Digital Commons Network^™

Heller's Gridlock Economy In Perspective: Why There Is Too Little, Not Too Much Private Property, Richard A. Epstein

Articles

This Article critiques Michael Heller's important contribution in The Gridlock Economy. At no point does this Article take the position that gridlock, or the associated anticommons, is not a serious issue in the design of a legal system. But gridlock is not the major source of social dislocation; nor is private ownership the major source of gridlock. More concretely, this Article examines the other important sources of economic distortion that are unrelated to economic gridlock from private action. These include the use of excessive government subsidies (as with health care); misguided government licenses (as with broadcast licenses); the unwise use …

Wikileaks And The First Amendment (Fcba Distinguished Speaker Series), Geoffrey R. Stone

Articles

No abstract provided.

What Controls Toxic Phytoplankton Blooms In Long Island Sound?, Hans G. Dam Ph.D., Michael Finiguerra, Christina Senft-Batoh, Haley Flores

Wrack Lines

TIny phytoplankton organisms known as dinoflagellates can accumulate and cause toxic blooms that can kill fish and even make people ill. It's rare in Long Island Sound but can happen. What drives this phenomenon? Professor Hans G. Dam and his lab team explain in this easy-to-understand article.

Unrequited Love, Destinee Paynter

The Angle

No abstract provided.

Full Issue, No Author

The Angle

No abstract provided.

Nationalism In The Era Of The Nation State, 1870-1945, Pieter M. Judson

History Faculty Works

No abstract provided.

Birth And Weaning Traits In Crossbred Cattle From Hereford, Angus, Brahman, Boran, Tuli, And Belgian Blue Sires, E. Casas, R. M. Thallman, L. V. Cundiff

Roman L. Hruska U.S. Meat Animal Research Center: Reports

The objective of this study was to characterize breeds representing diverse biological types for birth and weaning traits in crossbred cattle. Gestation length, calving difficulty, percentage of unassisted calving, percentage of perinatal survival, percentage of survival from birth to weaning, birth weight, BW at 200 d, and ADG were measured in 2,500 calves born and 2,395 calves weaned. Calves were obtained by mating Hereford, Angus, and U.S. Meat Animal Research Center III (one-fourth Hereford, one-fourth Angus, one-fourth Pinzgauer, and one-fourth Red Poll) mature cows to Hereford or Angus (British breed), Brahman, Tuli, Boran, and Belgian Blue sires. Calves were born …

Penitence, M. Therese Lysaught

Institute of Pastoral Studies: Faculty Publications and Other Works

No abstract provided.

Fragments Of The Historical Jesus: A Reading Of Mark 11,11-[26], Edmondo Lupieri

Theology: Faculty Publications and Other Works

No abstract provided.

The Rock 2011, School Of Engineering And Computer Science

The Rock

No abstract provided.

Pay Attention! Can The Type Of Interaction Between Handler And Dog Preceding An Agility Run Affect A Dog’S Attention During A Run?, Jillian Faustino

Undergraduate Review

There has been an increase of interest in investigating human-dog interactions in recent years. One area of interest for dog owners and animal behaviorists is how interactions and play between humans and dogs affect performance on object choice and detour tasks (Rooney & Bradshaw, 2002, Rooney & Bradshaw, 2003, Schwab & Huber, 2006, Pongracz, Miklosi, Timar-Geng, & Csanyi, 2004, Call, Brauer, Kaminski & Tomasell, 2003). Previous research has suggested that play (a pleasurable game or activity which involves both humans and dogs, such as tug-of-war or fetch) is a very important part in a dog’s social, cognitive and motor development …

An Enlightened Woman: Judith Sargent Murray And The Call To Equality, Mary Hughes

Undergraduate Review

The political and social upheaval of 18th century America is well documented in the writings of many great thinkers of that time. As the Age of Enlightenment stirred debate in many quarters, causing men like Thomas Jefferson to ponder the merits of equality among men, so too did it inspire women to question their own status in an emerging American culture. A little-known writer named Judith Sargent Murray emerged as an early contributor to the discussions of the role women in a changing society. The Sargent family’s openness to the study of a progressive faith, Universalism, and rejection of status …

