Digital Commons Network^™

Joseph Hersey Pratt, M.D.: The Man Who Would Be Osler, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Joseph Hersey Pratt (1872-1956) was a member of the second class of the Johns Hopkins Medical School, where he became a devoted student of William Osler and life-long disciple. Pratt received his medical degree in 1898 and spent his professional career in Boston. He maintained a close association with Osler until the latter's death in 1919, when Osler's deification as a secular medical saint began. When Pratt died in 1956 at age 83, the Boston Globe eulogized him in an editorial which read, "Dr. Pratt earned a place in the group of Boston medical immortals who have done so much …

A New Hepato-Protective Flavone Glycoside From The Flowers Of Onopordum Alexandrinum Growing In Egypt, Maha Salama, Shahira Mohammed Ezzat

Pharmacy

A bioactivity-guided fractionation of the ethyl acetate fraction of the flowers of Onopordum alexandrinum L. (Asteraceae) yielded a new flavonoidal glycoside designated as acacetin-7-O-galacturonide (9), alongside with nine known flavonoids; 6-methoxy-apigenin (hispidulin) (1), acacetin (2), apigenin (3), luteolin (4), kaempferol (5), eriodictyol (6), apigenin-7-O-glucoside (7), luteolin-7-O-glucoside (8), and kaempferol-3-O-rutinoside (10). The compounds were assayed for their hepatoprotective activity against CCl4-induced hepatic cell damage in rats and free radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Compounds 4, 6, 9, and 10 have not been previously reported from flowers of O. alexandrinum L., and this is the first report of acacetin-7-O-galacturonide (9) in …

Temple Elements In Ancient Religious Communities, Brent J. Schmidt

BYU Studies

The idea of Zion or utopia has fascinated the human race since ancient times. This topic has special meaning to Mormons, since latter-day scripture revealed to Joseph Smith is replete with references to building Zion. What, then, can Latter-day Saints learn from attempts by other groups? One thing we learn, writes Brent Schmidt, is that certain characteristics appeared in some successful ancient communities, characteristics that invoke the temple as known in the Bible and in Latter-day Saint use.

Temple teachings were known and widely dispersed throughout antiquity as a means of forming good communities within religious groups. Indeed, temple themes …

Cxcr7 Antagonism Prevents Axonal Injury During Experimental Autoimmune Encephalomyelitis As Revealed By In Vivo Axial Diffusivity, Lillian Cruz-Orengo, Ying-Jr Chen, Joong Hee Kim, Denise Dorsey, Sheng-Kwei Song, Robyn S. Klein

Open Access Publications

No abstract provided.

Engraftment Of Insulin-Producing Cells From Porcine Islets In Non-Immune-Suppressed Rats Or Nonhuman Primates Transplanted Previously With Embryonic Pig Pancreas, Marc R. Hammerman

Open Access Publications

No abstract provided.

Dynamic Analysis Of Amyloid Β-Protein In Behaving Mice Reveals Opposing Changes In Isf Versus Parenchymal Aβ During Age-Related Plaque Formation, Soyon Hong, Omar Quintero-Monzon, Beth L. Ostaszewski, Daniel R. Podlisny, William T. Cavanaugh, Ting Yang, David M. Holtzman, John R. Cirrito, Dennis J. Selkoe

Open Access Publications

No abstract provided.

Micrornas Modulate Schwann Cell Response To Nerve Injury By Reinforcing Transcriptional Silencing Of Dedifferentiation-Related Genes, Andreu Viader, Li-Wei Chang, Timothy Fahrner, Rakesh Nagarajan, Jeffrey Milbrandt

Open Access Publications

No abstract provided.

Resorufin Analogs Preferentially Bind Cerebrovascular Amyloid: Potential Use As Imaging Ligands For Cerebral Amyloid Angiopathy, Byung Hee Han, Meng-Liang Zhou, Ananth K. Vellimana, Eric Milner, David H. Kim, Jacob K. Greenberg, Wenhua Chu, Robert H. Mach, Gregory J. Zipfel

Open Access Publications

No abstract provided.

Pregnancy In Multiple System Atrophy: A Case Report, Lirong Zhu, Nigel J. Cairns, Samer D. Tabbal, Brad A. Racette

Open Access Publications

No abstract provided.

