Digital Commons Network^™

Aging Impacts Isolated Lymphoid Follicle Development And Function, Keely G. Mcdonald, Matthew R. Leach, Conway Huang, Caihong Wang, Rodney D. Newberry

Open Access Publications

No abstract provided.

Mglu2 Metabotropic Glutamate Receptors Restrain Inflammatory Pain And Mediate The Analgesic Activity Of Dual Mglu2/Mglu3 Receptor Agonists, Magda Zammataro, Santina Chiechio, Michael C. Montana, Anna Traficante, Agata Copani, Ferdinando Nicoletti, Robert W. Gereau Iv

Open Access Publications

No abstract provided.

Biomarkers Predicting Alzheimer's Disease In Cognitively Normal Aging, Yong S. Shim, John C. Morris

Open Access Publications

No abstract provided.

Tunepal: Searching A Digital Library Of Traditional Music Scores, Bryan Duggan, Brendan O'Shea

Reports

Purpose – This paper aims to describe the Tunepal project as an example of a music information retrieval (MIR) system that is having an impact on how musicians access, learn and play traditional Irish music around the world. Design/methodology/approach – This paper describes the functionality of the Tunepal system: consisting of the tune corpus, the web site tunepal.org and mobile apps supporting iOS and Android OS. Tunepal facilitates query-by-title and query-by-playing music (QBP) searches and allows a musician to retrieve and playback scores amongst other supported functions. Findings – Tunepal has been favorably received and musicians report that the system …

Genetic Incorporation Of Human Metallothionein Into The Adenovirus Protein Ix For Non-Invasive Spect Imaging, J. Michael Mathis, Shilpa Bhatia, Alok Khandelwal, Imre Kovesdi, Stephen J. Lokitz, Yoshi Odaka, Amol M. Takalkar, Tracee Terry, David T. Curiel

Open Access Publications

No abstract provided.

Batf3-Dependent Cd11b Peripheral Dendritic Cells Are Gm-Csf-Independent And Are Not Required For Th Cell Priming After Subcutaneous Immunization, Brian T. Edelson, Tara R. Bradstreet, Wumesh Kc, Kai Hildner, Jeremy W. Herzog, Julia Sim, John H. Russell, Theresa L. Murphy, Emil R. Unanue, Kenneth M. Murphy

Open Access Publications

No abstract provided.

Correlation Of Cag Repeat Length Between The Maternal And Paternal Allele Of The Huntingtin Gene: Evidence For Assortative Mating, Peg Nopoulos, Eric A. Epping, Tom Wassink, Bradley L. Schlaggar, Joel Perlmutter

Open Access Publications

No abstract provided.

Adipose Tissue Endocannabinoid System Gene Expression: Depot Differences And Effects Of Diet And Exercise, Tongjian You, Beth L. Disanzo, Xuewen Wang, Rongze Yang, Dawei Gong

Open Access Publications

No abstract provided.

Linkage Analysis Merging Replicate Phenotypes: An Application To Three Quantitative Phenotypes In Two African Samples, Anthony L. Hinrichs, Robert C. Culverhouse, Brian K. Suarez

Open Access Publications

No abstract provided.

Rnai Effector Diversity In Nematodes, Jonathan J. Dalzell, Paul Mcveigh, Neil D. Warnock, Makedonka Mitreva, David Mck Bird, Pierre Abad, Colin C. Fleming, Tim A. Day, Angela Mousley, Nikki J. Marks, Aaron G. Maule

Open Access Publications

No abstract provided.

Deficiency Of The Mitochondrial Electron Transport Chain In Muscle Does Not Cause Insulin Resistance, Dong-Ho Han, Chad R. Hancock, Su Ryun Jung, Kazuhiko Higashida, Sang Hyun Kim, John O. Holloszy

Open Access Publications

No abstract provided.

Sap Transporter Mediated Import And Subsequent Degradation Of Antimicrobial Peptides In Haemophilus, Catherine L. Shelton, Forrest K. Raffel, Wandy L. Beatty, Sara M. Johnson, Kevin M. Mason

Open Access Publications

No abstract provided.

Catheter-Associated Nocardia Higoensis Bacteremia In A Child With Acute Lymphocytic Leukemia, Michael E. Watson Jr., Michele M. Eastabrook, Carey-Ann D. Burnham

Open Access Publications

No abstract provided.

Role Of Fatty Acid Transporters In Epidermis: Implications For Health And Disease, Denis Khnykin, Jeffrey H. Miner, Frode Jahnsen

Open Access Publications

No abstract provided.

Differential Microbicidal Effects Of Human Histone Proteins H2a And H2b On Leishmania Promastigotes And Amastigotes, Yingwei Wang, Yang Chen, Lijun Xin, Stephen M. Beverley, Eric D. Carlsen, Vsevolod Popov, Kwang-Poo Chang, Ming Wang, Lynn Soong

Open Access Publications

No abstract provided.