A Noneuclidean Universe, Frank A. Farris

Mathematics and Computer Science

Let us construct a hypothetical universe, if for no other reason than to challenge our preconceptions about space. We call it a noneuclidean universe because it contradicts some of the notions central to euclidean geometry, where, for instance, the angle measures in a triangle add up to 180 degrees. There are many noneuclidean universes; ours is of a type called hyperbolic. This hypothetical universe has been constructed before. It is often called the Poincaré Upper Halfplane, in honor of French mathematician Henri Poincaré (1854-1912). I admire Poincaré because he is said to have been the last person in the world …

Structure Function Analysis Of An Adp-Ribosyltransferase Type Iii Effector And Its Rna-Binding Target In Plant Immunity, Byeong-Ryool Jeong, Yan Lin, Anna Joe, Ming Guo, Christin Korneli, Huirong Yang, Ping Wang, Min Yu, Ronald Cerny, Dorothee Staiger, James R. Alfano, Yanhui Xu

Ronald Cerny Publications

Background: HopU1 ADP-ribosylates GRP7, suppressing plant immunity.

Results: The HopU1 structure has two novel loops required for GRP7 recognition, and HopU1 ribosylates GRP7 at an arginine in position 49 disrupting its function.

Conclusion: HopU1 targets a conserved arginine in GRP7, disabling its ability to bind immunity-related RNA.

Significance: The mechanistic details of how HopU1 recognizes its substrate reveal how HopU1 contributes to pathogenesis.

Distribution Of Culicoides Sonorensis (Diptera: Ceratopogonidae) In Nebraska, South Dakota, And North Dakota: Clarifying The Epidemiology Of Bluetongue Disease In The Northern Great Plains Region Of The United States, E. T. Schmidtmann, M. V. Herrero, A. L. Green, D. A. Dargatz, J. M. Rodriquez, T. E. Walton

Zoonotics and Wildlife Disease: Publications

The presence or absence of the biting midge Culicoides sonorensis Wirth & Jones (Diptera: Ceratopogonidae), a primary vector of bluetongue viruses (genus Orbivirus, family Reoviridae, BTV) in North America, was assessed on ranches and farms across the Northern Great Plains region of the United States, specifically Nebraska, South Dakota, and North Dakota, as part of a 2-yr regional study of BTV exposure among cattle. Blacklight/suction trap samples totaling 280 2-night intervals were taken at 140 aquatic sites (potential larval habitat for C. sonorensis) on 82 livestock operations (ranches and farms) that span a south-to-north gradient of expected decreasing …

Bovine Tuberculosis In A Nebraska Herd Of Farmed Elk And Fallow Deer: A Failure Of The Tuberculin Skin Test And Opportunities For Serodiagnosis, W. Ray Waters, Gary E. Stevens, Mark A. Schoenbaum, Kathy A. Orloski, Suelee Robbe-Austerman, N. Beth Harris, S. Mark Hall, Bruce V. Thomsen, Arach J. Wilson, Roger E. Brannian, Jeffrey T. Nelson, Shawn Schafer, Javan Esfandiari, Meghan Dutton, Rena Greenwald, Konstantin P. Lyashchenko

Zoonotics and Wildlife Disease: Publications

In 2009, Mycobacterium bovis infection was detected in a herd of 60 elk (Cervus elaphus) and 50 fallow deer (Dama dama) in Nebraska, USA. Upon depopulation of the herd, the prevalence of bovine tuberculosis (TB) was estimated at ∼71–75%, based upon histopathology and culture results. Particularly with elk, gross lesions were often severe and extensive. One year ago, the majority of the elk had been tested for TB by single cervical test (SCT), and all were negative. After initial detection of a tuberculous elk in this herd, 42 of the 59 elk were tested by SCT. …

Automated Analysis Of Mouse Serum Peptidome Using Restricted Access Media And Nanoliquid Chromatography–Tandem Mass Spectrometry, Geun-Cheol Gil, Jim Brennan, Dan Throckmorton, Steven Branda, Gabriela Chirica