Sequencing A Mouse Acute Promyelocytic Leukemia Genome Reveals Genetic Events Relevant For Disease Progression, Lukas D. Wartman, David E. Larson, Zhifu Xiang, Li Ding, Ken Chen, Ling Lin, Patrick Cahan, Jeffery M. Klco, John S. Welch, Cheng Li, Jacqueline E. Payton, Geoffrey L. Uy, Nobish Varghese, Rhonda E. Ries, Et Al.

Open Access Publications

No abstract provided.

Structural Correlates Of Cytoplasmic And Chloroplast Lipid Body Synthesis In Chlamydomonas Reinhardtii And Stimulation Of Lipid Body Production With Acetate Boost, Carrie Goodson, Robyn Roth, Zi Teng Wang, Ursula Goodenough

Open Access Publications

No abstract provided.

The Transcriptional Diversity Of 25 Drosophila Cell Lines, Marijke J. Van Baren, Laura Langton, Aaron E. Tenney, Michael R. Brent

Open Access Publications

No abstract provided.

Investigation Of A Pharmaceutical Compound With Artificial Streams: Effects Of The Antihistamine Cimetidine On Stream Ecosystem Function., Paul David Hoppe

Master's Theses

Pharmaceutical compounds have been widely detected in surface waters but their effects on stream ecosystems are unknown. Cimetidine (Tagamet®), a widely used H2 histamine antagonist has been detected in surface waters. To measure chronic effects of cimetidine on stream invertebrates, I conducted a long-term (83d) artificial-stream experiment. A range of cimetidine concentrations (0.07 μg L-1 to 70.0 μg L-1) were added to streams supporting populations of the amphipod Gammarus fasciatus and beetle Psephenus herricki. P. herricki individual growth rates were reduced in the presence of cimetidine, but G. fasciatus individual growth rates were not different among treatments. G. fasciatus size …

The Highest Good And The Best Activity: Aristotle On The Well-Lived Life, Philip William Bauchan

Master's Theses

The question of how Aristotle characterizes eudaimonia, or living-well, in the Nicomachean Ethics has long been a contentious issue amongst Aristotelian scholars. The secondary literature has been roughly divided between inclusivist readers, who argue that Aristotle designates both theoria, or contemplation, and the practical virtues, and exclusivist readers, who argue that Aristotle singles out theoria alone. This thesis seeks to forge a middle ground between these two perspectives by focusing on the central claim of Book I that the eudaimonia is virtuous activity. Reading Book X in light of Book I's claim then allows one to show that both the …

Pterin Chemistry And Its Relationship To The Molybdenum Cofactor, Partha Basu, Sharon J. Nieter Burgmayer

Chemistry Faculty Research and Scholarship

The molybdenum cofactor is composed of a molybdenum coordinated by one or two rather complicated ligands known as either molybdopterin or pyranopterin. Pterin is one of a large family of bicyclic N-heterocycles called pteridines. Such molecules are widely found in Nature, having various forms to perform a variety of biological functions. This article describes the basic nomenclature of pterin, their biological roles, structure, chemical synthesis and redox reactivity. In addition, the biosynthesis of pterin sand current models of the molybdenum cofactor are discussed.

Video-Rate Fluorescence Diffuse Optical Tomography For In Vivo Sentinel Lymph Node Imaging, Metasebya Solomon, Brian R. White, Ralph E. Nothdruft, Walter Akers, Gail Sudlow, Adam T. Eggebrecht, Samuel Achilefu, Joseph P. Culver

Open Access Publications

No abstract provided.

Study Of Rotational Dynamics Of Receptor-Targeted Contrast Agents In Cancerous And Normal Prostate Tissues Using Time-Resolved Picosecond Emission Spectroscopy, Yang Pu, Wubao B. Wang, Samuel Achilefu, Robert R. Alfano

Open Access Publications

No abstract provided.

Dietary Carbohydrate Modifies The Inverse Association Between Saturated Fat Intake And Cholesterol On Very Low-Density Lipoproteins, A. C. Wood, E. K. Kabagambe, I. B. Borecki, H. K. Tiwari, J. M. Ordovas, D. K. Arnett

Open Access Publications

No abstract provided.