Lentiviral-Mediated Gene Transfer To The Sheep Brain: Implications For Gene Therapy In Batten Disease, Kathryn S. Linterman, David N. Palmer, Graham W. Kay, Lucy A. Barry, Nadia L. Mitchell, Robin G. Mcfarlane, Michael A. Black, Mark S. Sands, Stephanie M. Hughes

Open Access Publications

No abstract provided.

Introduction, Dale Kinney

History of Art Faculty Research and Scholarship

No abstract provided.

Off The Page And Beyond Antiquity: Ancient Romance In Medieval Byzantine Silver, Alicia Walker

History of Art Faculty Research and Scholarship

No abstract provided.

Specific Objects: Lee Bontecou’S Steel And Canvas Reliefs, 1959-1964, Lesley E. Shipley

Bryn Mawr College Dissertations and Theses

This dissertation focuses on the reception and interpretation of the welded steel and canvas reliefs that the American artist Lee Bontecou created between 1959 and 1964.In Chapter 1,I present an overview of the initial critical reception of Bontecou’s steel and canvas reliefs, highlighting those exhibitions and texts from the first half of the 1960s that stand out as important records of this work’s reception. In Chapter 2, I examine the feminist claiming of Bontecou’s reliefs that occurred between 1965 and 1976.Here, I contextualize the feminist response to Bontecou’s art within its historical moment, in order to consider how feminism has …

Teaching Intersections, Not Assessments: Celebrating The Surprise Of Gift Giving And Gift Getting In The Cultural Commons, Anne Dalke, Alice Lesnick

Literatures in English Faculty Research and Scholarship

Unlike current assessment protocols, which emphasize prediction and control—often at the expense of engagement with the unknown, emergent, and new—we explore here our experiences as professors opening to surprise, in pedagogical interactions that have unpredictable outcomes. We imagine and advocate for institutional structures that, rather than predetermining goals and measuring how well we have achieved them, necessitate surprise and strengthen us to respond creatively and liberally to it. Without room for surprise, we argue, education is denied, and distorted by the loss of, one of its central energies: the circulation of the gifts of chance and serendipity.

The Hypoxia-Adenosine Link During Myocardial Ischemia—Reperfusion Injury, Diana Panesso, Maria C Montealegre, Sandra Rincón, Maria F Mojica, Louis B Rice, Kavindra V Singh, Barbara E Murray, Cesar A Arias

Faculty, Staff and Student Publications

BACKGROUND: Plasmids containing hylEfm (pHylEfm) were previously shown to increase gastrointestinal colonization and lethality of Enterococcus faecium in experimental peritonitis. The hylEfm gene, predicting a glycosyl hydrolase, has been considered as a virulence determinant of hospital-associated E. faecium, although its direct contribution to virulence has not been investigated. Here, we constructed mutants of the hylEfm-region and we evaluated their effect on virulence using a murine peritonitis model.

RESULTS: Five mutants of the hylEfm-region of pHylEfmTX16 from the sequenced endocarditis strain (TX16 [DO]) were obtained using an adaptation of the PheS* system and were evaluated in a commensal strain TX1330RF to …

Evaluation Of Mass Spectrometric Methods For Detection Of The Anti-Protozoal Drug Imidocarb, A. F. Lehner, J. A. Hitron, J. May, C. Hughes, R. Eisenberg, N. Schwint, D. P. Knowles, P. Timoney, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Imidocarb [N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea, C₁₉H₂₀N₆O₁, m.w. 348.41] is a symmetrical carbanilide derivative used to treat disease caused by protozoans of the Babesia genus. Imidocarb, however, is also considered capable of suppressing Babesia-specific immune responses, allowing Babesia-positive horses to pass a complement fixation test (CFT) without eliminating the infection. This scenario could enable Babesia-infected horses to pass CFT-based importation tests. It is imperative to unequivocally identify and quantify equine tissue residues of imidocarb by mass spectrometry to address this issue. As a pretext to development of sensitive tissue assays, we have investigated possibilities of mass …

Chronic Pulmonary Cavitary Tuberculosis In Rabbits: A Failed Host Immune Response, Selvakumar Subbian, Liana Tsenova, Guibin Yang, Paul O'Brien, Sven Parsons, Blas Peixoto, Leslie Taylor, Dorothy Fallows, Gilla Kaplan

Publications and Research

The molecular determinants of the immune response to Mycobacterium tuberculosis HN878 infection in a rabbit model of pulmonary cavitary tuberculosis were studied. Aerosol infection of rabbits resulted in a highly differentially expressed global transcriptome in the lungs at 2 weeks, which dropped at 4 weeks and then gradually increased. While IFNγ was progressively upregulated throughout the infection, several other genes in the IFNγ network were not. T-cell activation network genes were gradually upregulated and maximally induced at 12 weeks. Similarly, the IL4 and B-cell activation networks were progressively upregulated, many reaching high levels between 12 and 16 weeks. Delayed peak …