United States Department of Energy: Publications

We demonstrate use of restricted access media with reversed phase functionality (RAM-RP) for analysis of low molecular weight proteins and peptides in mouse serum (75ml) using a custom designed modular automated processing system (MAPS). RAM-RP fractionation with simultaneous removal of high molecular weight and high abundance proteins is integrated with a follow-on buffer exchange module (BE) to ensure compatibility with subsequent processing steps (trypsin digestion and intact peptide separation prior to mass spectrometric analysis). The high sample capacity afforded by chromatographic methods generates enough sample to achieve comprehensive serum peptidome identification (357 proteins) through tandem mass spectrometric analysis of both …

Modification Of Native Grasses For Biofuel Production May Increase Virus Susceptibility, Abbie C. Schrotenboer, Michael S. Allen, Carolyn M. Malmstrom

United States Department of Energy: Publications

Bioenergy production is driving modifications to native plant species for use as novel biofuel crops. Key aims are to increase crop growth rates and to enhance conversion efficiency by reducing biomass recalcitrance to digestion. However, selection for these biofuel-valuable traits has potential to compromise plant defenses and alter interactions with pests and pathogens. Insect-vectored plant viruses are of particular concern because perennial crops have potential to serve as virus reservoirs that influence regional disease dynamics. In this study, we examined relationships between growth rates and biomass recalcitrance in five switchgrass (Panicum virgatum) populations, ranging from near wild type …

Ecosystem Services Altered By Human Changes In The Nitrogen Cycle: A New Perspective For Us Decision Making, Jana E. Compton, John A. Harrison, Robin L. Dennis, Tara L. Greaver, Brian H. Hill, Stephen J. Jordan, Henry Walker, Holly V. Campbell

United States Environmental Protection Agency: Publications

Human alteration of the nitrogen (N) cycle has produced benefits for health and well-being, but excess N has altered many ecosystems and degraded air and water quality. US regulations mandate protection of the environment in terms that directly connect to ecosystem services. Here, we review the science quantifying effects of N on key ecosystem services, and compare the costs of N-related impacts or mitigation using the metric of cost per unit of N. Damage costs to the provision of clean air, reflected by impaired human respiratory health, are well characterized and fairly high (e.g. costs of ozone and particulate damages …

Toxicity And Recovery In The Pregnant Mouse After Gestational Exposure To The Cyanobacterial Toxin, Cylindrospermopsin, N. Chernoff, E. H. Rogers, R. D. Zehr, M. I. Gage, D. E. Malarkey, C. A. Bradfield, Y. Liu, J. E. Schmid, R. H. Jaskot, J. H. Richards, C. R. Wood, M. B. Rosen

United States Environmental Protection Agency: Publications

Cylindrospermopsin (CYN) is a tricyclic alkaloid toxin produced by fresh water cyanobacterial species worldwide. CYN has been responsible for both livestock and human poisoning after oral exposure. This study investigated the toxicity of CYN to pregnant mice exposed during different segments of gestation. The course of recovery and individual responses to the toxin were evaluated. Adverse effects of CYN were monitored up to 7 weeks post-dosing by clinical examination, histopathology, biochemistry and gene expression. Exposure on gestational days (GD) 8–12 induced significantly more lethality than GD13–17 exposure. Periorbital, gastrointestinal and distal tail hemorrhages were seen in both groups. Serum markers …

Maternal Influences On Epigenetic Programming Of The Developing Hypothalamic-Pituitary-Adrenal Axis, Curtis E. Grace, Sung-Je Kim, John M. Rogers

United States Environmental Protection Agency: Publications

Parental and environmental factors during the prenatal and postnatal periods permanently affect the physiology and metabolism of offspring, potentially increasing disease risk later in life. Underlying mechanisms are being elucidated, and effects on a number of organs and metabolic pathways are likely involved. In this review, we consider effects on the developing hypothalamic-pituitary-adrenal (HPA) axis, which may represent a common pathway for developmental programming. The focus is on prenatal and early postnatal development, during which the HPA axis may be programmed in a manner that affects health for a lifetime. Programming of the HPA axis involves, at least in part, …