Tnf-Stimulated Map Kinase Activation Mediated By A Rho Family Gtpase Signaling Pathway, Shashi Kant, Wojciech Swat, Sheng Zhang, Zhong-Yin Zhang, Benjamin G. Neel, Richard A. Flavell

Open Access Publications

No abstract provided.

Fine-Tuning P53 Activity Through C-Terminal Modification Significantly Contributes To Hsc Homeostasis And Mouse Radiosensitivity, Yunyuan V. Wang, Mathias Leblanc, Norma Fox, Jian-Hua Mao, Kelsey L. Tinkum, Kurt Krummel, Dannielle Engle, David Piwnica-Worms, Helen Piwnica-Worms, Allan Balmain, Kenneth Kaushanszy, Geoffrey M. Wahl

Open Access Publications

No abstract provided.

The Nuclear Receptor Pparβ/Δ Programs Muscle Glucose Metabolism In Cooperation With Ampk And Mef2, Zhenji Gan, Eileen M. Burkart-Hartman, Dong-Ho Han, Brian Finck, Teresa C. Leone, Emily Y. Smith, Julio E. Ayala, John Holloszy, Daniel P. Kelly

Open Access Publications

No abstract provided.

Detection Of Blast-Related Traumatic Brain Injury In U.S. Military Personnel, Christine L. Mac Donald, Ann M. Johnson, Dana Cooper, Elliot C. Nelson, Nicole J. Werner, Joshua S. Shimony, Abraham Z. Synder, Marcus E. Raichle, David L. Brody, John R. Witherow, Raymond Fang, Stephen F. Flaherty

Open Access Publications

No abstract provided.

Type I Interferon Negatively Controls Plasmacytoid Dendritic Cell Numbers In Vivo, Melissa Swiecki, Yaming Wang, William Vermi, Susan Gilfillan, Robert D. Schreiber, Marco Colonna

Open Access Publications

No abstract provided.

The Mammalian Cone Visual Cycle Promotes Rapid M/L-Cone Pigment Regeneration Independently Of The Interphotoreceptor Retinoid-Binding Protein, Alexander V. Kolesnikov, Peter H. Tang, Ryan O. Parker, Rosalie K. Crouch, Vladimir J. Kefalov

Open Access Publications

No abstract provided.

Critical Role Of Astroglial Apolipoprotein E And Liver X Receptor-Α Expression For Microglial Aβ Phagocytosis, Dick Terwel, Knut R. Steffensen, Philip B. Verghese, Markus P. Kummer, Jan-Åke Gustafsson, David M. Holtzman, Michael T. Heneka

Open Access Publications

No abstract provided.

Specification Of A Foxj1-Dependent Lineage In The Forebrain Is Required For Embryonic-To-Postnatal Transition Of Neurogenesis In The Olfactory Bulb, Benoit V. Jacquet, Nagendran Muthusamy, Laura J. Sommerville, Guanxi Xiao, Huixuan Liang, Yong Zhang, Michael J. Holtzman, H. T. Ghashghaei

Open Access Publications

No abstract provided.

A Sensitive High-Throughput Assay For Evaluating Host-Pathogen Interactions In Cryptococcus Neoformans Infection, Deepa Srikanta, Meng Yang, Matthew Williams, Tamara L. Doering

Open Access Publications

No abstract provided.

Opposing Synaptic Regulation Of Amyloid-Β Metabolism By Nmda Receptors In Vivo, Deborah K. Verges, Jessica L. Restivo, Whitney D. Goebel, David M. Holtzman, John R. Cirrito

Open Access Publications

No abstract provided.

Exenatide Improves Glucose Homeostasis And Prolongs Survival In A Murine Model Of Dilated Cardiomyopathy, Arpita Kalla Vyas, Kai-Chen Yang, Dennis Woo, Anatoly Tzekov, Attila Kovacs, Patrick Y. Jay, Paul W. Hruz

Open Access Publications

No abstract provided.

Interferon Regulatory Factor-1 (Irf-1) Shapes Both Innate And Cd8⁺ T Cell Immune Responses Against West Nile Virus Infection, James D. Brien, Stephane Daffis, Helen M. Lazear, Hyelim Cho, Mehul S. Suthar, Michael Gale Jr, Michael S. Diamond

Open Access Publications

No abstract provided.