Public Access To Private Land For Walking: Environmental And Individual Responsibility As Rationale For Limiting The Right To Exclude, Heidi Gorovitz Robertson

Law Faculty Articles and Essays

Whether people have an independent right of access to walk on land they do not own is a question answered differently throughout the world, largely due to cultural, historical, and political variations amongst regions. In this decade, English citizens gained a legislated right to roam on privately owned land designated by the government for public access. The British government now designates land as access land by evaluating the nature of the land itself, not its ownership status. In Sweden, the right to roam on land owned by another has long been a deeply rooted cultural tradition, though not codified in …

Significant Inhibition Of Corneal Scarring In Vivo With Tissue-Selective, Targeted Aav5 Decorin Gene Therapy, Rajiv R. Mohan, Ashish Tandon, Ajay Sharma, John W. Cowden, Jonathan C. K. Tovey

Pharmacy Faculty Articles and Research

PURPOSE. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the stroma with adeno-associated virus serotype 5 (AAV5) inhibits corneal fibrosis in vivo without significant side effects.

METHODS. An in vivo rabbit model of corneal fibrosis was used. Targeted decorin gene therapy was delivered to the rabbit cornea by a single topical application of AAV5 (100 L; 6.5 1012 g/mL) onto the bare stroma for 2 minutes. The levels of corneal fibrosis were determined with stereomicroscopy, slit lamp biomicroscopy, -smooth muscle actin ( SMA), fibronectin, and F-actin immunocytochemistry, and/or immunoblotting. CD11b, F4/80 immunocytochemistry, and TUNEL assay …

Collagen Matrices As An Improved Model For In Vitro Study Of Live Cells Using Raman Microspectroscopy, Franck Bonnier, Peter Knief, Aidan Meade, Jennifer Dorney, Kunal Bhattacharya, Fiona Lyng, Hugh Byrne

Conference papers

Due to its high lateral resolution, Raman microspectrsocopy is rapidly becoming an accepted technique for the subcellular imaging of single cells. Although the potential of the technique has frequently been demonstrated, many improvements have still to be realised to enhance the relevancy of the data collected. Although often employed, chemical fixation of cells can cause modifications to the molecular composition and therefore influence the observations made. However, the weak contribution of water to Raman spectra offers the potential to study live cells cultured in vitro using an immersion lens, giving the possibility to record highly specific spectra from cells in …

Distributed Supply Chain Simulation Portal: Design And Implementation, Amr Arisha, Ayman Tobail, John Crowe

Conference papers

The emerging paradigm of eLearning is becoming increasingly in evidence across many academic disciplines acknowledging the concept that learning processes no longer support traditional teaching methods alone. It can be argued that today’s third level education students are part of a new virtual era where the blackboard has been replaced with an interactive whiteboard. To assist in the transition from traditional learning to eLearning, more interactive and virtually orientated teaching aids are needed. A simulation-based learning framework that integrates web-based simulation and a web content management hierarchy model is the key objective of this paper. Using the highly complex subject …

Voice, Listening And Social Justice: A Multimediated Engagement With New Immigrant Communities And Publics In Ireland, Alan Grossman

Conference Papers

No abstract provided.

A Vision Based Feedback Mechanism For 6-Dof Stewart Platform, Utku Büyükşahi̇n

Turkish Journal of Electrical Engineering and Computer Sciences

Eyes are the most ubiquitous sensors of humankind. However, ``Vision Based Sensors" are not as common as what this fact would suggest. A survey of the previous work on image processing would reveal that the bulk of the research in this area have been conducted since the year 2000. These facts clearly show that image processing is the technology of our century, and is very open to further development. In this work, a system that combines a classical mechanism of the 20th century with the recent technology of the 21st century is presented and the design, theoretical background, the software …

Sequence Analysis Of The Angiotensin Ii Type 1 Receptor (Agtr1) Gene For Mutations Contributing To Pulmonary Hypertension In The Chicken (Gallus Gallus), John Russell Burks

Inquiry: The University of Arkansas Undergraduate Research Journal

Our multidisciplinary group at the University of Arkansas has been investigating the suitability of the chicken as a medical model for pulmonary arterial hypertension (PAH) in humans. There are several forms of PAH in humans arising from elevated pulmonary arterial pressure and pulmonary vascular resistance. Spontaneous cases of PAH are known as idiopathic PAH (IPAH), where the exact physiological causes are not known. IPAH patients that do not respond to standard treatments have a prognosis of only a few years. Currently, there is no acceptable animal model for IPAH. As part of our effort to pursue the chicken as model …