Current And Future Needs For Developmental Toxicity Testing, Susan L. Makris, James H. Kim, Amy Ellis, Willem Faber, Wafa Harrouk, Joseph M. Lewis, Merle G. Paule, Jennifer Seed, Melissa Tassinari, Rochelle Tyl

United States Environmental Protection Agency: Publications

A review is presented of the use of developmental toxicity testing in the United States and international regulatory assessment of human health risks associated with exposures to pharmaceuticals (human and veterinary), chemicals (agricultural, industrial, and environmental), food additives, cosmetics, and consumer products. Developmental toxicology data are used for prioritization and screening of pharmaceuticals and chemicals, for evaluating and labeling of pharmaceuticals, and for characterizing hazards and risk of exposures to industrial and environmental chemicals. The in vivo study designs utilized in hazard characterization and dose-response assessment for developmental outcomes have not changed substantially over the past 30 years and have …

Aryl Hydrocarbon Receptor Activation During Pregnancy, And In Adult Nulliparous Mice, Delays The Subsequent Development Of Dmba-Induced Mammary Tumors, Tao Wang, Heather M. Gavin, Volker M. Arlt, B. Paige Lawrence, Suzanne E. Fenton, Daniel Medina, Beth A. Vorderstrasse

United States Environmental Protection Agency: Publications

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the prototypic ligand for the aryl hydrocarbon receptor (AhR), promotes tumor formation in some model systems. However, with regard to breast cancer, epidemiological and animal studies are inconclusive as to whether exposure increases tumor incidence or may instead be protective. We have previously reported that mice exposed to TCDD during pregnancy have impaired differentiation of mammary tissue, including decreased branching and poor development of lobuloalveolar structures. Because normal pregnancy-induced mammary differentiation may protect against subsequent neoplastic transformation, we hypothesized that TCDD-treated mice would be more susceptible to chemical carcinogenesis after parturition. To test this, mice were …

Evolution Of Natural History Information In The 21st Century – Developing An Integrated Framework For Biological And Geographical Data, Deborah A. Reusser, Henry Lee Ii

United States Environmental Protection Agency: Publications

Threats to marine and estuarine species operate over many spatial scales, from nutrient enrichment at the watershed/estuarine scale to invasive species and climate change at regional and global scales. To help address research questions across these scales, we provide here a standardized framework for a biogeographical information system containing queriable biological data that allows extraction of information on multiple species, across a variety of spatial scales based on species distributions, natural history attributes and habitat requirements. As scientists shift from research on localized impacts on individual species to regional and global scale threats, macroecological approaches of studying multiple species over …

Effects Of Biologically-Active Chemical Mixtures On Fish In A Wastewater-Impacted Urban Stream, Larry B. Barber, Gregory K. Brown, Todd G. Nettesheim, Elizabeth W. Murphy, Stephen E. Bartell, Heiko L. Schoenfuss

United States Environmental Protection Agency: Publications

Stream flow in urban aquatic ecosystems often is maintained by water-reclamation plant (WRP) effluents that contain mixtures of natural and anthropogenic chemicals that persist through the treatment processes. In effluent-impacted streams, aquatic organisms such as fish are continuously exposed to biologically-active chemicals throughout their life cycles. The North Shore Channel of the Chicago River (Chicago, Illinois) is part of an urban ecosystem in which >80% of the annual flow consists of effluent from the North Side WRP. In this study, multiple samplings of the effluent and stream water were conducted and fish (largemouth bass and carp) were collected on 2 …

Web-Based Automated Remediation Performance Monitoring And Visualization Of Contaminant Mass Flux And Discharge, Mark L. Kram, Steve Airhart, Daniel Tyler, Amy Dindal, Andrew Barton, John L. Mckernan, Gregg Gustafson

