachers and 2 directors at Circle of Children Preschool in Santa Monica, California, and emphasized positive emotions and their implications in the workplace in an effort to enhance awareness of emotions and inspire increased levels of positive emotions. A sample set of the staff evaluated the workshop and its effectiveness. The sample was surveyed and interviewed for levels of positive emotions prior to the workshop and, …

The Use Of Ct Analysis To Assess The Ages Of A Modern Human Tooth Sample: A Comparision With Dental Attrition And The Lamendin Method, Kristina Galdes

Graduate Student Theses, Dissertations, & Professional Papers

An analysis of 81 contemporary adult human teeth was conducted in order to determine which of three methods best determines age at death. The teeth were loaned from the University of Tennessee body farm to the University of Michigan’s Biomedical Research Laboratory and were comprised of central incisors, lateral incisors and canines. Each tooth was of known age and most were also associated with sex and ancestry. Three observers used Lovejoy’s (1985) method of dental attrition, the Lamendin et al. (1992) periodontosis method and micro computed tomography to determine how accurately each method was able to assess the ages at …

Wildland Firefighter Health And Safety, Joseph Wimand Domitrovich

Graduate Student Theses, Dissertations, & Professional Papers

Over the past fifty years the University of Montana, in conjunction with the United States Forest Service, has been investigating the job demands of wildland firefighters. This document is a combination of three research projects with a connection of health and safety of wildland firefighters.

Smokejumpers are unique because they parachute into remote fires and are used primarily as initial attack wildland firefighters. Studies have shown that initial attack is the most energy intensive part of wildland firefighting. The first study identifies maximal and sustainable aerobic fitness possessed by US Smokejumpers. The maximal aerobic characteristic of US smokejumpers is well …

The Dwellers Between: Yup'ik Shamans And Cultural Change In Western Alaska, Ahnie Litecky

Graduate Student Theses, Dissertations, & Professional Papers

This paper examines the history of the Yup'ik Eskimos of western Alaska and explores how their shamans shaped the response to introduced epidemic disease. As in the experiences of so many other Native American groups, disease epidemics played an important role in the history of relations between the Yup'ik Eskimos and white settlers in the nineteenth and twentieth centuries. I argue here that while the Yup'ik Eskimos grappled with the devastating effects of introduced diseases, they did not repudiate their shamans and traditional faith, which sets the Yup'ik people apart from other Native Americans. Before contact with Europeans, the Yup'ik …

Cultural Landscapes In Conflict: Addressing The Interests And Landscape Perceptions Of Native Americans, The National Park Service, And The American Public In National Parks, Emily Anne Eide

Graduate Student Theses, Dissertations, & Professional Papers

The Prayer and Fasting Project of 2010 from Glacier National Park produced startling results indicating that many areas which have cultural significance to Native American peoples have been adversely impacted by national park recreationalists. This thesis addresses the significance of these impacts along with other management issues associated with conflicting landscape perceptions of national park lands. These concerns are explored through the examination of past and present archaeological theories along with cultural resource management approaches to landscapes. The need to identify and consider different cultural perceptions of landscapes in research and management scenarios is stressed throughout this work. The inclusion …