United States Environmental Protection Agency: Publications

Environmental monitoring, data processing, and reporting methods are expensive, labor- and resource-intensive, time-consuming, and often inaccurate. An innovative project management platform was developed for integrating environmental monitoring sensors, telemetry, geographical information systems, models, and geostatistical algorithms for automatically generating contour maps and time-stamped renderings of sensor attributes and multivariate analyses.More specifically, algorithms converting sensor-derived head and solute concentration values allow for automated monitoring of mass flux and discharge to evaluate groundwater remediation system performance and contaminant discharges from aquifers to surface-water receptors. Life-cycle costs and carbon footprints were reduced due to the elimination of energy and labor expenditures associated with …

Use Of Comparative Genomics Approaches To Characterize Interspecies Differences In Response To Environmental Chemicals: Challenges, Opportunities, And Research Needs, Sarah L. Burgess-Herbert, Susan Y. Euling

United States Environmental Protection Agency: Publications

A critical challenge for environmental chemical risk assessment is the characterization and reduction of uncertainties introduced when extrapolating inferences from one species to another. The purpose of this article is to explore the challenges, opportunities, and research needs surrounding the issue of how genomics data and computational and systems level approaches can be applied to inform differences in response to environmental chemical exposure across species. We propose that the data, tools, and evolutionary framework of comparative genomics be adapted to inform interspecies differences in chemical mechanisms of action. We compare and contrast existing approaches, from disciplines as varied as evolutionary …

Integrating Mechanistic And Polymorphism Data To Characterize Human Genetic Susceptibility For Environmental Chemical Risk Assessment In The 21st Century, Holly M. Mortensen, Susan Y. Euling

United States Environmental Protection Agency: Publications

Response to environmental chemicals can vary widely among individuals and between population groups. In human health risk assessment, data on susceptibility can be utilized by deriving risk levels based on a study of a susceptible population and/or an uncertainty factor may be applied to account for the lack of information about susceptibility. Defining genetic susceptibility in response to environmental chemicals across human populations is an area of interest in the NAS' new paradigm of toxicity pathway-based risk assessment. Data from highthroughput/ high content (HT/HC), including -omics (e.g., genomics, transcriptomics, proteomics, metabolomics) technologies, have been integral to the identification and characterization …

Isolation And Transcriptome Analysis Of Adult Zebrafish Cells Enriched For Skeletal Muscle Progenitors, Matthew S. Alexander, Genri Kawahara, Alvin T. Kho, Melanie H. Howell, Timothy J. Pusack, Jennifer A. Myers, Federica Monanaro, Leonard I. Zon, Jeffrey R. Guyon, Louis M. Kunkel

United States Department of Commerce: Staff Publications

Introduction: Over the past 10 years, the use of zebrafish for scientific research in the area of muscle development has increased dramatically. Although several protocols exist for the isolation of adult myoblast progenitors from larger fish, no standardized protocol exists for the isolation of myogenic progenitors from adult zebrafish muscle.

Methods: Using a variant of a mammalian myoblast isolation protocol, zebrafish muscle progenitors have been isolated from the total dorsal myotome. These zebrafish myoblast progenitors can be cultured for several passages and then differentiated into multinucleated, mature myotubes.

Results: Transcriptome analysis of these cells during myogenic differentiation revealed a strong …

Small-Scale Fisheries Of Peru: A Major Sink For Marine Turtles In The Pacific, Joanna Alfaro-Shigueto, Jeffrey C. Mangel, Francisco Bernedo, Peter H. Dutton, Jeffrey A. Seminoff, Brendan J. Godley

United States Department of Commerce: Staff Publications

1. Over the last few decades, evidence of marine vertebrate bycatch has been collected for a range of industrial fisheries. It has recently been acknowledged that large impacts may also result from similar interactions with small-scale fisheries (SSF) due largely to their diffuse effort and large number of vessels in operation. Marine mammals, seabirds, turtles as well as some shark species have been reported as being impacted by SSF worldwide.

2. From 2000 to 2007, we used both shore-based and onboard observer programmes from three SSF ports in Peru to assess the impact on marine turtles of small-scale longline, bottom …